Browsing toxins
Showing 1-10 out of 3023
T3DB ID  |
Name CAS Number |
Formula Weight |
Structure | Compound Type | Mechanism of Action |
|---|---|---|---|---|---|
T3D0001
|
Arsenic 7440-38-2 |
[As]3+ 74.921600 |
 |
|
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing ... |
| T3D0002
|
Lead 7439-92-1 |
[Pb]2+ 207.976654 |
 |
|
Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example, lead ha... |
| T3D0003
|
Mercury 7439-97-6 |
[Hg]2+ 201.970642 |
 |
|
High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterat... |
| T3D0004
|
Vinyl chloride 75-01-4 |
C2H3Cl 61.992330 |
|
Vinyl chloride poisoning exhibits many of the characteristics of autoimmune diseases. This is believed to be the result of a reactive vinyl chloride intermediate metabolite bi... | |
| T3D0006
|
Benzene 71-43-2 |
C6H6 78.046950 |
|
The toxic agents of benzene are its metabolites. Benzene is able increase its toxicity by inducing cytochrome P450 2E1, its main metabolic enzyme. Benzene's primary toxic effe... | |
| T3D0007
|
Cadmium 7440-43-9 |
[Cd]2+ 113.903358 |
 |
|
Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothio... |
| T3D0009
|
Benzo[a]pyrene 50-32-8 |
C20H12 252.093900 |
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 enzymes, ... | |
| T3D0010
|
Benzo[b]fluoranthene 205-99-2 |
C20H12 252.093900 |
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 enzymes, ... | |
| T3D0011
|
Chloroform 67-66-3 |
CHCl3 117.914380 |
 |
|
Chloroform and the reactive intermediates of chloroform metabolism, especially phosgene, bind covalently and irreversibly to cellular macromolecules and cause cellular damage ... |
| T3D0012
|
P,P'-DDT 50-29-3 |
C14H9Cl5 351.914690 |
|
DDT toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDT reduces potassium transport across the membrane. DDT inhibits the inactivation o... |
Showing 1-10 out of 3023