Showing toxin card for Mercury (T3D0003)

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Version	1.0
Creation Date	2009-03-06 18:57:54
Update Date	2010-03-18 21:52:14
Accession Number	T3D0003
Name	Mercury
Compound Type	Cosmetic Toxin Inorganic Compound Mercury Compound Metal
Description	A heavy, silvery d-block metal, mercury is one of six elements that are liquid at or near room temperature and pressure. It is a naturally occuring substance, and combines with other elements such as chlorine, sulfur, or oxygen to form inorganic mercury compounds (salts). Mercury also combines with carbon to make organic mercury compounds. It is mostly obtained by reduction from the mineral cinnabar. (R005)
Synonyms	Azogue Blue mass Colloidal mercury Hydrargyrum Kwik [dutch] Liquid silver Marcero Mercure [french] Mercurio [italian] Mercury vapor Elemental mercury Elemental and inorganic forms mercury Metallic mercury Vapor Mercury Quecksilber [german]Quick silver Rtec [polish] mercury(0)
Chemical IUPAC Name	mercury(2+) ion
Chemical Formula	Hg
Chemical Structure
CAS Registry Number	7439-97-6
InChI Identifier	InChI=1S/Hg/q+2
InChI Key	InChIKey=BQPIGGFYSBELGY-UHFFFAOYSA-N
PubChem Compound ID	23931
KEGG ID	C01319
UniProt ID	Not Available
OMIM ID	Not Available
ChEBI ID	16170
BioCyc ID	CPD-29
SuperToxic ID	Not Available
CTD ID	D008628
Stitch ID	Mercury
DrugBank ID	Not Available
PDB ID	Not Available
ACToR ID	6477
Wikipedia Link	http://en.wikipedia.org/wiki/Mercury
Monoisotopic Mass	201.970626
MOL File	Show
PDB File	Show
SDF File	Show
SMILES	[Hg++]
Appearance	Silver metallic liquid.
Melting Point	-38.8 °C
Solubility	6e-05 mg/mL at 25 °C [ROSENBLATT,DH et al. (1975)]
Predicted LogP	0.62
Route of Exposure	Inhalation (R022) ; oral (R022)
Mechanism of Action	High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (R022, R025, R066, R067)
Metabolism	Mercury is absorbed mainly via ingestion and inhalation, then distributed throughout the body via the bloodstream, where a portion binds to sulfhydryl groups on haemoglobin. Being lipid soluble, mercury vapor readily enters the red blood cells and the central nervous system following inhalation exposure. Once inside the cell, mercury vapor can undergo oxidation to mercuric mercury, which takes place via the catalase–hydrogen peroxide pathway. The mercury atom is able to diffuse down the cleft in the catalase enzyme to reach the active site where the heme ring is located. Oxidation most likely occurs in all tissue, as the catalase hydrogen peroxide pathway is ubiquitous. Following oxidation, mercury tends to accumulate in the kidneys. Organic and elemental mercury can also penetrate the placenta and blood-brain barrier, and thus also accumulate in the brain. Mercury is excreted mainly by exhalation and in the faeces. (R021, R022)
Toxicity Values	Not Available
Lethal Dose	1 to 4 grams or 14 to 57 mg/kg for a 70-kg adult human. (R024)
Carcinogenicity (IARC Classification)	3, not classifiable as to its carcinogenicity to humans. (R264)
Uses/Sources	Metallic mercury is used to produce chlorine gas and caustic soda. It is also used in thermometers, dental fillings, and batteries. Mercury salts are sometimes used in skin lightening creams and as antiseptic creams and ointments. (R022)
Minimum Risk Level	Chronic Inhalation: 0.0002 mg/m3 (R260)
Health Effects	Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (R022)
Symptoms	Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (R020)
Treatment	Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (R023)
General References	R023 - Clifton JC 2nd: Mercury exposure and public health. Pediatr Clin North Am. 2007 Apr;54(2):237-69, viii. [PubMed ] R024 - US Environmental Protection Agency (1994). Summary Review of Health Effects Associated with Mercuric Chloride: Health Issue Assessment. EPA/600/R-92/199. Washington, DC: Office of Health and Environmental Assessment. R066 - Ziemba SE, Menard SL, McCabe MJ Jr, Rosenspire AJ: T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury. FASEB J. 2009 Jun;23(6):1663-71. Epub 2009 Jan 23. [PubMed ] R057 - Wikipedia. Mercury poisoning. Last Updated 8 March 2009. R005 - Fred Senese (2005). "Why is mercury a liquid at STP?". General Chemistry Online at Frostburg State University. R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. R025 - Madsen KM, Christensen EI: Effects of mercury on lysosomal protein digestion in the kidney proximal tubule. Lab Invest. 1978 Feb;38(2):165-74. [PubMed ] R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ] R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R164 - Wikipedia. Metallothionein. Last Updated 20 December 2008. R020 - Horowitz Y, Greenberg D, Ling G, Lifshitz M: Acrodynia: a case report of two siblings. Arch Dis Child. 2002 Jun;86(6):453. [PubMed ] R021 - Clarkson TW, Magos L: The toxicology of mercury and its chemical compounds. Crit Rev Toxicol. 2006 Sep;36(8):609-62. [PubMed ] R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Targets	Alkaline phosphatase, tissue-nonspecific isozyme Aquaporin-1 Aquaporin-10 Aquaporin-11 Aquaporin-12A Aquaporin-12B Aquaporin-2 Aquaporin-3 Aquaporin-4 Aquaporin-5 Aquaporin-6 Aquaporin-7 Aquaporin-8 Aquaporin-9 Lens fiber major intrinsic protein Protein kinase C alpha type Protein kinase C beta type Protein kinase C delta type Protein kinase C epsilon type Protein kinase C eta type Protein kinase C gamma type Protein kinase C iota type Protein kinase C theta type Protein kinase C zeta type Proto-oncogene tyrosine-protein kinase LCK Putative tubulin beta chain-like protein ENSP00000290377 Putative tubulin beta-4q chain Putative tubulin-like protein alpha-4B Tubulin alpha chain-like 3 Tubulin alpha-1A chain Tubulin alpha-1B chain Tubulin alpha-1C chain Tubulin alpha-3C/D chain Tubulin alpha-3E chain Tubulin alpha-4A chain Tubulin alpha-8 chain Tubulin beta chain Tubulin beta-1 chain Tubulin beta-2A chain Tubulin beta-2B chain Tubulin beta-2C chain Tubulin beta-3 chain Tubulin beta-4 chain Tubulin beta-6 chain Tubulin beta-8 chain Tubulin beta-8 chain B Tubulin delta chain Tubulin epsilon chain Tubulin gamma-1 chain Tubulin gamma-2 chain

Target 1 [top]

Target 1 ID

272

Target 1 Name

Alkaline phosphatase, tissue-nonspecific isozyme

Target 1 Mechanism of Action

Mercury affects the nervous system by inhibiting alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 1 Description

This isozyme may play a role in skeletal mineralization

Target 1 Synonyms

AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme

Target 1 Gene Name

ALPL

Target 1 Protein Sequence

>Alkaline phosphatase, tissue-nonspecific isozyme

MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

Target 1 Number of Residues

524

Target 1 Molecular Weight

57304.4

Target 1 Theoretical pI

6.66

Target 1 GO Classification

Function
Not Available
Process
physiological process metabolism
Component
Not Available

Target 1 General Function

Inorganic ion transport and metabolism

Target 1 Pathways

Not Available

Target 1 Reactions

Not Available

Target 1 Signals

1-17

Target 1 Transmembrane Regions

None

Target 1 Essentiality

Non Essential

Target 1 Domain Function

PF00245:Alk_phosphatase

Target 1 GenBank ID Protein

Not Available

Target 1 UniProtKB ID

P05186

Target 1 Cellular Location

Cell membrane

Target 1 Gene Sequence

>1575 bp

ATGATTTCACCATTCTTAGTACTGGCCATTGGCACCTGCCTTACTAACTCCTTAGTGCCA
GAGAAAGAGAAAGACCCCAAGTACTGGCGAGACCAAGCGCAAGAGACACTGAAATATGCC
CTGGAGCTTCAGAAGCTCAACACCAACGTGGCTAAGAATGTCATCATGTTCCTGGGAGAT
GGGATGGGTGTCTCCACAGTGACGGCTGCCCGCATCCTCAAGGGTCAGCTCCACCACAAC
CCTGGGGAGGAGACCAGGCTGGAGATGGACAAGTTCCCCTTCGTGGCCCTCTCCAAGACG
TACAACACCAAAGCCCAGGTCCCTGACAGCGCCGGCACCGCCACCGCCTACCTGTGTGGG
GTGAAGGCCAATGAGGGCACCGTGGGGGTAAGCGCAGCCACTGAGCGTTCCCGGTGCAAC
ACCACCCAGGGGAACGAGGTCACCTCCATCCTGCGCTGGGCCAAGGACGCTGGGAAATCT
GTGGGCATTGTGACCACCACGAGAGTGAACCATGCCACCCCCAGCGCCGCCTACGCCCAC
TCGGCTGACCGGGACTGGTACTCAGACAACGAGATGCCCCCTGAGGCCTTGAGCCAGGGC
TGTAAGGACATCGCCTACCAGCTCATGCATAACATCAGGGACATTGACGTGATCATGGGG
GGTGGCCGGAAATACATGTACCCCAAGAATAAAACTGATGTGGAGTATGAGAGTGACGAG
AAAGCCAGGGGCACGAGGCTGGACGGCCTGGACCTCGTTGACACCTGGAAGAGCTTCAAA
CCGAGACACAAGCACTCCCACTTCATCTGGAACCGCACGGAACTCCTGACCCTTGACCCC
CACAATGTGGACTACCTATTGGGTCTCTTCGAGCCGGGGGACATGCAGTACGAGCTGAAC
AGGAACAACGTGACGGACCCGTCACTCTCCGAGATGGTGGTGGTGGCCATCCAGATCCTG
CGGAAGAACCCCAAAGGCTTCTTCTTGCTGGTGGAAGGAGGCAGAATTGACCACGGGCAC
CATGAAGGAAAAGCCAAGCAGGCCCTGCATGAGGCGGTGGAGATGGACCGGGCCATCGGG
CAGGCAGGCAGCTTGACCTCCTCGGAAGACACTCTGACCGTGGTCACTGCGGACCATTCC
CACGTCTTCACATTTGGTGGATACACCCCCCGTGGCAACTCTATCTTTGGTCTGGCCCCC
ATGCTGAGTGACACAGACAAGAAGCCCTTCACTGCCATCCTGTATGGCAATGGGCCTGGC
TACAAGGTGGTGGGCGGTGAACGAGAGAATGTCTCCATGGTGGACTATGCTCACAACAAC
TACCAGGCGCAGTCTGCTGTGCCCCTGCGCCACGAGACCCACGGCGGGGAGGACGTGGCC
GTCTTCTCCAAGGGCCCCATGGCGCACCTGCTGCACGGCGTCCACGAGCAGAACTACGTC
CCCCACGTGATGGCGTATGCAGCCTGCATCGGGGCCAACCTCGGCCACTGTGCTCCTGCC
AGCTCGGCAGGCAGCCTTGCTGCAGGCCCCCTGCTGCTCGCGCTGGCCCTCTACCCCCTG
AGCGTCCTGTTCTGA

Target 1 GenBank Gene ID

Not Available

Target 1 GeneCard ID

ALPL

Target 1 GenAtlas ID

ALPL

Target 1 HGNC ID

HGNC:438

Target 1 Chromosome Location

Not Available

Target 1 Locus

1p36.12

Target 1 SNPs

SNPJam Report Link Image

Target 1 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 1 General References

3532105; 3165380; 2928120; 9747027; 16710414; 15489334; 3954357; 1458595; 14517339

Target 2 [top]

Target 2 ID

234

Target 2 Name

Aquaporin-1

Target 2 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 2 Description

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient

Target 2 Synonyms

AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule; Urine water channel

Target 2 Gene Name

AQP1

Target 2 Protein Sequence

>Aquaporin-1

MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSI
ATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLT
GNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGH
LLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTD
RVKVWTSGQVEEYDLDADDINSRVEMKPK

Target 2 Number of Residues

269

Target 2 Molecular Weight

28525.7

Target 2 Theoretical pI

7.50

Target 2 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 2 General Function

Carbohydrate transport and metabolism

Target 2 Pathways

Not Available

Target 2 Reactions

Not Available

Target 2 Signals

None

Target 2 Transmembrane Regions

8-36
49-66
77-84
95-115
137-155
167-183
193-200
208-228

Target 2 Essentiality

Non Essential

Target 2 Domain Function

PF00230:MIP

Target 2 GenBank ID Protein

Not Available

Target 2 UniProtKB ID

P29972

Target 2 Cellular Location

Membrane

Target 2 Gene Sequence

>810 bp

ATGGCCAGCGAGTTCAAGAAGAAGCTCTTCTGGAGGGCAGTGGTGGCCGAGTTCCTGGCC
ACGACCCTCTTTGTCTTCATCAGCATCGGTTCTGCCCTGGGCTTCAAATACCCGGTGGGG
AACAACCAGACGGCGGTCCAGGACAACGTGAAGGTGTCGCTGGCCTTCGGGCTGAGCATC
GCCACGCTGGCGCAGAGTGTGGGCCACATCAGCGGCGCCCACCTCAACCCGGCTGTCACA
CTGGGGCTGCTGCTCAGCTGCCAGATCAGCATCTTCCGTGCCCTCATGTACATCATCGCC
CAGTGCGTGGGGGCCATCGTCGCCACCGCCATCCTCTCAGGCATCACCTCCTCCCTGACT
GGGAACTCGCTTGGCCGCAATGACCTGGCTGATGGTGTGAACTCGGGCCAGGGCCTGGGC
ATCGAGATCATCGGGACCCTCCAGCTGGTGCTATGCGTGCTGGCTACTACCGACCGGAGG
CGCCGTGACCTTGGTGGCTCAGCCCCCCTTGCCATCGGCCTCTCTGTAGCCCTTGGACAC
CTCCTGGCTATTGACTACACTGGCTGTGGGATTAACCCTGCTCGGTCCTTTGGCTCCGCG
GTGATCACACACAACTTCAGCAACCACTGGATTTTCTGGGTGGGGCCATTCATCGGGGGA
GCCCTGGCTGTACTCATCTACGACTTCATCCTGGCCCCACGCAGCAGTGACCTCACAGAC
CGCGTGAAGGTGTGGACCAGCGGCCAGGTGGAGGAGTATGACCTGGATGCCGACGACATC
AACTCCAGGGTGGAGATGAAGCCCAAATAG

Target 2 GenBank Gene ID

Not Available

Target 2 GeneCard ID

AQP1

Target 2 GenAtlas ID

AQP1

Target 2 HGNC ID

HGNC:633

Target 2 Chromosome Location

Not Available

Target 2 Locus

7p14

Target 2 SNPs

SNPJam Report Link Image

Target 2 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 2 General References

1722319; 8340403; 8703970; 7517253; 12853948; 15489334; 2007592; 1373524

Target 3 [top]

Target 3 ID

214

Target 3 Name

Aquaporin-10

Target 3 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 3 Description

Forms a water channel. Not permeable to urea and glycerol. May contribute to water transport in the upper portion of small intestine

Target 3 Synonyms

AQP-10; Small intestine aquaporin

Target 3 Gene Name

AQP10

Target 3 Protein Sequence

>Aquaporin-10

MVFTQAPAEIMGHLRIRSLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFL
AGSLAVTIAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYV
LYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDR
RNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPARDLGPRLFTYVAGWGPEVFSAGNG
WWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVSAQHKASELETPASAQMLECK
L

Target 3 Number of Residues

301

Target 3 Molecular Weight

31763.0

Target 3 Theoretical pI

6.78

Target 3 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 3 General Function

Carbohydrate transport and metabolism

Target 3 Pathways

Not Available

Target 3 Reactions

Not Available

Target 3 Signals

None

Target 3 Transmembrane Regions

28-48
53-73
102-122
157-177
188-208

Target 3 Essentiality

Non Essential

Target 3 Domain Function

PF00230:MIP

Target 3 GenBank ID Protein

Not Available

Target 3 UniProtKB ID

Q96PS8

Target 3 Cellular Location

Membrane

Target 3 Gene Sequence

>795 bp

ATGGTCTTCACTCAGGCCCCGGCTGAAATCATGGGCCACCTCCGGATACGCAGCCTCCTG
GCCCGGCAGTGCCTGGCAGAGTTTCTGGGTGTGTTTGTACTCATGCTCCTCACCCAAGGA
GCTGTGGCCCAGGCTGTCACCAGTGGAGAAACCAAAGGCAACTTCTTCACCATGTTTCTG
GCTGGCTCTCTGGCCGTTACGATAGCCATCTACGTGGGTGGTAACGTCTCAGGGGCCCAC
CTGAATCCAGCCTTCTCCCTGGCCATGTGCATCGTTGGACGCCTCCCCTGGGTCAAGCTC
CCCATTTACATCTTGGTGCAGTTGCTGTCTGCTTTCTGTGCTTCGGGAGCCACCTATGTT
CTCTACCATGATGCCCTACAGAACTATACAGGTGGGAACCTGACAGTGACTGGCCCCAAG
GAGACAGCCTCCATTTTTGCCACCTATCCTGCCCCCTATCTGTCCCTGAACAATGGCTTC
CTGGATCAGGTTCTGGGCACCGGGATGCTGATTGTGGGGCTCTTGGCCATCCTGGACAGA
CGGAACAAGGGAGTCCCTGCGGGTCTGGAGCCTGTGGTGGTGGGGATGCTGATCCTGGCC
CTCGGGTTATCCATGGGTGCCAACTGCGGGATTCCACTCAACCCTGCCCGGGACCTGGGC
CCACGTCTCTTCACCTACGTGGCTGGCTGGGGTCCTGAAGTCTTCAGGTGGGAGACAGAC
TCTCCTGGTGCTGGCCTCCACTCACCTTCCTCTGCTAAGGGCTCTGTCCCTGGGTCCACA
GCACTCTGCCTTTAA

Target 3 GenBank Gene ID

Not Available

Target 3 GeneCard ID

AQP10

Target 3 GenAtlas ID

AQP10

Target 3 HGNC ID

HGNC:16029 Link Image

Target 3 Chromosome Location

Not Available

Target 3 Locus

1q21.3

Target 3 SNPs

SNPJam Report Link Image

Target 3 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 3 General References

11573934; 12084581; 16710414; 15489334

Target 4 [top]

Target 4 ID

Target 4 Name

Aquaporin-11

Target 4 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 4 Description

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)

Target 4 Synonyms

AQP-11

Target 4 Gene Name

AQP11

Target 4 Protein Sequence

>Aquaporin-11

MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCC
THELQLLSEQHPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPETGAVR
LLAQLVSALCSRYCTSALWSLGLTQYHVSERSFACKNPIRVDLLKAVITEAVCSFLFHSA
LLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFMCFDEAFPQFFIVYW
LAPSLGILLMILMFSFFLPWLHNNHTINKKE

Target 4 Number of Residues

271

Target 4 Molecular Weight

30202.6

Target 4 Theoretical pI

7.95

Target 4 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane

Target 4 General Function

Involved in transporter activity

Target 4 Pathways

Not Available

Target 4 Reactions

Not Available

Target 4 Signals

None

Target 4 Transmembrane Regions

15-35
42-62
75-95
164-184
195-215
235-255

Target 4 Essentiality

Non Essential

Target 4 Domain Function

Not Available

Target 4 GenBank ID Protein

Not Available

Target 4 UniProtKB ID

Q8NBQ7

Target 4 Cellular Location

Membrane

Target 4 Gene Sequence

>816 bp

ATGTCGCCGCTGCTGGGGCTCCGGTCCGAGCTGCAGGACACCTGCACCTCGCTGGGACTG
ATGCTGTCGGTGGTGCTGCTCATGGGGCTGGCCCGCGTAGTCGCCCGGCAGCAGCTGCAC
AGGCCGGTGGCCCACGCCTTCGTCCTGGAGTTTCTAGCCACCTTCCAGCTCTGCTGCTGC
ACCCACGAGCTGCAACTGCTGAGCGAACAGCACCCCGCGCACCCCACCTGGACGCTGACG
CTCGTCTACTTCTTCTCGCTTGTGCATGGCCTGACTCTGGTGGGCACGTCCAGCAACCCG
TGCGGCGTGATGATGCAGATGATGCTGGGGGGCATGTCCCCCGAGACGGGTGCGGTGAGG
CTATTGGCTCAGCTGGTTAGTGCCCTGTGCAGCAGGTACTGCACAAGCGCCTTGTGGAGC
TTGGGTCTGACCCAGTATCACGTCAGCGAGAGGAGCTTCGCTTGCAAGAATCCCATCCGA
GTCGACTTGCTCAAAGCGGTCATCACAGAGGCCGTCTGCTCCTTTCTCTTCCACAGCGCT
CTGCTGCACTTCCAGGAAGTCCGAACCAAGCTTCGTATCCACCTGCTGGCTGCACTCATC
ACCTTTTTGGTCTATGCAGGAGGAAGTCTAACAGGAGCTGTATTTAATCCAGCTTTGGCA
CTTTCGCTACATTTCATGTGTTTTGATGAAGCATTCCCTCAGTTTTTTATAGTATACTGG
CTGGCTCCTTCTTTAGGTATATTGTTGATGATTTTGATGTTCAGCTTTTTCCTTCCATGG
CTGCATAACAACCATACAATTAATAAAAAGGAATAA

Target 4 GenBank Gene ID

Not Available

Target 4 GeneCard ID

AQP11

Target 4 GenAtlas ID

AQP11

Target 4 HGNC ID

HGNC:19940 Link Image

Target 4 Chromosome Location

Chromosome:11

Target 4 Locus

11q14.1

Target 4 SNPs

SNPJam Report Link Image

Target 4 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 4 General References

16303743; 15489334

Target 5 [top]

Target 5 ID

Target 5 Name

Aquaporin-12A

Target 5 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 5 Description

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)

Target 5 Synonyms

AQP-12

Target 5 Gene Name

AQP12A

Target 5 Protein Sequence

>Aquaporin-12A

MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLL
LTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLC
WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAV
ALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQG
RLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS

Target 5 Number of Residues

295

Target 5 Molecular Weight

31474.2

Target 5 Theoretical pI

8.30

Target 5 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane

Target 5 General Function

Involved in transporter activity

Target 5 Pathways

Not Available

Target 5 Reactions

Not Available

Target 5 Signals

None

Target 5 Transmembrane Regions

1-21
55-75
100-126
146-166
179-199
216-236

Target 5 Essentiality

Non Essential

Target 5 Domain Function

Not Available

Target 5 GenBank ID Protein

Not Available

Target 5 UniProtKB ID

Q8IXF9

Target 5 Cellular Location

Membrane

Target 5 Gene Sequence

>888 bp

ATGGCAGGTCTTAACGTGTCCCTCTCCTTCTTCTTTGCCACCTTCGCCCTCTGTGAGGCG
GCCAGGCGGGCCTCCAAGGCCCTGCTCCCAGTGGGCGCCTATGAAGTCTTCGCCCGGGAG
GCGATGAGGACGCTGGTCGAGCTCGGGCCCTGGGCTGGGGACTTTGGGCCTGACCTGCTG
CTCACCCTGCTCTTCCTGCTCTTCCTGGCGCACGGGGTCACCTTGGACGGGGCCTCGGCC
AACCCCACTGTGTCCCTGCAGGAGTTCCTCATGGCCGAGCAGTCTCTGCCTGGCACGCTG
TTGAAGCTGGCGGCACAGGGGCTGGGCATGCAGGCCGCCTGCACCCTGATGCGCCTCTGC
TGGGCCTGGGAGCTCAGTGACCTGCACCTGCTGCAGAGCCTCATGGCCCAGAGCTGCAGC
TCGGCCCTGCGCACATCCGTGCCCCACGGGGCGCTTGTGGAGGCCGCCTGCGCCTTTTGT
TTCCATCTGACCCTCCTGCACCTGCGGCACAGTCCTCCCGCCTACAGCGGGCCCGCTGTG
GCTCTGTTGGTCACCGTCACGGCCTACACGGCCGGGCCCTTCACGTCTGCCTTCTTCAAC
CCTGCCCTGGCCGCCTCTGTGACCTTTGCCTGCTCGGGACACACCTTACTGGAGTACGTG
CAGGTGTACTGGCTGGGCCCTCTGACAGGGATGGTCCTGGCTGTGCTGCTGCACCAGGGC
CGCCTTCCCCACCTTTTCCAGAGGAACCTGTTCTACGGCCAGAAGAACAAGTACCGAGCA
CCCCGAGGGAAGCCGGCCCCGGCCTCAGGGGACACCCAGACCCCTGCAAAGGGGTCCAGT
GTCCGGGAGCCTGGGCGCAGTGGTGTTGAGGGGCCACATTCCAGCTGA

Target 5 GenBank Gene ID

Not Available

Target 5 GeneCard ID

AQP12A

Target 5 GenAtlas ID

AQP12A

Target 5 HGNC ID

HGNC:19941 Link Image

Target 5 Chromosome Location

Not Available

Target 5 Locus

2q37.3

Target 5 SNPs

SNPJam Report Link Image

Target 5 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 5 General References

15809071

Target 6 [top]

Target 6 ID

381

Target 6 Name

Aquaporin-12B

Target 6 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 6 Description

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)

Target 6 Synonyms

AQP-12B

Target 6 Gene Name

AQP12B

Target 6 Protein Sequence

>Aquaporin-12B

MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLL
LTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLC
WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAV
ALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQG
RLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS

Target 6 Number of Residues

295

Target 6 Molecular Weight

31475.1

Target 6 Theoretical pI

8.09

Target 6 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane

Target 6 General Function

Involved in transporter activity

Target 6 Pathways

Not Available

Target 6 Reactions

Not Available

Target 6 Signals

None

Target 6 Transmembrane Regions

1-21
55-75
100-126
146-166
179-199
216-236

Target 6 Essentiality

Non Essential

Target 6 Domain Function

Not Available

Target 6 GenBank ID Protein

Not Available

Target 6 UniProtKB ID

A6NM10

Target 6 Cellular Location

Membrane

Target 6 Gene Sequence

>924 bp

ATGGCAGGTCTTAACGTGTCCCTCTCCTTCTTCTTTGCCACCTTCACCCTCTGTGAGGCA
GCCAGGCGGGCCTCCAAGGCCCTGCTCCCAGTGGGCGCCTATGAAGTCTTCGCCCGGGAG
GCGGTGGGCGCGGTGCAGCTCGGGGCCTGCTTCCTGGAGATGAGGACGCTGGTCGAGCTC
GGGCCCTGGGCTGGGGACTTTGGGCCTGACCTGCTGCTCACCCTGCTCTTCCTGCTCTTC
CTGGCGCACGGGGTCACCTTGGACGGGGCCTCGGCCAACCCCACCGTGTCCCTGCAGGAG
TTCCTCATGGCCGAGGAGTCTCTGCCTGGCACGCTGCTGAAGCTGGCGGCACAGGGGCTG
GGCATGCAGGCCGCCTGCACCCTGACGCGCCTCTGCTGGGCCTGGGAGCTCAGTGACCTG
CACCTGCTGCAGAGCCTCATGGCCCAGAGCTGCAGCTCGGCCCTGCGCACATCCGTGCCC
CACGGGGCGCTTGTGGAGGCCGCCTGCGCCTTTTGTTTCCATCTGACCCTCCTGCACCTG
CGGCACAGTCCTCCCGCCTACAGCGGGCCCGCTGTGGCTCTGTTGGTCACCGTCACGGCC
TACACGGCCGGGCCCTTCACGTCTGCCTTCTTCAACCCTGCCCTGGCCGCCTCTGTGACC
TTTGCCTGCTCGGGACACACCTTACTGGAGTACGTGCAGGTGTACTGGCTGGGCCCTCTG
ACAGGGATGGTCCTGGCTGTGCTGCTGCACCAGGGCCGCCTTCCCCACCTTTTCCAGAGG
AACCTGTTCTACGGCCAGAAGAACAAGTACCGAGCACCCCGAGGGAAGCCGGCCCCGGCC
TCAGGGGACACCCAGACCCCTGCAAAGGGGTCCAGTGTCCGGGAGCCTGGGCGCAGTGGT
GTTGAGGGGCCACATTCCAGCTGA

Target 6 GenBank Gene ID

Not Available

Target 6 GeneCard ID

AQP12B

Target 6 GenAtlas ID

AQP12B

Target 6 HGNC ID

HGNC:6096

Target 6 Chromosome Location

Not Available

Target 6 Locus

2q37.3

Target 6 SNPs

SNPJam Report Link Image

Target 6 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 6 General References

15815621; 15489334

Target 7 [top]

Target 7 ID

120

Target 7 Name

Aquaporin-2

Target 7 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 7 Description

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient

Target 7 Synonyms

AQP-2; Aquaporin-CD; AQP-CD; Water channel protein for renal collecting duct; ADH water channel; Collecting duct water channel protein; WCH-CD

Target 7 Gene Name

AQP2

Target 7 Protein Sequence

>Aquaporin-2

MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG
HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA
LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG
CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL
EPDTDWEEREVRRRQSVELHSPQSLPRGTKA

Target 7 Number of Residues

271

Target 7 Molecular Weight

28837.2

Target 7 Theoretical pI

6.95

Target 7 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 7 General Function

Carbohydrate transport and metabolism

Target 7 Pathways

Not Available

Target 7 Reactions

Not Available

Target 7 Signals

None

Target 7 Transmembrane Regions

17-34
41-59
86-107
128-148
157-176
203-224

Target 7 Essentiality

Non Essential

Target 7 Domain Function

PF00230:MIP

Target 7 GenBank ID Protein

Not Available

Target 7 UniProtKB ID

P41181

Target 7 Cellular Location

Apical cell membrane

Target 7 Gene Sequence

>816 bp

ATGTGGGAGCTCCGCTCCATAGCCTTCTCCAGGGCTGTGTTCGCAGAGTTCCTGGCCACA
CTCCTCTTCGTCTTCTTTGGCCTCGGCTCTGCCCTCAACTGGCCACAGGCCCTGCCCTCT
GTGCTACAGATTGCCATGGCGTTTGGCTTGGGTATTGGCACCCTGGTACAGGCTCTGGGC
CACATAAGCGGGGCCCACATCAACCCTGCCGTGACTGTGGCCTGCCTGGTGGGCTGCCAC
GTCTCCGTTCTCCGAGCCGCCTTCTACGTGGCTGCCCAGCTGCTGGGGGCTGTGGCCGGA
GCCGCTCTGCTCCATGAGATCACGCCAGCAGACATCCGCGGGGACCTGGCTGTCAATGCT
CTCAGCAACAGCACGACGGCTGGCCAGGCGGTGACTGTGGAGCTCTTCCTGACACTGCAG
CTGGTGCTCTGCATCTTCGCCTCCACCGATGAGCGCCGCGGAGAGAACCCGGGCACCCCT
GCTCTCTCCATAGGCTTCTCCGTGGCCCTGGGCCACCTCCTTGGGATCCATTACACCGGC
TGCTCTATGAATCCTGCCTGCTCCCTGGCTCCAGCTGTCGTCACTGGCAAATTTGATGAC
CACTGGGTCTTCTGGATCGGACCCCTGGTGGGCGCCATCCTGGGCTCCCTCCTCTACAAC
TACGTGCTGTTTCCGCCAGCCAAGAGCCTGTCGGAGCGCCTGGCAGTGCTGAAGGGCCTG
GAGCCGGACACCGATTGGGAGGAGCGCGAGGTGCGACGGCGGCAGTCGGTGGAGCTGCAC
TCGCCGCAGAGCCTGCCACGGGGTACCAAGGCCTGA

Target 7 GenBank Gene ID

Not Available

Target 7 GeneCard ID

AQP2

Target 7 GenAtlas ID

AQP2

Target 7 HGNC ID

HGNC:634

Target 7 Chromosome Location

Chromosome:12

Target 7 Locus

12q12-q13

Target 7 SNPs

SNPJam Report Link Image

Target 7 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 7 General References

8140421; 7522228; 7524315; 7510718; 11929850; 15489334; 12194985; 8882880; 9302264; 9048343

Target 8 [top]

Target 8 ID

240

Target 8 Name

Aquaporin-3

Target 8 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 8 Description

Forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. May function as a water and urea exit mechanism in antidiuresis in collecting duct cells. Also slightly permeable to urea and glycerol. May play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity)

Target 8 Synonyms

AQP-3

Target 8 Gene Name

AQP3

Target 8 Protein Sequence

>Aquaporin-3

MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTIN
LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVF
GLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVD
PYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQ
HWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI

Target 8 Number of Residues

292

Target 8 Molecular Weight

31543.6

Target 8 Theoretical pI

7.25

Target 8 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 8 General Function

Carbohydrate transport and metabolism

Target 8 Pathways

Not Available

Target 8 Reactions

Not Available

Target 8 Signals

None

Target 8 Transmembrane Regions

29-49
54-74
110-130
158-178
189-209
245-265

Target 8 Essentiality

Non Essential

Target 8 Domain Function

PF00230:MIP

Target 8 GenBank ID Protein

Not Available

Target 8 UniProtKB ID

Q92482

Target 8 Cellular Location

Basolateral cell membrane

Target 8 Gene Sequence

>879 bp

ATGGGTCGACAGAAGGAGCTGGTGTCCCGCTGCGGGGAGATGCTCCACATCCGCTACCGG
TTGCTCCGACAGGCGCTGGCCGAGTGCCTGGGGACCCTCATCCTCGTGATGTTTGGCTGT
GGCTCCGTGGCCCAGGTTGTGCTCAGCCGGGGCACCCACGGTGGTTTCCTCACCATCAAC
CTGGCCTTTGGCTTTGCTGTCACTCTGGGCATCCTCATCGCTGGCCAGGTCTCTGGGGCC
CACCTGAACCCTGCCGTGACCTTTGCCATGTGCTTCCTGGCTCGTGAGCCCTGGATCAAG
CTGCCCATCTACACCCTGGCACAGACGCTGGGAGCCTTCTTGGGTGCTGGAATAGTTTTT
GGGCTGTATTATGATGCAATCTGGCACTTTGCCGACAACCAGCTTTTTGTTTCGGGCCCC
AATGGCACAGCCGGCATCTTTGCTACCTACCCCTCTGGACACTTGGATATGATCAATGGC
TTCTTTGACCAGTTCATAGGCACAGCCTCCCTTATCGTGTGTGTGCTGGCCATTGTTGAC
CCTTACAACAACCCCGTCCCCCGAGGCCTGGAGGCCTTCACCGTGGGCCTGGTGGTCCTG
GTCATTGGCACCTCCATGGGCTTCAACTCCGGCTATGCCGTCAACCCTGCCCGGGACTTT
GGCCCCCGCCTTTTTACAGCCCTTGCGGGCTGGGGCTCTGCAGTCTTCACGACCGGCCAG
CATTGGTGGTGGGTGCCCATCGTGTCCCCACTCCTGGGCTCCATTGCGGGTGTCTTCGTG
TACCAGCTGATGATCGGCTGCCACCTGGAGCAGCCCCCACCCTCCAACGAGGAAGAGAAT
GTGAAGCTGGCCCATGTGAAGCACAAGGAGCAGATCTGA

Target 8 GenBank Gene ID

Not Available

Target 8 GeneCard ID

AQP3

Target 8 GenAtlas ID

AQP3

Target 8 HGNC ID

HGNC:636

Target 8 Chromosome Location

Not Available

Target 8 Locus

9p13

Target 8 SNPs

SNPJam Report Link Image

Target 8 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 8 General References

7558005; 12239222; 15164053; 15489334

Target 9 [top]

Target 9 ID

Target 9 Name

Aquaporin-4

Target 9 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 9 Description

Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system

Target 9 Synonyms

AQP-4; WCH4; Mercurial-insensitive water channel; MIWC

Target 9 Gene Name

AQP4

Target 9 Protein Sequence

>Aquaporin-4

MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
VIDVDRGEEKKGKDQSGEVLSSV

Target 9 Number of Residues

323

Target 9 Molecular Weight

34829.4

Target 9 Theoretical pI

7.75

Target 9 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 9 General Function

Carbohydrate transport and metabolism

Target 9 Pathways

Not Available

Target 9 Reactions

Not Available

Target 9 Signals

None

Target 9 Transmembrane Regions

37-57
65-85
116-136
156-176
185-205
232-252

Target 9 Essentiality

Non Essential

Target 9 Domain Function

PF00230:MIP

Target 9 GenBank ID Protein

Not Available

Target 9 UniProtKB ID

P55087

Target 9 Cellular Location

Membrane

Target 9 Gene Sequence

>1026 bp

ATGAGGAAAAATCATGCCTGTTTTGTTGAAACTCCAAATCTGGCTGGGGAAGGCATGAGT
GACAGACCCACAGCAAGGCGGTGGGGTAAGTGTGGACCTTTGTGTACCAGAGAGAACATC
ATGGTGGCTTTCAAAGGGGTCTGGACTCAAGCTTTCTGGAAAGCAGTCACAGCGGAATTT
CTGGCCATGCTTATTTTTGTTCTCCTCAGCCTGGGATCCACCATCAACTGGGGTGGAACA
GAAAAGCCTTTACCGGTCGACATGGTGCTCATCTCCCTTTGCTTTGGACTCAGCATTGCA
ACCATGGTGCAGTGCTTTGGCCATATCAGCGGTGGCCACATCAACCCTGCAGTGACTGTG
GCCATGGTGTGCACCAGGAAGATCAGCATCGCCAAGTCTGTCTTCTACATCGCAGCCCAG
TGCCTGGGGGCCATCATTGGAGCAGGAATCCTCTATCTGGTCACACCTCCCAGTGTGGTG
GGAGGCCTGGGAGTCACCATGGTTCATGGAAATCTTACCGCTGGTCATGGTCTCCTGGTT
GAGTTGATAATCACATTTCAATTGGTGTTTACTATCTTTGCCAGCTGTGATTCCAAACGG
ACTGATGTCACTGGCTCAATAGCTTTAGCAATTGGGTTTTCTGTTGCAATTGGACATTTA
TTTGCAATCAATTATACTGGTGCCAGCATGAATCCCGCCCGATCCTTTGGACCTGCAGTT
ATCATGGGAAATTGGGAAAACCATTGGATATATTGGGTTGGGCCCATCATAGGAGCTGTC
CTCGCTGGTGCCCTTTATGAGTATGTCTTCTGTCCAGATGTTGAATTCAAACGTCGTTTT
AAAGAAGCCTTCAGCAAAGCTGCCCAGCAAACAAAAGGAAGCTACATGGAGGTGGAGGAC
AACAGGAGTCAGGCAAAGACGGATGACCTGATTCTAAAACTTGGAGTGGTGCATGTGATT
GACGTTGACCGGGGAGAGGAGAAGAAGGGGAAAGACCAATCTGGAGAGGTATTGTCTTCA
GTATGA

Target 9 GenBank Gene ID

Not Available

Target 9 GeneCard ID

AQP4

Target 9 GenAtlas ID

AQP4

Target 9 HGNC ID

HGNC:637

Target 9 Chromosome Location

Chromosome:18

Target 9 Locus

18q11.2-q12.1

Target 9 SNPs

SNPJam Report Link Image

Target 9 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 9 General References

7559426; 8601457; 8855281; 15489334

Target 10 [top]

Target 10 ID

100

Target 10 Name

Aquaporin-5

Target 10 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 10 Description

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions

Target 10 Synonyms

AQP-5

Target 10 Gene Name

AQP5

Target 10 Protein Sequence

>Aquaporin-5

MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQAL
GPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVN
ALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFT
GCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIK
GTYEPDEDWEEQREERKKTMELTTR

Target 10 Number of Residues

265

Target 10 Molecular Weight

28291.9

Target 10 Theoretical pI

8.82

Target 10 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 10 General Function

Carbohydrate transport and metabolism

Target 10 Pathways

Not Available

Target 10 Reactions

Not Available

Target 10 Signals

None

Target 10 Transmembrane Regions

13-33
37-57
88-108
127-147
162-182
206-226

Target 10 Essentiality

Non Essential

Target 10 Domain Function

PF00230:MIP

Target 10 GenBank ID Protein

Not Available

Target 10 UniProtKB ID

P55064

Target 10 Cellular Location

Membrane

Target 10 Gene Sequence

Not Available

Target 10 GenBank Gene ID

Not Available

Target 10 GeneCard ID

AQP5

Target 10 GenAtlas ID

AQP5

Target 10 HGNC ID

HGNC:638

Target 10 Chromosome Location

Chromosome:12

Target 10 Locus

12q13

Target 10 SNPs

SNPJam Report Link Image

Target 10 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 10 General References

8621489; 15489334

Target 11 [top]

Target 11 ID

Target 11 Name

Aquaporin-6

Target 11 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 11 Description

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism (By similarity)

Target 11 Synonyms

AQP-6; Aquaporin-2-like; Kidney-specific aquaporin; hKID

Target 11 Gene Name

AQP6

Target 11 Protein Sequence

>Aquaporin-6

MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAI
TFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYG
VMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISV
ALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTK
TLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV

Target 11 Number of Residues

282

Target 11 Molecular Weight

29370.2

Target 11 Theoretical pI

8.86

Target 11 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 11 General Function

Carbohydrate transport and metabolism

Target 11 Pathways

Not Available

Target 11 Reactions

Not Available

Target 11 Signals

None

Target 11 Transmembrane Regions

31-48
55-73
100-121
142-162
169-188
215-236

Target 11 Essentiality

Non Essential

Target 11 Domain Function

PF00230:MIP

Target 11 GenBank ID Protein

Not Available

Target 11 UniProtKB ID

Q13520

Target 11 Cellular Location

Cytoplasmic vesicle membrane

Target 11 Gene Sequence

>849 bp

ATGGATGCTGAGGTGCCAGGGGGACGTGGCTGGGCCAGCATGTTGGCGTGCAGGCTTTGG
AAAGCCATCAGCAGGGCGCTGTTTGCAGAGTTCCTGGCCACGGGGCTGTATGTGTTCTTT
GGCGTGGGCTCAGTCATGCGCTGGCCCACAGCACTTCCCTCCGTGCTACAGATTGCCATC
ACCTTCAACCTGGTCACCGCCATGGCTGTGCAGGTCACCTGGAAGACCAGCGGGGCCCAC
GCCAACCCCGCCGTGACGCTGGCCTTCCTCGTAGGCTCCCACATCTCTCTGCCCCGTGCT
GTGGCCTATGTGGCTGCCCAGCTGGTGGGGGCCACGGTGGGGGCTGCTCTGCTTTATGGG
GTCATGCCGGGAGACATCCGAGAGACCCTTGGGATCAACGTGGTCCGGAACAGTGTCTCA
ACTGGCCAGGCGGTGGCAGTGGAGCTGCTTCTGACCCTGCAGCTGGTGCTCTGTGTCTTC
GCTTCCACCGACAGCCGTCAGACATCAGGCTCCCCGGCCACCATGATTGGGATCTCTTGG
GCACTGGGCCACCTCATTGGGATCCTCTTCACTGGCTGCTCCATGAATCCAGCCCGCTCC
TTCGGCCCTGCCATCATCATTGGGAAGTTCACAGTCCACTGGGTCTTCTGGGTGGGGCCC
CTGATGGGAGCCCTCCTGGCCTCACTGATCTACAACTTCGTCCTGTTCCCCGACACCAAG
ACCCTGGCGCAGCGGCTGGCTATCCTCACAGGCACCGTAGAGGTGGGGACAGGGGCACGG
GCAGGGGCGGAGCCCCTGAAGAAGGAATCCCAGCCGGGTTCGGGAGCCGTGGAGATGGAG
AGTGTGTGA

Target 11 GenBank Gene ID

Not Available

Target 11 GeneCard ID

AQP6

Target 11 GenAtlas ID

AQP6

Target 11 HGNC ID

HGNC:639

Target 11 Chromosome Location

Chromosome:12

Target 11 Locus

12q13

Target 11 SNPs

SNPJam Report Link Image

Target 11 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 11 General References

8812490; 16541075

Target 12 [top]

Target 12 ID

235

Target 12 Name

Aquaporin-7

Target 12 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 12 Description

Forms a channel for water and glycerol

Target 12 Synonyms

AQP-7; Aquaporin-7-like; Aquaporin adipose; AQPap

Target 12 Gene Name

AQP7

Target 12 Protein Sequence

>Aquaporin-7

MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVL
NKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQF
LGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTG
MLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIA
GWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITV
LPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF

Target 12 Number of Residues

342

Target 12 Molecular Weight

37231.3

Target 12 Theoretical pI

9.22

Target 12 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 12 General Function

Carbohydrate transport and metabolism

Target 12 Pathways

Not Available

Target 12 Reactions

Not Available

Target 12 Signals

None

Target 12 Transmembrane Regions

37-57
66-86
114-134
171-191
197-217
256-276

Target 12 Essentiality

Non Essential

Target 12 Domain Function

PF00230:MIP

Target 12 GenBank ID Protein

Not Available

Target 12 UniProtKB ID

O14520

Target 12 Cellular Location

Membrane

Target 12 Gene Sequence

>1029 bp

ATGGTTCAAGCATCCGGGCACAGGCGGTCCACCCGTGGCTCCAAAATGGTCTCCTGGTCC
GTGATAGCAAAGATCCAGGAAATACTGCAGAGGAAGATGGTGCGAGAGTTCCTGGCCGAG
TTCATGAGCACATATGTCATGATGGTATTCGGCCTTGGTTCCGTGGCCCATATGGTTCTA
AATAAAAAATATGGGAGCTACCTTGGTGTCAACTTGGGTTTTGGCTTCGGAGTCACCATG
GGAGTGCACGTGGCAGGCCGCATCTCTGGAGCCCACATGAACGCAGCTGTGACCTTTGCT
AACTGTGCGCTGGGCCGCGTGCCCTGGAGGAAGTTTCCGGTCTATGTGCTGGGGCAGTTC
CTGGGCTCCTTCCTGGCGGCTGCCACCATCTACAGTCTCTTCTACACGGCCATTCTCCAC
TTTTCGGGTGGACAGCTGATGGTGACCGGTCCCGTCGCTACAGCTGGCATTTTTGCCACC
TACCTTCCTGATCACATGACATTGTGGCGGGGCTTCCTGAATGAGGCGTGGCTGACCGGG
ATGCTCCAGCTGTGTCTCTTCGCCATCACGGACCAGGAGAACAACCCAGCACTGCCAGGA
ACAGAGGCGCTGGTGATAGGCATCCTCGTGGTCATCATCGGGGTGTCCCTTGGCATGAAC
ACAGGATATGCCATCAACCCGTCCCGGGACCTGCCCCCCCGCATCTTCACCTTCATTGCT
GGTTGGGGCAAACAGGTCTTCAGCAATGGGGAGAACTGGTGGTGGGTGCCAGTGGTGGCA
CCACTTCTGGGTGCCTATCTAGGTGGCATCATCTACCTGGTCTTCATTGGCTCCACCATC
CCACGGGAGCCCCTGAAATTGGAGGATTCTGTGGCGTATGAAGACCACGGGATAACCGTA
TTGCCCAAGATGGGATCTCATGAACCCACGATCTCTCCCCTCACCCCCGTCTCTGTGAGC
CCTGCCAACAGATCTTCAGTCCACCCTGCCCCACCCTTACATGAATCCATGGCCCTAGAG
CACTTCTAA

Target 12 GenBank Gene ID

Not Available

Target 12 GeneCard ID

AQP7

Target 12 GenAtlas ID

AQP7

Target 12 HGNC ID

HGNC:640

Target 12 Chromosome Location

Not Available

Target 12 Locus

9p13

Target 12 SNPs

SNPJam Report Link Image

Target 12 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 12 General References

9405233; 15164053

Target 13 [top]

Target 13 ID

177

Target 13 Name

Aquaporin-8

Target 13 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 13 Description

Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

Target 13 Synonyms

AQP-8

Target 13 Gene Name

AQP8

Target 13 Protein Sequence

>Aquaporin-8

MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENG
TDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLG
GMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEK
TKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLL
VGLLIRCFIGDGKTRLILKAR

Target 13 Number of Residues

261

Target 13 Molecular Weight

27381.0

Target 13 Theoretical pI

6.90

Target 13 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane

Target 13 General Function

Carbohydrate transport and metabolism

Target 13 Pathways

Not Available

Target 13 Reactions

Not Available

Target 13 Signals

None

Target 13 Transmembrane Regions

37-57
85-105
108-128
157-177
184-204
229-249

Target 13 Essentiality

Non Essential

Target 13 Domain Function

PF00230:MIP

Target 13 GenBank ID Protein

Not Available

Target 13 UniProtKB ID

O94778

Target 13 Cellular Location

Membrane

Target 13 Gene Sequence

>786 bp

ATGTCTGGAGAGATAGCCATGTGTGAGCCTGAATTTGGCAATGACAAGGCCAGGGAGCCG
AGCGTGGGTGGCAGGTGGCGAGTGTCCTGGTACGAACGGTTTGTGCAGCCATGTCTGGTC
GAACTGCTGGGCTCTGCTCTCTTCATCTTCATCGGGTGCCTGTCGGTCATTGAGAATGGG
ACGGACACTGGGCTGCTGCAGCCGGCCCTGGCCCACGGGCTGGCTTTGGGGCTCGTGATT
GCCACGCTGGGGAATATCAGTGGTGGACACTTCAACCCTGCGGTGTCCCTGGCAGCCATG
CTGATCGGAGGCCTCAACCTGGTGATGCTCCTCCCGTACTGGGTCTCACAGCTGCTCGGG
GGGATGCTCGGGGCTGCCTTGGCCAAGGTGGTGAGTCCTGAGGAGAGGTTCTGGAATGCA
TCTGGGGCGGCCTTTGTGACAGTCCAGGAGCAGGGGCAGGTGGCAGGGGCGTTGGTGGCA
GAGATCATCCTGACGACGCTGCTGGCCCTGGCTGTATGCATGGGTGCCATCAATGAGAAG
ACAAAGGGCCCTCTGGCCCCGTTCTCCATCGGCTTTGCCGTCACCGTGGATATCCTGGCT
GGGGGCCCTGTGTCTGGAGGCTGCATGAATCCCGCCCGTGCTTTTGGACCTGCGGTGGTG
GCCAACCACTGGAACTTCCACTGGATCTACTGGCTGGGCCCACTCCTGGCTGGCCTGCTT
GTTGGACTGCTCATTAGGTGCTTCATTGGAGATGGGAAGACCCGCCTCATCCTGAAGGCT
CGGTGA

Target 13 GenBank Gene ID

Not Available

Target 13 GeneCard ID

AQP8

Target 13 GenAtlas ID

AQP8

Target 13 HGNC ID

HGNC:642

Target 13 Chromosome Location

Chromosome:16

Target 13 Locus

16p12

Target 13 SNPs

SNPJam Report Link Image

Target 13 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 13 General References

9806845; 15489334; 16959974

Target 14 [top]

Target 14 ID

233

Target 14 Name

Aquaporin-9

Target 14 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 14 Description

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea but not to glycerol

Target 14 Synonyms

AQP-9; Small solute channel 1

Target 14 Gene Name

AQP9

Target 14 Protein Sequence

>Aquaporin-9

MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITI
NVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATV
FGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIF
DSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAG
NNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKAEQSEDKPEKYELSVIM

Target 14 Number of Residues

295

Target 14 Molecular Weight

31400.7

Target 14 Theoretical pI

7.95

Target 14 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 14 General Function

Carbohydrate transport and metabolism

Target 14 Pathways

Not Available

Target 14 Reactions

Not Available

Target 14 Signals

None

Target 14 Transmembrane Regions

30-50
55-75
111-131
159-179
190-210
246-266

Target 14 Essentiality

Non Essential

Target 14 Domain Function

PF00230:MIP

Target 14 GenBank ID Protein

Not Available

Target 14 UniProtKB ID

O43315

Target 14 Cellular Location

Membrane

Target 14 Gene Sequence

>888 bp

ATGCAGCCTGAGGGAGCAGAAAAGGGAAAAAGCTTCAAGCAGAGACTGGTCTTGAAGAGC
AGCTTAGCGAAAGAAACCCTCTCTGAGTTCTTGGGCACGTTCATCTTGATTGTCCTTGGA
TGTGGCTGTGTTGCCCAAGCTATTCTCAGTCGAGGACGTTTTGGAGGGGTCATCACTATC
AATGTTGGATTTTCAATGGCAGTTGCAATGGCCATTTATGTGGCTGGCGGTGTCTCTGGT
GGTCACATCAACCCAGCTGTGTCTTTAGCAATGTGTCTCTTTGGACGGATGAAATGGTTC
AAATTGCCATTTTATGTGGGAGCCCAGTTCTTGGGAGCCTTTGTGGGGGCTGCAACCGTC
TTTGGCATTTACTATGATGGACTTATGTCCTTTGCTGGTGGAAAACTGCTGATCGTGGGA
GAAAATGCAACAGCACACATTTTTGCAACATACCCAGCTCCGTATCTATCTCTGGCGAAC
GCATTTGCAGATCAAGTGGTGGCCACCATGATACTCCTCATAATCGTCTTTGCCATTTTT
GACTCCAGAAACTTGGGAGCCCCCAGAGGCCTAGAGCCCATTGCCATCGGCCTCCTGATT
ATTGTCATTGCTTCCTCCCTGGGACTGAACAGTGGCTGTGCCATGAACCCAGCTCGAGAC
CTGAGTCCCAGACTTTTCACTGCCTTGGCAGGCTGGGGGTTTGAAGTCTTCAGAGCTGGA
AACAACTTCTGGTGGATTCCTGTAGTGGGCCCTTTGGTTGGTGCTGTCATTGGAGGCCTC
ATCTATGTTCTTGTCATTGAAATCCACCATCCAGAGCCTGACTCAGTCTTTAAGGCAGAA
CAATCTGAGGACAAACCAGAGAAATATGAACTCAGTGTCATCATGTAG

Target 14 GenBank Gene ID

Not Available

Target 14 GeneCard ID

AQP9

Target 14 GenAtlas ID

AQP9

Target 14 HGNC ID

HGNC:643

Target 14 Chromosome Location

Chromosome:15

Target 14 Locus

15q22.1-q22.2

Target 14 SNPs

SNPJam Report Link Image

Target 14 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 14 General References

9514918; 10564231; 15489334; 17081983

Target 15 [top]

Target 15 ID

382

Target 15 Name

Lens fiber major intrinsic protein

Target 15 Mechanism of Action

Mercury is known to inhibit aquaporins, halting water flow across the cell membrane and resulting in cell injury and death. (R067)

Target 15 Description

Water channel. May be responsible for regulating the osmolarity of the lens

Target 15 Synonyms

Aquaporin-0; MIP26; MP26

Target 15 Gene Name

MIP

Target 15 Protein Sequence

>Lens fiber major intrinsic protein

MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG
HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT
LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG
AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA
KPDVSNGQPEVTGEPVELNTQAL

Target 15 Number of Residues

263

Target 15 Molecular Weight

28121.5

Target 15 Theoretical pI

8.67

Target 15 GO Classification

Function
transporter activity
Process
physiological process cellular physiological process transport
Component
cell membrane intrinsic to membrane integral to membrane

Target 15 General Function

Carbohydrate transport and metabolism

Target 15 Pathways

Not Available

Target 15 Reactions

Not Available

Target 15 Signals

None

Target 15 Transmembrane Regions

17-37
41-60
86-107
124-149
157-178
197-219

Target 15 Essentiality

Non Essential

Target 15 Domain Function

PF00230:MIP

Target 15 GenBank ID Protein

Not Available

Target 15 UniProtKB ID

P30301

Target 15 Cellular Location

Cell membrane

Target 15 Gene Sequence

>792 bp

ATGTGGGAACTGCGATCAGCCTCCTTTTGGAGGGCCATATTCGCTGAGTTCTTTGCCACC
CTCTTCTATGTCTTCTTTGGGCTGGGGTCCTCACTGCGCTGGGCTCCTGGACCCCTGCAT
GTTCTGCAGGTGGCTATGGCATTTGGCTTGGCCCTGGCTACACTGGTGCAGTCTGTGGGC
CACATCAGTGGAGCCCACGTCAATCCTGCAGTCACTTTTGCTTTCCTTGTGGGCTCCCAG
ATGTCCCTGCTCCGTGCCTTCTGCTATATGGCAGCCCAGCTCCTGGGAGCTGTGGCTGGG
GCCGCTGTGCTGTATAGCGTTACCCCACCTGCTGTCCGAGGAAACCTAGCACTCAACACG
TTGCACCCTGCGGTGAGCGTGGGCCAGGCAACCACAGTGGAGATCTTCCTGACGCTCCAG
TTCGTGCTCTGCATCTTTGCCACATACGACGAGAGGCGGAATGGCCAACTGGGCTCCGTG
GCCCTGGCCGTTGGCTTCTCCCTTGCCCTGGGGCACCTCTTTGGGATGTATTATACTGGT
GCAGGCATGAATCCTGCCCGCTCCTTTGCTCCTGCCATTCTCACTGGGAACTTCACTAAC
CACTGGGTGTACTGGGTAGGCCCAATCATTGGAGGGGGTCTGGGCAGCCTCCTGTACGAC
TTTCTTCTCTTCCCCCGGCTCAAGAGTATTTCTGAGAGACTGTCTGTCCTCAAGGGTGCC
AAACCCGATGTCTCCAATGGACAACCAGAGGTCACAGGGGAACCTGTTGAACTGAACACC
CAGGCCCTGTAG

Target 15 GenBank Gene ID

Not Available

Target 15 GeneCard ID

MIP

Target 15 GenAtlas ID

MIP

Target 15 HGNC ID

HGNC:7103

Target 15 Chromosome Location

Chromosome:12

Target 15 Locus

12q13

Target 15 SNPs

SNPJam Report Link Image

Target 15 Toxin References

R067 - Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. [PubMed ]

Target 15 General References

1840563; 15489334; 10634618; 10802646; 11001937

Target 16 [top]

Target 16 ID

178

Target 16 Name

Protein kinase C alpha type

Target 16 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 16 Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters

Target 16 Synonyms

PKC-alpha; PKC-A

Target 16 Gene Name

PRKCA

Target 16 Protein Sequence

>Protein kinase C alpha type

MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV

Target 16 Number of Residues

672

Target 16 Molecular Weight

76763.5

Target 16 Theoretical pI

7.05

Target 16 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 16 General Function

Involved in ATP binding

Target 16 Pathways

REACT_604-Hemostasis;

Target 16 Reactions

Not Available

Target 16 Signals

None

Target 16 Transmembrane Regions

None

Target 16 Essentiality

Non Essential

Target 16 Domain Function

PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C

Target 16 GenBank ID Protein

Not Available

Target 16 UniProtKB ID

P17252

Target 16 Cellular Location

Cytoplasm (By similarity). Cell membrane

Target 16 Gene Sequence

>2019 bp

ATGGCTGACGTTTTCCCGGGCAACGACTCCACGGCGTCTCAGGACGTGGCCAACCGCTTC
GCCCGCAAAGGGGCGCTGAGGCAGAAGAACGTGCACGAGGTGAAGGACCACAAATTCATC
GCGCGCTTCTTCAAGCAGCCCACCTTCTGCAGCCACTGCACCGACTTCATCTGGGGGTTT
GGGAAACAAGGCTTCCAGTGCCAAGTTTGCTGTTTTGTGGTCCACAAGAGGTGCCATGAA
TTTGTTACTTTTTCTTGTCCGGGTGCGGATAAGGGACCCGACACTGATGACCCCAGGAGC
AAGCACAAGTTCAAAATCCACACTTACGGAAGCCCCACCTTCTGCGATCACTGTGGGTCA
CTGCTCTATGGACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCAC
AAGCAATGCGTCATCAATGTCCCCAGCCTCTGCGGAATGGATCACACTGAGAAGAGGGGG
CGGATTTACCTAAAGGCTGAGGTTGCTGATGAAAAGCTCCATGTCACAGTACGAGATGCA
AAAAATCTAATCCCTATGGATCCAAACGGGCTTTCAGATCCTTATGTGAAGCTGAAACTT
ATTCCTGATCCCAAGAATGAAAGCAAGCAAAAAACCAAAACCATCCGCTCCACACTAAAT
CCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTG
TCTGTAGAAATCTGGGACTGGGATCGAACAACAAGGAATGACTTCATGGGATCCCTTTCC
TTTGGAGTTTCGGAGCTGATGAAGATGCCGGCCAGTGGATGGTACAAGTTGCTTAACCAA
GAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAA
CTCAGGCAGAAATTCGAGAAAGCCAAACTTGGCCCTGCTGGCAACAAAGTCATCAGTCCC
TCTGAAGACAGGAAACAACCTTCCAACAACCTTGACCGAGTGAAACTCACGGACTTCAAT
TTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGC
ACAGAAGAACTGTATGCAATCAAAATCCTGAAGAAGGATGTGGTGATTCAGGATGATGAC
GTGGAGTGCACCATGGTAGAAAAGCGAGTCTTGGCCCTGCTTGACAAACCCCCGTTCTTG
ACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTC
AACGGTGGGGACCTCATGTACCACATTCAGCAAGTAGGAAAATTTAAGGAACCACAAGCA
GTATTCTATGCGGCAGAGATTTCCATCGGATTGTTCTTTCTTCATAAAAGAGGAATCATT
TATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCT
GACTTTGGGATGTGCAAGGAACACATGATGGATGGAGTCACGACCAGGACCTTCTGTGGG
ACTCCAGATTATATCGCCCCAGAGATAATCGCTTATCAGCCGTATGGAAAATCTGTGGAC
TGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGT
GAAGATGAAGACGAGCTATTTCAGTCTATCATGGAGCACAACGTTTCCTATCCAAAATCC
TTGTCCAAGGAGGCTGTTTCTATCTGCAAAGGACTGATGACCAAACACCCAGCCAAGCGG
CTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATC
GACTGGGAAAAACTGGAGAACAGGGAGATCCAGCCACCATTCAAGCCCAAAGTGTGTGGC
AAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAGGACAGCCCGTCTTAACACCACCT
GATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAAC
CCCCAGTTTGTGCACCCCATCTTACAGAGTGCAGTATGA

Target 16 GenBank Gene ID

Not Available

Target 16 GeneCard ID

PRKCA

Target 16 GenAtlas ID

PRKCA

Target 16 HGNC ID

HGNC:9393

Target 16 Chromosome Location

Chromosome:17

Target 16 Locus

17q22-q23.2

Target 16 SNPs

SNPJam Report Link Image

Target 16 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 16 General References

2336401; 15489334; 1714454; 12665801; 12893243; 15247289; 15504744; 17081983; 16964243

Target 17 [top]

Target 17 ID

Target 17 Name

Protein kinase C beta type

Target 17 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 17 Description

This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity)

Target 17 Synonyms

PKC-beta; PKC-B

Target 17 Gene Name

PRKCB

Target 17 Protein Sequence

>Protein kinase C beta type

MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV

Target 17 Number of Residues

671

Target 17 Molecular Weight

76868.4

Target 17 Theoretical pI

7.00

Target 17 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 17 General Function

Involved in ATP binding

Target 17 Pathways

REACT_604-Hemostasis;

Target 17 Reactions

Not Available

Target 17 Signals

None

Target 17 Transmembrane Regions

None

Target 17 Essentiality

Non Essential

Target 17 Domain Function

PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C

Target 17 GenBank ID Protein

Not Available

Target 17 UniProtKB ID

P05771

Target 17 Cellular Location

Cytoplasm (By similarity). Membrane

Target 17 Gene Sequence

>2022 bp

ATGGCTGACCCGGCTGCGGGGCCGCCGCCGAGCGAGGGCGAGGAGAGCACCGTGCGCTTC
GCCCGCAAAGGCGCCCTCAGGCAGAAGAACGTGCATGAGGTCAAGAACCACAAATTCACC
GCCCGCTTCTTCAAGCAGCCCACCTTCTGCAGCCACTGCACCGACTTCATCTGGGGCTTC
GGGAAGCAGGGATTCCAGTGCCAAGTTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAA
TTTGTCACATTCTCCTGCCCTGGCGCTGACAAGGGTCCAGCCTCCGATGACCCCCGCAGC
AAACACAAGTTTAAGATCCACACGTACTCCAGCCCCACGTTTTGTGACCACTGTGGGTCA
CTGCTGTATGGACTCATCCACCAGGGGATGAAATGTGACACCTGCATGATGAACGTGCAC
AAGCGCTGCGTGATGAATGTTCCCAGCCTGTGTGGCACGGACCACACGGAGCGCCGCGGC
CGCATCTACATCCAGGCCCACATCGACAGGGACGTCCTCATTGTCCTCGTAAGAGATGCT
AAAAACCTTGTACCTATGGACCCCAATGGCCTGTCAGATCCCTACGTAAAACTGAAACTG
ATTCCCGATCCCAAAAGTGAGAGCAAACAGAAGACCAAAACCATCAAATGCTCCCTCAAC
CCTGAGTGGAATGAGACATTTAGATTTCAGCTGAAAGAATCGGACAAAGACAGAAGACTG
TCAGTAGAGATTTGGGATTGGGATTTGACCAGCAGGAATGACTTCATGGGATCTTTGTCC
TTTGGGATTTCTGAACTTCAGAAAGCCAGTGTTGATGGCTGGTTTAAGTTACTGAGCCAG
GAGGAAGGCGAGTACTTCAATGTGCCTGTGCCACCAGAAGGAAGTGAGGCCAATGAAGAA
CTGCGGCAGAAATTTGAGAGGGCCAAGATCAGTCAGGGAACCAAGGTCCCGGAAGAAAAG
ACGACCAACACTGTCTCCAAATTTGACAACAATGGCAACAGAGACCGGATGAAACTGACC
GATTTTAACTTCCTAATGGTGCTGGGGAAAGGCAGCTTTGGCAAGGTCATGCTTTCAGAA
CGAAAAGGCACAGATGAGCTCTATGCTGTGAAGATCCTGAAGAAGGACGTTGTGATCCAA
GATGATGACGTGGAGTGCACTATGGTGGAGAAGCGGGTGTTGGCCCTGCCCGGGAAGCCG
CCCTTCCTGACCCAGCTCCACTCCTGCTTCCAGACCATGGACCGCCTGTACTTTGTGATG
GAGTACGTGAATGGGGGCGACCTCATGTATCACATCCAGCAAGTCGGCCGGTTCAAGGAG
CCCCATGCTGTATTTTACGCTGCAGAAATTGCCATCGGTCTGTTCTTCTTACAGAGTAAG
GGCATCATTTACCGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATC
AAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACA
TTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAG
TCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCC
TTTGAAGGGGAGGATGAGGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTAT
CCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCA
GGCAAACGTCTGGGTTGTGGACCTGAAGGTGAACGTGATATCAAAGAGCATGCATTTTTC
CGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATTCAGCCCCCTTATAAGCCAAAA
GCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTA
ACACCTCCTGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCC
TTTGTTAACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAA

Target 17 GenBank Gene ID

Not Available

Target 17 GeneCard ID

PRKCB

Target 17 GenAtlas ID

PRKCB

Target 17 HGNC ID

HGNC:9395

Target 17 Chromosome Location

Chromosome:16

Target 17 Locus

16p11.2

Target 17 SNPs

SNPJam Report Link Image

Target 17 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 17 General References

3755548; 3666134; 10493829; 15489334; 7880442; 1556124; 1400396; 12665801; 3677994

Target 18 [top]

Target 18 ID

143

Target 18 Name

Protein kinase C delta type

Target 18 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 18 Description

This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin

Target 18 Synonyms

nPKC-delta

Target 18 Gene Name

PRKCD

Target 18 Protein Sequence

>Protein kinase C delta type

MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
AGFSFVNPKFEHLLED

Target 18 Number of Residues

676

Target 18 Molecular Weight

77504.4

Target 18 Theoretical pI

7.81

Target 18 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 18 General Function

Involved in ATP binding

Target 18 Pathways

Not Available

Target 18 Reactions

Not Available

Target 18 Signals

None

Target 18 Transmembrane Regions

None

Target 18 Essentiality

Non Essential

Target 18 Domain Function

PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C

Target 18 GenBank ID Protein

Not Available

Target 18 UniProtKB ID

Q05655

Target 18 Cellular Location

Cytoplasm (By similarity). Membrane

Target 18 Gene Sequence

>2031 bp

ATGGCGCCGTTCCTGCGCATCGCCTTCAACTCCTATGAGCTGGGCTCCCTGCAGGCCGAG
GACGAGGCGAACCAGCCCTTCTGTGCCGTGAAGATGAAGGAGGCGCTCAGCACAGAGCGT
GGGAAAACACTGGTGCAGAAGAAGCCGACCATGTATCCTGAGTGGAAGTCGACGTTCGAT
GCCCACATCTATGAGGGGCGCGTCATCCAGATTGTGCTAATGCGGGCAGCAGAGGAGCCA
GTGTCTGAGGTGACCGTGGGTGTGTCGGTGCTGGCCGAGCGCTGCAAGAAGAACAATGGC
AAGGCTGAGTTCTGGCTGGACCTGCAGCCTCAGGCCAAGGTGTTGATGTCTGTTCAGTAT
TTCCTGGAGGACGTGGATTGCAAACAATCTATGCGCAGTGAGGACGAGGCCAAGTTCCCA
ACGATGAACCGCCGCGGAGCCATCAAACAGGCCAAAATCCACTACATCAAGAACCATGAG
TTTATCGCCACCTTCTTTGGGCAACCCACCTTCTGTTCTGTGTGCAAAGACTTTGTCTGG
GGCCTCAACAAGCAAGGCTACAAATGCAGGCAATGTAACGCTGCCATCCACAAGAAATGC
ATCGACAAGATCATCGGCAGATGCACTGGCACCGCGGCCAACAGCCGGGACACTATATTC
CAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTACATGAGC
CCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAG
TGTGAAGACTGCGGCATGAATGTGCACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGC
GGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCCTCCCGG
AGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACC
GGAGTTGCTGGGGAGGACATGCAAGACAACAGTGGGACCTACGGCAAGATCTGGGAGGGC
AGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGCAGCTTC
GGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTCTGCCATCAAGGCCCTC
AAGAAGGATGTGGTCCTGATCGACGACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTG
CTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAGACCAAG
GACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAG
GACAAAGGCCGCTTTGAACTCTACCGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGA
CTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAATGTGCTG
TTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTC
GGGGAGAGCCGGGCCAGCACCTTCTGCGGCACCCCTGACTATATCGCCCCTGAGATCCTA
CAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTGTACGAG
ATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATC
CGTGTGGACACGCCACATTATCCCCGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAG
AAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAATGACGGGAAACATCAAAATCCAC
CCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCCTTC
AGGCCCAAAGTGAAGTCACCCAGAGACTACAGTAACTTTGACCAGGAGTTCCTGAACGAG
AAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCTGCATTC
GCTGGCTTCTCCTTTGTGAACCCCAAATTCGAGCACCTCCTGGAAGATTGA

Target 18 GenBank Gene ID

Not Available

Target 18 GeneCard ID

PRKCD

Target 18 GenAtlas ID

PRKCD

Target 18 HGNC ID

HGNC:9399

Target 18 Chromosome Location

Not Available

Target 18 Locus

3p21.31

Target 18 SNPs

SNPJam Report Link Image

Target 18 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 18 General References

8357834; 14702039; 15489334; 9427282; 7988719; 11877440; 12628935; 15302935

Target 19 [top]

Target 19 ID

Target 19 Name

Protein kinase C epsilon type

Target 19 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 19 Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters

Target 19 Synonyms

nPKC-epsilon

Target 19 Gene Name

PRKCE

Target 19 Protein Sequence

>Protein kinase C epsilon type

MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
NQEEFKGFSYFGEDLMP

Target 19 Number of Residues

737

Target 19 Molecular Weight

83673.2

Target 19 Theoretical pI

7.13

Target 19 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 19 General Function

Involved in ATP binding

Target 19 Pathways

Not Available

Target 19 Reactions

Not Available

Target 19 Signals

None

Target 19 Transmembrane Regions

None

Target 19 Essentiality

Non Essential

Target 19 Domain Function

PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C

Target 19 GenBank ID Protein

Not Available

Target 19 UniProtKB ID

Q02156

Target 19 Cellular Location

Not Available

Target 19 Gene Sequence

>2214 bp

ATGGTAGTGTTCAATGGCCTTCTTAAGATCAAAATCTGCGAGGCCGTGAGCTTGAAGCCC
ACAGCCTGGTCGCTGCGCCATGCGGTGGGACCCCGGCCGCAGACTTTCCTTCTCGACCCC
TACATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACC
AACAGCCCGGCCTGGCACGACGAGTTCGTCACCGATGTGTGCAACGGACGCAAGATCGAG
CTGGCTGTCTTTCACGATGCCCCCATAGGCTACGACGACTTCGTGGCCAACTGCACCATC
CAGTTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAG
CCAGAAGGAAGAGTGTATGTGATCATCGATCTCTCAGGGTCGTCGGGTGAAGCCCCTAAA
GACAATGAAGAGCGTGTGTTCAGGGAACGCATGCGGCCGAGGAAGCGGCAGGGGGCCGTC
AGGCGCAGGGTCCATCAGGTCAACGGCCACAAGTTCATGGCCACCTATCTTCGGCAGCCC
ACCTACTGCTCCCATTGCAGAGACTTCATCTGGGGTGTCATAGGAAAGCAGGGATACCAG
TGTCAAGTCTGCACCTGCGTGGTCCACAAGCGGTGCCACGAGCTCATAATCACAAAGTGT
GCTGGGTTAAAGAAGCAGGAGACCCCCGACCAGGTGGGCTCCCAGCGGTTCAGCGTCAAC
ATGCCCCACAAGTTCGGTATCCACAACTACAAGGTCCCTACCTTCTGCGATCACTGTGGG
TCCCTGCTCTGGGGACTCTTGCGGCAGGGTTTGCAGTGTAAAGTCTGCAAAATGAATGTT
CACCGTCGATGTGAGACCAACGTGGCTCCCAACTGTGGAGTGGATGCCAGAGGAATCGCC
AAAGTACTGGCCGACCTGGGCGTTACCCCAGACAAAATCACCAACAGCGGCCAGAGAAGG
AAAAAGCTCATTGCTGGTGCCGAGTCCCCGCAGCCTGCTTCTGGAAGCTCACCATCTGAG
GAAGATCGATCCAAGTCAGCACCCACCTCCCCTTGTGACCAGGAAATAAAAGAACTTGAG
AACAACATTCGGAAAGCCTTGTCATTTGACAACCGAGGAGAGGAGCACCGGGCAGCATCG
TCTCCTGATGGCCAGCTGATGAGCCCCGGTGAGAATGGCGAAGTCCGGCAAGGCCAGGCC
AAGCGCCTGGGCCTGGATGAGTTCAACTTCATCAAGGTGTTGGGCAAAGGCAGCTTTGGC
AAGGTCATGTTGGCAGAACTCAAGGGCAAAGATGAAGTATATGCTGTGAAGGTCTTAAAG
AAGGACGTCATCCTTCAGGATGATGACGTGGACTGCACAATGACAGAGAAGAGGATTTTG
GCTCTGGCACGGAAACACCCGTACCTTACCCAACTCTACTGCTGCTTCCAGACCAAGGAC
CGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGC
TCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTC
ATGTTCCTCCATCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTG
GATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAAT
GGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAG
GAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATG
ATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTC
CATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCT
TTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGAC
GCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAG
ATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAA
GACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATC
AACCAGGAGGAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGA

Target 19 GenBank Gene ID

Not Available

Target 19 GeneCard ID

PRKCE

Target 19 GenAtlas ID

PRKCE

Target 19 HGNC ID

HGNC:9401

Target 19 Chromosome Location

Not Available

Target 19 Locus

2p21

Target 19 SNPs

SNPJam Report Link Image

Target 19 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 19 General References

1382605; 15815621; 15489334; 11964154; 15632189; 18691976; 18669648; 16959974; 17344846

Target 20 [top]

Target 20 ID

Target 20 Name

Protein kinase C eta type

Target 20 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 20 Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters

Target 20 Synonyms

nPKC-eta; PKC-L

Target 20 Gene Name

PRKCH

Target 20 Protein Sequence

>Protein kinase C eta type

MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK
QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELRGTTGASDTFEG
WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR
QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF
GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV
ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV
LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF
CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL
KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM
GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL
TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE
GHLPMINQDEFRNFSYVSPELQP

Target 20 Number of Residues

683

Target 20 Molecular Weight

77771.9

Target 20 Theoretical pI

7.80

Target 20 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 20 General Function

Involved in ATP binding

Target 20 Pathways

Not Available

Target 20 Reactions

Not Available

Target 20 Signals

None

Target 20 Transmembrane Regions

None

Target 20 Essentiality

Non Essential

Target 20 Domain Function

PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C

Target 20 GenBank ID Protein

Not Available

Target 20 UniProtKB ID

P24723

Target 20 Cellular Location

Not Available

Target 20 Gene Sequence

>2049 bp

ATGTCGTCTGGCACCATGAAGTTCAATGGCTATTTGAGGGTCCGCATCGGTGAGGCAGTG
GGGCTGCAGCCCACCCGCTGGTCCCTGCGCCACTCGCTCTTCAAGAAGGGCCACCAGCTG
CTGGACCCCTATCTGACGGTGAGCGTGGACCAGGTGCGCGTGGGCCAGACCAGCACCAAG
CAGAAGACCAACAAACCCACGTACAACGAGGAGTTTTGCGCTAACGTCACCGACGGCGGC
CACCTCGAGTTGGCCGTCTTCCACGAGACCCCCCTGGGCTACGACTTCGTGGCCAACTGC
ACCCTGCAGTTCCAGGAGCTCGTCGGCACGACCGGCGCCTCGGACACCTTCGAGGGTTGG
GTGGATCTCGAGCCAGAGGGGAAAGTATTTGTGGTAATAACCCTTACCGGGAGTTTCACT
GAAGCTACTCTCCAGAGAGACCGGATCTTCAAACATTTTACCAGGAAGCGCCAAAGGGCT
ATGCGAAGGCGAGTCCACCAGATCAATGGACACAAGTTCATGGCCACGTATCTGAGGCAG
CCCACCTACTGCTCTCACTGCAGGGAGTTTATCTGGGGAGTGTTTGGGAAACAGGGTTAT
CAGTGCCAAGTGTGCACCTGTGTCGTCCATAAACGCTGCCATCATCTAATTGTTACAGCC
TGTACTTGCCAAAACAATATTAACAAAGTGGATTCAAAGATTGCAGAACAGAGGTTCGGG
ATCAACATCCCACACAAGTTCAGCATCCACAACTACAAAGTGCCAACATTCTGCGATCAC
TGTGGCTCACTGCTCTGGGGAATAATGCGACAAGGACTTCAGTGTAAAATATGTAAAATG
AATGTGCATATTCGATGTCAAGCGAACGTGGCCCCTAACTGTGGGGTAAATGCGGTGGAA
CTTGCCAAGACCCTGGCAGGGATGGGTCTCCAACCCGGAAATATTTCTCCAACCTCGAAA
CTCGTTTCCAGATCGACCCTAAGACGACAGGGAAAGGAGAGCAGCAAAGAAGGAAATGGG
ATTGGGGTTAATTCTTCCAACCGACTTGGTATCGACAACTTTGAGTTCATCCGAGTGTTG
GGGAAGGGGAGTTTTGGGAAGGTGATGCTTGCAAGAGTAAAAGAAACAGGAGACCTCTAT
GCTGTGAAGGTGCTGAAGAAGGACGTGATTCTGCTGGATGATGATGTGGAATGCACCATG
ACCGAGAAAAGGATCCTGTCTCTGGCCCGCAATCACCCCTTCCTCACTCAGTTGTTCTGC
TGCTTTCAGACCCCCGATCGTCTGTTTTTTGTGATGGAGTTTGTGAATGGGGGTGACTTG
ATGTTCCACATTCAGAAGTCTCGTCGTTTTGATGAAGCACGAGCTCGCTTCTATGCTGCA
GAAATCATTTCGGCTCTCATGTTCCTCCATGATAAAGGAATCATCTATAGAGATCTGAAA
CTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGC
AAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATC
GCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGC
GTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAATGAAGATGAC
CTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCC
ACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACT
CAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAG
CTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTC
AGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGA
CATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTG
CAACCATAG

Target 20 GenBank Gene ID

Not Available

Target 20 GeneCard ID

PRKCH

Target 20 GenAtlas ID

PRKCH

Target 20 HGNC ID

HGNC:9403

Target 20 Chromosome Location

Chromosome:14

Target 20 Locus

14q22-q23

Target 20 SNPs

SNPJam Report Link Image

Target 20 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 20 General References

1986216; 1545821; 14702039; 15489334; 7988719; 15632189; 16973127; 17206144; 17344846

Target 21 [top]

Target 21 ID

Target 21 Name

Protein kinase C gamma type

Target 21 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 21 Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters

Target 21 Synonyms

PKC-gamma

Target 21 Gene Name

PRKCG

Target 21 Protein Sequence

>Protein kinase C gamma type

MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG
KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL
LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA
RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL
SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ
KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG
SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL
HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD
LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS
FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS
GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL
VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM

Target 21 Number of Residues

697

Target 21 Molecular Weight

78447.2

Target 21 Theoretical pI

7.49

Target 21 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 21 General Function

Involved in ATP binding

Target 21 Pathways

Not Available

Target 21 Reactions

Not Available

Target 21 Signals

None

Target 21 Transmembrane Regions

None

Target 21 Essentiality

Non Essential

Target 21 Domain Function

PF00130:C1_1 PF00168:C2 PF00069:Pkinase PF00433:Pkinase_C

Target 21 GenBank ID Protein

Not Available

Target 21 UniProtKB ID

P05129

Target 21 Cellular Location

Not Available

Target 21 Gene Sequence

>2094 bp

ATGGCTGGTCTGGGCCCCGGCGTAGGCGATTCAGAGGGGGGACCCCGGCCCCTGTTCTGC
AGAAAGGGGGCTCTGAGGCAGAAGGTGGTCCACGAAGTCAAGAGCCACAAGTTCACCGCT
CGCTTCTTCAAGCAGCCCACCTTCTGCAGCCACTGCACCGACTTCATCTGGGGTATCGGA
AAGCAGGGCCTGCAATGTCAAGTCTGCAGCTTTGTGGTTCATCGACGATGCCACGAATTT
GTGACCTTCGAGTGTCCAGGCGCTGGGAAGGGCCCCCAGACGGACGACCCCCGGAACAAA
CACAAGTTCCGCCTGCATAGCTACAGCAGCCCCACCTTCTGCGACCACTGTGGCTCCCTC
CTCTACGGGCTTGTGCACCAGGGCATGAAATGTTCTTGCTGCGAGATGAACGTGCACCGG
CGCTGTGTGCGTAGCGTGCCCTCTCTGTGCGGTGTGGACCACACCGAGCGCCGCGGGCGC
CTGCAGCTGGAGATCCGGGCTCCCACAGCAGATGAGATCCACGTAACTGTTGGCGAGGCC
CGTAACCTAATTCCTATGGACCCCAATGGTCTCTCTGATCCCTATGTGAAACTGAAGCTC
ATCCCAGACCCTCGGAACCTGACGAAACAGAAGACCCGAACGGTGAAAGCCACGCTAAAC
CCTGTGTGGAATGAGACCTTTGTGTTCAACCTGAAGCCAGGGGATGTGGAGCGCCGGCTC
AGCGTGGAGGTGTGGGACTGGGACCGGACCTCCCGCAACGACTTCATGGGGGCCATGTCC
TTTGGCGTCTCGGAGCTGCTCAAGGCGCCCGTGGATGGCTGGTACAAGTTACTGAACCAG
GAGGAGGGCGAGTATTACAATGTGCCGGTGGCCGATGCTGACAACTGCAGCCTCCTCCAG
AAGTTTGAGGCTTGTAACTACCCCCTGGAATTGTATGAGCGGGTGCGGATGGGCCCCTCT
TCCTCTCCCATCCCCTCCCCTTCCCCTAGTCCCACCGACCCCAAGCGCTGCTTCTTCGGG
GCGAGTCCAGGACGCCTGCACATCTCCGACTTCAGCTTCCTCATGGTTCTAGGAAAAGGC
AGTTTTGGGAAGGTGATGCTGGCCGAGCGCAGGGGCTCTGATGAGCTCTACGCCATCAAG
ATCTTGAAAAAGGACGTGATCGTCCAGGACGACGATGTGGACTGCACGCTGGTGGAGAAA
CGTGTGCTGGCGCTGGGGGGCCGGGGTCCTGGCGGCCGGCCCCACTTCCTCACCCAGCTC
CACTCCACCTTCCAGACCCCGGACCGCCTGTATTTCGTGATGGAGTACGTCACCGGGGGA
GACTTGATGTACCACATTCAACAGCTGGGCAAGTTTAAGGAGCCCCATGCAGCGTTCTAC
GCGGCAGAAATCGCTATCGGCCTCTTCTTCCTTCACAATCAGGGCATCATCTACAGGGAC
CTGAAGCTGGACAATGTGATGCTGGATGCTGAGGGACACATCAAGATCACTGACTTTGGC
ATGTGTAAGGAGAACGTCTTCCCCGGGACGACAACCCGCACCTTCTGCGGGACCCCGGAC
TACATAGCCCCGGAGATCATTGCCTACCAGCCCTATGGGAAGTCTGTCGATTGGTGGTCC
TTTGGAGTTCTGCTGTATGAGATGTTGGCAGGACAGCCTCCCTTCGATGGGGAGGACGAG
GAGGAGCTGTTTCAGGCCATCATGGAACAAACTGTCACCTACCCCAAGTCGCTTTCCCGG
GAAGCCGTGGCCATCTGCAAGGGGTTCCTGACCAAGCACCCAGGGAAGCGCCTGGGCTCA
GGGCCTGATGGGGAACCTACCATCCGTGCACATGGCTTTTTCCGCTGGATTGACTGGGAG
CGGCTGGAACGATTGGAGATCCCGCCTCCTTTCAGACCCCGCCCGTGTGGCCGCAGCGGC
GAGAACTTTGACAAGTTCTTCACGCGGGCGGCGCCAGCGCTGACCCCTCCAGACCGCCTA
GTCCTGGCCAGCATCGACCAGGCCGATTTCCAGGGCTTCACCTACGTGAACCCCGACTTC
GTGCACCCGGATGCCCGCAGCCCCACCAGCCCAGTGCCTGTGCCCGTCATGTAA

Target 21 GenBank Gene ID

Not Available

Target 21 GeneCard ID

PRKCG

Target 21 GenAtlas ID

PRKCG

Target 21 HGNC ID

HGNC:9402

Target 21 Chromosome Location

Chromosome:19

Target 21 Locus

19q13.4

Target 21 SNPs

SNPJam Report Link Image

Target 21 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 21 General References

15489334; 3755548; 8375396; 15851033; 18083107; 18691976; 18669648; 9545390

Target 22 [top]

Target 22 ID

209

Target 22 Name

Protein kinase C iota type

Target 22 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 22 Description

Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs)

Target 22 Synonyms

nPKC-iota; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; PRKC-lambda/iota

Target 22 Gene Name

PRKCI

Target 22 Protein Sequence

>Protein kinase C iota type

MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV

Target 22 Number of Residues

596

Target 22 Molecular Weight

68261.9

Target 22 Theoretical pI

5.68

Target 22 GO Classification

Function
ion binding cation binding transition metal ion binding zinc ion binding signal transducer activity receptor activity phorbol ester receptor activity protein kinase C activity atypical protein kinase C activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 22 General Function

Involved in ATP binding

Target 22 Pathways

Not Available

Target 22 Reactions

Not Available

Target 22 Signals

None

Target 22 Transmembrane Regions

None

Target 22 Essentiality

Non Essential

Target 22 Domain Function

PF00130:C1_1 PF00564:PB1 PF00069:Pkinase PF00433:Pkinase_C

Target 22 GenBank ID Protein

Not Available

Target 22 UniProtKB ID

P41743

Target 22 Cellular Location

Cytoplasm. Membrane. Endosome. Nucleus

Target 22 Gene Sequence

>1764 bp

ATGTCCCACACGGTCGCAGGCGGCGGCAGCGGGGACCATTCCCACCAGGTCCGGGTGAAA
GCCTACTACCGCGGGGATATCATGATAACACATTTTGAACCTTCCATCTCCTTTGAGGGC
CTTTGCAATGAGGTTCGAGACATGTGTTCTTTTGACAACGAACAGCTCTTCACCATGAAA
TGGATAGATGAGGAAGGAGACCCGTGTACAGTATCATCTCAGTTGGAGTTAGAAGAAGCC
TTTAGACTTTATGAGCTAAACAAGGATTCTGAACTCTTGATTCATGTGTTCCCTTGTGTA
CCAGAACGTCCTGGGATGCCTTGTCCAGGAGAAGATAAATCCATCTACCGTAGAGGTGCA
CGCCGCTGGAGAAAGCTTTATTGTGCCAATGGCCACACTTTCCAAGCCAAGCGTTTCAAC
AGGCGTGCTCACTGTGCCATCTGCACAGACCGAATATGGGGACTTGGACGCCAAGGATAT
AAGTGCATCAACTGCAAACTCTTGGTTCATAAGAAGTGCCATAAACTCGTCACAATTGAA
TGTGGGCGGCATTCTTTGCCACAGGAACCAGTGATGCCCATGGATCAGTCATCCATGCAT
TCTGACCATGCACAGACAGTAATTCCATATAATCCTTCAAGTCATGAGAGTTTGGATCAA
GTTGGTGAAGAAAAAGAGGCAATGAACACCAGGGAAAGTGGCAAAGCTTCATCCAGTCTA
GGTCTTCAGGATTTTGATTTGCTCCGGGTAATAGGAAGAGGAAGTTATGCCAAAGTACTG
TTGGTTCGATTAAAAAAAACAGATCGTATTTATGCAATGAAAGTTGTGAAAAAAGAGCTT
GTTAATGATGATGAGGATATTGATTGGGTACAGACAGAGAAGCATGTGTTTGAGCAGGCA
TCCAATCATCCTTTCCTTGTTGGGCTGCATTCTTGCTTTCAGACAGAAAGCAGATTGTTC
TTTGTTATAGAGTATGTAAATGGAGGAGACCTAATGTTTCATATGCAGCGACAAAGAAAA
CTTCCTGAAGAACATGCCAGATTTTACTCTGCAGAAATCAGTCTAGCATTAAATTATCTT
CATGAGCGAGGGATAATTTATAGAGATTTGAAACTGGACAATGTATTACTGGACTCTGAA
GGCCACATTAAACTCACTGACTACGGCATGTGTAAGGAAGGATTACGGCCAGGAGATACA
ACCAGCACTTTCTGTGGTACTCCTAATTACATTGCTCCTGAAATTTTAAGAGGAGAAGAT
TATGGTTTCAGTGTTGACTGGTGGGCTCTTGGAGTGCTCATGTTTGAGATGATGGCAGGA
AGGTCTCCATTTGATATTGTTGGGAGCTCCGATAACCCTGACCAGAACACAGAGGATTAT
CTCTTCCAAGTTATTTTGGAAAAACAAATTCGCATACCACGTTCTCTGTCTGTAAAAGCT
GCAAGTGTTCTGAAGAGTTTTCTTAATAAGGACCCTAAGGAACGATTGGGTTGTCATCCT
CAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCGAAATGTTGATTGGGATATG
ATGGAGCAAAAACAGGTGGTACCTCCCTTTAAACCAAATATTTCTGGGGAATTTGGTTTG
GACAACTTTGATTCTCAGTTTACTAATGAACCTGTCCAGCTCACTCCAGATGACGATGAC
ATTGTGAGGAAGATTGATCAGTCTGAATTTGAAGGTTTTGAGTATATCAATCCTCTTTTG
ATGTCTGCAGAAGAATGTGTCTGA

Target 22 GenBank Gene ID

Not Available

Target 22 GeneCard ID

PRKCI

Target 22 GenAtlas ID

PRKCI

Target 22 HGNC ID

HGNC:9404

Target 22 Chromosome Location

Not Available

Target 22 Locus

3q26.3

Target 22 SNPs

SNPJam Report Link Image

Target 22 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 22 General References

8226978; 7607695; 15489334; 8524286; 9566925; 10356400; 11260256; 11257119; 11724794; 11713277

Target 23 [top]

Target 23 ID

168

Target 23 Name

Protein kinase C theta type

Target 23 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 23 Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters

Target 23 Synonyms

nPKC-theta

Target 23 Gene Name

PRKCQ

Target 23 Protein Sequence

>Protein kinase C theta type

MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS

Target 23 Number of Residues

706

Target 23 Molecular Weight

81864.1

Target 23 Theoretical pI

7.64

Target 23 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 23 General Function

Involved in ATP binding

Target 23 Pathways

Not Available

Target 23 Reactions

Not Available

Target 23 Signals

None

Target 23 Transmembrane Regions

None

Target 23 Essentiality

Non Essential

Target 23 Domain Function

PF00130:C1_1 PF00069:Pkinase PF00433:Pkinase_C

Target 23 GenBank ID Protein

Not Available

Target 23 UniProtKB ID

Q04759

Target 23 Cellular Location

Not Available

Target 23 Gene Sequence

>2121 bp

ATGTCGCCATTTCTTCGGATTGGCTTGTCCAACTTTGACTGCGGGTCCTGCCAGTCTTGT
CAGGGCGAGGCTGTTAACCCTTACTGTGCTGTGCTCGTCAAAGAGTATGTCGAATCAGAG
AACGGGCAGATGTATATCCAGAAAAAGCCTACCATGTACCCACCCTGGGACAGCACTTTT
GATGCCCATATCAACAAGGGAAGAGTCATGCAGATCATTGTGAAAGGCAAAAACGTGGAC
CTCATCTCTGAAACCACCGTGGAGCTCTACTCGCTGGCTGAGAGGTGCAGGAAGAACAAC
GGGAAGACAGAAATATGGTTAGAGCTGAAACCTCAAGGCCGAATGCTAATGAATGCAAGA
TACTTTCTGGAAATGAGTGACACAAAGGACATGAATGAATTTGAGACGGAAGGCTTCTTT
GCTTTGCATCAGCGCCGGGGTGCCATCAAGCAGGCAAAGGTCCACCACGTCAAGTGCCAC
GAGTTCACTGCCACCTTCTTCCCACAGCCCACATTTTGCTCTGTCTGCCACGAGTTTGTC
TGGGGCCTGAACAAACAGGGCTACCAGTGCCGACAATGCAATGCAGCAATTCACAAGAAG
TGTATTGATAAAGTTATAGCAAAGTGCACAGGATCAGCTATCAATAGCCGAGAAACCATG
TTCCACAAGGAGAGATTCAAAATTGACATGCCACACAGATTTAAAGTCTACAATTACAAG
AGCCCGACCTTCTGTGAACACTGTGGGACCCTGCTGTGGGGACTGGCACGGCAAGGACTC
AAGTGTGATGCATGTGGCATGAATGTGCATCATAGATGCCAGACAAAGGTGGCCAACCTT
TGTGGCATAAACCAGAAGCTAATGGCTGAAGCGCTGGCCATGATTGAGAGCACTCAACAG
GCTCGCTGCTTAAGAGATACTGAACAGATCTTCAGAGAAGGTCCGGTTGAAATTGGTCTC
CCATGCTCCATCAAAAATGAAGCAAGGCTGCCATGTTTACCGACACCGGGAAAAAGAGAG
CCTCAGGGCATTTCCTGGGAGTCTCCGTTGGATGAGGTGGATAAAATGTGCCATCTTCCA
GAACCTGAACTGAACAAAGAAAGACCATCTCTGCAGATTAAACTAAAAATTGAGGATTTT
ATCTTGCACAAAATGTTGGGGAAAGGAAGTTTTGGCAAGGTCTTCCTGGCAGAATTCAAG
AAAACCAATCAATTTTTCGCAATAAAGGCCTTAAAGAAAGATGTGGTCTTGATGGACGAT
GATGTTGAGTGCACGATGGTAGAGAAGAGAGTTCTTTCCTTGGCCTGGGAGCATCCGTTT
CTGACGCACATGTTTTGTACATTTCAGACCAAGGAAAACCTCTTTTTTGTGATGGAGTAC
CTCAACGGAGGGGACTTAATGTACCACATCCAAAGCTGCCACAAGTTCGACCTTTCCAGA
GCGACGTTTTATGCTGCTGAAATCATTCTTGGTCTGCAGTTCCTTCATTCCAAAGGAATA
GTCTACAGGGACCTGAAGCTAGATAACATCCTGTTAGACAAAGATGGACATATCAAGATC
GCGGATTTTGGAATGTGCAAGGAGAACATGTTAGGAGATGCCAAGACGAATACCTTCTGT
GGGACACCTGACTACATCGCCCCAGAGATCTTGCTGGGTCAGAAATACAACCACTCTGTG
GACTGGTGGTCCTTCGGGGTTCTCCTTTATGAAATGCTGATTGGTCAGTCGCCTTTCCAC
GGGCAGGATGAGGAGGAGCTCTTCCACTCCATCCGCATGGACAATCCCTTTTACCCACGG
TGGCTGGAGAAGGAAGCAAAGGACCTTCTGGTGAAGCTCTTCGTGCGAGAACCTGAGAAG
AGGCTGGGCGTGAGGGGAGACATCCGCCAGCACCCTTTGTTTCGGGAGATCAACTGGGAG
GAACTTGAACGGAAGGAGATTGACCCACCGTTCCGGCCGAAAGTGAAATCACCATTTGAC
TGCAGCAATTTCGACAAAGAATTCTTAAACGAGAAGCCCCGGCTGTCATTTGCCGACAGA
GCACTGATCAACAGCATGGACCAGAATATGTTCAGGAACTTTTCCTTCATGAACCCCCGG
ATGGAGCGGCTGATATCCTGA

Target 23 GenBank Gene ID

Not Available

Target 23 GeneCard ID

PRKCQ

Target 23 GenAtlas ID

PRKCQ

Target 23 HGNC ID

HGNC:9410

Target 23 Chromosome Location

Chromosome:10

Target 23 Locus

10p15

Target 23 SNPs

SNPJam Report Link Image

Target 23 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 23 General References

7686153; 7983077; 8444877; 15164054; 15489334; 10636891; 16252004; 17192257; 18691976

Target 24 [top]

Target 24 ID

245

Target 24 Name

Protein kinase C zeta type

Target 24 Mechanism of Action

Mercury affects the nervous system by inhibiting protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. (R022)

Target 24 Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization

Target 24 Synonyms

nPKC-zeta

Target 24 Gene Name

PRKCZ

Target 24 Protein Sequence

>Protein kinase C zeta type

MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV

Target 24 Number of Residues

592

Target 24 Molecular Weight

67659.3

Target 24 Theoretical pI

5.52

Target 24 GO Classification

Function
ion binding cation binding transition metal ion binding zinc ion binding signal transducer activity receptor activity phorbol ester receptor activity protein kinase C activity atypical protein kinase C activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity protein serine/threonine kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 24 General Function

Involved in ATP binding

Target 24 Pathways

Not Available

Target 24 Reactions

Not Available

Target 24 Signals

None

Target 24 Transmembrane Regions

None

Target 24 Essentiality

Non Essential

Target 24 Domain Function

PF00130:C1_1 PF00564:PB1 PF00069:Pkinase PF00433:Pkinase_C

Target 24 GenBank ID Protein

Not Available

Target 24 UniProtKB ID

Q05513

Target 24 Cellular Location

Cytoplasm. Endosome

Target 24 Gene Sequence

Not Available

Target 24 GenBank Gene ID

Not Available

Target 24 GeneCard ID

PRKCZ

Target 24 GenAtlas ID

PRKCZ

Target 24 HGNC ID

HGNC:9412

Target 24 Chromosome Location

Not Available

Target 24 Locus

1p36.33-p36.2

Target 24 SNPs

SNPJam Report Link Image

Target 24 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 24 General References

8224878; 14702039; 16710414; 15489334; 8375396; 9566925; 9768361; 10356400; 11260256

Target 25 [top]

Target 25 ID

173

Target 25 Name

Proto-oncogene tyrosine-protein kinase LCK

Target 25 Mechanism of Action

Mercury inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. (R066)

Target 25 Description

Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR

Target 25 Synonyms

Lymphocyte cell-specific protein-tyrosine kinase; p56-LCK; LSK; T cell-specific protein-tyrosine kinase

Target 25 Gene Name

LCK

Target 25 Protein Sequence

>Proto-oncogene tyrosine-protein kinase LCK

MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP

Target 25 Number of Residues

509

Target 25 Molecular Weight

58000.1

Target 25 Theoretical pI

5.03

Target 25 GO Classification

Function
protein-tyrosine kinase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups kinase activity protein kinase activity
Process
cellular process cell communication signal transduction intracellular signaling cascade physiological process metabolism macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid phosphorylation
Component
Not Available

Target 25 General Function

Involved in ATP binding

Target 25 Pathways

Not Available

Target 25 Reactions

Not Available

Target 25 Signals

None

Target 25 Transmembrane Regions

None

Target 25 Essentiality

Non Essential

Target 25 Domain Function

PF07714:Pkinase_Tyr PF00017:SH2 PF00018:SH3_1

Target 25 GenBank ID Protein

Not Available

Target 25 UniProtKB ID

P06239

Target 25 Cellular Location

Cytoplasm. Cell membrane

Target 25 Gene Sequence

>1524 bp

ATGGGCTGTGGCTGCAGCTCACACCCGGAAGATGACTGGATGGAAAACATCGATGTGTGT
GAGAACTGCCATTATCCCATAGTCCCACTGGATGGCAAGGGCACGCTGCTCATCCGAAAT
GGCTCTGAGGTGCGGGACCCACTGGTTACCTACGAAGGCTCCAATCCGCCGGCTTCCCCA
CTGCAAGACAACCTGGTTATCGCTCTGCACAGCTATGAGCCCTCTCACGACGGAGATCTG
GGCTTTGAGAAGGGGGAACAGCTCCGCATCCTGGAGCAGAGCGGCGAGTGGTGGAAGGCG
CAGTCCCTGACCACGGGCCAGGAAGGCTTCATCCCCTTCAATTTTGTGGCCAAAGCGAAC
AGCCTGGAGCCCGAACCCTGGTTCTTCAAGAACCTGAGCCGCAAGGACGCGGAGCGGCAG
CTCCTGGCGCCCGGGAACACTCACGGCTCCTTCCTCATCCGGGAGAGCGAGAGCACCGCG
GGATCGTTTTCACTGTCGGTCCGGGACTTCGACCAGAACCAGGGAGAGGTGGTGAAACAT
TACAAGATCCGTAATCTGGACAACGGTGGCTTCTACATCTCCCCTCGAATCACTTTTCCC
GGCCTGCATGAACTGGCCTCCGCCATTACACCAATCGCTTCAGATGGGCTGTGCACACGG
TTGAGCCGCCCCTGCCAGACCCAGAAGCCCCAGAAGCCGTGGTGGGAGGACGAGTGGGAG
GTTCCCAGGGAGACGCTGAAGCTGGTGGAGCGGCTGGGGGCTGGACAGTTCGGGAGGTGT
GGATGGGGTACTACAACGGGCACAACGAAGGTGGCGGTGAAGAGCCTGAAGCAGGGCAGC
ATGTCCGCCGGACGCCTTCCTGCCGAGGCCAACCTCATGAAGCAGCTGCAACACCAGCGG
CTGGTTCGGCTCTACGCTGTGGTCACCCAGGAGCCCATCTACATCATCACTGAATACATG
GAGAATGGGAGTCTAGTGGATTTTCTCAAGACCCCTTCAGGCATCAAGTTGACCATCAAC
AAACTCCTGGACATGGCAGCCCAAATTGCAGAAGGCATGGCATTCATTGAAGAGCGGAAT
TATATTCATCGTGACCTTCGGGCTGCCAACATTCTGGTGTCTGACACCCTGAGCTGCAAG
ATTGCAGACTTTGGCCTAGCACGCCTCATTGAGGACAACGAGTACACAGCCAGGGAGGGG
GCCAAGTTTCCCATTAAGTGGACAGCGCCAGAAGCCATTAACTACGGGACATTCACCATC
AAGTCAGATGTGTGGTCTTTTGGGATCCTGCTGACGGAAATTGTCACCCACGGCCGCATC
CCTTACCCAGGGATGACCAACCCGGAGGTGATTCAGAACCTGGAGCGAGGCTACCGCATG
GTGCGCCCTGACAACTGTCCAGAGGAGCTGTACCAACTCATGAGGCTGTGCTGGAAGGAG
CGCCCAGAGGACCGGCCCACCTTTGACTACCTGCGCAGTGTGCTGGAGGACTTCTTCACG
GCCACAGAGGGCAGTACAGCCTAG

Target 25 GenBank Gene ID

Not Available

Target 25 GeneCard ID

LCK

Target 25 GenAtlas ID

LCK

Target 25 HGNC ID

HGNC:6524

Target 25 Chromosome Location

Not Available

Target 25 Locus

1p34.3

Target 25 SNPs

SNPJam Report Link Image

Target 25 Toxin References

R066 - Ziemba SE, Menard SL, McCabe MJ Jr, Rosenspire AJ: T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury. FASEB J. 2009 Jun;23(6):1663-71. Epub 2009 Jan 23. [PubMed ]

Target 25 General References

3493153; 3265417; 2558056; 8139546; 7495859; 12401726; 16710414; 15489334; 2850479

Target 26 [top]

Target 26 ID

425

Target 26 Name

Putative tubulin beta chain-like protein ENSP00000290377

Target 26 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 26 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 26 Synonyms

Not Available

Target 26 Gene Name

Not Available

Target 26 Protein Sequence

>Putative tubulin beta chain-like protein ENSP00000290377

MDSVRSGPFGQVLRPDNFIFGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQG
FQLTHSLGGGTGSGMVTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQL
IENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRK
LAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMRAARDPRHGRYLT
AAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAICDIPPRGLKMSASFIGNNA
AIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAKE
EEDEEYAEEEVA

Target 26 Number of Residues

372

Target 26 Molecular Weight

41774.7

Target 26 Theoretical pI

4.50

Target 26 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 26 General Function

Cell cycle control, cell division, chromosome partitioning

Target 26 Pathways

Not Available

Target 26 Reactions

Not Available

Target 26 Signals

None

Target 26 Transmembrane Regions

None

Target 26 Essentiality

Non Essential

Target 26 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 26 GenBank ID Protein

Not Available

Target 26 UniProtKB ID

A6NKZ8

Target 26 Cellular Location

Cytoplasmic

Target 26 Gene Sequence

Not Available

Target 26 GenBank Gene ID

Not Available

Target 26 GeneCard ID

Not Available

Target 26 GenAtlas ID

Not Available

Target 26 HGNC ID

Not Available

Target 26 Chromosome Location

Not Available

Target 26 Locus

Not Available

Target 26 SNPs

Not Available

Target 26 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 26 General References

15164053

Target 27 [top]

Target 27 ID

426

Target 27 Name

Putative tubulin beta-4q chain

Target 27 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 27 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 27 Synonyms

Not Available

Target 27 Gene Name

TUBB4Q

Target 27 Protein Sequence

>Putative tubulin beta-4q chain

MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVRSGPFAEVFRPDNFISRQCGAGNNWAKGRYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATVSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSQGSQQYRALTVAELTQQMFDAKNMM
AARDPRHGCYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNIKTAVCDIPPWG
LKMSVTFTGNNTAVQELKRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSE
YQQYQDATAEGEGV

Target 27 Number of Residues

434

Target 27 Molecular Weight

48434.2

Target 27 Theoretical pI

4.91

Target 27 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 27 General Function

Cell cycle control, cell division, chromosome partitioning

Target 27 Pathways

Not Available

Target 27 Reactions

Not Available

Target 27 Signals

None

Target 27 Transmembrane Regions

None

Target 27 Essentiality

Non Essential

Target 27 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 27 GenBank ID Protein

Not Available

Target 27 UniProtKB ID

Q99867

Target 27 Cellular Location

Cytoplasmic

Target 27 Gene Sequence

Not Available

Target 27 GenBank Gene ID

Not Available

Target 27 GeneCard ID

TUBB4Q

Target 27 GenAtlas ID

TUBB4Q

Target 27 HGNC ID

HGNC:12413 Link Image

Target 27 Chromosome Location

Not Available

Target 27 Locus

4q35

Target 27 SNPs

SNPJam Report Link Image

Target 27 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 27 General References

10828619

Target 28 [top]

Target 28 ID

427

Target 28 Name

Putative tubulin-like protein alpha-4B

Target 28 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 28 Description

Not Available

Target 28 Synonyms

Alpha-tubulin 4B

Target 28 Gene Name

TUBA4B

Target 28 Protein Sequence

>Putative tubulin-like protein alpha-4B

MRHQQTERQDPSQPLSRQHGTYRQIFHPEQLITGKEDAANNYAWGHYTIGKEFIDLLLDR
IRKLADQCTGLQGFLVFHSLGRGTGSDVTSFLMEWLSVNYGKKSKLGFSIYPAPQVSTAM
VQPYNSILTTHTTLEHSDCAFMVDNKAIYDICHCNLDIERPTYTNLNRLISQIVSSITAS
LRFDGALNVDLTEFQTNLVSYLTSTSPWPPMHQSSLQKRYTTSSCWWQRLPMPALSLPTR
W

Target 28 Number of Residues

241

Target 28 Molecular Weight

27551.0

Target 28 Theoretical pI

7.93

Target 28 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 28 General Function

Involved in GTP binding

Target 28 Pathways

Not Available

Target 28 Reactions

Not Available

Target 28 Signals

None

Target 28 Transmembrane Regions

None

Target 28 Essentiality

Non Essential

Target 28 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 28 GenBank ID Protein

Not Available

Target 28 UniProtKB ID

Q9H853

Target 28 Cellular Location

Cytoplasmic

Target 28 Gene Sequence

>726 bp

ATGCGGCACCAGCAGACAGAGAGACAAGACCCCAGCCAGCCCCTGTCCAGGCAGCATGGC
ACATACCGCCAGATCTTCCATCCAGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAAT
AACTATGCCTGGGGCCACTACACCATTGGGAAGGAGTTCATCGACCTGCTACTGGACCGG
ATTCGGAAGCTGGCTGACCAGTGCACAGGACTTCAGGGCTTCCTGGTGTTCCACAGCCTT
GGTCGGGGCACTGGCTCTGACGTCACCTCATTCCTGATGGAGTGGCTTTCTGTTAACTAT
GGCAAGAAATCCAAGCTGGGATTCTCCATCTACCCAGCCCCCCAGGTGTCTACAGCCATG
GTCCAGCCCTACAACTCTATCCTGACCACCCACACCACCCTGGAGCACTCAGACTGTGCC
TTCATGGTGGACAACAAAGCAATCTATGACATCTGCCACCGCAACCTAGACATTGAGCGC
CCAACCTACACCAACCTCAATCGCCTCATTAGCCAAATTGTCTCCTCCATCACAGCTTCT
CTGCGCTTTGACGGGGCCCTCAATGTGGACCTGACAGAGTTCCAGACCAACCTGGTGTCC
TACCTCACATCCACTTCCCCCTGGCCACCTATGCACCAGTCATCTCTGCAGAAAAAGTAT
ACCACGAGCAGCTGTCGGTGGCAGAGATTACCAATGCCTGCTTTGAGCCTGCCAACCAGA
TGGTGA

Target 28 GenBank Gene ID

Not Available

Target 28 GeneCard ID

TUBA4B

Target 28 GenAtlas ID

TUBA4B

Target 28 HGNC ID

HGNC:18637 Link Image

Target 28 Chromosome Location

Not Available

Target 28 Locus

Not Available

Target 28 SNPs

SNPJam Report Link Image

Target 28 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 28 General References

14702039; 15815621

Target 29 [top]

Target 29 ID

399

Target 29 Name

Tubulin alpha chain-like 3

Target 29 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 29 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 29 Synonyms

Not Available

Target 29 Gene Name

TUBAL3

Target 29 Protein Sequence

>Tubulin alpha chain-like 3

MRECLSIHIGQAGIQIGDACWELYCLEHGIQPNGVVLDTQQDQLENAKMEHTNASFDTFF
CETRAGKHVPRALFVDLEPTVIDGIRTGQHRSLFHPEQLLSGKEDAANNYARGRYSVGSE
VIDLVLERTRKLAEQCGGLQGFLIFRSFGGGTGSGFTSLLMERLTGEYSRKTKLEFSVYP
APRISTAVVEPYNSVLTTHSTTEHTDCTFMVDNEAVYDICHRKLGVECPSHASINRLVVQ
VVSSITASLRFEGPLNVDLIEFQTNLVPYPRIHFPMTAFAPIVSADKAYHEQFSVSDITT
ACFESSNQLVKCDPRLGKYMACCLLYRGDVVPKEVNAAIAATKSRHSVQFVDWCPTGFKV
GINNRPPTVMPGGDLAKVHRSICMLSNTTAIVEAWARLDHKFDLMYAKRAFLHWYLREGM
EEAEFLEAREDLAALERDYEEVAQSF

Target 29 Number of Residues

446

Target 29 Molecular Weight

49908.3

Target 29 Theoretical pI

5.96

Target 29 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 29 General Function

Involved in GTP binding

Target 29 Pathways

Not Available

Target 29 Reactions

Not Available

Target 29 Signals

None

Target 29 Transmembrane Regions

None

Target 29 Essentiality

Non Essential

Target 29 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 29 GenBank ID Protein

Not Available

Target 29 UniProtKB ID

A6NHL2

Target 29 Cellular Location

Cytoplasmic

Target 29 Gene Sequence

>1341 bp

ATGAGGGAGTGCCTTTCCATCCACATCGGTCAAGCTGGCATCCAGATTGGGGACGCCTGC
TGGGAACTCTATTGCCTGGAACATGGAATCCAGCCAAATGGCGTTGTTCTTGACACTCAA
CAGGATCAGCTGGAAAATGCAAAAATGGAGCACACAAATGCATCTTTCGATACCTTCTTC
TGTGAGACAAGAGCTGGGAAGCATGTGCCTAGAGCACTCTTCGTGGACTTGGAGCCAACT
GTTATAGATGGGATCCGGACGGGCCAGCACCGTTCACTCTTCCACCCCGAGCAGCTCCTT
AGCGGAAAGGAGGATGCTGCCAACAATTACGCGCGAGGCCGTTACTCTGTGGGGTCGGAG
GTCATCGACCTTGTGCTGGAGAGGACCCGGAAGCTGGCAGAACAGTGTGGTGGACTTCAG
GGATTTTTGATTTTCCGAAGCTTTGGAGGAGGCACTGGTTCAGGGTTTACGTCTCTCTTA
ATGGAGAGGCTCACAGGAGAATATAGCAGAAAGACTAAGCTGGAGTTCTCGGTCTACCCA
GCCCCCAGGATCTCCACTGCCGTGGTAGAGCCTTATAACTCTGTCCTCACCACCCACTCC
ACCACAGAGCACACGGACTGTACCTTCATGGTGGACAACGAGGCCGTCTATGATATATGC
CATCGTAAACTCGGTGTTGAATGCCCCTCTCATGCCAGCATCAATAGATTGGTGGTTCAG
GTGGTATCTTCCATCACTGCCTCCCTCCGGTTTGAAGGGCCCTTGAATGTAGACCTAATT
GAATTCCAGACCAACCTGGTACCTTATCCGAGAATACATTTCCCCATGACAGCCTTCGCC
CCCATCGTCTCTGCTGACAAAGCCTACCATGAGCAGTTCTCTGTGTCAGACATCACCACT
GCTTGCTTTGAGTCCTCCAACCAGCTGGTCAAGTGTGATCCTCGGCTTGGGAAGTACATG
GCCTGCTGCCTACTCTATAGAGGGGATGTGGTCCCCAAGGAAGTGAATGCAGCAATCGCA
GCCACGAAGTCGAGGCACTCTGTTCAGTTTGTAGATTGGTGTCCAACTGGTTTCAAGGTG
GGCATCAACAATCGGCCGCCCACGGTGATGCCGGGTGGGGACCTGGCCAAAGTCCACCGG
TCCATCTGCATGCTGAGCAACACCACGGCGATTGTGGAGGCCTGGGCCCGCCTGGACCAC
AAGTTTGACCTCATGTACGCCAAGAGAGCATTTCTGCACTGGTACCTCAGAGAAGGCATG
GAAGAAGCAGAGTTCTTGGAGGCCAGGGAAGATCTGGCAGCCCTGGAGAGGGACTATGAG
GAAGTGGCGCAAAGTTTCTGA

Target 29 GenBank Gene ID

Not Available

Target 29 GeneCard ID

TUBAL3

Target 29 GenAtlas ID

TUBAL3

Target 29 HGNC ID

HGNC:23534 Link Image

Target 29 Chromosome Location

Chromosome:10

Target 29 Locus

10p15.1

Target 29 SNPs

SNPJam Report Link Image

Target 29 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 29 General References

14702039; 15164054; 15489334; 17924679

Target 30 [top]

Target 30 ID

Target 30 Name

Tubulin alpha-1A chain

Target 30 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 30 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 30 Synonyms

Tubulin B-alpha-1; Tubulin alpha-3 chain; Alpha-tubulin 3

Target 30 Gene Name

TUBA1A

Target 30 Protein Sequence

>Tubulin alpha-1A chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Target 30 Number of Residues

451

Target 30 Molecular Weight

50135.2

Target 30 Theoretical pI

4.70

Target 30 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 30 General Function

Involved in GTP binding

Target 30 Pathways

Not Available

Target 30 Reactions

Not Available

Target 30 Signals

None

Target 30 Transmembrane Regions

None

Target 30 Essentiality

Non Essential

Target 30 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 30 GenBank ID Protein

Not Available

Target 30 UniProtKB ID

Q71U36

Target 30 Cellular Location

Cytoplasmic

Target 30 Gene Sequence

>1356 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGGGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAACTTATCACAGGCAAAGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCCGACCAGTGCACGGGTCTCCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATTGAG
CGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTATCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAACGTGCCTTTGTTCACTGGTACGTTGGGGAGGGGATGGAGGAAGGTGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA

Target 30 GenBank Gene ID

Not Available

Target 30 GeneCard ID

TUBA1A

Target 30 GenAtlas ID

TUBA1A

Target 30 HGNC ID

HGNC:20766 Link Image

Target 30 Chromosome Location

Chromosome:12

Target 30 Locus

12q12-q14.3

Target 30 SNPs

SNPJam Report Link Image

Target 30 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 30 General References

3839072; 11504633; 15489334; 6646120; 17081983; 17584854; 18669648; 19524510

Target 31 [top]

Target 31 ID

223

Target 31 Name

Tubulin alpha-1B chain

Target 31 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 31 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 31 Synonyms

Tubulin alpha-ubiquitous chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1

Target 31 Gene Name

TUBA1B

Target 31 Protein Sequence

>Tubulin alpha-1B chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Target 31 Number of Residues

451

Target 31 Molecular Weight

50151.2

Target 31 Theoretical pI

4.70

Target 31 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 31 General Function

Involved in GTP binding

Target 31 Pathways

Not Available

Target 31 Reactions

Not Available

Target 31 Signals

None

Target 31 Transmembrane Regions

None

Target 31 Essentiality

Non Essential

Target 31 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 31 GenBank ID Protein

Not Available

Target 31 UniProtKB ID

P68363

Target 31 Cellular Location

Cytoplasmic

Target 31 Gene Sequence

>1356 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAG
CACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCCGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGCCTGTCAGTTGAT
TATGGCAAGAAATCCAAGCTGGAGTTCTCCATTTACCCGGCACCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTC
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGACATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTGGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCACG
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA

Target 31 GenBank Gene ID

Not Available

Target 31 GeneCard ID

TUBA1B

Target 31 GenAtlas ID

TUBA1B

Target 31 HGNC ID

HGNC:18809 Link Image

Target 31 Chromosome Location

Chromosome:12

Target 31 Locus

12q13.12

Target 31 SNPs

SNPJam Report Link Image

Target 31 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 31 General References

6646120; 15489334; 8619814; 15592455; 19007248; 18781797

Target 32 [top]

Target 32 ID

145

Target 32 Name

Tubulin alpha-1C chain

Target 32 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 32 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 32 Synonyms

Tubulin alpha-6 chain; Alpha-tubulin 6

Target 32 Gene Name

TUBA1C

Target 32 Protein Sequence

>Tubulin alpha-1C chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSADGEDEGEEY

Target 32 Number of Residues

449

Target 32 Molecular Weight

49894.9

Target 32 Theoretical pI

4.73

Target 32 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 32 General Function

Involved in GTP binding

Target 32 Pathways

Not Available

Target 32 Reactions

Not Available

Target 32 Signals

None

Target 32 Transmembrane Regions

None

Target 32 Essentiality

Non Essential

Target 32 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 32 GenBank ID Protein

Not Available

Target 32 UniProtKB ID

Q9BQE3

Target 32 Cellular Location

Cytoplasmic

Target 32 Gene Sequence

>1350 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAAACGGGTGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTACTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTATACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATTAATTACCAGCCTCCC
ACTGTGGTGCCTGGCGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAT
ACCACAGCTGTTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGAGCAGATAGTGCT
GACGGAGAGGATGAGGGTGAAGAGTATTAA

Target 32 GenBank Gene ID

Not Available

Target 32 GeneCard ID

TUBA1C

Target 32 GenAtlas ID

TUBA1C

Target 32 HGNC ID

HGNC:20768 Link Image

Target 32 Chromosome Location

Chromosome:12

Target 32 Locus

12q12-q14

Target 32 SNPs

SNPJam Report Link Image

Target 32 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 32 General References

15489334; 15592455; 17081983; 19007248; 18691976; 18669648; 19524510

Target 33 [top]

Target 33 ID

147

Target 33 Name

Tubulin alpha-3C/D chain

Target 33 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 33 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 33 Synonyms

Alpha-tubulin 3C/D; Tubulin alpha-2 chain; Alpha-tubulin 2

Target 33 Gene Name

TUBA3C

Target 33 Protein Sequence

>Tubulin alpha-3C/D chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY

Target 33 Number of Residues

450

Target 33 Molecular Weight

49959.1

Target 33 Theoretical pI

4.74

Target 33 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 33 General Function

Involved in GTP binding

Target 33 Pathways

Not Available

Target 33 Reactions

Not Available

Target 33 Signals

None

Target 33 Transmembrane Regions

None

Target 33 Essentiality

Non Essential

Target 33 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 33 GenBank ID Protein

Not Available

Target 33 UniProtKB ID

Q13748

Target 33 Cellular Location

Cytoplasmic

Target 33 Gene Sequence

>1257 bp

ATGCGTGAGTGTATCTCTATCCACGTGGGGCAGGCAGGAGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTGGAACATGGAATTCAGCCCGATGGTCAGATGCCAAGTGATAAA
ACCATTGGTGGTGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGAACCTATAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCGGCC
AATAATTACGCCAGAGGCCATTACACCATCGGCAAGGAGATCGTCGACCTGGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACGGGACTGCAGGGCTTCCTCATCTTCCACAGT
TTTGGGGGTGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACGGCAAGAAGTCCAAGCTAGAATTTGCCATTTACCCAGCCCCCCAGGTCTCCACGGCC
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATCGAG
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGACGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTAGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCGGTCATCTCAGCCGAGAAG
GCCTACCACGAGCAGCTGTCCGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCACGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGATGTGGTCCCGAAAGATGTCAACGCGGCCATCGCCACCATCAAGACCAAGCGCACC
ATCCAGTTTGTAGATTGGTGCCCAACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACGGTGGTCCCTGGGGGAGACCTGGCCAAGGTGCAGCGGGCTGTGTGCATGCTGAGCAAC
ACCACGGCCATCGCGGAGGCCTGGGCTCGCCTGGACCTGGCAGCTCTGGAGAAGGATTAT
GAAGAGGTGGGCGTGGATTCCGTGGAAGCCGAGGCTGAAGAAGGTGAAGAATACTGA

Target 33 GenBank Gene ID

Not Available

Target 33 GeneCard ID

TUBA3C

Target 33 GenAtlas ID

TUBA3C

Target 33 HGNC ID

HGNC:12408 Link Image

Target 33 Chromosome Location

Chromosome:13

Target 33 Locus

13q11

Target 33 SNPs

SNPJam Report Link Image

Target 33 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 33 General References

9465305; 15057823; 15489334; 17924679; 19524510

Target 34 [top]

Target 34 ID

Target 34 Name

Tubulin alpha-3E chain

Target 34 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 34 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 34 Synonyms

Alpha-tubulin 3E

Target 34 Gene Name

TUBA3E

Target 34 Protein Sequence

>Tubulin alpha-3E chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAASNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYSKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGMEEGEFSE
AREDLAALEKDCEEVGVDSVEAEAEEGEAY

Target 34 Number of Residues

450

Target 34 Molecular Weight

49858.1

Target 34 Theoretical pI

4.77

Target 34 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 34 General Function

Involved in GTP binding

Target 34 Pathways

Not Available

Target 34 Reactions

Not Available

Target 34 Signals

None

Target 34 Transmembrane Regions

None

Target 34 Essentiality

Non Essential

Target 34 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 34 GenBank ID Protein

Not Available

Target 34 UniProtKB ID

Q6PEY2

Target 34 Cellular Location

Cytoplasmic

Target 34 Gene Sequence

>1353 bp

ATGCGCGAGTGTATCTCTATCCACGTGGGGCAGGCGGGTGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTTGAACATGGAATTCAGCCCGATGGTCAAATGCCAAGTGATAAA
ACCATTGGTGGCGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGGACCTACAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCAGCC
AGTAATTACGCCAGGGGCCATTACACCATCGGCAAGGAGATTGTTGACCTAGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACAGGACTGCAGGGCTTCCTCATCTTCCACAGC
TTTGGGGGCGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACAGCAAGAAGTCCAAGCTAGAGTTTGCCATTTACCCAGCCCCCCAGGTCTCCACAGCC
GTGGTGGAGCCCTACAACTCCATCCTAACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATTGAA
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGATGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTCGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCAGTCATCTCAGCTGAGAAG
GCCTACCATGAGCAGCTGTCTGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCATGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGACGTGGTCCCCAAAGACGTCAATGCGGCCATCGCCACCATCAAGACCAAGCGCACT
ATCCAGTTTGTGGATTGGTGCCCGACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACAGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTGTGCATGCTGAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTGGTCCATAAGTTCGATCTCATGTATGCC
AAGTGGGCCTTTGTGCACTGGTACGTGGGCGAAGGCATGGAAGAGGGAGAGTTCTCTGAG
GCCCGCGAGGACCTGGCAGCTCTAGAGAAGGATTGTGAAGAGGTGGGCGTGGATTCCGTG
GAAGCTGAGGCTGAAGAAGGCGAAGAATACTGA

Target 34 GenBank Gene ID

Not Available

Target 34 GeneCard ID

TUBA3E

Target 34 GenAtlas ID

TUBA3E

Target 34 HGNC ID

HGNC:20765 Link Image

Target 34 Chromosome Location

Not Available

Target 34 Locus

2q21.1

Target 34 SNPs

SNPJam Report Link Image

Target 34 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 34 General References

15815621; 15489334; 16565220; 19524510

Target 35 [top]

Target 35 ID

Target 35 Name

Tubulin alpha-4A chain

Target 35 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 35 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 35 Synonyms

Tubulin alpha-1 chain; Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha

Target 35 Gene Name

TUBA4A

Target 35 Protein Sequence

>Tubulin alpha-4A chain

MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK
HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD
RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGIDSYEDEDEGEE

Target 35 Number of Residues

448

Target 35 Molecular Weight

49924.0

Target 35 Theoretical pI

4.69

Target 35 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 35 General Function

Involved in GTP binding

Target 35 Pathways

Not Available

Target 35 Reactions

Not Available

Target 35 Signals

None

Target 35 Transmembrane Regions

None

Target 35 Essentiality

Non Essential

Target 35 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 35 GenBank ID Protein

Not Available

Target 35 UniProtKB ID

P68366

Target 35 Cellular Location

Cytoplasmic

Target 35 Gene Sequence

Not Available

Target 35 GenBank Gene ID

Not Available

Target 35 GeneCard ID

TUBA4A

Target 35 GenAtlas ID

TUBA4A

Target 35 HGNC ID

HGNC:12407 Link Image

Target 35 Chromosome Location

Not Available

Target 35 Locus

2q35

Target 35 SNPs

SNPJam Report Link Image

Target 35 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 35 General References

3029670; 15489334; 15592455; 17924679; 18088087; 18691976; 18669648

Target 36 [top]

Target 36 ID

134

Target 36 Name

Tubulin alpha-8 chain

Target 36 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 36 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 36 Synonyms

Alpha-tubulin 8; Tubulin alpha chain-like 2

Target 36 Gene Name

TUBA8

Target 36 Protein Sequence

>Tubulin alpha-8 chain

MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGK
HVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLD
RIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNS
QMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGTDSFEEENEGEEF

Target 36 Number of Residues

449

Target 36 Molecular Weight

50093.1

Target 36 Theoretical pI

4.70

Target 36 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 36 General Function

Involved in GTP binding

Target 36 Pathways

Not Available

Target 36 Reactions

Not Available

Target 36 Signals

None

Target 36 Transmembrane Regions

None

Target 36 Essentiality

Non Essential

Target 36 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 36 GenBank ID Protein

Not Available

Target 36 UniProtKB ID

Q9NY65

Target 36 Cellular Location

Cytoplasmic

Target 36 Gene Sequence

>1350 bp

ATGCGGGAATGCATATCAGTCCACGTGGGCCAAGCGGGAGTTCAGATTGGCAATGCCTGC
TGGGAGCTCTTCTGCCTGGAACACGGCATCCAGGCAGACGGCACTTTTGATGCTCAAGCT
AGCAAGATCAACGATGATGACTCCTTCACCACCTTTTTCAGCGAGACTGGCAATGGGAAG
CATGTGCCCCGGGCCGTCATGATAGATCTGGAGCCTACTGTAGTGGATGAGGTTCGGGCA
GGAACCTACCGCCAGCTCTTCCATCCAGAGCAGCTGATCACAGGAAAGGAGGATGCAGCC
AACAACTATGCCCGGGGCCACTACACGGTGGGCAAGGAGAGCATTGACCTGGTGCTGGAC
CGCATACGGAAGCTGACAGATGCTTGCTCTGGCCTGCAGGGCTTCCTGATTTTCCACAGT
TTTGGTGGGGGCACTGGCTCCGGCTTCACTTCTCTGCTGATGGAACGCCTCTCCCTGGAT
TATGGCAAGAAATCCAAGCTGGAGTTTGCCATCTACCCAGCCCCCCAGGTCTCTACTGCA
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACCACACTGGAACATTCAGATTGT
GCTTTCATGGTGGACAACGAAGCCATCTATGACATCTGCCGCAGGAACCTTGACATTGAG
CGCCCTACCTATACCAACCTCAACCGCCTCATCAGTCAGATTGTGTCCTCAATCACTGCT
TCTCTCCGCTTTGACGGGGCCCTCAATGTGGACCTCACTGAGTTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCGCTGGTCACCTACGCGCCCATCATCTCTGCCGAGAAA
GCCTATCACGAACAGCTCTCTGTGGCCGAGATAACCAGCTCCTGCTTTGAGCCCAACAGC
CAGATGGTGAAGTGCGACCCGAGACATGGCAAGTACATGGCCTGCTGCATGCTCTACCGG
GGCGACGTGGTGCCCAAGGATGTGAATGTCGCTATTGCTGCCATCAAGACCAAGAGGACC
ATCCAGTTTGTAGACTGGTGTCCCACAGGCTTCAAGGTGGGCATCAACTACCAGCCCCCG
ACCGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTCTGCATGCTCAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTCGACCACAAGTTCGACCTCATGTACGCC
AAGCGGGCCTTTGTGCATTGGTATGTGGGAGAGGGGATGGAAGAAGGAGAATTTTCTGAG
GCCAGGGAAGACTTAGCTGCCCTGGAGAAGGATTATGAAGAAGTGGGGACTGATTCGTTT
GAAGAAGAAAATGAAGGGGAGGAATTTTAA

Target 36 GenBank Gene ID

Not Available

Target 36 GeneCard ID

TUBA8

Target 36 GenAtlas ID

TUBA8

Target 36 HGNC ID

HGNC:12410 Link Image

Target 36 Chromosome Location

Chromosome:22

Target 36 Locus

22q11.1

Target 36 SNPs

SNPJam Report Link Image

Target 36 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 36 General References

10772959; 15461802; 15489334; 19524510

Target 37 [top]

Target 37 ID

Target 37 Name

Tubulin beta chain

Target 37 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 37 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 37 Synonyms

Tubulin beta-5 chain

Target 37 Gene Name

TUBB

Target 37 Protein Sequence

>Tubulin beta chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA

Target 37 Number of Residues

444

Target 37 Molecular Weight

49670.5

Target 37 Theoretical pI

4.52

Target 37 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 37 General Function

Cell cycle control, cell division, chromosome partitioning

Target 37 Pathways

Not Available

Target 37 Reactions

Not Available

Target 37 Signals

None

Target 37 Transmembrane Regions

None

Target 37 Essentiality

Non Essential

Target 37 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 37 GenBank ID Protein

Not Available

Target 37 UniProtKB ID

P07437

Target 37 Cellular Location

Cytoplasmic

Target 37 Gene Sequence

>1335 bp

ATGAGGGAAATCGTGCACATCCAGGCTGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTC
TGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGACCGCATCTCTGTGTACTACAATGAAGCCACAGGTGGCAAATATGTT
CCTCGTGCCATCCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCT
TTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAAC
TGGGCCAAAGGCCACTACACAGAGGGCGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTA
CGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGC
GGGGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAATACCCT
GATCGCATCATGAATACCTTCAGTGTGGTGCCTTCACCCAAAGTGTCTGACACCGTGGTC
GAGCCCTACAATGCCACCCTCTCCGTCCATCAGTTGGTAGAGAATACTGATGAGACCTAT
TGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGCACTCTGAAGCTGACCACACCA
ACCTACGGGGATCTGAACCACCTTGTCTCAGCCACCATGAGTGGTGTCACCACCTGCCTC
CGTTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAGTTGGCAGTCAACATGGTCCCCTTC
CCACGTCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAG
TATCGAGCTCTCACAGTGCCGGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATG
GCTGCCTGTGACCCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGG
ATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAGAACAGCAGCTAC
TTTGTGGAATGGATCCCCAACAATGTCAAGACAGCCGTCTGTGACATCCCACCTCGTGGC
CTCAAGATGGCAGTCACCTTCATTGGCAATAGCACAGCCATCCAGGAGCTCTTCAAGCGC
ATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCTGAGAGCAACATGAACGACCTCGTCTCT
GAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCC
GAAGAGGAGGCCTAA

Target 37 GenBank Gene ID

Not Available

Target 37 GeneCard ID

TUBB

Target 37 GenAtlas ID

TUBB

Target 37 HGNC ID

HGNC:20778 Link Image

Target 37 Chromosome Location

Chromosome:6
Entrez Gene cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33

Target 37 Locus

6p21.33

Target 37 SNPs

SNPJam Report Link Image

Target 37 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 37 General References

6688039; 6865944; 11504633; 15489334

Target 38 [top]

Target 38 ID

Target 38 Name

Tubulin beta-1 chain

Target 38 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 38 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 38 Synonyms

Not Available

Target 38 Gene Name

TUBB1

Target 38 Protein Sequence

>Tubulin beta-1 chain

MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH

Target 38 Number of Residues

451

Target 38 Molecular Weight

50326.6

Target 38 Theoretical pI

4.82

Target 38 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 38 General Function

Cell cycle control, cell division, chromosome partitioning

Target 38 Pathways

Not Available

Target 38 Reactions

Not Available

Target 38 Signals

None

Target 38 Transmembrane Regions

None

Target 38 Essentiality

Non Essential

Target 38 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 38 GenBank ID Protein

Not Available

Target 38 UniProtKB ID

Q9H4B7

Target 38 Cellular Location

Cytoplasmic

Target 38 Gene Sequence

>1356 bp

ATGCGTGAAATTGTCCATATTCAGATTGGCCAGTGTGGCAACCAGATCGGAGCCAAGTTC
TGGGAGATGATTGGTGAGGAACACGGGATCGACTTGGCTGGGAGCGACCGCGGGGCCTCG
GCCTTGCAGCTGGAGAGAATCAGCGTGTACTACAACGAAGCCTACGGTAGGAAATATGTG
CCCCGAGCAGTCTTGGTGGACCTAGAACCTGGGACGATGGACAGCATTCGATCTAGCAAA
TTAGGAGCTCTCTTTCAACCCGACAGTTTTGTCCATGGTAACTCTGGGGCTGGCAACAAC
TGGGCCAAAGGCCACTACACGGAGGGAGCCGAGCTGATCGAGAATGTCCTAGAGGTGGTG
AGGCACGAGAGTGAGAGCTGTGACTGCCTGCAGGGCTTCCAGATCGTCCACTCCCTGGGC
GGGGGCACAGGCTCCGGGATGGGCACTCTGCTCATGAACAAGATTAGAGAGGAGTACCCG
GACCGGATCATGAATTCCTTCAGCGTCATGCCTTCTCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAACGCGGTTCTGTCTATCCACCAGCTGATTGAGAATGCAGATGCCTGTTTC
TGCATTGACAATGAGGCCCTCTATGACATCTGCTTCCGTACCCTGAAGCTGACGACACCC
ACCTATGGGGATCTCAACCACCTAGTGTCCTTGACCATGAGCGGCATAACCACCTCCCTC
CGGTTCCCGGGTCAGCTCAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTCCCCTTC
CCCCGCCTGCACTTCTTTATGCCCGGCTTTGCCCCACTCACGGCCCAGGGCAGCCAGCAG
TACCGAGCCCTCTCCGTGGCCGAGCTCACCCAGCAGATGTTCGATGCCCGCAATACCATG
GCTGCCTGTGACCTCCGCCGTGGCCGCTACCTCACAGTGGCCTGCATTTTCCGGGGCAAG
ATGTCCACCAAGGAAGTGGACCAGCAACTGCTCTCCGTGCAGACCAGGAACAGCAGCTGC
TTTGTGGAGTGGATTCCCAACAACGTCAAGGTGGCTGTCTGCGACATCCCGCCCCGGGGG
CTGAGCATGGCCGCCACCTTCATTGGCAACAACACGGCCATCCAAGAGATCTTTAATAGG
GTCTCTGAGCATTTCTCAGCCATGTTCAAAAGGAAAGCTTTTGTGCACTGGTACACCAGC
GAAGGGATGGACATAAACGAATTTGGGGAAGCTGAAAATAACATCCATGATTTGGTATCC
GAGTACCAACAATTTCAAGATGCCAAAGCAGTTCTAGAGGAAGATGAAGAGGTCACGGAG
GAGGCAGAAATGGAGCCAGAAGATAAGGGACATTAA

Target 38 GenBank Gene ID

Not Available

Target 38 GeneCard ID

TUBB1

Target 38 GenAtlas ID

TUBB1

Target 38 HGNC ID

HGNC:16257 Link Image

Target 38 Chromosome Location

Chromosome:20

Target 38 Locus

20q13.32

Target 38 SNPs

SNPJam Report Link Image

Target 38 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 38 General References

11780052; 15489334; 12665801; 19524510

Target 39 [top]

Target 39 ID

219

Target 39 Name

Tubulin beta-2A chain

Target 39 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 39 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 39 Synonyms

Not Available

Target 39 Gene Name

TUBB2A

Target 39 Protein Sequence

>Tubulin beta-2A chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Target 39 Number of Residues

445

Target 39 Molecular Weight

49906.7

Target 39 Theoretical pI

4.52

Target 39 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 39 General Function

Cell cycle control, cell division, chromosome partitioning

Target 39 Pathways

Not Available

Target 39 Reactions

Not Available

Target 39 Signals

None

Target 39 Transmembrane Regions

None

Target 39 Essentiality

Non Essential

Target 39 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 39 GenBank ID Protein

Not Available

Target 39 UniProtKB ID

Q13885

Target 39 Cellular Location

Cytoplasmic

Target 39 Gene Sequence

>1338 bp

ATGCGCGAGATCGTGCACATCCAGGCGGGCCAGTGCGGCAACCAGATCGGCGCCAAGTTT
TGGGAGGTCATCAGCGATGAGCATGGGATCGACCCCACAGGCAGTTACCATGGAGACAGT
GACTTGCAGCTGGAGAGAATCAACGTGTACTACAATGAGGCTGCTGGTAACAAATATGTA
CCTCGGGCCATCCTGGTGGATCTGGAGCCTGGCACCATGGACTCTGTCAGGTCTGGACCC
TTCGGCCAGATCTTCAGACCAGACAACTTCGTGTTCGGCCAGAGTGGAGCCGGGAATAAC
TGGGCCAAGGGCCACTACACAGAGGGAGCCGAGCTGGTCGACTCGGTCCTGGATGTGGTG
AGGAAGGAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCTCTGGGG
GGCGGCACGGGGTCCGGGATGGGCACCCTGCTCATCAGCAAGATCCGGGAAGAGTACCCA
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACCCTCTCGGTCCACCAGCTGGTGGAAAACACAGATGAAACCTAC
TCCATTGATAACGAGGCCCTGTATGACATCTGCTTCCGCACCCTGAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCGCCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTCACGGTGCCCGAGCTCACCCAGCAGATGTTCGACTCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCTGCCATCTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTCAACGTGCAGAACAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGTCGGCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGACGAACAAGGGGAGTTCGAGGAGGAGGAG
GGCGAGGACGAGGCTTAA

Target 39 GenBank Gene ID

Not Available

Target 39 GeneCard ID

TUBB2A

Target 39 GenAtlas ID

TUBB2A

Target 39 HGNC ID

HGNC:12412 Link Image

Target 39 Chromosome Location

Not Available

Target 39 Locus

6p25

Target 39 SNPs

SNPJam Report Link Image

Target 39 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 39 General References

14574404; 15489334; 19524510; 16959974

Target 40 [top]

Target 40 ID

247

Target 40 Name

Tubulin beta-2B chain

Target 40 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 40 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 40 Synonyms

Not Available

Target 40 Gene Name

TUBB2B

Target 40 Protein Sequence

>Tubulin beta-2B chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Target 40 Number of Residues

445

Target 40 Molecular Weight

49952.8

Target 40 Theoretical pI

4.52

Target 40 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 40 General Function

Cell cycle control, cell division, chromosome partitioning

Target 40 Pathways

Not Available

Target 40 Reactions

Not Available

Target 40 Signals

None

Target 40 Transmembrane Regions

None

Target 40 Essentiality

Non Essential

Target 40 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 40 GenBank ID Protein

Not Available

Target 40 UniProtKB ID

Q9BVA1

Target 40 Cellular Location

Cytoplasmic

Target 40 Gene Sequence

Not Available

Target 40 GenBank Gene ID

Not Available

Target 40 GeneCard ID

TUBB2B

Target 40 GenAtlas ID

TUBB2B

Target 40 HGNC ID

HGNC:30829 Link Image

Target 40 Chromosome Location

Not Available

Target 40 Locus

6p25

Target 40 SNPs

SNPJam Report Link Image

Target 40 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 40 General References

14574404; 15489334; 19524510

Target 41 [top]

Target 41 ID

Target 41 Name

Tubulin beta-2C chain

Target 41 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 41 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 41 Synonyms

Tubulin beta-2 chain

Target 41 Gene Name

TUBB2C

Target 41 Protein Sequence

>Tubulin beta-2C chain

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA

Target 41 Number of Residues

445

Target 41 Molecular Weight

49830.7

Target 41 Theoretical pI

4.52

Target 41 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 41 General Function

Cell cycle control, cell division, chromosome partitioning

Target 41 Pathways

Not Available

Target 41 Reactions

Not Available

Target 41 Signals

None

Target 41 Transmembrane Regions

None

Target 41 Essentiality

Non Essential

Target 41 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 41 GenBank ID Protein

Not Available

Target 41 UniProtKB ID

P68371

Target 41 Cellular Location

Cytoplasmic

Target 41 Gene Sequence

>1338 bp

ATGAGGGAAATCGTGCACTTGCAGGCCGGGCAGTGCGGCAACCAAATCGGCGCCAAGTTT
TGGGAGGTGATCAGCGATGAGCACGGCATCGACCCCACGGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGAACGCATCAACGTGTACTACAATGAGGCCACCGGCGGCAAGTACGTG
CCCCGCGCCGTGCTCGTGGATCTGGAGCCCGGCACCATGGACTCCGTGCGCTCGGGGCCC
TTCGGGCAGATCTTCCGGCCGGACAACTTCGTTTTCGGTCAGAGTGGTGCTGGGAACAAC
TGGGCCAAGGGGCACTACACAGAAGGCGCGGAGCTGGTGGACTCGGTGCTGGATGTTGTG
AGAAAGGAGGCTGAGAGCTGTGACTGCCTGCAGGGTTTCCAGCTGACCCACTCCCTGGGT
GGGGGGACTGGGTCTGGGATGGGTACCCTCCTCATCAGCAAGATCCGGGAGGAGTACCCA
GACAGGATCATGAACACGTTTAGTGTGGTGCCTTCGCCCAAAGTGTCAGACACAGTGGTG
GAGCCCTACAACGCCACCCTCTCAGTCCACCAGCTCGTAGAAAACACAGACGAGACCTAC
TGCATTGATAACGAAGCTCTCTACGACATTTGCTTCAGAACCCTAAAGCTGACCACGCCC
ACCTATGGTGACCTGAACCACCTGGTGTCTGCTACCATGAGTGGGGTCACCACCTGCCTG
CGCTTCCCAGGCCAGCTCAATGCTGACCTGCGGAAGCTGGCTGTGAACATGGTCCCGTTT
CCCCGGCTGCACTTCTTCATGCCCGGCTTTGCCCCACTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTGACCGTGCCCGAGCTCACCCAGCAGATGTTTGATGCCAAGAACATGATG
GCTGCCTGCGACCCCCGCCATGGCCGCTACCTGACGGTTGCCGCCGTGTTCAGGGGCCGC
ATGTCCATGAAGGAGGTGGATGAGCAAATGCTTAATGTCCAAAACAAAAACAGCAGCTAT
TTTGTTGAGTGGATCCCCAACAATGTGAAAACGGCTGTCTGTGACATCCCACCTCGGGGG
CTAAAAATGTCCGCCACCTTCATTGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTGTCC
GAGTACCAGCAGTACCAGGATGCCACAGCCGAGGAGGAGGGCGAGTTCGAGGAGGAGGCT
GAGGAGGAGGTGGCCTAG

Target 41 GenBank Gene ID

Not Available

Target 41 GeneCard ID

TUBB2C

Target 41 GenAtlas ID

TUBB2C

Target 41 HGNC ID

HGNC:20771 Link Image

Target 41 Chromosome Location

Not Available

Target 41 Locus

9q34

Target 41 SNPs

SNPJam Report Link Image

Target 41 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 41 General References

3999141; 15164053; 15489334; 17081983; 19007248; 18691976; 18669648; 19524510

Target 42 [top]

Target 42 ID

242

Target 42 Name

Tubulin beta-3 chain

Target 42 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 42 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 42 Synonyms

Tubulin beta-III; Tubulin beta-4

Target 42 Gene Name

TUBB3

Target 42 Protein Sequence

>Tubulin beta-3 chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK

Target 42 Number of Residues

450

Target 42 Molecular Weight

50432.4

Target 42 Theoretical pI

4.57

Target 42 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 42 General Function

Cell cycle control, cell division, chromosome partitioning

Target 42 Pathways

Not Available

Target 42 Reactions

Not Available

Target 42 Signals

None

Target 42 Transmembrane Regions

None

Target 42 Essentiality

Non Essential

Target 42 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 42 GenBank ID Protein

Not Available

Target 42 UniProtKB ID

Q13509

Target 42 Cellular Location

Cytoplasmic

Target 42 Gene Sequence

>1353 bp

ATGCGGGAGATCGTGCACATCCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTC
TGGGAAGTCATCAGTGATGAGCATGGCATCGACCCCAGCGGCAACTACGTGGGCGACTCG
GACTTGCAGCTGGAGCGGATCAGCGTCTACTACAACGAGGCCTCTTCTCACAAGTACGTG
CCTCGAGCCATTCTGGTGGACCTGGAACCCGGAACCATGGACAGTGTCCGCTCAGGGGCC
TTTGGACATCTCTTCAGGCCTGACAATTTCATCTTTGGTCAGAGTGGGGCCGGCAACAAC
TGGGCCAAGGGTCACTACACGGAGGGGGCGGAGCTGGTGGATTCGGTCCTGGATGTGGTG
CGGAAGGAGTGTGAAAACTGCGACTGCCTGCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGGGGGACGGGCTCCGGCATGGGCACGTTGCTCATCAGCAAGGTGCGTGAGGAGTATCCC
GACCGCATCATGAACACCTTCAGCGTCGTGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAACCCTACAACGCCACGCTGTCCATCCACCAGCTGGTGGAAAACACGGATGAAACCTAC
TGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGGCCACGCCC
ACCTACGGGGACCTCAACCACCTGGTATCGGCCACCATGAGCGGAGTCACCACCTCCTTG
CGCTTCCCGGGCCAGCTCAACGCTGACCTGCGCAAGCTGGCCGTCAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCCGGCTTCGCCCCCCTCACCAGGCGGGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCCACCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGGTGGCCGTGTGTGACATCCCGCCCCGCGGC
CTCAAGATGTCCTCCACCTTCATCGGGAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAAGAGGGCGAGATGTACGAAGACGAC
GAGGAGGAGTCGGAGGCCCAGGGCCCCAAGTGA

Target 42 GenBank Gene ID

Not Available

Target 42 GeneCard ID

TUBB3

Target 42 GenAtlas ID

TUBB3

Target 42 HGNC ID

HGNC:20772 Link Image

Target 42 Chromosome Location

Chromosome:16

Target 42 Locus

16q24.3

Target 42 SNPs

SNPJam Report Link Image

Target 42 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 42 General References

9473684; 15489334; 19524510

Target 43 [top]

Target 43 ID

136

Target 43 Name

Tubulin beta-4 chain

Target 43 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 43 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 43 Synonyms

Tubulin 5 beta

Target 43 Gene Name

TUBB4

Target 43 Protein Sequence

>Tubulin beta-4 chain

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA

Target 43 Number of Residues

444

Target 43 Molecular Weight

49585.5

Target 43 Theoretical pI

4.51

Target 43 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 43 General Function

Cell cycle control, cell division, chromosome partitioning

Target 43 Pathways

Not Available

Target 43 Reactions

Not Available

Target 43 Signals

None

Target 43 Transmembrane Regions

None

Target 43 Essentiality

Non Essential

Target 43 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 43 GenBank ID Protein

Not Available

Target 43 UniProtKB ID

P04350

Target 43 Cellular Location

Cytoplasmic

Target 43 Gene Sequence

>1335 bp

ATGCGGGAGATCGTGCACCTGCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTT
TGGGAGGTTATCAGTGACGAACATGGCATCGACCCCACAGGCACATACCATGGGGACAGT
GACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCCACAGGAGGAAATTATGTC
CCCAGAGCGGTGCTGGTGGACCTGGAACCCGGCACCATGGACTCTGTCCGTTCTGGCCCC
TTCGGTCAGATCTTTCGGCCGGACAACTTCGTGTTTGGCCAATCCGGAGCCGGCAACAAC
TGGGCAAAGGGGCACTACACGGAGGGCGCAGAGCTGGTGGACGCTGTCCTGGACGTAGTC
CGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGTGGCACGGGGTCCGGAATGGGCACGCTGCTCATCAGTAAGATCCGCGAGGAGTTCCCA
GACCGCATCATGAACACCTTCAGCGTGGTGCCCTCGCCCAAAGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACGCTGTCTGTGCACCAGCTGGTGGAGAATACGGATGAGACCTAC
TGCATCGACAACGAGGCACTCTACGACATCTGTTTCCGCACCCTCAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCCGTCAACATGGTCCCCTTT
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCACCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCCCTGACGGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCGGCGTGCGACCCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCGCGACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCTTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTATCT
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAGGGCGAGTTCGAGGAGGAGGCGGAG
GAGGAGGTGGCCTAG

Target 43 GenBank Gene ID

Not Available

Target 43 GeneCard ID

TUBB4

Target 43 GenAtlas ID

TUBB4

Target 43 HGNC ID

HGNC:20774 Link Image

Target 43 Chromosome Location

Chromosome:19

Target 43 Locus

19p13.3

Target 43 SNPs

SNPJam Report Link Image

Target 43 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 43 General References

6462917; 15489334; 8619814; 16565220; 19524510

Target 44 [top]

Target 44 ID

Target 44 Name

Tubulin beta-6 chain

Target 44 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 44 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 44 Synonyms

Not Available

Target 44 Gene Name

TUBB6

Target 44 Protein Sequence

>Tubulin beta-6 chain

MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYV
PRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVV
RKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMM
AACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATANDGEEAFEDEEEEIDG

Target 44 Number of Residues

446

Target 44 Molecular Weight

49856.8

Target 44 Theoretical pI

4.51

Target 44 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 44 General Function

Involved in GTP binding

Target 44 Pathways

Not Available

Target 44 Reactions

Not Available

Target 44 Signals

None

Target 44 Transmembrane Regions

None

Target 44 Essentiality

Non Essential

Target 44 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 44 GenBank ID Protein

Not Available

Target 44 UniProtKB ID

Q9BUF5

Target 44 Cellular Location

Cytoplasmic

Target 44 Gene Sequence

>1341 bp

ATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGGCACCAAGTTT
TGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCG
GCGCTGCAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTG
CCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCGGTCTGGGCCT
TTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGGCCAGACGGGTGCAGGGAACAAC
TGGGCGAAAGGGCACTACACGGAGGGCGCGGAGCTGGTGGACGCAGTGCTGGACGTGGTG
CGGAAGGAGTGCGAGCACTGCGACTGCCTGCAGGGCTTCCAGCTCACGCACTCGCTGGGC
GGCGGCACGGGCTCAGGCATGGGCACGCTGCTCATCAGCAAGATCCGTGAGGAGTTCCCG
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCGCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAATGCCACACTGTCGGTGCACCAGCTGGTGGAGAATACAGACGAGACCTAC
TGCATCGACAACGAGGCGCTCTATGACATCTGCTTCCGCACTCTGAAGCTGACAACGCCC
ACCTACGGGGACCTCAACCACCTGGTGTCCGCCACCATGAGTGGGGTCACCACCTCGCTG
CGCTTCCCGGGCCAGCTCAATGCTGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCTGGCTTCGCGCCGCTCACCAGCCGCGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGACGCCAGGAACATGATG
GCCGCCTGCGATCCGCGCCATGGCCGCTACCTGACCGTGGCCACCGTGTTCCGCGGGCCC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGTAAGAACAGCAGCTAC
TTCGTGGAGTGGATTCCCAACAACGTGAAGGTGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCTCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCTCAGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTTCACGGGT
GAGGGCATGGATGAAATGGAGTTCACCGAGGCGGAGAGCAACATGAACGACCTGGTATCC
GAGTACCAGCAGTACCAGGATGCCACCGCCAATGACGGGGAGGAAGCTTTTGAGGATGAG
GAAGAGGAGATCGATGGATAG

Target 44 GenBank Gene ID

Not Available

Target 44 GeneCard ID

TUBB6

Target 44 GenAtlas ID

TUBB6

Target 44 HGNC ID

HGNC:20776 Link Image

Target 44 Chromosome Location

Chromosome:18

Target 44 Locus

18p11.21

Target 44 SNPs

SNPJam Report Link Image

Target 44 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 44 General References

14702039; 15489334; 17525332; 19524510

Target 45 [top]

Target 45 ID

228

Target 45 Name

Tubulin beta-8 chain

Target 45 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 45 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 45 Synonyms

Not Available

Target 45 Gene Name

TUBB8

Target 45 Protein Sequence

>Tubulin beta-8 chain

MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA

Target 45 Number of Residues

444

Target 45 Molecular Weight

49775.7

Target 45 Theoretical pI

4.52

Target 45 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 45 General Function

Cell cycle control, cell division, chromosome partitioning

Target 45 Pathways

Not Available

Target 45 Reactions

Not Available

Target 45 Signals

None

Target 45 Transmembrane Regions

None

Target 45 Essentiality

Non Essential

Target 45 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 45 GenBank ID Protein

Not Available

Target 45 UniProtKB ID

Q3ZCM7

Target 45 Cellular Location

Cytoplasmic

Target 45 Gene Sequence

Not Available

Target 45 GenBank Gene ID

Not Available

Target 45 GeneCard ID

TUBB8

Target 45 GenAtlas ID

Not Available

Target 45 HGNC ID

Not Available

Target 45 Chromosome Location

Not Available

Target 45 Locus

Not Available

Target 45 SNPs

SNPJam Report Link Image

Target 45 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 45 General References

11731935; 15164054; 15489334; 19524510

Target 46 [top]

Target 46 ID

400

Target 46 Name

Tubulin beta-8 chain B

Target 46 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 46 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 46 Synonyms

Not Available

Target 46 Gene Name

Not Available

Target 46 Protein Sequence

>Tubulin beta-8 chain B

MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA

Target 46 Number of Residues

444

Target 46 Molecular Weight

49572.3

Target 46 Theoretical pI

4.49

Target 46 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 46 General Function

Cell cycle control, cell division, chromosome partitioning

Target 46 Pathways

Not Available

Target 46 Reactions

Not Available

Target 46 Signals

None

Target 46 Transmembrane Regions

None

Target 46 Essentiality

Non Essential

Target 46 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 46 GenBank ID Protein

Not Available

Target 46 UniProtKB ID

A6NNZ2

Target 46 Cellular Location

Cytoplasmic

Target 46 Gene Sequence

Not Available

Target 46 GenBank Gene ID

Not Available

Target 46 GeneCard ID

Not Available

Target 46 GenAtlas ID

Not Available

Target 46 HGNC ID

Not Available

Target 46 Chromosome Location

Not Available

Target 46 Locus

Not Available

Target 46 SNPs

Not Available

Target 46 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 46 General References

16177791; 19524510

Target 47 [top]

Target 47 ID

102

Target 47 Name

Tubulin delta chain

Target 47 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 47 Description

In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head (By similarity)

Target 47 Synonyms

Delta-tubulin

Target 47 Gene Name

TUBD1

Target 47 Protein Sequence

>Tubulin delta chain

MSIVTVQLGQCGNQIGFEVFDALLSDSHSSQGLCSMRENEAYQASCKERFFSEEENGVPI
ARAVLVDMEPKVINQMLSKAAQSGQWKYGQHACFCQKQGSGNNWAYGYSVHGPRHEESIM
NIIRKEVEKCDSFSGFFIIMSMAGGTGSGLGAFVTQNLEDQYSNSLKMNQIIWPYGTGEV
IVQNYNSILTLSHLYRSSDALLLHENDAIHKICAKLMNIKQISFSDINQVLAHQLGSVFQ
PTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGLLKHLR
QMLISNAKMEEGIDRHVWPPLSGLPPLSKMSLNKDLHFNTSIANLVILRGKDVQSADVEG
FKDPALYTSWLKPVNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASK
AYIHQYTKFGIEEEDFLDSFTSLEQVVASYCNL

Target 47 Number of Residues

453

Target 47 Molecular Weight

51033.9

Target 47 Theoretical pI

6.83

Target 47 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 47 General Function

Involved in GTP binding

Target 47 Pathways

Not Available

Target 47 Reactions

Not Available

Target 47 Signals

None

Target 47 Transmembrane Regions

None

Target 47 Essentiality

Non Essential

Target 47 Domain Function

PF00091:Tubulin

Target 47 GenBank ID Protein

Not Available

Target 47 UniProtKB ID

Q9UJT1

Target 47 Cellular Location

Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm. Nucleus

Target 47 Gene Sequence

Not Available

Target 47 GenBank Gene ID

Not Available

Target 47 GeneCard ID

TUBD1

Target 47 GenAtlas ID

TUBD1

Target 47 HGNC ID

HGNC:16811 Link Image

Target 47 Chromosome Location

Chromosome:17

Target 47 Locus

17q23.1

Target 47 SNPs

SNPJam Report Link Image

Target 47 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 47 General References

10620804; 15081367; 14702039; 15489334

Target 48 [top]

Target 48 ID

125

Target 48 Name

Tubulin epsilon chain

Target 48 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 48 Description

Not Available

Target 48 Synonyms

Epsilon-tubulin

Target 48 Gene Name

TUBE1

Target 48 Protein Sequence

>Tubulin epsilon chain

MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDEAISSFFRNVDTRVVGDGGSIS
KGKICSLKARAVLIDMEEGVVNEILQGPLRDVFDTKQLITDISGSGNNWAVGHKVFGSLY
QDQILEKFRKSAEHCDCLQCFFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTSIYPS
GEDDVITSPYNSILAMKELNEHADCVLPIDNQSLFDIISKIDLMVNSGKLGTTVKPKSLV
TSSSGALKKQHKKPFDAMNNIVANLLLNLTSSARFEGSLNMDLNEISMNLVPFPQLHYLV
SSLTPLYTLTDVNIPPRRLDQMFSDAFSKDHQLLRADPKHSLYLACALMVRGNVQISDLR
RNIERLKPSLQFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELKERFMRLY
KKKAHLHHYLQVEGMEESCFTEAVSSLSALIQEYDQLDATKNMPVQDLPRLSIAM

Target 48 Number of Residues

475

Target 48 Molecular Weight

52931.4

Target 48 Theoretical pI

6.62

Target 48 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 48 General Function

Involved in GTP binding

Target 48 Pathways

Not Available

Target 48 Reactions

Not Available

Target 48 Signals

None

Target 48 Transmembrane Regions

None

Target 48 Essentiality

Non Essential

Target 48 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 48 GenBank ID Protein

Not Available

Target 48 UniProtKB ID

Q9UJT0

Target 48 Cellular Location

Cytoplasm, cytoskeleton, centrosome

Target 48 Gene Sequence

Not Available

Target 48 GenBank Gene ID

Not Available

Target 48 GeneCard ID

TUBE1

Target 48 GenAtlas ID

TUBE1

Target 48 HGNC ID

HGNC:20775 Link Image

Target 48 Chromosome Location

Not Available

Target 48 Locus

6q21

Target 48 SNPs

SNPJam Report Link Image

Target 48 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 48 General References

10620804; 15489334

Target 49 [top]

Target 49 ID

Target 49 Name

Tubulin gamma-1 chain

Target 49 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 49 Description

Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly

Target 49 Synonyms

Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1

Target 49 Gene Name

TUBG1

Target 49 Protein Sequence

>Tubulin gamma-1 chain

MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE
MDTSREIVQQLIDEYHAATRPDYISWGTQEQ

Target 49 Number of Residues

451

Target 49 Molecular Weight

51169.5

Target 49 Theoretical pI

6.06

Target 49 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 49 General Function

Involved in GTP binding

Target 49 Pathways

Not Available

Target 49 Reactions

Not Available

Target 49 Signals

None

Target 49 Transmembrane Regions

None

Target 49 Essentiality

Non Essential

Target 49 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 49 GenBank ID Protein

Not Available

Target 49 UniProtKB ID

P23258

Target 49 Cellular Location

Cytoplasm, cytoskeleton, centrosome

Target 49 Gene Sequence

>1356 bp

ATGCCGAGGGAAATCATCACCCTACAGTTGGGCCAGTGCGGCAATCAGATTGGGTTCGAG
TTCTGGAAACAGCTGTGCGCCGAGCATGGTATCAGCCCCGAGGCGATCGTGGAGGAGTTC
GCCACCGAGGGCACTGACCGCAAGGACGTCTTTTTCTACCAGGCAGACGATGAGCACTAC
ATCCCCCGGGCCGTGCTGCTGGACTTGGAACCCCGGGTGATCCACTCCATCCTCAACTCC
CCCTATGCCAAGCTCTACAACCCAGAGAACATCTACCTGTCGGAACATGGAGGAGGAGCT
GGCAACAACTGGGCCAGCGGATTCTCCCAGGGAGAAAAGATCCATGAGGACATTTTTGAC
ATCATAGACCGGGAGGCAGATGGTAGTGACAGTCTAGAGGGCTTTGTGCTGTGTCACTCC
ATTGCTGGGGGGACAGGCTCTGGACTGGGTTCCTACCTCTTAGAACGGCTGAATGACAGG
TATCCTAAGAAGCTGGTGCAGACATACTCAGTGTTTCCCAACCAGGACGAGATGAGCGAT
GTGGTGGTCCAGCCTTACAATTCACTCCTCACACTCAAGAGGCTGACGCAGAATGCAGAC
TGTCTGGTGGTGCTGGACAACACAGCCCTGAACCGGATTGCCACAGACCGCCTGCACATC
CAGAACCCATCCTTCTCCCAGATCAACCAGCTGGTGTCTACCATCATGTCAGCCAGCACC
ACCACCCTGCGCTACCCTGGCTACATGAACAATGACCTCATCGGCCTCATCGCCTCGCTC
ATTCCCACCCCACGGCTCCACTTCCTCATGACCGGCTACACCCCTCTCACTACGGACCAG
TCAGTGGCCAGCGTGAGGAAGACCACGGTCCTGGATGTCATGAGGCGGCTGCTGCAGCCC
AAGAACGTGATGGTGTCCACAGGCCGAGACCGCCAGACCAACCACTGCTACATCGCCATC
CTCAACATCATCCAGGGAGAGGTGGACCCCACCCAGGTCCACAAGAGCTTGCAGAGGATC
CGGGAACGCAAGTTGGCCAACTTCATCCCGTGGGGCCCCGCCAGCATCCAGGTGGCCCTG
TCGAGGAAGTCTCCCTACCTGCCCTCGGCCCACCGGGTCAGCGGGCTCATGATGGCCAAC
CACACCAGCATCTCCTCGCTCTTCGAGAGAACCTGTCGCCAGTATGACAAGCTGCGTAAG
CGGGAGGCCTTCCTGGAGCAGTTCCGCAAGGAGGACATGTTCAAGGACAACTTTGATGAG
ATGGACACATCCAGGGAGATTGTGCAGCAGCTCATCGATGAGTACCATGCGGCCACACGG
CCAGACTACATCTCCTGGGGCACCCAGGAGCAGTGA

Target 49 GenBank Gene ID

Not Available

Target 49 GeneCard ID

TUBG1

Target 49 GenAtlas ID

TUBG1

Target 49 HGNC ID

HGNC:12417 Link Image

Target 49 Chromosome Location

Chromosome:17

Target 49 Locus

17q21

Target 49 SNPs

SNPJam Report Link Image

Target 49 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 49 General References

1904010; 15489334; 11840567; 9566969

Target 50 [top]

Target 50 ID

180

Target 50 Name

Tubulin gamma-2 chain

Target 50 Mechanism of Action

Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. (R022)

Target 50 Description

Target 50 Synonyms

Gamma-2-tubulin

Target 50 Gene Name

TUBG2

Target 50 Protein Sequence

>Tubulin gamma-2 chain

MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDE
MDRSREVVQELIDEYHAATQPDYISWGTQEQ

Target 50 Number of Residues

451

Target 50 Molecular Weight

51091.3

Target 50 Theoretical pI

5.59

Target 50 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 50 General Function

Involved in GTP binding

Target 50 Pathways

Not Available

Target 50 Reactions

Not Available

Target 50 Signals

None

Target 50 Transmembrane Regions

None

Target 50 Essentiality

Non Essential

Target 50 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 50 GenBank ID Protein

Not Available

Target 50 UniProtKB ID

Q9NRH3

Target 50 Cellular Location

Cytoplasmic

Target 50 Gene Sequence

>1356 bp

ATGCCCCGGGAGATCATCACCCTGCAGCTGGGCCAGTGCGGCAACCAGATTGGGTTCGAG
TTCTGGAAACAGCTGTGCGCCGAGCATGGTATCAGCCCCGAGGGCATCGTGGAGGAGTTC
GCCACCGAGGGCACTGACCGCAAGGACGTCTTTTTCTACCAGGCAGACGATGAGCACTAC
ATCCCCCGGGCCGTGCTGCTGGACTTGGAACCCCGGGTGATCCACTCCATCCTCAACTCC
CCCTATGCCAAGCTCTACAACCCAGAGAACATCTACCTGTCGGAACATGGAGGAGGAGCT
GGCAACAACTGGGCCAGCGGATTCTCCCAGGGTGAGAAAATTCATGAAGACATCTTTGAC
ATCATAGACCGAGAAGCAGATGGAAGTGACAGTTTGGAGGGCTTCGTGCTGTGTCACTCC
ATCGCTGGGGGTACGGGTTCTGGCCTGGGCTCCTACCTCCTGGAGCGACTGAATGACAGG
TACCCCAAGAAGCTAGTGCAGACTTATTCAGTGTTTCCCTACCAGGACGAGATGAGCGAC
GTAGTGGTTCAGCCCTACAATTCACTCCTGACACTCAAGAGGCTGACGCAGAACGCAGAT
TGTGTGGTGGTGCTGGACAACACAGCCCTGAACCGGATTGCCACAGACCGCCTGCACATC
CAGAACCCGTCCTTCTCCCAGATCAACCAGCTGGTGTCCACCATCATGTCGGCCAGCACC
ACCACCCTGCGCTACCCCGGCTACATGAACAATGACCTCATCGGCCTCATCGCCTCGCTC
ATTCCCACCCCACGGCTCCACTTTCTCATGACCGGCTACACCCCGCTCACTACAGACCAG
TCAGTGGCCAGCGTGAGGAAGACCACGGTCCTGGATGTCATGAGGCGGCTGCTGCAGCCC
AAGAACGTGATGGTGTCCACAGGCCGAGACCGCCAGACCAACCACTGCTACATCGCCATC
CTCAACATCATCCAGGGAGAGGTGGACCCCACCCAGGTCCACAAGAGCCTGCAGAGGATC
CGGGAACGGAAGTTGGCCAACTTCATCCCGTGGGGCCCCGCCAGCATCCAGGTGGCCCTG
TCGAGGAAGTCTCCCTACCTGCCCTCGGCCCACCGGGTCAGCGGGCTCATGATGGCCAAC
CACACCAGCATCTCCTCGCTCTTTGAAAGTTCCTGCCAGCAGTTTGACAAGCTGCGGAAG
CGGGATGCCTTCCTCGAGCAGTTCCGTAAGGAGGACATGTTCAAGGACAACTTTGATGAG
ATGGACAGGTCTAGGGAGGTTGTTCAGGAGCTCATTGATGAGTACCATGCGGCCACCCAG
CCAGACTACATTTCCTGGGGCACCCAGGAGCAGTGA

Target 50 GenBank Gene ID

Not Available

Target 50 GeneCard ID

TUBG2

Target 50 GenAtlas ID

TUBG2

Target 50 HGNC ID

HGNC:12419 Link Image

Target 50 Chromosome Location

Chromosome:17

Target 50 Locus

17q21

Target 50 SNPs

SNPJam Report Link Image

Target 50 Toxin References

R022 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 50 General References

10903841; 14702039; 16625196; 15489334

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.