Showing toxin card for Benzene (T3D0006)

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Version	1.0
Creation Date	2009-03-06 18:57:54
Update Date	2010-05-18 20:48:27
Accession Number	T3D0006
Name	Benzene
Compound Type	Aromatic Hydrocarbon Gasoline Additive/Component Industrial Precursor/Intermediate Organic Compound Solvent
Description	Benzene is an aromatic hydrocarbon formed both naturally and from human activities. It can be found in crude oil, gasoline, and cigarette smoke, and made mostly from petroleum sources. Benzene is a highly flammable, colorless liquid with a sweet odor. (R016)
Synonyms	Annulene Benzeen [dutch] Benzen [polish] Benzin Benzin (obs.) Benzin B70 Benzinum Benzol Benzol 90 Benzol diluent Benzole Benzolene Benzoline Benzolo [italian] Benzolum Benzyna do lakierow c [polish] Bicarburet of hydrogen Canadol Cyclohexatriene Deutero benzene Fenzen [czech] Herbitox Light ligroin Ligroin Ligroine Motor benzol Nitration benzene Phene Phenyl hydride Polystream Pyrobenzol Pyrobenzole Seneca oil Super VMP Transgenic model evaluation II (benzene) Varsol Virol [6]Annulene
Chemical IUPAC Name	benzene
Chemical Formula	C₆H₆
Chemical Structure
CAS Registry Number	71-43-2
InChI Identifier	InChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6H
InChI Key	InChIKey=UHOVQNZJYSORNB-UHFFFAOYSA-N
PubChem Compound ID	241
KEGG ID	C01407
UniProt ID	Not Available
OMIM ID	111300
ChEBI ID	16716
BioCyc ID	BENZENE
SuperToxic ID	Not Available
CTD ID	D001554
Stitch ID	Benzene
DrugBank ID	Not Available
PDB ID	Not Available
ACToR ID	136
Wikipedia Link	http://en.wikipedia.org/wiki/Benzene
Monoisotopic Mass	78.04695
MOL File	Show
PDB File	Show
SDF File	Show
SMILES	C1=CC=CC=C1
Appearance	Colorless liquid.
Melting Point	5.5 °C
Solubility	1.79 mg/mL at 25 °C [MAY,WE et al. (1983)]
Predicted LogP	1.9732
Route of Exposure	Inhalation (R016)
Mechanism of Action	The toxic agents of benzene are its metabolites. Benzene is able increase its toxicity by inducing cytochrome P450 2E1, its main metabolic enzyme. Benzene's primary toxic effects are decreases in haematological cell counts and bone marrow cellularity. The decrease in blood cell count may be due to the binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin. In the bone marrow, phenolic metabolites can be metabolized by bone marrow peroxidases to highly reactive semiquinone radicals and quinones that stimulate the production of reactive oxygen species. This and direct metabolite binding leads to damage to tubulin, histone proteins, and topoisomerase II. Some metabolites also exert mutagenic effects by inhibiting other DNA associated proteins, such as mitochondrial DNA polymerase and ribonucleotide reductase, as well as covalently binding to DNA itself, causing effects such as strand breakage, mitotic recombination, chromosome translocations, and aneuploidy. (R016)
Metabolism	Benzene is absorbed readily following inhalation or oral exposure. It enters the bloodstream and is rapidly distributed throughout the body, tending to accumulate in fatty tissues. Benzene is exhaled unchanged by the lungs, as well as metabolized in the liver to benzene oxide by cytochrome P450 enzymes. Benzene oxide is further converted into phenol, catechol, and hydroquinone, which are excreted in the urine as glucuronide or sulfate conjugates. (R017)
Toxicity Values	LD50: 3306 mg/kg (Oral, Rat) (R263) LD50 340 mg/kg (Intraperitoneal, Mouse) (R263) LC50: 9980 ppm (Inhalation, Mouse) (R263)
Lethal Dose	50-500 mg/kg (oral) or 20 000 ppm (inhaled) for an adult human. (R270)
Carcinogenicity (IARC Classification)	1, carcinogenic to humans. (R264)
Uses/Sources	Benzene is often used as an intermediate to make chemicals needed for the production of plastics, resins, and nylon and other synthetic fibers. It is also used to make some types of rubbers, lubricants, dyes, detergents, drugs, and pesticides. Natural sources of benzene include emissions from volcanoes, forest fires, crude oil, gasoline, and cigarette smoke. (R016)
Minimum Risk Level	Acute Inhalation: 0.009 ppm (R260) Intermediate Inhalation: 0.006 ppm (R260) Chronic Inhalation: 0.003 ppm (R260) Chronic Oral: 0.0005 mg/kg/day (R260)
Health Effects	Benzene causes harmful effects on the bone marrow and also decreases blood cell counts, leading to blood disorders such as anemia. It can also cause excessive bleeding and affect the immune system, increasing the chance for infection. Benzene is also a known carcinogen, as chronic exposure to high levels has been shown to cause leukemia, particularly acute myelogenous leukemia. (R016)
Symptoms	Breathing benzene can cause drowsiness, dizziness, rapid heart rate, headaches, tremors, confusion, and unconsciousness. Ingestion can result in vomiting, irritation of the stomach, dizziness, sleepiness, convulsions, and rapid heart rate. (R016)
Treatment	There is no known antidote for benzene and poisoning is first treated by preventing further exposure. If inhaled, respiratory assist may be necessary. If ingested, gastric lavage may be performed, or activated charcoal can be administered. (R018)
General References	R263 - Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold. R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. R270 - HSDB: Hazardous Substances Data Bank. National Library of Medicine (2001). R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R017 - Henderson RF, Sabourin PJ, Bechtold WE, Griffith WC, Medinsky MA, Birnbaum LS, Lucier GW. The effect of dose, dose rate, route of administration, and species on tissue and blood level of benzene metabolites. Environ Health Perspect. 1989;82: 9-17. R018 - Rumack BH (2008). POISINDEX(R) Information System. Englewood, CO: Micromedex, Inc. CCIS Volume 138, edition expires Nov, 2008. R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Targets	Hemoglobin subunit alpha Hemoglobin subunit beta Hemoglobin subunit gamma-1 Hemoglobin subunit gamma-2 Hemoglobin subunit delta Hemoglobin subunit epsilon Hemoglobin subunit theta-1 Hemoglobin subunit zeta Serum albumin Histone H4 Histone H3.1 Histone H3.1t Histone H3.3 DNA polymerase subunit gamma-1 Ribonucleoside-diphosphate reductase large subunit Ribonucleoside-diphosphate reductase subunit M2 Tubulin alpha-1B chain Tubulin alpha-3C/D chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-2A chain Tubulin beta-2C chain Tubulin beta-3 chain Tubulin beta-4 chain Tubulin gamma-1 chain DNA topoisomerase 2-alpha DNA topoisomerase 2-beta Tubulin alpha-1A chain Tubulin alpha-1C chain Tubulin alpha-3E chain Tubulin alpha-8 chain Tubulin beta-1 chain Tubulin beta-2B chain Tubulin beta-6 chain Tubulin beta-8 chain Tubulin delta chain Tubulin epsilon chain Tubulin gamma-2 chain Histone H3.2 Ribonucleoside-diphosphate reductase subunit M2 B DNA polymerase subunit gamma-2, mitochondrial Tubulin alpha chain-like 3 Tubulin beta-8 chain B Putative tubulin beta chain-like protein ENSP00000290377 Putative tubulin beta-4q chain Putative tubulin-like protein alpha-4B Histone H1.0 Histone H1.1 Histone H1.2 Histone H1.3 Histone H1.4 Histone H1.5 Histone H1oo Histone H1t Histone H1x Histone H2A type 1 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2B type 1-K Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone H2A-Bbd type 1 Histone H2A-Bbd type 2/3 Histone H2A.J Histone H2A.V Histone H2A.x Histone H2A.Z Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 2-F Histone H2B type 3-B Histone H2B type F-M Histone H2B type F-S Histone H2B type W-T Histone H3-like Histone H3-like centromeric protein A Histone H4-like protein type G Testis-specific H1 histone Putative histone H2B type 2-C Putative histone H2B type 2-D DNA

Target 1 [top]

Target 1 ID

Target 1 Name

Hemoglobin subunit alpha

Target 1 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 1 Description

Involved in oxygen transport from the lung to the various peripheral tissues

Target 1 Synonyms

Hemoglobin alpha chain; Alpha-globin

Target 1 Gene Name

HBA1

Target 1 Protein Sequence

>Hemoglobin subunit alpha

MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG
KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP
AVHASLDKFLASVSTVLTSKYR

Target 1 Number of Residues

142

Target 1 Molecular Weight

15257.4

Target 1 Theoretical pI

9.09

Target 1 GO Classification

Function
oxygen binding binding
Process
gas transport oxygen transport physiological process cellular physiological process transport
Component
protein complex hemoglobin complex

Target 1 General Function

Involved in heme binding

Target 1 Pathways

Not Available

Target 1 Reactions

Not Available

Target 1 Signals

None

Target 1 Transmembrane Regions

None

Target 1 Essentiality

Non Essential

Target 1 Domain Function

PF00042:Globin

Target 1 GenBank ID Protein

Not Available

Target 1 UniProtKB ID

P69905

Target 1 Cellular Location

Not Available

Target 1 Gene Sequence

>429 bp

ATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGGCAAGGTTGGCGCG
CACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCCTGTCCTTCCCCACCACC
AAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTGCCCAGGTTAAGGGCCACGGC
AAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCGCACGTGGACGACATGCCCAACGCG
CTGTCCGCCCTGAGCGACCTGCACGCGCACAAGCTTCGGGTGGACCCGGTCAACTTCAAG
CTCCTAAGCCACTGCCTGCTGGTGACCCTGGCCGCCCACCTCCCCGCCGAGTTCACCCCT
GCGGTGCACGCCTCCCTGGACAAGTTCCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAA
TACCGTTAA

Target 1 GenBank Gene ID

Not Available

Target 1 GeneCard ID

HBA1

Target 1 GenAtlas ID

HBA1

Target 1 HGNC ID

HGNC:4823

Target 1 Chromosome Location

Chromosome:16

Target 1 Locus

16p13.3

Target 1 SNPs

SNPJam Report Link Image

Target 1 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 1 General References

7448866; 6244294; 6452630; 6946451; 11410421; 11402454; 16728641

Target 2 [top]

Target 2 ID

Target 2 Name

Hemoglobin subunit beta

Target 2 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 2 Description

LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure

Target 2 Synonyms

Hemoglobin beta chain; Beta-globin; LVV-hemorphin-7

Target 2 Gene Name

HBB

Target 2 Protein Sequence

>Hemoglobin subunit beta

MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG
KEFTPPVQAAYQKVVAGVANALAHKYH

Target 2 Number of Residues

147

Target 2 Molecular Weight

15998.3

Target 2 Theoretical pI

7.32

Target 2 GO Classification

Function
oxygen binding binding tetrapyrrole binding heme binding
Process
physiological process cellular physiological process transport gas transport oxygen transport
Component
protein complex hemoglobin complex

Target 2 General Function

Involved in heme binding

Target 2 Pathways

Not Available

Target 2 Reactions

Not Available

Target 2 Signals

None

Target 2 Transmembrane Regions

None

Target 2 Essentiality

Non Essential

Target 2 Domain Function

PF00042:Globin

Target 2 GenBank ID Protein

Not Available

Target 2 UniProtKB ID

P68871

Target 2 Cellular Location

Not Available

Target 2 Gene Sequence

>444 bp

ATGGTNCAYYTNACNCCNGTGGAGAAGTCYGCYGTNACNGCNCTNTGGGGYAAGGTNAAY
GTGGATGAAGYYGGYGGYGAGGCCCTGGGCAGNCTGCTNGTGGTCTACCCTTGGACCCAG
AGGTTCTTNGANTCNTTYGGGGATCTGNNNACNCCNGANGCAGTTATGGGCAACCCTAAG
GTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGAC
AACCTCAAGGGCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTNCAYGTGGAT
CCTGAGAACTTCAGGCTNCTNGGCAACGTGYTNGTCTGYGTGCTGGCCCATCACTTTGGC
AAAGAATTCACCCCACCAGTGCANGCNGCCTATCAGAAAGTGGTNGCTGGTGTNGCTAAT
GCCCTGGCCCACAAGTATCACTAA

Target 2 GenBank Gene ID

Not Available

Target 2 GeneCard ID

HBB

Target 2 GenAtlas ID

HBB

Target 2 HGNC ID

HGNC:4827

Target 2 Chromosome Location

Chromosome:11

Target 2 Locus

11p15.5

Target 2 SNPs

SNPJam Report Link Image

Target 2 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 2 General References

1019344; 6254664; 16175509

Target 3 [top]

Target 3 ID

Target 3 Name

Hemoglobin subunit gamma-1

Target 3 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 3 Description

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

Target 3 Synonyms

Hemoglobin gamma-1 chain; Gamma-1-globin; Hemoglobin gamma-A chain; Hb F Agamma

Target 3 Gene Name

HBG1

Target 3 Protein Sequence

>Hemoglobin subunit gamma-1

MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPK
VKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFG
KEFTPEVQASWQKMVTAVASALSSRYH

Target 3 Number of Residues

147

Target 3 Molecular Weight

16140.4

Target 3 Theoretical pI

7.23

Target 3 GO Classification

Function
oxygen binding binding tetrapyrrole binding heme binding
Process
physiological process cellular physiological process transport gas transport oxygen transport
Component
protein complex hemoglobin complex

Target 3 General Function

Involved in heme binding

Target 3 Pathways

Not Available

Target 3 Reactions

Not Available

Target 3 Signals

None

Target 3 Transmembrane Regions

None

Target 3 Essentiality

Non Essential

Target 3 Domain Function

PF00042:Globin

Target 3 GenBank ID Protein

Not Available

Target 3 UniProtKB ID

P69891

Target 3 Cellular Location

Not Available

Target 3 Gene Sequence

>444 bp

ATGGGTCATTTCACAGAGGAGGACAAGGCTACTATCACAAGCCTGTGGGGCAAGGTGAAT
GTGGAAGATGCTGGAGGAGAAACCCTGGGAAGGCTCCTGGTTGTCTACCCATGGACCCAG
AGGTTCTTTGACAGCTTTGGCAACCTGTCCTCTGCCTCTGCCATCATGGGCAACCCCAAA
GTCAAGGCACATGGCAAGAAGGTGCTGACTTCCTTGGGAGATGCCACAAAGCACCTGGAT
GATCTCAAGGGCACCTTTGCCCAGCTGAGTGAACTGCACTGTGACAAGCTGCATGTGGAT
CCTGAGAACTTCAAGCTCCTGGGAAATGTGCTGGTGACCGTTTTGGCAATCCATTTCGGC
AAAGAATTCACCCCTGAGGTGCAGGCTTCCTGGCAGAAGATGGTGACTGCAGTGGCCAGT
GCCCTGTCCTCCAGATACCACTGA

Target 3 GenBank Gene ID

Not Available

Target 3 GeneCard ID

HBG1

Target 3 GenAtlas ID

HBG1

Target 3 HGNC ID

HGNC:4831

Target 3 Chromosome Location

Chromosome:11

Target 3 Locus

11p15.5

Target 3 SNPs

SNPJam Report Link Image

Target 3 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 3 General References

7438203; 7332928; 15489334; 7690768; 11514664; 5554303; 2454900; 2417989

Target 4 [top]

Target 4 ID

Target 4 Name

Hemoglobin subunit gamma-2

Target 4 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 4 Description

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

Target 4 Synonyms

Hemoglobin gamma-2 chain; Gamma-2-globin; Hemoglobin gamma-G chain; Hb F Ggamma

Target 4 Gene Name

HBG2

Target 4 Protein Sequence

>Hemoglobin subunit gamma-2

MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPK
VKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFG
KEFTPEVQASWQKMVTGVASALSSRYH

Target 4 Number of Residues

147

Target 4 Molecular Weight

16126.3

Target 4 Theoretical pI

7.23

Target 4 GO Classification

Function
oxygen binding binding tetrapyrrole binding heme binding
Process
physiological process cellular physiological process transport gas transport oxygen transport
Component
protein complex hemoglobin complex

Target 4 General Function

Involved in heme binding

Target 4 Pathways

Not Available

Target 4 Reactions

Not Available

Target 4 Signals

None

Target 4 Transmembrane Regions

None

Target 4 Essentiality

Non Essential

Target 4 Domain Function

PF00042:Globin

Target 4 GenBank ID Protein

Not Available

Target 4 UniProtKB ID

P69892

Target 4 Cellular Location

Not Available

Target 4 Gene Sequence

>444 bp

ATGGGTCATTTCACAGAGGAGGACAAGGCTACTATCACAAGCCTGTGGGGCAAGGTGAAT
GTGGAAGATGCTGGAGGAGAAACCCTGGGAAGGCTCCTGGTTGTCTACCCATGGACCCAG
AGGTTCTTTGACAGCTTTGGCAACCTGTCCTCTGCCTCTGCCATCATGGGCAACCCCAAA
GTCAAGGCACATGGCAAGAAGGTGCTGACTTCCTTGGGAGATGCCATAAAGCACCTGGAT
GATCTCAAGGGCACCTTTGCCCAGCTGAGTGAACTGCACTGTGACAAGCTGCATGTGGAT
CCTGAGAACTTCAAGCTCCTGGGAAATGTGCTGGTGACCGTTTTGGCAATCCATTTCGGC
AAAGAATTCACCCCTGAGGTGCAGGCTTCCTGGCAGAAGATGGTGACTGGAGTGGCCAGT
GCCCTGTCCTCCAGATACCACTGA

Target 4 GenBank Gene ID

Not Available

Target 4 GeneCard ID

HBG2

Target 4 GenAtlas ID

HBG2

Target 4 HGNC ID

HGNC:4832

Target 4 Chromosome Location

Chromosome:11

Target 4 Locus

11p15.5

Target 4 SNPs

SNPJam Report Link Image

Target 4 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 4 General References

7438203; 7250702; 15489334; 14087393; 2581851; 18083107; 881729

Target 5 [top]

Target 5 ID

Target 5 Name

Hemoglobin subunit delta

Target 5 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 5 Description

Involved in oxygen transport from the lung to the various peripheral tissues

Target 5 Synonyms

Hemoglobin delta chain; Delta-globin

Target 5 Gene Name

HBD

Target 5 Protein Sequence

>Hemoglobin subunit delta

MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFG
KEFTPQMQAAYQKVVAGVANALAHKYH

Target 5 Number of Residues

147

Target 5 Molecular Weight

16055.4

Target 5 Theoretical pI

8.26

Target 5 GO Classification

Function
oxygen binding binding tetrapyrrole binding heme binding
Process
physiological process cellular physiological process transport gas transport oxygen transport
Component
protein complex hemoglobin complex

Target 5 General Function

Involved in heme binding

Target 5 Pathways

Not Available

Target 5 Reactions

Not Available

Target 5 Signals

None

Target 5 Transmembrane Regions

None

Target 5 Essentiality

Non Essential

Target 5 Domain Function

PF00042:Globin

Target 5 GenBank ID Protein

Not Available

Target 5 UniProtKB ID

P02042

Target 5 Cellular Location

Not Available

Target 5 Gene Sequence

>444 bp

ATGGTGCATCTGACTCCTGAGGAGAAGACTGCTGTCAATGCCCTGTGGGGCAAAGTGAAC
GTGGATGCAGTTGGTGGTGAGGCCCTGGGCAGATTACTGGTGGTCTACCCTTGGACCCAG
AGGTTCTTTGAGTCCTTTGGGGATCTGTCCTCTCCTGATGCTGTTATGGGCAACCCTAAG
GTGAAGGCTCATGGCAAGAAGGTGCTAGGTGCCTTTAGTGATGGCCTGGCTCACCTGGAC
AACCTCAAGGGCACTTTTTCTCAGCTGAGTGAGCTGCACTGTGACAAGCTGCACGTGGAT
CCTGAGAACTTCAGGCTCTTGGGCAATGTGCTGGTGTGTGTGCTGGCCCGCAACTTTGGC
AAGGAATTCACCCCACAAATGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCTAAT
GCCCTGGCTCACAAGTACCATTGA

Target 5 GenBank Gene ID

Not Available

Target 5 GeneCard ID

HBD

Target 5 GenAtlas ID

HBD

Target 5 HGNC ID

HGNC:4829

Target 5 Chromosome Location

Chromosome:11

Target 5 Locus

11p15.5

Target 5 SNPs

SNPJam Report Link Image

Target 5 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 5 General References

7438204; 16370491; 15489334; 680638; 18083107; 5956309; 5678016

Target 6 [top]

Target 6 ID

Target 6 Name

Hemoglobin subunit epsilon

Target 6 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 6 Description

The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin

Target 6 Synonyms

Hemoglobin epsilon chain; Epsilon-globin

Target 6 Gene Name

HBE1

Target 6 Protein Sequence

>Hemoglobin subunit epsilon

MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPK
VKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFG
KEFTPEVQAAWQKLVSAVAIALAHKYH

Target 6 Number of Residues

147

Target 6 Molecular Weight

16202.7

Target 6 Theoretical pI

9.10

Target 6 GO Classification

Function
oxygen binding binding tetrapyrrole binding heme binding
Process
physiological process cellular physiological process transport gas transport oxygen transport
Component
protein complex hemoglobin complex

Target 6 General Function

Involved in heme binding

Target 6 Pathways

Not Available

Target 6 Reactions

Not Available

Target 6 Signals

None

Target 6 Transmembrane Regions

None

Target 6 Essentiality

Non Essential

Target 6 Domain Function

PF00042:Globin

Target 6 GenBank ID Protein

Not Available

Target 6 UniProtKB ID

P02100

Target 6 Cellular Location

Not Available

Target 6 Gene Sequence

>444 bp

ATGGTGCATTTTACTGCTGAGGAGAAGGCTGCCGTCACTAGCCTGTGGAGCAAGATGAAT
GTGGAAGAGGCTGGAGGTGAAGCCTTGGGCAGACTCCTCGTTGTTTACCCCTGGACCCAG
AGATTTTTTGACAGCTTTGGAAACCTGTCGTCTCCCTCTGCCATCCTGGGCAACCCCAAG
GTCAAGGCCCATGGCAAGAAGGTGCTGACTTCCTTTGGAGATGCTATTAAAAACATGGAC
AACCTCAAGCCCGCCTTTGCTAAGCTGAGTGAGCTGCACTGTGACAAGCTGCATGTGGAT
CCTGAGAACTTCAAGCTCCTGGGTAACGTGATGGTGATTATTCTGGCTACTCACTTTGGC
AAGGAGTTCACCCCTGAAGTGCAGGCTGCCTGGCAGAAGCTGGTGTCTGCTGTCGCCATT
GCCCTGGCCCATAAGTACCACTGA

Target 6 GenBank Gene ID

Not Available

Target 6 GeneCard ID

HBE1

Target 6 GenAtlas ID

HBE1

Target 6 HGNC ID

HGNC:4830

Target 6 Chromosome Location

Chromosome:11

Target 6 Locus

11p15.5

Target 6 SNPs

SNPJam Report Link Image

Target 6 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 6 General References

6254663; 15489334; 6172865; 18083107; 9665850

Target 7 [top]

Target 7 ID

190

Target 7 Name

Hemoglobin subunit theta-1

Target 7 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 7 Description

Not Available

Target 7 Synonyms

Hemoglobin theta-1 chain; Theta-1-globin

Target 7 Gene Name

HBQ1

Target 7 Protein Sequence

>Hemoglobin subunit theta-1

MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYFSHLDLSPGSSQVRAHG
QKVADALSLAVERLDDLPHALSALSHLHACQLRVDPASFQLLGHCLLVTLARHYPGDFSP
ALQASLDKFLSHVISALVSEYR

Target 7 Number of Residues

142

Target 7 Molecular Weight

15507.6

Target 7 Theoretical pI

7.74

Target 7 GO Classification

Function
oxygen binding binding tetrapyrrole binding heme binding
Process
physiological process cellular physiological process transport gas transport oxygen transport
Component
protein complex hemoglobin complex

Target 7 General Function

Involved in heme binding

Target 7 Pathways

Not Available

Target 7 Reactions

Not Available

Target 7 Signals

None

Target 7 Transmembrane Regions

None

Target 7 Essentiality

Non Essential

Target 7 Domain Function

PF00042:Globin

Target 7 GenBank ID Protein

Not Available

Target 7 UniProtKB ID

P09105

Target 7 Cellular Location

Not Available

Target 7 Gene Sequence

>429 bp

ATGGCGCTGTCCGCGGAGGACCGGGCGCTGGTGCGCGCCCTGTGGAAGAAGCTGGGCAGC
AACGTCGGCGTCTACACGACAGAGGCCCTGGAAAGGACCTTCCTGGCTTTCCCCGCCACG
AAGACCTACTTCTCCCACCTGGACCTGAGCCCCGGCTCCTCACAAGTCAGAGCCCACGGC
CAGAAGGTGGCGGACGCGCTGAGCCTCGCCGTGGAGCGCCTGGACGACCTACCCCACGCG
CTGTCCGCGCTGAGCCACCTGCACGCGTGCCAGCTGCGAGTGGACCCGGCCAGCTTCCAG
CTCCTGGGCCACTGCCTGCTGGTAACCCTCGCCCGGCACTACCCCGGAGACTTCAGCCCC
GCGCTGCAGGCGTCGCTGGACAAGTTCCTGAGCCACGTTATCTCGGCGCTGGTTTCCGAG
TACCGCTGA

Target 7 GenBank Gene ID

Not Available

Target 7 GeneCard ID

HBQ1

Target 7 GenAtlas ID

HBQ1

Target 7 HGNC ID

HGNC:4833

Target 7 Chromosome Location

Chromosome:16

Target 7 Locus

16p13.3

Target 7 SNPs

SNPJam Report Link Image

Target 7 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 7 General References

3422341; 3408475; 16728641; 11157797; 15489334; 2569721

Target 8 [top]

Target 8 ID

167

Target 8 Name

Hemoglobin subunit zeta

Target 8 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 8 Description

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac

Target 8 Synonyms

Hemoglobin zeta chain; Zeta-globin; HBAZ

Target 8 Gene Name

HBZ

Target 8 Protein Sequence

>Hemoglobin subunit zeta

MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHG
SKVVAAVGDAVKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTA
EAHAAWDKFLSVVSSVLTEKYR

Target 8 Number of Residues

142

Target 8 Molecular Weight

15636.8

Target 8 Theoretical pI

8.51

Target 8 GO Classification

Function
oxygen binding binding
Process
gas transport oxygen transport physiological process cellular physiological process transport
Component
protein complex hemoglobin complex

Target 8 General Function

Involved in heme binding

Target 8 Pathways

Not Available

Target 8 Reactions

Not Available

Target 8 Signals

None

Target 8 Transmembrane Regions

None

Target 8 Essentiality

Non Essential

Target 8 Domain Function

PF00042:Globin

Target 8 GenBank ID Protein

Not Available

Target 8 UniProtKB ID

P02008

Target 8 Cellular Location

Not Available

Target 8 Gene Sequence

>429 bp

TGCAGCTGCCCACCCTGCCGCCATGTCTCTGACCAAGACTGAGAGGACCATCATTGTGTC
CATGTGGGCCAAGATCTCCACGCAGGCCGACACCATCGGCACCGAGACTCTGGAGAGGCT
CTTCCTCAGCCACCCGCAGACCAAGACCTACTTCCCGCACTTCGACCTGCACCCGGGGTC
CGCGCAGTTGCGCGCGCACGGCTCCAAGGTGGTGGCCGCCGTGGGCGACGCGGTGAAGAG
CATCGACGACATCGGCGGCGCCCTGTCCAAGCTGAGCGAGCTGCACGCCTACATCCTGCG
CGTGGACCCGGTCAACTTCAAGCTCCTGTCCCACTGCCTGCTGGTCACCCTGGCCGCGCG
CTTCCCCGCCGACTTCACGGCCGAGGCCCACGCCGCCTGGGACAAGTTCCTATCGGTCGT
ATCCTCTGT

Target 8 GenBank Gene ID

Not Available

Target 8 GeneCard ID

HBZ

Target 8 GenAtlas ID

HBZ

Target 8 HGNC ID

HGNC:4835

Target 8 Chromosome Location

Chromosome:16

Target 8 Locus

16p13.3

Target 8 SNPs

SNPJam Report Link Image

Target 8 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 8 General References

6297773; 6963223; 9054936; 11157797; 15489334; 6179844; 6171809; 6172357

Target 9 [top]

Target 9 ID

250

Target 9 Name

Serum albumin

Target 9 Mechanism of Action

The binding of metabolites such as benzene oxide to the blood proteins albumin and haemoglobin lead to decreases in haematological cell counts and bone marrow cellularity. (R016)

Target 9 Description

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

Target 9 Synonyms

Not Available

Target 9 Gene Name

ALB

Target 9 Protein Sequence

>Serum albumin

MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

Target 9 Number of Residues

609

Target 9 Molecular Weight

69365.9

Target 9 Theoretical pI

6.21

Target 9 GO Classification

Function
transporter activity carrier activity
Process
physiological process cellular physiological process transport
Component
extracellular region extracellular space

Target 9 General Function

Involved in antioxidant activity

Target 9 Pathways

REACT_604-Hemostasis;

Target 9 Reactions

Not Available

Target 9 Signals

1-18

Target 9 Transmembrane Regions

None

Target 9 Essentiality

Non Essential

Target 9 Domain Function

PF00273:Serum_albumin

Target 9 GenBank ID Protein

Not Available

Target 9 UniProtKB ID

P02768

Target 9 Cellular Location

Secreted

Target 9 Gene Sequence

>1830 bp

ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

Target 9 GenBank Gene ID

Not Available

Target 9 GeneCard ID

ALB

Target 9 GenAtlas ID

ALB

Target 9 HGNC ID

HGNC:399

Target 9 Chromosome Location

Not Available

Target 9 Locus

4q11-q13

Target 9 SNPs

SNPJam Report Link Image

Target 9 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 9 General References

6171778; 6275391; 3009475; 11483580

Target 10 [top]

Target 10 ID

Target 10 Name

Histone H4

Target 10 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 10 Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Target 10 Synonyms

Not Available

Target 10 Gene Name

HIST1H4A

Target 10 Protein Sequence

>Histone H4

MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Target 10 Number of Residues

103

Target 10 Molecular Weight

11367.3

Target 10 Theoretical pI

11.91

Target 10 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 10 General Function

Chromatin structure and dynamics

Target 10 Pathways

Not Available

Target 10 Reactions

Not Available

Target 10 Signals

None

Target 10 Transmembrane Regions

None

Target 10 Essentiality

Non Essential

Target 10 Domain Function

PF00125:Histone

Target 10 GenBank ID Protein

Not Available

Target 10 UniProtKB ID

P62805

Target 10 Cellular Location

Nucleus

Target 10 Gene Sequence

Not Available

Target 10 GenBank Gene ID

Not Available

Target 10 GeneCard ID

HIST1H4A

Target 10 GenAtlas ID

HIST1H4A

Target 10 HGNC ID

HGNC:4781

Target 10 Chromosome Location

Not Available

Target 10 Locus

6p21.3

Target 10 SNPs

SNPJam Report Link Image

Target 10 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 10 General References

6314274; 3035717; 1916825; 7626218; 9031620; 9439656; 9119399; 12408966; 8988030; 15527963

Target 11 [top]

Target 11 ID

252

Target 11 Name

Histone H3.1

Target 11 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 11 Description

Target 11 Synonyms

H3/a; H3/b; H3/c; H3/d; H3/f; H3/h; H3/i; H3/j; H3/k; H3/l

Target 11 Gene Name

HIST1H3A

Target 11 Protein Sequence

>Histone H3.1

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA

Target 11 Number of Residues

136

Target 11 Molecular Weight

15403.9

Target 11 Theoretical pI

11.71

Target 11 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 11 General Function

Chromatin structure and dynamics

Target 11 Pathways

Not Available

Target 11 Reactions

Not Available

Target 11 Signals

None

Target 11 Transmembrane Regions

None

Target 11 Essentiality

Non Essential

Target 11 Domain Function

PF00125:Histone

Target 11 GenBank ID Protein

Not Available

Target 11 UniProtKB ID

P68431

Target 11 Cellular Location

Nucleus

Target 11 Gene Sequence

Not Available

Target 11 GenBank Gene ID

Not Available

Target 11 GeneCard ID

HIST1H3A

Target 11 GenAtlas ID

HIST1H3A

Target 11 HGNC ID

HGNC:4766

Target 11 Chromosome Location

Not Available

Target 11 Locus

Not Available

Target 11 SNPs

SNPJam Report Link Image

Target 11 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 11 General References

6647026; 3013246; 1916825; 8227173; 9031620; 9119399; 9439656; 12408966; 14702039

Target 12 [top]

Target 12 ID

Target 12 Name

Histone H3.1t

Target 12 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 12 Description

Target 12 Synonyms

H3t; H3/t; H3/g

Target 12 Gene Name

HIST3H3

Target 12 Protein Sequence

>Histone H3.1t

MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLMREIAQDFKTDLRFQSSAVMALQEACESYLVGLFEDTNLCVIHAKRVTI
MPKDIQLARRIRGERA

Target 12 Number of Residues

136

Target 12 Molecular Weight

15508.1

Target 12 Theoretical pI

11.71

Target 12 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 12 General Function

Chromatin structure and dynamics

Target 12 Pathways

Not Available

Target 12 Reactions

Not Available

Target 12 Signals

None

Target 12 Transmembrane Regions

None

Target 12 Essentiality

Non Essential

Target 12 Domain Function

PF00125:Histone

Target 12 GenBank ID Protein

Not Available

Target 12 UniProtKB ID

Q16695

Target 12 Cellular Location

Nucleus

Target 12 Gene Sequence

Not Available

Target 12 GenBank Gene ID

Not Available

Target 12 GeneCard ID

HIST3H3

Target 12 GenAtlas ID

HIST3H3

Target 12 HGNC ID

HGNC:4778

Target 12 Chromosome Location

Not Available

Target 12 Locus

1q42

Target 12 SNPs

SNPJam Report Link Image

Target 12 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 12 General References

8834248; 12408966; 16710414; 15489334; 15782174; 18691976

Target 13 [top]

Target 13 ID

Target 13 Name

Histone H3.3

Target 13 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 13 Description

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Target 13 Synonyms

Not Available

Target 13 Gene Name

H3F3A

Target 13 Protein Sequence

>Histone H3.3

MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA

Target 13 Number of Residues

136

Target 13 Molecular Weight

15327.7

Target 13 Theoretical pI

11.83

Target 13 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 13 General Function

Chromatin structure and dynamics

Target 13 Pathways

Not Available

Target 13 Reactions

Not Available

Target 13 Signals

None

Target 13 Transmembrane Regions

None

Target 13 Essentiality

Non Essential

Target 13 Domain Function

PF00125:Histone

Target 13 GenBank ID Protein

Not Available

Target 13 UniProtKB ID

P84243

Target 13 Cellular Location

Nucleus

Target 13 Gene Sequence

>411 bp

ATGGCTCGTACAAAGCAGACTGCCCGCAAATCGACCGGTGGTAAAGCACCCAGGAAGCAA
CTGGCTACAAAAGCCGCTCGCAAGAGTGCGCCCTCTACTGGAGGGGTGAAGAAACCTCAT
CGTTACAGGCCTGGTACTGTGGCGCTCCGTGAAATTAGACGTTATCAGAAGTCCACTGAA
CTTCTGATTCGCAAACTTCCCTTCCAGCGTCTGGTGCGAGAAATTGCTCAGGACTTTAAA
ACAGATCTGCGCTTCCAGAGCGCAGCTATCGGTGCTTTGCAGGAGGCAAGTGAGGCCTAT
CTGGTTGGCCTTTTTGAAGACACCAACCTGTGTGCTATCCATGCCAAACGTGTAACAATT
ATGCCAAAAGACATCCAGCTAGCACGCCGCATACGTGGAGAACGTGCTTAA

Target 13 GenBank Gene ID

Not Available

Target 13 GeneCard ID

H3F3A

Target 13 GenAtlas ID

H3F3A

Target 13 HGNC ID

HGNC:4764

Target 13 Chromosome Location

Not Available

Target 13 Locus

1q41

Target 13 SNPs

SNPJam Report Link Image

Target 13 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 13 General References

2859593; 3031613; 8586426; 15498874; 17974005; 16710414; 15489334; 7309716; 16185088; 10464286

Target 14 [top]

Target 14 ID

Target 14 Name

DNA polymerase subunit gamma-1

Target 14 Mechanism of Action

Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)

Target 14 Description

Involved in the replication of mitochondrial DNA

Target 14 Synonyms

Mitochondrial DNA polymerase catalytic subunit; PolG-alpha

Target 14 Gene Name

POLG

Target 14 Protein Sequence

>DNA polymerase subunit gamma-1

MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQ
VLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPL
PDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGP
EGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLS
PADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMA
ISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVH
RLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPH
PVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYK
EDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQ
QDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTP
KLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHC
LEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALT
ARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQ
AGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAI
LPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAA
VLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQP
FAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWI
SLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCIS
RALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYL
VREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTP
SNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP

Target 14 Number of Residues

1239

Target 14 Molecular Weight

139561.1

Target 14 Theoretical pI

6.89

Target 14 GO Classification

Function
catalytic activity transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity DNA-directed DNA polymerase activity gamma DNA-directed DNA polymerase activity binding nucleic acid binding DNA binding
Process
physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism DNA metabolism DNA replication
Component
protein complex gamma DNA polymerase complex

Target 14 General Function

Replication, recombination and repair

Target 14 Pathways

Not Available

Target 14 Reactions

Not Available

Target 14 Signals

None

Target 14 Transmembrane Regions

None

Target 14 Essentiality

Non Essential

Target 14 Domain Function

PF00476:DNA_pol_A

Target 14 GenBank ID Protein

Not Available

Target 14 UniProtKB ID

P54098

Target 14 Cellular Location

Mitochondrion

Target 14 Gene Sequence

>3720 bp

ATGAGCCGCCTGCTCTGGAGGAAGGTGGCCGGCGCCACCGTCGGGCCAGGGCCGGTTCCA
GCTCCGGGGCGCTGGGTCTCCAGCTCCGTCCCCGCGTCCGACCCCAGCGACGGGCAGCGG
CGGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCCTCAGCAGCCGCAA
GTGCTATCCTCGGAGGGCGGGCAGCTGCGGCACAACCCATTGGACATCCAGATGCTCTCG
AGAGGGCTGCACGAGCAAATCTTCGGGCAAGGAGGGGAGATGCCTGGCGAGGCCGCGGTG
CGCCGCAGCGTCGAGCACCTGCAGAAGCACGGGCTCTGGGGGCAGCCAGCCGTGCCCTTG
CCCGACGTGGAGCTGCGCCTGCCGCCCCTCTACGGGGACAACCTGGACCAGCACTTCCGC
CTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCGGCCAACTTGCTGTTGCAGGCC
CAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCC
GAGGGGGAGGCCGTACCCGTGGCCATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAG
GTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTGGCCATATCCCCCTCGGCCTGG
TATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCG
CCGGCTGACCTCATCCCCCTGGAGGTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGAC
TGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGACCGAGCTCATATCAGGGAG
CAGTACCTGATCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCC
ATCTCAGGGCTAAGCAGCTTCCAGCGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACAC
AAGGTCCAGCCCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAGCCAGAAGAGGCCCA
GCGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGCAGAGGTGCAC
AGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGC
ACCATGAAGGACATTCGTGAGAACTTCCAGGACCTGATGCAGTACTGTGCCCAGGACGTG
TGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGGTGTCCCCAC
CCAGTGACTCTGGCCGGCATGCTGGAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAAC
TGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGCTCCAGCGGGAGATGAAG
AAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGTACAAA
GAAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCT
AAGAAGGTGAAGAAGGAACCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCTGGGGCC
CCTGGTGATCCCATGGATCAGGAAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAA
CAAGATGTCATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCC
AAGCGGCCCCAGCACCTTCCTGGACACCCTGGATGGTACCGGAAGCTCTGCCCCCGGCTA
GACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCT
AAACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGG
GGCTACTTGGTGCCTGGGCGGCGGGACAACCTGGCCAAGCTGCCGACAGGTACCACCCTG
GAGTCAGCTGGGGTGGTCTGCCCCTACAGAGCCATCGAGTCCCTGTACAGGAAGCACTGT
CTCGAACAGGGGAAGCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTG
CTCACTGACAATAGTGCCATATGGCAAACGGTAGAAGAACTGGATTACTTAGAAGTGGAG
GCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGACT
GCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCATGGCAATGGACCTTACAAC
GACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGGATGGTAATAGCTGT
AATGTGGGAAGCCCCTTTGCCAAGGACTTCCTGCCCAAGATGGAGGATGGCACCCTGCAG
GCTGGCCCAGGAGGTGCCAGTGGGCCCCGTGCTCTGGAAATCAACAAAATGATTTCTTTC
TGGAGGAACGCCCATAAACGTATCAGCTCCCAGATGGTGGTGTGGCTGCCCAGGTCAGCT
CTGCCCCGTGCTGTGATCAGGCACCCCGACTATGATGAGGAAGGCCTCTATGGGGCCATC
CTGCCCCAAGTGGTGACTGCCGGCACCATCACTCGCCGGGCTGTGGAGCCCACATGGCTC
ACCGCCAGCAATGCCCGGCCTGACCGAGTAGGCAGTGAGTTGAAAGCCATGGTGCAGGCC
CCACCTGGCTACACCCTTGTGGGTGCTGATGTGGACTCCCAAGAGCTGTGGATTGCAGCT
GTGCTTGGAGACGCCCACTTTGCCGGCATGCATGGCTGCACAGCCTTTGGGTGGATGACA
CTGCAGGGCAGGAAGAGCAGGGGCACTGATCTACACAGTAAGACAGCCACTACTGTGGGC
ATCAGCCGTGAGCATGCCAAAATCTTCAACTACGGCCGCATCTATGGTGCTGGGCAGCCC
TTTGCTGAGCGCTTACTAATGCAGTTTAACCACCGGCTCACACAGCAGGAGGCAGCTGAG
AAGGCCCAGCAGATGTACGCTGCCACCAAGGGCCTCCGCTGGTATCGGCTGTCGGATGAG
GGCGAGTGGCTGGTGAGGGAGTTGAACCTCCCAGTGGACAGGACTGAGGGTGGCTGGATT
TCCCTGCAGGATCTGCGCAAGGTCCAGAGAGAAACTGCAAGGAAGTCACAGTGGAAGAAG
TGGGAGGTGGTTGCTGAACGGGCATGGAAGGGGGGCACAGAGTCAGAAATGTTCAATAAG
CTTGAGAGCATTGCTACGTCTGACATACCACGTACCCCGGTGCTGGGCTGCTGCATCAGC
CGAGCCCTGGAGCCCTCGGCTGTCCAGGAAGAGTTTATGACCAGCCGTGTGAATTGGGTG
GTACAGAGCTCTGCTGTTGACTACTTACACCTCATGCTTGTGGCCATGAAGTGGCTGTTT
GAAGAGTTTGCCATAGATGGGCGCTTCTGCATCAGCATCCATGACGAGGTTCGCTACCTG
GTGCGGGAGGAGGACCGCTACCGCGCTGCCCTGGCCTTGCAGATCACCAACCTCTTGACC
AGGTGCATGTTTGCCTACAAGCTGGGTCTGAATGACTTGCCCCAGTCAGTCGCCTTTTTC
AGTGCAGTCGATATTGACCGGTGCCTCAGGAAGGAAGTGACCATGGATTGTAAAACCCCT
TCCAACCCAACTGGGATGGAAAGGAGATACGGGATTCCCCAGGGTGAAGCGCTGGATATT
TACCAGATAATTGAACTCACCAAAGGCTCCTTGGAAAAACGAAGCCAGCCTGGACCATAG

Target 14 GenBank Gene ID

Not Available

Target 14 GeneCard ID

POLG

Target 14 GenAtlas ID

POLG

Target 14 HGNC ID

HGNC:9179

Target 14 Chromosome Location

Chromosome:15

Target 14 Locus

15q25

Target 14 SNPs

SNPJam Report Link Image

Target 14 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 14 General References

8884268; 9034326; 15489334; 11431686; 12210792; 11897778; 12975295; 12825077

Target 15 [top]

Target 15 ID

113

Target 15 Name

Ribonucleoside-diphosphate reductase large subunit

Target 15 Mechanism of Action

Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)

Target 15 Description

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Target 15 Synonyms

Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit

Target 15 Gene Name

RRM1

Target 15 Protein Sequence

>Ribonucleoside-diphosphate reductase large subunit

MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS

Target 15 Number of Residues

792

Target 15 Molecular Weight

90069.4

Target 15 Theoretical pI

7.16

Target 15 GO Classification

Function
catalytic activity oxidoreductase activity oxidoreductase activity, acting on CH2 groups oxidoreductase activity, acting on CH2 groups, disulfide as acceptor ribonucleoside-diphosphate reductase activity
Process
physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism DNA metabolism DNA replication
Component
protein complex ribonucleoside-diphosphate reductase complex

Target 15 General Function

Nucleotide transport and metabolism

Target 15 Pathways

Genetic information processing; DNA replication

Target 15 Reactions

Not Available

Target 15 Signals

None

Target 15 Transmembrane Regions

None

Target 15 Essentiality

Non Essential

Target 15 Domain Function

PF03477:ATP-cone PF02867:Ribonuc_red_lgC PF00317:Ribonuc_red_lgN

Target 15 GenBank ID Protein

Not Available

Target 15 UniProtKB ID

P23921

Target 15 Cellular Location

Cytoplasm

Target 15 Gene Sequence

>2379 bp

ATGCATGTGATCAAGCGAGATGGCCGCCAAGAACGAGTCATGTTTGACAAAATTACATCT
CGAATCCAGAAGCTTTGTTATGGACTCAATATGGATTTTGTTGATCCTGCTCAGATCACC
ATGAAAGTAATCCAAGGCTTGTACAGTGGGGTCACCACAGTGGAACTAGATACTTTGGCT
GCTGAAACAGCTGCAACCTTGACTACTAAGCACCCTGACTATGCTATCCTGGCAGCCAGG
ATCGCTGTCTCTAACTTGCACAAAGAAACAAAGAAAGTGTTCAGTGATGTGATGGAAGAC
CTCTATAACTACATAAATCCACATAATGGCAAACACTCTCCCATGGTGGCCAAGTCAACA
TTGGATATTGTTCTGGCCAATAAAGATCGCCTGAATTCTGCTATTATCTATGACCGAGAT
TTCTCTTACAATTACTTCGGCTTTAAGACGCTAGAGCGGTCTTATTTGTTGAAGATCAAT
GGAAAAGTGGCTGAAAGACCACAACATATGTTGATGAGAGTATCTGTTGGGATCCACAAA
GAAGACATTGATGCAGCAATTGAAACATATAATCTTCTTTCTGAGAGGTGGTTTACTCAT
GCTTCGCCCACTCTCTTCAATGCTGGTACCAACCGCCCACAACTTTCTAGCTGTTTTCTT
CTGAGTATGAAAGATGACAGCATTGAAGGCATTTATGACACTCTAAAGCAATGTGCATTG
ATTTCTAAGTCTGCTGGAGGAATTGGTGTTGCTGTGAGTTGTATTCGGGCTACTGGCAGC
TACATTGCTGGGACTAATGGCAATTCCAATGGCCTTGTACCGATGCTGAGAGTATATAAC
AACACAGCTCGATATGTGGATCAAGGTGGGAACAAGCGTCCTGGGGCATTTGCTATTTAC
CTGGAGCCTTGGCATTTAGACATCTTTGAATTCCTTGATTTAAAGAAGAACACAGGAAAG
GAAGAGCAGCGTGCCAGAGATCTTTTCTTTGCTCTTTGGATTCCGGATCTCTTCATGAAA
CGAGTGGAGACTAATCAGGACTGGTCTTTGATGTGTCCAAATGAGTGTCCTGGTCTGGAT
GAGGTTTGGGGAGAGGAATTTGAGAAACTATATGCAAGTTATGAGAAACAAGGTCGTGTC
CGCAAAGTTGTAAAAGCTCAGCAGCTTTGGTATGCCATCATTGAGTCTCAGACGGAAACA
GGCACCCCGTATATGCTCTACAAAGATTCCTGTAATCGAAAGAGCAACCAGCAGAACCTG
GGAACCATCAAATGCAGCAACCTGTGCACAGAAATAGTGGAGTACACCAGCAAAGATGAG
GTTGCTGTTTGTAATTTGGCTTCCCTGGCCCTGAATATGTATGTCACATCAGAACACACA
TACGACTTTAAGAAGTTGGCTGAAGTCACTAAAGTCGTTGTCCGAAACTTGAATAAAATT
ATTGATATAAACTACTATCCTGTACCAGAGGCATGCCTATCAAATAAACGCCATCGCCCC
ATTGGAATTGGGGTACAAGGTCTGGCAGATGCTTTTATCCTGATGAGATACCCTTTTGAG
AGTGCAGAAGCCCAGTTACTGAATAAGCAGATCTTTGAAACTATTTATTATGGTGCTCTG
GAAGCCAGCTGTGACCTTGCCAAGGAGCAGGGCCCATACGAAACCTATGAGGGCTCTCCA
GTTAGCAAAGGAATTCTTCAGTATGATATGTGGAATGTTACTCCTACAGACCTATGGGAC
TGGAAGGTTCTCAAGGAGAAGATTGCAAAGTATGGTATAAGAAACAGTTTACTTATTGCC
CCGATGCCTACAGCTTCCACTGCTCAGATCCTGGGGAATAATGAGTCCATTGAACCTTAC
ACCAGCAACATCTATACTCGCAGAGTCTTGTCAGGAGAATTTCAGATTGTAAATCCTCAC
TTATTGAAAGATCTTACCGAGCGGGGCCTATGGCATGAAGAGATGAAAAACCAGATTATT
GCATGCAATGGCTCTATTCAGAGCATACCAGAAATTCCTGATGACCTGAAGCAACTTTAT
AAAACTGTGTGGGAAATCTCTCAGAAAACTGTTCTCAAGATGGCAGCTGAGAGAGGTGCT
TTCATTGATCAAAGCCAATCTTTGAACATCCACATTGCTGAGCCTAACTATGGCAAACTC
ACTAGTATGCACTTCTACGGCTGGAAGCAGGGTTTGAAGACTGGGATGTATTATTTAAGG
ACGAGACCAGCAGCTAATCCAATCCAGTTCACTCTAAATAAGGAGAAGCTAAAAGATAAA
GAAAAGGTATCAAAAGAGGAAGAAGAGAAGGAGAGGAACACAGCAGCCATGGTGTGCTCT
TTGGAGAATAGAGATGAATGTCTGATGTGTGGATCCTGA

Target 15 GenBank Gene ID

Not Available

Target 15 GeneCard ID

RRM1

Target 15 GenAtlas ID

RRM1

Target 15 HGNC ID

HGNC:10451 Link Image

Target 15 Chromosome Location

Chromosome:11

Target 15 Locus

11p15.5

Target 15 SNPs

SNPJam Report Link Image

Target 15 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 15 General References

1840662; 1627826; 9933563; 15489334; 8188248; 12615712

Target 16 [top]

Target 16 ID

Target 16 Name

Ribonucleoside-diphosphate reductase subunit M2

Target 16 Mechanism of Action

Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)

Target 16 Description

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling

Target 16 Synonyms

Ribonucleotide reductase small subunit; Ribonucleotide reductase small chain

Target 16 Gene Name

RRM2

Target 16 Protein Sequence

>Ribonucleoside-diphosphate reductase subunit M2

MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF

Target 16 Number of Residues

389

Target 16 Molecular Weight

44877.2

Target 16 Theoretical pI

5.05

Target 16 GO Classification

Function
oxidoreductase activity, acting on CH2 groups oxidoreductase activity, acting on CH2 groups, disulfide as acceptor ribonucleoside-diphosphate reductase activity catalytic activity oxidoreductase activity
Process
physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism nucleotide metabolism nucleoside diphosphate metabolism deoxyribonucleoside diphosphate metabolism
Component
Not Available

Target 16 General Function

Nucleotide transport and metabolism

Target 16 Pathways

Genetic information processing; DNA replication

Target 16 Reactions

Not Available

Target 16 Signals

None

Target 16 Transmembrane Regions

None

Target 16 Essentiality

Non Essential

Target 16 Domain Function

PF00268:Ribonuc_red_sm

Target 16 GenBank ID Protein

Not Available

Target 16 UniProtKB ID

P31350

Target 16 Cellular Location

Cytoplasm

Target 16 Gene Sequence

>1170 bp

ATGCTCTCCCTCCGTGTCCCGCTCGCGCCCATCACGGACCCGCAGCAGCTGCAGCTCTCG
CCGCTGAAGGGGCTCAGCTTGGTCGACAAGGAGAACACGCCGCCGGCCCTGAGCGGGACC
CGCGTCCTGGCCAGCAAGACCGCGAGGAGGATCTTCCAGGAGCCCACGGAGCCGAAAACT
AAAGCAGCTGCCCCCGGCGTGGAGGATGAGCCGCTGCTGAGAGAAAACCCCCGCCGCTTT
GTCATCTTCCCCATCGAGTACCATGATATCTGGCAGATGTATAAGAAGGCAGAGGCTTCC
TTTTGGACCGCCGAGGAGGTTGACCTCTCCAAGGACATTCAGCACTGGGAATCCCTGAAA
CCCGAGGAGAGATATTTTATATCCCATGTTCTGGCTTTCTTTGCAGCAAGCGATGGCATA
GTAAATGAAAACTTGGTGGAGCGATTTAGCCAAGAAGTTCAGATTACAGAAGCCCGCTGT
TTCTATGGCTTCCAAATTGCCATGGAAAACATACATTCTGAAATGTATAGTCTTCTTATT
GACACTTACATAAAAGATCCCAAAGAAAGGGAATTTCTCTTCAATGCCATTGAAACGATG
CCTTGTGTCAAGAAGAAGGCAGACTGGGCCTTGCGCTGGATTGGGGACAAAGAGGCTACC
TATGGTGAACGTGTTGTAGCCTTTGCTGCAGTGGAAGGCATTTTCTTTTCCGGTTCTTTT
GCGTCGATATTCTGGCTCAAGAAACGAGGACTGATGCCTGGCCTCACATTTTCTAATGAA
CTTATTAGCAGAGATGAGGGTTTACACTGTGATTTTGCTTGCCTGATGTTCAAACACCTG
GTACACAAACCATCGGAGGAGAGAGTAAGAGAAATAATTATCAATGCTGTTCGGATAGAA
CAGGAGTTCCTCACTGAGGCCTTGCCTGTGAAGCTCATTGGGATGAATTGCACTCTAATG
AAGCAATACATTGAGTTTGTGGCAGACAGACTTATGCTGGAACTGGGTTTTAGCAAGGTT
TTCAGAGTAGAGAACCCATTTGACTTTATGGAGAATATTTCACTGGAAGGAAAGACTAAC
TTCTTTGAGAAGAGAGTAGGCGAGTATCAGAGGATGGGAGTGATGTCAAGTCCAACAGAG
AATTCTTTTACCTTGGATGCTGACTTCTAA

Target 16 GenBank Gene ID

Not Available

Target 16 GeneCard ID

RRM2

Target 16 GenAtlas ID

RRM2

Target 16 HGNC ID

HGNC:10452 Link Image

Target 16 Chromosome Location

Not Available

Target 16 Locus

2p25-p24

Target 16 SNPs

SNPJam Report Link Image

Target 16 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 16 General References

1627826; 11978970; 14702039; 15815621; 15489334; 16964243; 17924679; 17693683; 18187866; 18669648

Target 17 [top]

Target 17 ID

223

Target 17 Name

Tubulin alpha-1B chain

Target 17 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 17 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 17 Synonyms

Tubulin alpha-ubiquitous chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1

Target 17 Gene Name

TUBA1B

Target 17 Protein Sequence

>Tubulin alpha-1B chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Target 17 Number of Residues

451

Target 17 Molecular Weight

50151.2

Target 17 Theoretical pI

4.70

Target 17 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 17 General Function

Involved in GTP binding

Target 17 Pathways

Not Available

Target 17 Reactions

Not Available

Target 17 Signals

None

Target 17 Transmembrane Regions

None

Target 17 Essentiality

Non Essential

Target 17 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 17 GenBank ID Protein

Not Available

Target 17 UniProtKB ID

P68363

Target 17 Cellular Location

Cytoplasmic

Target 17 Gene Sequence

>1356 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAG
CACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCCGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGCCTGTCAGTTGAT
TATGGCAAGAAATCCAAGCTGGAGTTCTCCATTTACCCGGCACCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTC
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGACATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTGGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCACG
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA

Target 17 GenBank Gene ID

Not Available

Target 17 GeneCard ID

TUBA1B

Target 17 GenAtlas ID

TUBA1B

Target 17 HGNC ID

HGNC:18809 Link Image

Target 17 Chromosome Location

Chromosome:12

Target 17 Locus

12q13.12

Target 17 SNPs

SNPJam Report Link Image

Target 17 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 17 General References

6646120; 15489334; 8619814; 15592455; 19007248; 18781797

Target 18 [top]

Target 18 ID

147

Target 18 Name

Tubulin alpha-3C/D chain

Target 18 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 18 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 18 Synonyms

Alpha-tubulin 3C/D; Tubulin alpha-2 chain; Alpha-tubulin 2

Target 18 Gene Name

TUBA3C

Target 18 Protein Sequence

>Tubulin alpha-3C/D chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY

Target 18 Number of Residues

450

Target 18 Molecular Weight

49959.1

Target 18 Theoretical pI

4.74

Target 18 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 18 General Function

Involved in GTP binding

Target 18 Pathways

Not Available

Target 18 Reactions

Not Available

Target 18 Signals

None

Target 18 Transmembrane Regions

None

Target 18 Essentiality

Non Essential

Target 18 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 18 GenBank ID Protein

Not Available

Target 18 UniProtKB ID

Q13748

Target 18 Cellular Location

Cytoplasmic

Target 18 Gene Sequence

>1257 bp

ATGCGTGAGTGTATCTCTATCCACGTGGGGCAGGCAGGAGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTGGAACATGGAATTCAGCCCGATGGTCAGATGCCAAGTGATAAA
ACCATTGGTGGTGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGAACCTATAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCGGCC
AATAATTACGCCAGAGGCCATTACACCATCGGCAAGGAGATCGTCGACCTGGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACGGGACTGCAGGGCTTCCTCATCTTCCACAGT
TTTGGGGGTGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACGGCAAGAAGTCCAAGCTAGAATTTGCCATTTACCCAGCCCCCCAGGTCTCCACGGCC
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATCGAG
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGACGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTAGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCGGTCATCTCAGCCGAGAAG
GCCTACCACGAGCAGCTGTCCGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCACGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGATGTGGTCCCGAAAGATGTCAACGCGGCCATCGCCACCATCAAGACCAAGCGCACC
ATCCAGTTTGTAGATTGGTGCCCAACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACGGTGGTCCCTGGGGGAGACCTGGCCAAGGTGCAGCGGGCTGTGTGCATGCTGAGCAAC
ACCACGGCCATCGCGGAGGCCTGGGCTCGCCTGGACCTGGCAGCTCTGGAGAAGGATTAT
GAAGAGGTGGGCGTGGATTCCGTGGAAGCCGAGGCTGAAGAAGGTGAAGAATACTGA

Target 18 GenBank Gene ID

Not Available

Target 18 GeneCard ID

TUBA3C

Target 18 GenAtlas ID

TUBA3C

Target 18 HGNC ID

HGNC:12408 Link Image

Target 18 Chromosome Location

Chromosome:13

Target 18 Locus

13q11

Target 18 SNPs

SNPJam Report Link Image

Target 18 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 18 General References

9465305; 15057823; 15489334; 17924679; 19524510

Target 19 [top]

Target 19 ID

Target 19 Name

Tubulin alpha-4A chain

Target 19 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 19 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 19 Synonyms

Tubulin alpha-1 chain; Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha

Target 19 Gene Name

TUBA4A

Target 19 Protein Sequence

>Tubulin alpha-4A chain

MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK
HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD
RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGIDSYEDEDEGEE

Target 19 Number of Residues

448

Target 19 Molecular Weight

49924.0

Target 19 Theoretical pI

4.69

Target 19 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 19 General Function

Involved in GTP binding

Target 19 Pathways

Not Available

Target 19 Reactions

Not Available

Target 19 Signals

None

Target 19 Transmembrane Regions

None

Target 19 Essentiality

Non Essential

Target 19 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 19 GenBank ID Protein

Not Available

Target 19 UniProtKB ID

P68366

Target 19 Cellular Location

Cytoplasmic

Target 19 Gene Sequence

Not Available

Target 19 GenBank Gene ID

Not Available

Target 19 GeneCard ID

TUBA4A

Target 19 GenAtlas ID

TUBA4A

Target 19 HGNC ID

HGNC:12407 Link Image

Target 19 Chromosome Location

Not Available

Target 19 Locus

2q35

Target 19 SNPs

SNPJam Report Link Image

Target 19 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 19 General References

3029670; 15489334; 15592455; 17924679; 18088087; 18691976; 18669648

Target 20 [top]

Target 20 ID

Target 20 Name

Tubulin beta chain

Target 20 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 20 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 20 Synonyms

Tubulin beta-5 chain

Target 20 Gene Name

TUBB

Target 20 Protein Sequence

>Tubulin beta chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA

Target 20 Number of Residues

444

Target 20 Molecular Weight

49670.5

Target 20 Theoretical pI

4.52

Target 20 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 20 General Function

Cell cycle control, cell division, chromosome partitioning

Target 20 Pathways

Not Available

Target 20 Reactions

Not Available

Target 20 Signals

None

Target 20 Transmembrane Regions

None

Target 20 Essentiality

Non Essential

Target 20 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 20 GenBank ID Protein

Not Available

Target 20 UniProtKB ID

P07437

Target 20 Cellular Location

Cytoplasmic

Target 20 Gene Sequence

>1335 bp

ATGAGGGAAATCGTGCACATCCAGGCTGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTC
TGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGACCGCATCTCTGTGTACTACAATGAAGCCACAGGTGGCAAATATGTT
CCTCGTGCCATCCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCT
TTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAAC
TGGGCCAAAGGCCACTACACAGAGGGCGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTA
CGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGC
GGGGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAATACCCT
GATCGCATCATGAATACCTTCAGTGTGGTGCCTTCACCCAAAGTGTCTGACACCGTGGTC
GAGCCCTACAATGCCACCCTCTCCGTCCATCAGTTGGTAGAGAATACTGATGAGACCTAT
TGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGCACTCTGAAGCTGACCACACCA
ACCTACGGGGATCTGAACCACCTTGTCTCAGCCACCATGAGTGGTGTCACCACCTGCCTC
CGTTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAGTTGGCAGTCAACATGGTCCCCTTC
CCACGTCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAG
TATCGAGCTCTCACAGTGCCGGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATG
GCTGCCTGTGACCCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGG
ATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAGAACAGCAGCTAC
TTTGTGGAATGGATCCCCAACAATGTCAAGACAGCCGTCTGTGACATCCCACCTCGTGGC
CTCAAGATGGCAGTCACCTTCATTGGCAATAGCACAGCCATCCAGGAGCTCTTCAAGCGC
ATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCTGAGAGCAACATGAACGACCTCGTCTCT
GAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCC
GAAGAGGAGGCCTAA

Target 20 GenBank Gene ID

Not Available

Target 20 GeneCard ID

TUBB

Target 20 GenAtlas ID

TUBB

Target 20 HGNC ID

HGNC:20778 Link Image

Target 20 Chromosome Location

Chromosome:6
Entrez Gene cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33

Target 20 Locus

6p21.33

Target 20 SNPs

SNPJam Report Link Image

Target 20 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 20 General References

6688039; 6865944; 11504633; 15489334

Target 21 [top]

Target 21 ID

219

Target 21 Name

Tubulin beta-2A chain

Target 21 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 21 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 21 Synonyms

Not Available

Target 21 Gene Name

TUBB2A

Target 21 Protein Sequence

>Tubulin beta-2A chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Target 21 Number of Residues

445

Target 21 Molecular Weight

49906.7

Target 21 Theoretical pI

4.52

Target 21 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 21 General Function

Cell cycle control, cell division, chromosome partitioning

Target 21 Pathways

Not Available

Target 21 Reactions

Not Available

Target 21 Signals

None

Target 21 Transmembrane Regions

None

Target 21 Essentiality

Non Essential

Target 21 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 21 GenBank ID Protein

Not Available

Target 21 UniProtKB ID

Q13885

Target 21 Cellular Location

Cytoplasmic

Target 21 Gene Sequence

>1338 bp

ATGCGCGAGATCGTGCACATCCAGGCGGGCCAGTGCGGCAACCAGATCGGCGCCAAGTTT
TGGGAGGTCATCAGCGATGAGCATGGGATCGACCCCACAGGCAGTTACCATGGAGACAGT
GACTTGCAGCTGGAGAGAATCAACGTGTACTACAATGAGGCTGCTGGTAACAAATATGTA
CCTCGGGCCATCCTGGTGGATCTGGAGCCTGGCACCATGGACTCTGTCAGGTCTGGACCC
TTCGGCCAGATCTTCAGACCAGACAACTTCGTGTTCGGCCAGAGTGGAGCCGGGAATAAC
TGGGCCAAGGGCCACTACACAGAGGGAGCCGAGCTGGTCGACTCGGTCCTGGATGTGGTG
AGGAAGGAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCTCTGGGG
GGCGGCACGGGGTCCGGGATGGGCACCCTGCTCATCAGCAAGATCCGGGAAGAGTACCCA
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACCCTCTCGGTCCACCAGCTGGTGGAAAACACAGATGAAACCTAC
TCCATTGATAACGAGGCCCTGTATGACATCTGCTTCCGCACCCTGAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCGCCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTCACGGTGCCCGAGCTCACCCAGCAGATGTTCGACTCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCTGCCATCTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTCAACGTGCAGAACAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGTCGGCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGACGAACAAGGGGAGTTCGAGGAGGAGGAG
GGCGAGGACGAGGCTTAA

Target 21 GenBank Gene ID

Not Available

Target 21 GeneCard ID

TUBB2A

Target 21 GenAtlas ID

TUBB2A

Target 21 HGNC ID

HGNC:12412 Link Image

Target 21 Chromosome Location

Not Available

Target 21 Locus

6p25

Target 21 SNPs

SNPJam Report Link Image

Target 21 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 21 General References

14574404; 15489334; 19524510; 16959974

Target 22 [top]

Target 22 ID

Target 22 Name

Tubulin beta-2C chain

Target 22 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 22 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 22 Synonyms

Tubulin beta-2 chain

Target 22 Gene Name

TUBB2C

Target 22 Protein Sequence

>Tubulin beta-2C chain

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA

Target 22 Number of Residues

445

Target 22 Molecular Weight

49830.7

Target 22 Theoretical pI

4.52

Target 22 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 22 General Function

Cell cycle control, cell division, chromosome partitioning

Target 22 Pathways

Not Available

Target 22 Reactions

Not Available

Target 22 Signals

None

Target 22 Transmembrane Regions

None

Target 22 Essentiality

Non Essential

Target 22 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 22 GenBank ID Protein

Not Available

Target 22 UniProtKB ID

P68371

Target 22 Cellular Location

Cytoplasmic

Target 22 Gene Sequence

>1338 bp

ATGAGGGAAATCGTGCACTTGCAGGCCGGGCAGTGCGGCAACCAAATCGGCGCCAAGTTT
TGGGAGGTGATCAGCGATGAGCACGGCATCGACCCCACGGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGAACGCATCAACGTGTACTACAATGAGGCCACCGGCGGCAAGTACGTG
CCCCGCGCCGTGCTCGTGGATCTGGAGCCCGGCACCATGGACTCCGTGCGCTCGGGGCCC
TTCGGGCAGATCTTCCGGCCGGACAACTTCGTTTTCGGTCAGAGTGGTGCTGGGAACAAC
TGGGCCAAGGGGCACTACACAGAAGGCGCGGAGCTGGTGGACTCGGTGCTGGATGTTGTG
AGAAAGGAGGCTGAGAGCTGTGACTGCCTGCAGGGTTTCCAGCTGACCCACTCCCTGGGT
GGGGGGACTGGGTCTGGGATGGGTACCCTCCTCATCAGCAAGATCCGGGAGGAGTACCCA
GACAGGATCATGAACACGTTTAGTGTGGTGCCTTCGCCCAAAGTGTCAGACACAGTGGTG
GAGCCCTACAACGCCACCCTCTCAGTCCACCAGCTCGTAGAAAACACAGACGAGACCTAC
TGCATTGATAACGAAGCTCTCTACGACATTTGCTTCAGAACCCTAAAGCTGACCACGCCC
ACCTATGGTGACCTGAACCACCTGGTGTCTGCTACCATGAGTGGGGTCACCACCTGCCTG
CGCTTCCCAGGCCAGCTCAATGCTGACCTGCGGAAGCTGGCTGTGAACATGGTCCCGTTT
CCCCGGCTGCACTTCTTCATGCCCGGCTTTGCCCCACTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTGACCGTGCCCGAGCTCACCCAGCAGATGTTTGATGCCAAGAACATGATG
GCTGCCTGCGACCCCCGCCATGGCCGCTACCTGACGGTTGCCGCCGTGTTCAGGGGCCGC
ATGTCCATGAAGGAGGTGGATGAGCAAATGCTTAATGTCCAAAACAAAAACAGCAGCTAT
TTTGTTGAGTGGATCCCCAACAATGTGAAAACGGCTGTCTGTGACATCCCACCTCGGGGG
CTAAAAATGTCCGCCACCTTCATTGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTGTCC
GAGTACCAGCAGTACCAGGATGCCACAGCCGAGGAGGAGGGCGAGTTCGAGGAGGAGGCT
GAGGAGGAGGTGGCCTAG

Target 22 GenBank Gene ID

Not Available

Target 22 GeneCard ID

TUBB2C

Target 22 GenAtlas ID

TUBB2C

Target 22 HGNC ID

HGNC:20771 Link Image

Target 22 Chromosome Location

Not Available

Target 22 Locus

9q34

Target 22 SNPs

SNPJam Report Link Image

Target 22 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 22 General References

3999141; 15164053; 15489334; 17081983; 19007248; 18691976; 18669648; 19524510

Target 23 [top]

Target 23 ID

242

Target 23 Name

Tubulin beta-3 chain

Target 23 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 23 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 23 Synonyms

Tubulin beta-III; Tubulin beta-4

Target 23 Gene Name

TUBB3

Target 23 Protein Sequence

>Tubulin beta-3 chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK

Target 23 Number of Residues

450

Target 23 Molecular Weight

50432.4

Target 23 Theoretical pI

4.57

Target 23 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 23 General Function

Cell cycle control, cell division, chromosome partitioning

Target 23 Pathways

Not Available

Target 23 Reactions

Not Available

Target 23 Signals

None

Target 23 Transmembrane Regions

None

Target 23 Essentiality

Non Essential

Target 23 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 23 GenBank ID Protein

Not Available

Target 23 UniProtKB ID

Q13509

Target 23 Cellular Location

Cytoplasmic

Target 23 Gene Sequence

>1353 bp

ATGCGGGAGATCGTGCACATCCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTC
TGGGAAGTCATCAGTGATGAGCATGGCATCGACCCCAGCGGCAACTACGTGGGCGACTCG
GACTTGCAGCTGGAGCGGATCAGCGTCTACTACAACGAGGCCTCTTCTCACAAGTACGTG
CCTCGAGCCATTCTGGTGGACCTGGAACCCGGAACCATGGACAGTGTCCGCTCAGGGGCC
TTTGGACATCTCTTCAGGCCTGACAATTTCATCTTTGGTCAGAGTGGGGCCGGCAACAAC
TGGGCCAAGGGTCACTACACGGAGGGGGCGGAGCTGGTGGATTCGGTCCTGGATGTGGTG
CGGAAGGAGTGTGAAAACTGCGACTGCCTGCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGGGGGACGGGCTCCGGCATGGGCACGTTGCTCATCAGCAAGGTGCGTGAGGAGTATCCC
GACCGCATCATGAACACCTTCAGCGTCGTGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAACCCTACAACGCCACGCTGTCCATCCACCAGCTGGTGGAAAACACGGATGAAACCTAC
TGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGGCCACGCCC
ACCTACGGGGACCTCAACCACCTGGTATCGGCCACCATGAGCGGAGTCACCACCTCCTTG
CGCTTCCCGGGCCAGCTCAACGCTGACCTGCGCAAGCTGGCCGTCAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCCGGCTTCGCCCCCCTCACCAGGCGGGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCCACCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGGTGGCCGTGTGTGACATCCCGCCCCGCGGC
CTCAAGATGTCCTCCACCTTCATCGGGAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAAGAGGGCGAGATGTACGAAGACGAC
GAGGAGGAGTCGGAGGCCCAGGGCCCCAAGTGA

Target 23 GenBank Gene ID

Not Available

Target 23 GeneCard ID

TUBB3

Target 23 GenAtlas ID

TUBB3

Target 23 HGNC ID

HGNC:20772 Link Image

Target 23 Chromosome Location

Chromosome:16

Target 23 Locus

16q24.3

Target 23 SNPs

SNPJam Report Link Image

Target 23 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 23 General References

9473684; 15489334; 19524510

Target 24 [top]

Target 24 ID

136

Target 24 Name

Tubulin beta-4 chain

Target 24 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 24 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 24 Synonyms

Tubulin 5 beta

Target 24 Gene Name

TUBB4

Target 24 Protein Sequence

>Tubulin beta-4 chain

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA

Target 24 Number of Residues

444

Target 24 Molecular Weight

49585.5

Target 24 Theoretical pI

4.51

Target 24 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 24 General Function

Cell cycle control, cell division, chromosome partitioning

Target 24 Pathways

Not Available

Target 24 Reactions

Not Available

Target 24 Signals

None

Target 24 Transmembrane Regions

None

Target 24 Essentiality

Non Essential

Target 24 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 24 GenBank ID Protein

Not Available

Target 24 UniProtKB ID

P04350

Target 24 Cellular Location

Cytoplasmic

Target 24 Gene Sequence

>1335 bp

ATGCGGGAGATCGTGCACCTGCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTT
TGGGAGGTTATCAGTGACGAACATGGCATCGACCCCACAGGCACATACCATGGGGACAGT
GACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCCACAGGAGGAAATTATGTC
CCCAGAGCGGTGCTGGTGGACCTGGAACCCGGCACCATGGACTCTGTCCGTTCTGGCCCC
TTCGGTCAGATCTTTCGGCCGGACAACTTCGTGTTTGGCCAATCCGGAGCCGGCAACAAC
TGGGCAAAGGGGCACTACACGGAGGGCGCAGAGCTGGTGGACGCTGTCCTGGACGTAGTC
CGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGTGGCACGGGGTCCGGAATGGGCACGCTGCTCATCAGTAAGATCCGCGAGGAGTTCCCA
GACCGCATCATGAACACCTTCAGCGTGGTGCCCTCGCCCAAAGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACGCTGTCTGTGCACCAGCTGGTGGAGAATACGGATGAGACCTAC
TGCATCGACAACGAGGCACTCTACGACATCTGTTTCCGCACCCTCAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCCGTCAACATGGTCCCCTTT
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCACCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCCCTGACGGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCGGCGTGCGACCCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCGCGACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCTTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTATCT
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAGGGCGAGTTCGAGGAGGAGGCGGAG
GAGGAGGTGGCCTAG

Target 24 GenBank Gene ID

Not Available

Target 24 GeneCard ID

TUBB4

Target 24 GenAtlas ID

TUBB4

Target 24 HGNC ID

HGNC:20774 Link Image

Target 24 Chromosome Location

Chromosome:19

Target 24 Locus

19p13.3

Target 24 SNPs

SNPJam Report Link Image

Target 24 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 24 General References

6462917; 15489334; 8619814; 16565220; 19524510

Target 25 [top]

Target 25 ID

Target 25 Name

Tubulin gamma-1 chain

Target 25 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 25 Description

Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly

Target 25 Synonyms

Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1

Target 25 Gene Name

TUBG1

Target 25 Protein Sequence

>Tubulin gamma-1 chain

MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE
MDTSREIVQQLIDEYHAATRPDYISWGTQEQ

Target 25 Number of Residues

451

Target 25 Molecular Weight

51169.5

Target 25 Theoretical pI

6.06

Target 25 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 25 General Function

Involved in GTP binding

Target 25 Pathways

Not Available

Target 25 Reactions

Not Available

Target 25 Signals

None

Target 25 Transmembrane Regions

None

Target 25 Essentiality

Non Essential

Target 25 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 25 GenBank ID Protein

Not Available

Target 25 UniProtKB ID

P23258

Target 25 Cellular Location

Cytoplasm, cytoskeleton, centrosome

Target 25 Gene Sequence

>1356 bp

ATGCCGAGGGAAATCATCACCCTACAGTTGGGCCAGTGCGGCAATCAGATTGGGTTCGAG
TTCTGGAAACAGCTGTGCGCCGAGCATGGTATCAGCCCCGAGGCGATCGTGGAGGAGTTC
GCCACCGAGGGCACTGACCGCAAGGACGTCTTTTTCTACCAGGCAGACGATGAGCACTAC
ATCCCCCGGGCCGTGCTGCTGGACTTGGAACCCCGGGTGATCCACTCCATCCTCAACTCC
CCCTATGCCAAGCTCTACAACCCAGAGAACATCTACCTGTCGGAACATGGAGGAGGAGCT
GGCAACAACTGGGCCAGCGGATTCTCCCAGGGAGAAAAGATCCATGAGGACATTTTTGAC
ATCATAGACCGGGAGGCAGATGGTAGTGACAGTCTAGAGGGCTTTGTGCTGTGTCACTCC
ATTGCTGGGGGGACAGGCTCTGGACTGGGTTCCTACCTCTTAGAACGGCTGAATGACAGG
TATCCTAAGAAGCTGGTGCAGACATACTCAGTGTTTCCCAACCAGGACGAGATGAGCGAT
GTGGTGGTCCAGCCTTACAATTCACTCCTCACACTCAAGAGGCTGACGCAGAATGCAGAC
TGTCTGGTGGTGCTGGACAACACAGCCCTGAACCGGATTGCCACAGACCGCCTGCACATC
CAGAACCCATCCTTCTCCCAGATCAACCAGCTGGTGTCTACCATCATGTCAGCCAGCACC
ACCACCCTGCGCTACCCTGGCTACATGAACAATGACCTCATCGGCCTCATCGCCTCGCTC
ATTCCCACCCCACGGCTCCACTTCCTCATGACCGGCTACACCCCTCTCACTACGGACCAG
TCAGTGGCCAGCGTGAGGAAGACCACGGTCCTGGATGTCATGAGGCGGCTGCTGCAGCCC
AAGAACGTGATGGTGTCCACAGGCCGAGACCGCCAGACCAACCACTGCTACATCGCCATC
CTCAACATCATCCAGGGAGAGGTGGACCCCACCCAGGTCCACAAGAGCTTGCAGAGGATC
CGGGAACGCAAGTTGGCCAACTTCATCCCGTGGGGCCCCGCCAGCATCCAGGTGGCCCTG
TCGAGGAAGTCTCCCTACCTGCCCTCGGCCCACCGGGTCAGCGGGCTCATGATGGCCAAC
CACACCAGCATCTCCTCGCTCTTCGAGAGAACCTGTCGCCAGTATGACAAGCTGCGTAAG
CGGGAGGCCTTCCTGGAGCAGTTCCGCAAGGAGGACATGTTCAAGGACAACTTTGATGAG
ATGGACACATCCAGGGAGATTGTGCAGCAGCTCATCGATGAGTACCATGCGGCCACACGG
CCAGACTACATCTCCTGGGGCACCCAGGAGCAGTGA

Target 25 GenBank Gene ID

Not Available

Target 25 GeneCard ID

TUBG1

Target 25 GenAtlas ID

TUBG1

Target 25 HGNC ID

HGNC:12417 Link Image

Target 25 Chromosome Location

Chromosome:17

Target 25 Locus

17q21

Target 25 SNPs

SNPJam Report Link Image

Target 25 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 25 General References

1904010; 15489334; 11840567; 9566969

Target 26 [top]

Target 26 ID

175

Target 26 Name

DNA topoisomerase 2-alpha

Target 26 Mechanism of Action

Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)

Target 26 Description

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks

Target 26 Synonyms

DNA topoisomerase II, alpha isozyme

Target 26 Gene Name

TOP2A

Target 26 Protein Sequence

>DNA topoisomerase 2-alpha

MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

Target 26 Number of Residues

1531

Target 26 Molecular Weight

174383.9

Target 26 Theoretical pI

9.17

Target 26 GO Classification

Function
DNA topoisomerase (ATP-hydrolyzing) activity DNA topoisomerase activity DNA topoisomerase (ATP-hydrolyzing) activity nucleic acid binding DNA binding binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding
Process
DNA topological change physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism DNA metabolism
Component
Not Available

Target 26 General Function

Replication, recombination and repair

Target 26 Pathways

Not Available

Target 26 Reactions

Not Available

Target 26 Signals

None

Target 26 Transmembrane Regions

None

Target 26 Essentiality

Non Essential

Target 26 Domain Function

PF00204:DNA_gyraseB PF00521:DNA_topoisoIV PF08070:DTHCT PF02518:HATPase_c

Target 26 GenBank ID Protein

Not Available

Target 26 UniProtKB ID

P11388

Target 26 Cellular Location

Cytoplasm. Nucleus, nucleoplasm

Target 26 Gene Sequence

>4596 bp

ACCACCCAGTACCGATCCCTTCACGACCGTCACCATGGAAGTGTCACCATTGCAGCCTGT
AAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTC
TGTTGAAAGAATCTATCAAAAGAAAACACAATTGGAACATATTTTGCTCCGCCCAGACAC
CTACATTGGTTCTGTGGAATTAGTGACCCAGCAAATGTGGGTTTACGATGAAGATGTTGG
CATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCT
AGTTAATGCTGCGGACAACAAACAAAGGGACCCAAAAATGTCTTGTATTAGAGTCACAAT
TGATCCGGAAAACAATTTAATTAGTATATGGAATAATGGAAAAGGTATTCCTGTTGTTGA
ACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAG
TAACTATGATGATGATGAAAAGAAAGTGACAGGTGGTCGAAATGGCTATGGAGCCAAATT
GTGTAACATATTCAGTACCAAATTTACTGTGGAAACAGCCAGTAGAGAATACAAGAAAAT
GTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTT
CAATGGAGAAGATTATACATGTATCACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCA
AAGCCTGGACAAAGATATTGTTGCACTAATGGTCAGAAGAGCATATGATATTGCTGGATC
CACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAG
TTATGTGGACATGTATTTGAAGGACAAGTTGGATGAAACTGGTAACTCCTTGAAAGTAAT
ACATGAACAAGTAAACCACAGGTGGGAAGTGTGTTTAACTATGAGTGAAAAAGGCTTTCA
GCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGT
AGCTGATCAGATTGTGACTAAACTTGTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGT
TGCAGTAAAAGCACATCAGGTGAAAAATCACATGTGGATTTTTGTAAATGCCTTAATTGA
AAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGG
ATCAACATGCCAATTGAGTGAAAAATTTATCAAAGCTGCCATTGGCTGTGGTATTGTAGA
AAGCATACTAAACTGGGTGAAGTTTAAGGCCCAAGTCCAGTTAAACAAGAAGTGTTCAGC
TGTAAAACATAATAGAATCAAGGGAATTCCCAAACTCGATGATGCCAATGATGCAGGGGG
CCGAAACTCCACTGAGTGTACGCTTATCCTGACTGAGGGAGATTCAGCCAAAACTTTGGC
TGTTTCAGGCCTTGGTGTGGTTGGGAGAGACAAATATGGGGTTTTCCCTCTTAGAGGAAA
AATACTCAATGTTCGAGAAGCTTCTCATAAGCAGATCATGGAAAATGCTGAGATTAACAA
TATCATCAAGATTGTGGGTCTTCAGTACAAGAAAAACTATGAAGATGAAGATTCATTGAA
GACGCTTCGTTATGGGAAGATAATGATTATGACAGATCAGGACCAAGATGGTTCCCACAT
CAAAGGCTTGCTGATTAATTTTATCCATCACAACTGGCCCTCTCTTCTGCGACATCGTTT
TCTGGAGGAATTTATCACTCCCATTGTAAAGGTATCTAAAAACAAGCAAGAAATGGCATT
TTACAGCCTTCCTGAATTTGAAGAGTGGAAGAGTTCTACTCCAAATCATAAAAAATGGAA
AGTCAAATATTACAAAGGTTTGGGCACCAGCACATCAAAGGAAGCTAAAGAATACTTTGC
AGATATGAAAAGACATCGTATCCAGTTCAAATATTCTGGTCCTGAAGATGATGCTGCTAT
CAGCCTGGCCTTTAGCAAAAAACAGATAGATGATCGAAAGGAATGGTTAACTAATTTCAT
GGAGGATAGAAGACAACGAAAGTTACTTGGGCTTCCTGAGGATTACTTGTATGGACAAAC
TACCACATATCTGACATATAATGACTTCATCAACAAGGAACTTATCTTGTTCTCAAATTC
TGATAACGAGAGATCTATCCCTTCTATGGTGGATGGTTTGAAACCAGGTCAGAGAAAGGT
TTTGTTTACTTGCTTCAAACGGAATGACAAGCGAGAAGTAAAGGTTGCCCAATTAGCTGG
ATCAGTGGCTGAAATGTCTTCTTATCATCATGGTGAGATGTCACTAATGATGACCATTAT
CAATTTGGCTCAGAATTTTGTGGGTAGCAATAATCTAAACCTCTTGCAGCCCATTGGTCA
GTTTGGTACCAGGCTACATGGTGGCAAGGATTCTGCTAGTCCACGATACATCTTTACAAT
GCTCAGCTCTTTGGCTCGATTGTTATTTCCACCAAAAGATGATCACACGTTGAAGTTTTT
ATATGATGACAACCAGCGTGTTGAGCCTGAATGGTACATTCCTATTATTCCCATGGTGCT
GATAAATGGTGCTGAAGGAATCGGTACTGGGTGGTCCTGCAAAATCCCCAACTTTGATGT
GCGTGAAATTGTAAATAACATCAGGCGTTTGATGGATGGAGAAGAACCTTTGCCAATGCT
TCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTCCAAATCAATATGTGAT
TAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAG
AACATGGACCCAGACATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAA
GACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATACCACTGTGAAATTTGT
TGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTT
CAAACTCCAAACTAGTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTT
AAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTGAACTCAGACTTAAATA
TTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAA
TAATCAGGCTCGCTTTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCC
TAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATTCGGATCCTGTGAAGGC
CTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGA
AAAGGAAACTGAAAAGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCT
TGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAACTCTGCAGGCTAAGAAA
TGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGA
AGACTTGGCTACATTTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGA
ACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAAAAACACAAATGGCTGA
AGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGC
AGAGGCAGAAAAGAAAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCA
AGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAAAGAAACAGAAAAGAGA
ACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAA
GAAGAGAAATCCCTGGCCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGA
TGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAACAAAATTCACAATGGA
TTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGT
CCCATCAGATGCTAGTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACT
GAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATGTTAAGGGCAGTGTACC
ACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGT
TCCTAAAAAGAATGTGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCAC
TACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGGATCCAGCTTTGAATTC
TGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATC
CACTTCTGATGATTCTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAA
GAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACTCAGCTGTGGCTCCTCG
GGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTA

Target 26 GenBank Gene ID

Not Available

Target 26 GeneCard ID

TOP2A

Target 26 GenAtlas ID

TOP2A

Target 26 HGNC ID

HGNC:11989 Link Image

Target 26 Chromosome Location

Chromosome:17

Target 26 Locus

17q21-q22

Target 26 SNPs

SNPJam Report Link Image

Target 26 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 26 General References

2845399; 8393377; 9795238; 10095062; 16625196; 10942766

Target 27 [top]

Target 27 ID

Target 27 Name

DNA topoisomerase 2-beta

Target 27 Mechanism of Action

Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)

Target 27 Description

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene

Target 27 Synonyms

DNA topoisomerase II, beta isozyme

Target 27 Gene Name

TOP2B

Target 27 Protein Sequence

>DNA topoisomerase 2-beta

MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVE
SQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK
KKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTS
SGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDD
DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK
SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPS
SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP
GRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDV
DFAMFN

Target 27 Number of Residues

1626

Target 27 Molecular Weight

183265.8

Target 27 Theoretical pI

8.16

Target 27 GO Classification

Function
DNA topoisomerase (ATP-hydrolyzing) activity DNA topoisomerase activity DNA topoisomerase (ATP-hydrolyzing) activity nucleic acid binding DNA binding binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding
Process
DNA topological change physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism DNA metabolism
Component
Not Available

Target 27 General Function

Replication, recombination and repair

Target 27 Pathways

Not Available

Target 27 Reactions

Not Available

Target 27 Signals

None

Target 27 Transmembrane Regions

None

Target 27 Essentiality

Non Essential

Target 27 Domain Function

PF00204:DNA_gyraseB PF00521:DNA_topoisoIV PF08070:DTHCT PF02518:HATPase_c

Target 27 GenBank ID Protein

Not Available

Target 27 UniProtKB ID

Q02880

Target 27 Cellular Location

Cytoplasm. Nucleus, nucleolus

Target 27 Gene Sequence

Not Available

Target 27 GenBank Gene ID

Not Available

Target 27 GeneCard ID

TOP2B

Target 27 GenAtlas ID

TOP2B

Target 27 HGNC ID

HGNC:11990 Link Image

Target 27 Chromosome Location

Not Available

Target 27 Locus

3p24

Target 27 SNPs

SNPJam Report Link Image

Target 27 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 27 General References

1333583; 8383537; 2556712; 10095062; 2163884; 9168988; 8396237; 12821127; 12837248; 15302935

Target 28 [top]

Target 28 ID

Target 28 Name

Tubulin alpha-1A chain

Target 28 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 28 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 28 Synonyms

Tubulin B-alpha-1; Tubulin alpha-3 chain; Alpha-tubulin 3

Target 28 Gene Name

TUBA1A

Target 28 Protein Sequence

>Tubulin alpha-1A chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Target 28 Number of Residues

451

Target 28 Molecular Weight

50135.2

Target 28 Theoretical pI

4.70

Target 28 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 28 General Function

Involved in GTP binding

Target 28 Pathways

Not Available

Target 28 Reactions

Not Available

Target 28 Signals

None

Target 28 Transmembrane Regions

None

Target 28 Essentiality

Non Essential

Target 28 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 28 GenBank ID Protein

Not Available

Target 28 UniProtKB ID

Q71U36

Target 28 Cellular Location

Cytoplasmic

Target 28 Gene Sequence

>1356 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGGGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAACTTATCACAGGCAAAGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCCGACCAGTGCACGGGTCTCCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATTGAG
CGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTATCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAACGTGCCTTTGTTCACTGGTACGTTGGGGAGGGGATGGAGGAAGGTGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA

Target 28 GenBank Gene ID

Not Available

Target 28 GeneCard ID

TUBA1A

Target 28 GenAtlas ID

TUBA1A

Target 28 HGNC ID

HGNC:20766 Link Image

Target 28 Chromosome Location

Chromosome:12

Target 28 Locus

12q12-q14.3

Target 28 SNPs

SNPJam Report Link Image

Target 28 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 28 General References

3839072; 11504633; 15489334; 6646120; 17081983; 17584854; 18669648; 19524510

Target 29 [top]

Target 29 ID

145

Target 29 Name

Tubulin alpha-1C chain

Target 29 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 29 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 29 Synonyms

Tubulin alpha-6 chain; Alpha-tubulin 6

Target 29 Gene Name

TUBA1C

Target 29 Protein Sequence

>Tubulin alpha-1C chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSADGEDEGEEY

Target 29 Number of Residues

449

Target 29 Molecular Weight

49894.9

Target 29 Theoretical pI

4.73

Target 29 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 29 General Function

Involved in GTP binding

Target 29 Pathways

Not Available

Target 29 Reactions

Not Available

Target 29 Signals

None

Target 29 Transmembrane Regions

None

Target 29 Essentiality

Non Essential

Target 29 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 29 GenBank ID Protein

Not Available

Target 29 UniProtKB ID

Q9BQE3

Target 29 Cellular Location

Cytoplasmic

Target 29 Gene Sequence

>1350 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAAACGGGTGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTACTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTATACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATTAATTACCAGCCTCCC
ACTGTGGTGCCTGGCGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAT
ACCACAGCTGTTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGAGCAGATAGTGCT
GACGGAGAGGATGAGGGTGAAGAGTATTAA

Target 29 GenBank Gene ID

Not Available

Target 29 GeneCard ID

TUBA1C

Target 29 GenAtlas ID

TUBA1C

Target 29 HGNC ID

HGNC:20768 Link Image

Target 29 Chromosome Location

Chromosome:12

Target 29 Locus

12q12-q14

Target 29 SNPs

SNPJam Report Link Image

Target 29 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 29 General References

15489334; 15592455; 17081983; 19007248; 18691976; 18669648; 19524510

Target 30 [top]

Target 30 ID

Target 30 Name

Tubulin alpha-3E chain

Target 30 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 30 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 30 Synonyms

Alpha-tubulin 3E

Target 30 Gene Name

TUBA3E

Target 30 Protein Sequence

>Tubulin alpha-3E chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAASNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYSKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGMEEGEFSE
AREDLAALEKDCEEVGVDSVEAEAEEGEAY

Target 30 Number of Residues

450

Target 30 Molecular Weight

49858.1

Target 30 Theoretical pI

4.77

Target 30 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 30 General Function

Involved in GTP binding

Target 30 Pathways

Not Available

Target 30 Reactions

Not Available

Target 30 Signals

None

Target 30 Transmembrane Regions

None

Target 30 Essentiality

Non Essential

Target 30 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 30 GenBank ID Protein

Not Available

Target 30 UniProtKB ID

Q6PEY2

Target 30 Cellular Location

Cytoplasmic

Target 30 Gene Sequence

>1353 bp

ATGCGCGAGTGTATCTCTATCCACGTGGGGCAGGCGGGTGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTTGAACATGGAATTCAGCCCGATGGTCAAATGCCAAGTGATAAA
ACCATTGGTGGCGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGGACCTACAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCAGCC
AGTAATTACGCCAGGGGCCATTACACCATCGGCAAGGAGATTGTTGACCTAGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACAGGACTGCAGGGCTTCCTCATCTTCCACAGC
TTTGGGGGCGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACAGCAAGAAGTCCAAGCTAGAGTTTGCCATTTACCCAGCCCCCCAGGTCTCCACAGCC
GTGGTGGAGCCCTACAACTCCATCCTAACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATTGAA
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGATGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTCGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCAGTCATCTCAGCTGAGAAG
GCCTACCATGAGCAGCTGTCTGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCATGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGACGTGGTCCCCAAAGACGTCAATGCGGCCATCGCCACCATCAAGACCAAGCGCACT
ATCCAGTTTGTGGATTGGTGCCCGACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACAGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTGTGCATGCTGAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTGGTCCATAAGTTCGATCTCATGTATGCC
AAGTGGGCCTTTGTGCACTGGTACGTGGGCGAAGGCATGGAAGAGGGAGAGTTCTCTGAG
GCCCGCGAGGACCTGGCAGCTCTAGAGAAGGATTGTGAAGAGGTGGGCGTGGATTCCGTG
GAAGCTGAGGCTGAAGAAGGCGAAGAATACTGA

Target 30 GenBank Gene ID

Not Available

Target 30 GeneCard ID

TUBA3E

Target 30 GenAtlas ID

TUBA3E

Target 30 HGNC ID

HGNC:20765 Link Image

Target 30 Chromosome Location

Not Available

Target 30 Locus

2q21.1

Target 30 SNPs

SNPJam Report Link Image

Target 30 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 30 General References

15815621; 15489334; 16565220; 19524510

Target 31 [top]

Target 31 ID

134

Target 31 Name

Tubulin alpha-8 chain

Target 31 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 31 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 31 Synonyms

Alpha-tubulin 8; Tubulin alpha chain-like 2

Target 31 Gene Name

TUBA8

Target 31 Protein Sequence

>Tubulin alpha-8 chain

MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGK
HVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLD
RIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNS
QMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGTDSFEEENEGEEF

Target 31 Number of Residues

449

Target 31 Molecular Weight

50093.1

Target 31 Theoretical pI

4.70

Target 31 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 31 General Function

Involved in GTP binding

Target 31 Pathways

Not Available

Target 31 Reactions

Not Available

Target 31 Signals

None

Target 31 Transmembrane Regions

None

Target 31 Essentiality

Non Essential

Target 31 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 31 GenBank ID Protein

Not Available

Target 31 UniProtKB ID

Q9NY65

Target 31 Cellular Location

Cytoplasmic

Target 31 Gene Sequence

>1350 bp

ATGCGGGAATGCATATCAGTCCACGTGGGCCAAGCGGGAGTTCAGATTGGCAATGCCTGC
TGGGAGCTCTTCTGCCTGGAACACGGCATCCAGGCAGACGGCACTTTTGATGCTCAAGCT
AGCAAGATCAACGATGATGACTCCTTCACCACCTTTTTCAGCGAGACTGGCAATGGGAAG
CATGTGCCCCGGGCCGTCATGATAGATCTGGAGCCTACTGTAGTGGATGAGGTTCGGGCA
GGAACCTACCGCCAGCTCTTCCATCCAGAGCAGCTGATCACAGGAAAGGAGGATGCAGCC
AACAACTATGCCCGGGGCCACTACACGGTGGGCAAGGAGAGCATTGACCTGGTGCTGGAC
CGCATACGGAAGCTGACAGATGCTTGCTCTGGCCTGCAGGGCTTCCTGATTTTCCACAGT
TTTGGTGGGGGCACTGGCTCCGGCTTCACTTCTCTGCTGATGGAACGCCTCTCCCTGGAT
TATGGCAAGAAATCCAAGCTGGAGTTTGCCATCTACCCAGCCCCCCAGGTCTCTACTGCA
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACCACACTGGAACATTCAGATTGT
GCTTTCATGGTGGACAACGAAGCCATCTATGACATCTGCCGCAGGAACCTTGACATTGAG
CGCCCTACCTATACCAACCTCAACCGCCTCATCAGTCAGATTGTGTCCTCAATCACTGCT
TCTCTCCGCTTTGACGGGGCCCTCAATGTGGACCTCACTGAGTTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCGCTGGTCACCTACGCGCCCATCATCTCTGCCGAGAAA
GCCTATCACGAACAGCTCTCTGTGGCCGAGATAACCAGCTCCTGCTTTGAGCCCAACAGC
CAGATGGTGAAGTGCGACCCGAGACATGGCAAGTACATGGCCTGCTGCATGCTCTACCGG
GGCGACGTGGTGCCCAAGGATGTGAATGTCGCTATTGCTGCCATCAAGACCAAGAGGACC
ATCCAGTTTGTAGACTGGTGTCCCACAGGCTTCAAGGTGGGCATCAACTACCAGCCCCCG
ACCGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTCTGCATGCTCAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTCGACCACAAGTTCGACCTCATGTACGCC
AAGCGGGCCTTTGTGCATTGGTATGTGGGAGAGGGGATGGAAGAAGGAGAATTTTCTGAG
GCCAGGGAAGACTTAGCTGCCCTGGAGAAGGATTATGAAGAAGTGGGGACTGATTCGTTT
GAAGAAGAAAATGAAGGGGAGGAATTTTAA

Target 31 GenBank Gene ID

Not Available

Target 31 GeneCard ID

TUBA8

Target 31 GenAtlas ID

TUBA8

Target 31 HGNC ID

HGNC:12410 Link Image

Target 31 Chromosome Location

Chromosome:22

Target 31 Locus

22q11.1

Target 31 SNPs

SNPJam Report Link Image

Target 31 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 31 General References

10772959; 15461802; 15489334; 19524510

Target 32 [top]

Target 32 ID

Target 32 Name

Tubulin beta-1 chain

Target 32 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 32 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 32 Synonyms

Not Available

Target 32 Gene Name

TUBB1

Target 32 Protein Sequence

>Tubulin beta-1 chain

MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH

Target 32 Number of Residues

451

Target 32 Molecular Weight

50326.6

Target 32 Theoretical pI

4.82

Target 32 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 32 General Function

Cell cycle control, cell division, chromosome partitioning

Target 32 Pathways

Not Available

Target 32 Reactions

Not Available

Target 32 Signals

None

Target 32 Transmembrane Regions

None

Target 32 Essentiality

Non Essential

Target 32 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 32 GenBank ID Protein

Not Available

Target 32 UniProtKB ID

Q9H4B7

Target 32 Cellular Location

Cytoplasmic

Target 32 Gene Sequence

>1356 bp

ATGCGTGAAATTGTCCATATTCAGATTGGCCAGTGTGGCAACCAGATCGGAGCCAAGTTC
TGGGAGATGATTGGTGAGGAACACGGGATCGACTTGGCTGGGAGCGACCGCGGGGCCTCG
GCCTTGCAGCTGGAGAGAATCAGCGTGTACTACAACGAAGCCTACGGTAGGAAATATGTG
CCCCGAGCAGTCTTGGTGGACCTAGAACCTGGGACGATGGACAGCATTCGATCTAGCAAA
TTAGGAGCTCTCTTTCAACCCGACAGTTTTGTCCATGGTAACTCTGGGGCTGGCAACAAC
TGGGCCAAAGGCCACTACACGGAGGGAGCCGAGCTGATCGAGAATGTCCTAGAGGTGGTG
AGGCACGAGAGTGAGAGCTGTGACTGCCTGCAGGGCTTCCAGATCGTCCACTCCCTGGGC
GGGGGCACAGGCTCCGGGATGGGCACTCTGCTCATGAACAAGATTAGAGAGGAGTACCCG
GACCGGATCATGAATTCCTTCAGCGTCATGCCTTCTCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAACGCGGTTCTGTCTATCCACCAGCTGATTGAGAATGCAGATGCCTGTTTC
TGCATTGACAATGAGGCCCTCTATGACATCTGCTTCCGTACCCTGAAGCTGACGACACCC
ACCTATGGGGATCTCAACCACCTAGTGTCCTTGACCATGAGCGGCATAACCACCTCCCTC
CGGTTCCCGGGTCAGCTCAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTCCCCTTC
CCCCGCCTGCACTTCTTTATGCCCGGCTTTGCCCCACTCACGGCCCAGGGCAGCCAGCAG
TACCGAGCCCTCTCCGTGGCCGAGCTCACCCAGCAGATGTTCGATGCCCGCAATACCATG
GCTGCCTGTGACCTCCGCCGTGGCCGCTACCTCACAGTGGCCTGCATTTTCCGGGGCAAG
ATGTCCACCAAGGAAGTGGACCAGCAACTGCTCTCCGTGCAGACCAGGAACAGCAGCTGC
TTTGTGGAGTGGATTCCCAACAACGTCAAGGTGGCTGTCTGCGACATCCCGCCCCGGGGG
CTGAGCATGGCCGCCACCTTCATTGGCAACAACACGGCCATCCAAGAGATCTTTAATAGG
GTCTCTGAGCATTTCTCAGCCATGTTCAAAAGGAAAGCTTTTGTGCACTGGTACACCAGC
GAAGGGATGGACATAAACGAATTTGGGGAAGCTGAAAATAACATCCATGATTTGGTATCC
GAGTACCAACAATTTCAAGATGCCAAAGCAGTTCTAGAGGAAGATGAAGAGGTCACGGAG
GAGGCAGAAATGGAGCCAGAAGATAAGGGACATTAA

Target 32 GenBank Gene ID

Not Available

Target 32 GeneCard ID

TUBB1

Target 32 GenAtlas ID

TUBB1

Target 32 HGNC ID

HGNC:16257 Link Image

Target 32 Chromosome Location

Chromosome:20

Target 32 Locus

20q13.32

Target 32 SNPs

SNPJam Report Link Image

Target 32 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 32 General References

11780052; 15489334; 12665801; 19524510

Target 33 [top]

Target 33 ID

247

Target 33 Name

Tubulin beta-2B chain

Target 33 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 33 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 33 Synonyms

Not Available

Target 33 Gene Name

TUBB2B

Target 33 Protein Sequence

>Tubulin beta-2B chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Target 33 Number of Residues

445

Target 33 Molecular Weight

49952.8

Target 33 Theoretical pI

4.52

Target 33 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 33 General Function

Cell cycle control, cell division, chromosome partitioning

Target 33 Pathways

Not Available

Target 33 Reactions

Not Available

Target 33 Signals

None

Target 33 Transmembrane Regions

None

Target 33 Essentiality

Non Essential

Target 33 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 33 GenBank ID Protein

Not Available

Target 33 UniProtKB ID

Q9BVA1

Target 33 Cellular Location

Cytoplasmic

Target 33 Gene Sequence

Not Available

Target 33 GenBank Gene ID

Not Available

Target 33 GeneCard ID

TUBB2B

Target 33 GenAtlas ID

TUBB2B

Target 33 HGNC ID

HGNC:30829 Link Image

Target 33 Chromosome Location

Not Available

Target 33 Locus

6p25

Target 33 SNPs

SNPJam Report Link Image

Target 33 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 33 General References

14574404; 15489334; 19524510

Target 34 [top]

Target 34 ID

Target 34 Name

Tubulin beta-6 chain

Target 34 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 34 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 34 Synonyms

Not Available

Target 34 Gene Name

TUBB6

Target 34 Protein Sequence

>Tubulin beta-6 chain

MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYV
PRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVV
RKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMM
AACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATANDGEEAFEDEEEEIDG

Target 34 Number of Residues

446

Target 34 Molecular Weight

49856.8

Target 34 Theoretical pI

4.51

Target 34 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 34 General Function

Involved in GTP binding

Target 34 Pathways

Not Available

Target 34 Reactions

Not Available

Target 34 Signals

None

Target 34 Transmembrane Regions

None

Target 34 Essentiality

Non Essential

Target 34 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 34 GenBank ID Protein

Not Available

Target 34 UniProtKB ID

Q9BUF5

Target 34 Cellular Location

Cytoplasmic

Target 34 Gene Sequence

>1341 bp

ATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGGCACCAAGTTT
TGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCG
GCGCTGCAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTG
CCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCGGTCTGGGCCT
TTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGGCCAGACGGGTGCAGGGAACAAC
TGGGCGAAAGGGCACTACACGGAGGGCGCGGAGCTGGTGGACGCAGTGCTGGACGTGGTG
CGGAAGGAGTGCGAGCACTGCGACTGCCTGCAGGGCTTCCAGCTCACGCACTCGCTGGGC
GGCGGCACGGGCTCAGGCATGGGCACGCTGCTCATCAGCAAGATCCGTGAGGAGTTCCCG
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCGCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAATGCCACACTGTCGGTGCACCAGCTGGTGGAGAATACAGACGAGACCTAC
TGCATCGACAACGAGGCGCTCTATGACATCTGCTTCCGCACTCTGAAGCTGACAACGCCC
ACCTACGGGGACCTCAACCACCTGGTGTCCGCCACCATGAGTGGGGTCACCACCTCGCTG
CGCTTCCCGGGCCAGCTCAATGCTGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCTGGCTTCGCGCCGCTCACCAGCCGCGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGACGCCAGGAACATGATG
GCCGCCTGCGATCCGCGCCATGGCCGCTACCTGACCGTGGCCACCGTGTTCCGCGGGCCC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGTAAGAACAGCAGCTAC
TTCGTGGAGTGGATTCCCAACAACGTGAAGGTGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCTCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCTCAGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTTCACGGGT
GAGGGCATGGATGAAATGGAGTTCACCGAGGCGGAGAGCAACATGAACGACCTGGTATCC
GAGTACCAGCAGTACCAGGATGCCACCGCCAATGACGGGGAGGAAGCTTTTGAGGATGAG
GAAGAGGAGATCGATGGATAG

Target 34 GenBank Gene ID

Not Available

Target 34 GeneCard ID

TUBB6

Target 34 GenAtlas ID

TUBB6

Target 34 HGNC ID

HGNC:20776 Link Image

Target 34 Chromosome Location

Chromosome:18

Target 34 Locus

18p11.21

Target 34 SNPs

SNPJam Report Link Image

Target 34 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 34 General References

14702039; 15489334; 17525332; 19524510

Target 35 [top]

Target 35 ID

228

Target 35 Name

Tubulin beta-8 chain

Target 35 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 35 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 35 Synonyms

Not Available

Target 35 Gene Name

TUBB8

Target 35 Protein Sequence

>Tubulin beta-8 chain

MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA

Target 35 Number of Residues

444

Target 35 Molecular Weight

49775.7

Target 35 Theoretical pI

4.52

Target 35 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 35 General Function

Cell cycle control, cell division, chromosome partitioning

Target 35 Pathways

Not Available

Target 35 Reactions

Not Available

Target 35 Signals

None

Target 35 Transmembrane Regions

None

Target 35 Essentiality

Non Essential

Target 35 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 35 GenBank ID Protein

Not Available

Target 35 UniProtKB ID

Q3ZCM7

Target 35 Cellular Location

Cytoplasmic

Target 35 Gene Sequence

Not Available

Target 35 GenBank Gene ID

Not Available

Target 35 GeneCard ID

TUBB8

Target 35 GenAtlas ID

Not Available

Target 35 HGNC ID

Not Available

Target 35 Chromosome Location

Not Available

Target 35 Locus

Not Available

Target 35 SNPs

SNPJam Report Link Image

Target 35 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 35 General References

11731935; 15164054; 15489334; 19524510

Target 36 [top]

Target 36 ID

102

Target 36 Name

Tubulin delta chain

Target 36 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 36 Description

In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head (By similarity)

Target 36 Synonyms

Delta-tubulin

Target 36 Gene Name

TUBD1

Target 36 Protein Sequence

>Tubulin delta chain

MSIVTVQLGQCGNQIGFEVFDALLSDSHSSQGLCSMRENEAYQASCKERFFSEEENGVPI
ARAVLVDMEPKVINQMLSKAAQSGQWKYGQHACFCQKQGSGNNWAYGYSVHGPRHEESIM
NIIRKEVEKCDSFSGFFIIMSMAGGTGSGLGAFVTQNLEDQYSNSLKMNQIIWPYGTGEV
IVQNYNSILTLSHLYRSSDALLLHENDAIHKICAKLMNIKQISFSDINQVLAHQLGSVFQ
PTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGLLKHLR
QMLISNAKMEEGIDRHVWPPLSGLPPLSKMSLNKDLHFNTSIANLVILRGKDVQSADVEG
FKDPALYTSWLKPVNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASK
AYIHQYTKFGIEEEDFLDSFTSLEQVVASYCNL

Target 36 Number of Residues

453

Target 36 Molecular Weight

51033.9

Target 36 Theoretical pI

6.83

Target 36 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 36 General Function

Involved in GTP binding

Target 36 Pathways

Not Available

Target 36 Reactions

Not Available

Target 36 Signals

None

Target 36 Transmembrane Regions

None

Target 36 Essentiality

Non Essential

Target 36 Domain Function

PF00091:Tubulin

Target 36 GenBank ID Protein

Not Available

Target 36 UniProtKB ID

Q9UJT1

Target 36 Cellular Location

Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm. Nucleus

Target 36 Gene Sequence

Not Available

Target 36 GenBank Gene ID

Not Available

Target 36 GeneCard ID

TUBD1

Target 36 GenAtlas ID

TUBD1

Target 36 HGNC ID

HGNC:16811 Link Image

Target 36 Chromosome Location

Chromosome:17

Target 36 Locus

17q23.1

Target 36 SNPs

SNPJam Report Link Image

Target 36 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 36 General References

10620804; 15081367; 14702039; 15489334

Target 37 [top]

Target 37 ID

125

Target 37 Name

Tubulin epsilon chain

Target 37 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 37 Description

Not Available

Target 37 Synonyms

Epsilon-tubulin

Target 37 Gene Name

TUBE1

Target 37 Protein Sequence

>Tubulin epsilon chain

MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDEAISSFFRNVDTRVVGDGGSIS
KGKICSLKARAVLIDMEEGVVNEILQGPLRDVFDTKQLITDISGSGNNWAVGHKVFGSLY
QDQILEKFRKSAEHCDCLQCFFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTSIYPS
GEDDVITSPYNSILAMKELNEHADCVLPIDNQSLFDIISKIDLMVNSGKLGTTVKPKSLV
TSSSGALKKQHKKPFDAMNNIVANLLLNLTSSARFEGSLNMDLNEISMNLVPFPQLHYLV
SSLTPLYTLTDVNIPPRRLDQMFSDAFSKDHQLLRADPKHSLYLACALMVRGNVQISDLR
RNIERLKPSLQFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELKERFMRLY
KKKAHLHHYLQVEGMEESCFTEAVSSLSALIQEYDQLDATKNMPVQDLPRLSIAM

Target 37 Number of Residues

475

Target 37 Molecular Weight

52931.4

Target 37 Theoretical pI

6.62

Target 37 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 37 General Function

Involved in GTP binding

Target 37 Pathways

Not Available

Target 37 Reactions

Not Available

Target 37 Signals

None

Target 37 Transmembrane Regions

None

Target 37 Essentiality

Non Essential

Target 37 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 37 GenBank ID Protein

Not Available

Target 37 UniProtKB ID

Q9UJT0

Target 37 Cellular Location

Cytoplasm, cytoskeleton, centrosome

Target 37 Gene Sequence

Not Available

Target 37 GenBank Gene ID

Not Available

Target 37 GeneCard ID

TUBE1

Target 37 GenAtlas ID

TUBE1

Target 37 HGNC ID

HGNC:20775 Link Image

Target 37 Chromosome Location

Not Available

Target 37 Locus

6q21

Target 37 SNPs

SNPJam Report Link Image

Target 37 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 37 General References

10620804; 15489334

Target 38 [top]

Target 38 ID

180

Target 38 Name

Tubulin gamma-2 chain

Target 38 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 38 Description

Target 38 Synonyms

Gamma-2-tubulin

Target 38 Gene Name

TUBG2

Target 38 Protein Sequence

>Tubulin gamma-2 chain

MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDE
MDRSREVVQELIDEYHAATQPDYISWGTQEQ

Target 38 Number of Residues

451

Target 38 Molecular Weight

51091.3

Target 38 Theoretical pI

5.59

Target 38 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 38 General Function

Involved in GTP binding

Target 38 Pathways

Not Available

Target 38 Reactions

Not Available

Target 38 Signals

None

Target 38 Transmembrane Regions

None

Target 38 Essentiality

Non Essential

Target 38 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 38 GenBank ID Protein

Not Available

Target 38 UniProtKB ID

Q9NRH3

Target 38 Cellular Location

Cytoplasmic

Target 38 Gene Sequence

>1356 bp

ATGCCCCGGGAGATCATCACCCTGCAGCTGGGCCAGTGCGGCAACCAGATTGGGTTCGAG
TTCTGGAAACAGCTGTGCGCCGAGCATGGTATCAGCCCCGAGGGCATCGTGGAGGAGTTC
GCCACCGAGGGCACTGACCGCAAGGACGTCTTTTTCTACCAGGCAGACGATGAGCACTAC
ATCCCCCGGGCCGTGCTGCTGGACTTGGAACCCCGGGTGATCCACTCCATCCTCAACTCC
CCCTATGCCAAGCTCTACAACCCAGAGAACATCTACCTGTCGGAACATGGAGGAGGAGCT
GGCAACAACTGGGCCAGCGGATTCTCCCAGGGTGAGAAAATTCATGAAGACATCTTTGAC
ATCATAGACCGAGAAGCAGATGGAAGTGACAGTTTGGAGGGCTTCGTGCTGTGTCACTCC
ATCGCTGGGGGTACGGGTTCTGGCCTGGGCTCCTACCTCCTGGAGCGACTGAATGACAGG
TACCCCAAGAAGCTAGTGCAGACTTATTCAGTGTTTCCCTACCAGGACGAGATGAGCGAC
GTAGTGGTTCAGCCCTACAATTCACTCCTGACACTCAAGAGGCTGACGCAGAACGCAGAT
TGTGTGGTGGTGCTGGACAACACAGCCCTGAACCGGATTGCCACAGACCGCCTGCACATC
CAGAACCCGTCCTTCTCCCAGATCAACCAGCTGGTGTCCACCATCATGTCGGCCAGCACC
ACCACCCTGCGCTACCCCGGCTACATGAACAATGACCTCATCGGCCTCATCGCCTCGCTC
ATTCCCACCCCACGGCTCCACTTTCTCATGACCGGCTACACCCCGCTCACTACAGACCAG
TCAGTGGCCAGCGTGAGGAAGACCACGGTCCTGGATGTCATGAGGCGGCTGCTGCAGCCC
AAGAACGTGATGGTGTCCACAGGCCGAGACCGCCAGACCAACCACTGCTACATCGCCATC
CTCAACATCATCCAGGGAGAGGTGGACCCCACCCAGGTCCACAAGAGCCTGCAGAGGATC
CGGGAACGGAAGTTGGCCAACTTCATCCCGTGGGGCCCCGCCAGCATCCAGGTGGCCCTG
TCGAGGAAGTCTCCCTACCTGCCCTCGGCCCACCGGGTCAGCGGGCTCATGATGGCCAAC
CACACCAGCATCTCCTCGCTCTTTGAAAGTTCCTGCCAGCAGTTTGACAAGCTGCGGAAG
CGGGATGCCTTCCTCGAGCAGTTCCGTAAGGAGGACATGTTCAAGGACAACTTTGATGAG
ATGGACAGGTCTAGGGAGGTTGTTCAGGAGCTCATTGATGAGTACCATGCGGCCACCCAG
CCAGACTACATTTCCTGGGGCACCCAGGAGCAGTGA

Target 38 GenBank Gene ID

Not Available

Target 38 GeneCard ID

TUBG2

Target 38 GenAtlas ID

TUBG2

Target 38 HGNC ID

HGNC:12419 Link Image

Target 38 Chromosome Location

Chromosome:17

Target 38 Locus

17q21

Target 38 SNPs

SNPJam Report Link Image

Target 38 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 38 General References

10903841; 14702039; 16625196; 15489334

Target 39 [top]

Target 39 ID

253

Target 39 Name

Histone H3.2

Target 39 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 39 Description

Target 39 Synonyms

H3/m; H3/o

Target 39 Gene Name

HIST2H3A

Target 39 Protein Sequence

>Histone H3.2

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA

Target 39 Number of Residues

136

Target 39 Molecular Weight

15387.9

Target 39 Theoretical pI

11.83

Target 39 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 39 General Function

Chromatin structure and dynamics

Target 39 Pathways

Not Available

Target 39 Reactions

Not Available

Target 39 Signals

None

Target 39 Transmembrane Regions

None

Target 39 Essentiality

Non Essential

Target 39 Domain Function

PF00125:Histone

Target 39 GenBank ID Protein

Not Available

Target 39 UniProtKB ID

Q71DI3

Target 39 Cellular Location

Nucleus

Target 39 Gene Sequence

>411 bp

ATGGCCCGTACTAAGCAGACTGCTCGCAAGTCGACCGGCGGCAAGGCCCCGAGGAAGCAG
CTGGCCACCAAGGCGGCCCGCAAGAGCGCGCCGGCCACGGGCGGGGTGAAGAAGCCGCAC
CGCTACCGGCCCGGCACCGTAGCCCTGCGGGAGATCCGGCGCTACCAGAAGTCCACGGAG
CTGCTGATCCGCAAGCTGCCCTTCCAGCGGCTGGTACGCGAGATCGCGCAGGACTTTAAG
ACGGACCTGCGCTTCCAGAGCTCGGCCGTGATGGCGCTGCAGGAGGCCAGCGAGGCCTAC
CTGGTGGGGCTGTTCGAAGACACGAACCTGTGCGCCATCCACGCCAAGCGCGTGACCATT
ATGCCCAAGGACATCCAGCTGGCCCGCCGCATCCGTGGAGAGCGGGCTTAA

Target 39 GenBank Gene ID

Not Available

Target 39 GeneCard ID

HIST2H3A

Target 39 GenAtlas ID

HIST2H3A

Target 39 HGNC ID

HGNC:20505 Link Image

Target 39 Chromosome Location

Not Available

Target 39 Locus

Not Available

Target 39 SNPs

SNPJam Report Link Image

Target 39 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 39 General References

12408966; 15527963; 16710414; 15489334; 16185088; 10464286; 7309716; 11242053; 11856369; 12560483

Target 40 [top]

Target 40 ID

227

Target 40 Name

Ribonucleoside-diphosphate reductase subunit M2 B

Target 40 Mechanism of Action

Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)

Target 40 Description

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage

Target 40 Synonyms

TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2

Target 40 Gene Name

RRM2B

Target 40 Protein Sequence

>Ribonucleoside-diphosphate reductase subunit M2 B

MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ
ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA
RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK
STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ
YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS
KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF

Target 40 Number of Residues

351

Target 40 Molecular Weight

40736.1

Target 40 Theoretical pI

4.61

Target 40 GO Classification

Function
oxidoreductase activity, acting on CH2 groups oxidoreductase activity, acting on CH2 groups, disulfide as acceptor ribonucleoside-diphosphate reductase activity catalytic activity oxidoreductase activity
Process
physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism nucleotide metabolism nucleoside diphosphate metabolism deoxyribonucleoside diphosphate metabolism
Component
Not Available

Target 40 General Function

Nucleotide transport and metabolism

Target 40 Pathways

Genetic information processing; DNA replication

Target 40 Reactions

Not Available

Target 40 Signals

None

Target 40 Transmembrane Regions

186-208

Target 40 Essentiality

Non Essential

Target 40 Domain Function

PF00268:Ribonuc_red_sm

Target 40 GenBank ID Protein

Not Available

Target 40 UniProtKB ID

Q7LG56

Target 40 Cellular Location

Cytoplasm. Nucleus

Target 40 Gene Sequence

>1056 bp

ATGGGCGACCCGGAAAGGCCGGAAGCGGCCGGGCTGGATCAGGATGAGAGATCATCTTCA
GACACCAACGAAAGTGAAATAAAGTCAAATGAAGAGCCACTCCTAAGAAAGAGTTCTCGC
CGGTTTGTCATCTTTCCAATCCAGTACCCTGATATTTGGAAAATGTATAAACAGGCACAG
GCTTCCTTCTGGACAGCAGAAGAGGTCGACTTATCAAAGGATCTCCCTCACTGGAACAAG
CTTAAAGCAGATGAGAAGTACTTCATCTCTCACATCTTAGCCTTTTTTGCAGCCAGTGAT
GGAATTGTAAATGAAAATTTGGTGGAGCGCTTTAGTCAGGAGGTGCAGGTTCCAGAGGCT
CGCTGTTTCTATGGCTTTCAAATTCTCATCGAGAATGTTCACTCAGAGATGTACAGTTTG
CTGATAGACACTTACATCAGAGATCCCAAGAAAAGGGAATTTTTATTTAATGCAATTGAA
ACCATGCCCTATGTTAAGAAAAAAGCAGATTGGGCCTTGCGATGGATAGCAGATAGAAAA
TCTACTTTTGGGGAAAGAGTGGTGGCCTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGA
TCTTTTGCTGCTATATTCTGGCTAAAGAAGAGAGGTCTTATGCCAGGACTCACTTTTTCC
AATGAACTCATCAGCAGAGATGAAGGACTTCACTGTGACTTTGCTTGCCTGATGTTCCAA
TACTTAGTAAATAAGCCTTCAGAAGAAAGGGTCAGGGAGATCATTGTTGATGCTGTCAAA
ATTGAGCAGGAGTTTTTAACAGAAGCCTTGCCAGTTGGCCTCATTGGAATGAATTGCATT
TTGATGAAACAGTACATTGAGTTTGTAGCTGACAGATTACTTGTGGAACTTGGATTCTCA
AAGGTTTTTCAGGCAGAAAATCCTTTTGATTTTATGGAAAACATTTCTTTAGAAGGAAAA
ACAAATTTCTTTGAGAAACGAGTTTCAGAGTATCAGCGTTTTGCAGTTATGGCAGAAACC
ACAGATAACGTCTTCACCTTGGATGCAGATTTTTAA

Target 40 GenBank Gene ID

Not Available

Target 40 GeneCard ID

RRM2B

Target 40 GenAtlas ID

RRM2B

Target 40 HGNC ID

HGNC:17296 Link Image

Target 40 Chromosome Location

Not Available

Target 40 Locus

8q23.1

Target 40 SNPs

SNPJam Report Link Image

Target 40 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 40 General References

10716435; 14702039; 17974005; 15489334; 11517226; 11719458; 12615712; 14583450

Target 41 [top]

Target 41 ID

131

Target 41 Name

DNA polymerase subunit gamma-2, mitochondrial

Target 41 Mechanism of Action

Benzene binding of DNA associated proteins leads to mutagenic effects. (R016)

Target 41 Description

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA

Target 41 Synonyms

Mitochondrial DNA polymerase accessory subunit; PolG-beta; MtPolB; DNA polymerase gamma accessory 55 kDa subunit; p55

Target 41 Gene Name

POLG2

Target 41 Protein Sequence

>DNA polymerase subunit gamma-2, mitochondrial

MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAP
GSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVV
FREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGK
LRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLV
WFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELI
ETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENS
FTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLET
MQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYIS
SAKNV

Target 41 Number of Residues

485

Target 41 Molecular Weight

54910.7

Target 41 Theoretical pI

8.48

Target 41 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding catalytic activity ligase activity ligase activity, forming phosphoric ester bonds RNA ligase activity tRNA ligase activity
Process
physiological process metabolism macromolecule metabolism macromolecule biosynthesis protein biosynthesis
Component
Not Available

Target 41 General Function

Translation, ribosomal structure and biogenesis

Target 41 Pathways

Not Available

Target 41 Reactions

Not Available

Target 41 Signals

None

Target 41 Transmembrane Regions

None

Target 41 Essentiality

Non Essential

Target 41 Domain Function

PF03129:HGTP_anticodon

Target 41 GenBank ID Protein

Not Available

Target 41 UniProtKB ID

Q9UHN1

Target 41 Cellular Location

Mitochondrion

Target 41 Gene Sequence

>1458 bp

ATGCGCTCTCGTGTAGCCGTCAGGGCCTGCCATAAGGTCTGCAGGTGCCTGTTGTCTGGG
TTTGGGGGTCGAGTAGATGCGGGGCAGCCGGAGCTGTTGACGGAAAGGAGTAGCCCCAAA
GGAGGGCATGTGAAGTCGCACGCGGAGCTCGAGGGGAACGGCGAGCACCCAGAAGCCCCC
GGGTCTGGAGAGGGAAGCGAGGCGCTGTTAGAGATCTGTCAGAGAAGGCATTTCCTAAGT
GGAAGCAAGCAGCAGCTTAGCCGGGATTCTCTTCTGAGTGGGTGCCACCCCGGCTTCGGA
CCCTTGGGCGTAGAGTTGCGGAAGAACCTGGCCGCAGAATGGTGGACCTCGGTGGTGGTG
TTCAGGGAGCAGGTATTCCCGGTGGACGCCCTCCACCACAAACCAGGCCCTTTGCTACCC
GGGGACAGTGCCTTCAGGTTAGTTTCTGCAGAAACTCTACGCGAAATCTTGCAAGACAAA
GAGCTGAGTAAGGAACAGCTAGTAGCATTTCTTGAGAACGTATTAAAAACTTCTGGGAAA
CTACGGGAGAACCTTCTTCACGGTGCCTTGGAACACTATGTTAATTGCCTGGATCTGGTA
AACAAGAGGCTACCTTATGGCCTTGCTCAGATTGGAGTGTGTTTTCATCCTGTTTTTGAC
ACTAAGCAGATACGAAATGGTGTTAAAAGTATTGGTGAGAAGACTGAAGCTTCGTTAGTA
TGGTTTACTCCTCCGAGAACTTCAAACCAGTGGCTTGATTTCTGGTTACGTCATCGACTC
CAGTGGTGGAGAAAGTTTGCCATGAGTCCATCTAACTTCAGCAGCAGTGACTGTCAGGAT
GAAGAAGGCCGGAAAGGAAACAAACTTTACTACAATTTTCCCTGGGGAAAGGAGTTAATA
GAAACCCTGTGGAACCTAGGAGATCACGAACTTTTACACATGTATCCTGGCAATGTGTCT
AAATTACATGGCCGAGATGGACGAAAAAATGTGGTTCCTTGTGTTCTCTCTGTAAATGGG
GACCTAGACCGAGGCATGCTGGCCTACCTCTATGATTCTTTCCAGCTGACAGAGAACTCC
TTTACAAGAAAGAAAAATCTTCATAGAAAGGTACTTAAACTTCACCCTTGTTTAGCCCCT
ATTAAGGTTGCTTTGGATGTAGGAAGAGGCCCCACATTGGAACTAAGACAGGTTTGTCAA
GGGCTATTTAATGAGTTACTAGAAAATGGGATTTCTGTGTGGCCTGGTTATTTGGAAACT
ATGCAGTCCTCATTGGAACAACTTTATTCGAAGTATGATGAAATGAGTATTCTCTTCACA
GTTTTGGTTACTGAAACTACTTTGGAGAATGGATTAATACATCTGAGAAGCAGAGACACC
ACAATGAAGGAAATGATGCATATATCCAAATTAAAAGACTTTTTGATTAAGTATATATCA
TCAGCTAAGAATGTATAG

Target 41 GenBank Gene ID

Not Available

Target 41 GeneCard ID

POLG2

Target 41 GenAtlas ID

POLG2

Target 41 HGNC ID

HGNC:9180

Target 41 Chromosome Location

Chromosome:17

Target 41 Locus

17q

Target 41 SNPs

SNPJam Report Link Image

Target 41 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 41 General References

10608893; 10666468; 10677218; 15489334; 9153213; 16685652

Target 42 [top]

Target 42 ID

399

Target 42 Name

Tubulin alpha chain-like 3

Target 42 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 42 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 42 Synonyms

Not Available

Target 42 Gene Name

TUBAL3

Target 42 Protein Sequence

>Tubulin alpha chain-like 3

MRECLSIHIGQAGIQIGDACWELYCLEHGIQPNGVVLDTQQDQLENAKMEHTNASFDTFF
CETRAGKHVPRALFVDLEPTVIDGIRTGQHRSLFHPEQLLSGKEDAANNYARGRYSVGSE
VIDLVLERTRKLAEQCGGLQGFLIFRSFGGGTGSGFTSLLMERLTGEYSRKTKLEFSVYP
APRISTAVVEPYNSVLTTHSTTEHTDCTFMVDNEAVYDICHRKLGVECPSHASINRLVVQ
VVSSITASLRFEGPLNVDLIEFQTNLVPYPRIHFPMTAFAPIVSADKAYHEQFSVSDITT
ACFESSNQLVKCDPRLGKYMACCLLYRGDVVPKEVNAAIAATKSRHSVQFVDWCPTGFKV
GINNRPPTVMPGGDLAKVHRSICMLSNTTAIVEAWARLDHKFDLMYAKRAFLHWYLREGM
EEAEFLEAREDLAALERDYEEVAQSF

Target 42 Number of Residues

446

Target 42 Molecular Weight

49908.3

Target 42 Theoretical pI

5.96

Target 42 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 42 General Function

Involved in GTP binding

Target 42 Pathways

Not Available

Target 42 Reactions

Not Available

Target 42 Signals

None

Target 42 Transmembrane Regions

None

Target 42 Essentiality

Non Essential

Target 42 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 42 GenBank ID Protein

Not Available

Target 42 UniProtKB ID

A6NHL2

Target 42 Cellular Location

Cytoplasmic

Target 42 Gene Sequence

>1341 bp

ATGAGGGAGTGCCTTTCCATCCACATCGGTCAAGCTGGCATCCAGATTGGGGACGCCTGC
TGGGAACTCTATTGCCTGGAACATGGAATCCAGCCAAATGGCGTTGTTCTTGACACTCAA
CAGGATCAGCTGGAAAATGCAAAAATGGAGCACACAAATGCATCTTTCGATACCTTCTTC
TGTGAGACAAGAGCTGGGAAGCATGTGCCTAGAGCACTCTTCGTGGACTTGGAGCCAACT
GTTATAGATGGGATCCGGACGGGCCAGCACCGTTCACTCTTCCACCCCGAGCAGCTCCTT
AGCGGAAAGGAGGATGCTGCCAACAATTACGCGCGAGGCCGTTACTCTGTGGGGTCGGAG
GTCATCGACCTTGTGCTGGAGAGGACCCGGAAGCTGGCAGAACAGTGTGGTGGACTTCAG
GGATTTTTGATTTTCCGAAGCTTTGGAGGAGGCACTGGTTCAGGGTTTACGTCTCTCTTA
ATGGAGAGGCTCACAGGAGAATATAGCAGAAAGACTAAGCTGGAGTTCTCGGTCTACCCA
GCCCCCAGGATCTCCACTGCCGTGGTAGAGCCTTATAACTCTGTCCTCACCACCCACTCC
ACCACAGAGCACACGGACTGTACCTTCATGGTGGACAACGAGGCCGTCTATGATATATGC
CATCGTAAACTCGGTGTTGAATGCCCCTCTCATGCCAGCATCAATAGATTGGTGGTTCAG
GTGGTATCTTCCATCACTGCCTCCCTCCGGTTTGAAGGGCCCTTGAATGTAGACCTAATT
GAATTCCAGACCAACCTGGTACCTTATCCGAGAATACATTTCCCCATGACAGCCTTCGCC
CCCATCGTCTCTGCTGACAAAGCCTACCATGAGCAGTTCTCTGTGTCAGACATCACCACT
GCTTGCTTTGAGTCCTCCAACCAGCTGGTCAAGTGTGATCCTCGGCTTGGGAAGTACATG
GCCTGCTGCCTACTCTATAGAGGGGATGTGGTCCCCAAGGAAGTGAATGCAGCAATCGCA
GCCACGAAGTCGAGGCACTCTGTTCAGTTTGTAGATTGGTGTCCAACTGGTTTCAAGGTG
GGCATCAACAATCGGCCGCCCACGGTGATGCCGGGTGGGGACCTGGCCAAAGTCCACCGG
TCCATCTGCATGCTGAGCAACACCACGGCGATTGTGGAGGCCTGGGCCCGCCTGGACCAC
AAGTTTGACCTCATGTACGCCAAGAGAGCATTTCTGCACTGGTACCTCAGAGAAGGCATG
GAAGAAGCAGAGTTCTTGGAGGCCAGGGAAGATCTGGCAGCCCTGGAGAGGGACTATGAG
GAAGTGGCGCAAAGTTTCTGA

Target 42 GenBank Gene ID

Not Available

Target 42 GeneCard ID

TUBAL3

Target 42 GenAtlas ID

TUBAL3

Target 42 HGNC ID

HGNC:23534 Link Image

Target 42 Chromosome Location

Chromosome:10

Target 42 Locus

10p15.1

Target 42 SNPs

SNPJam Report Link Image

Target 42 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 42 General References

14702039; 15164054; 15489334; 17924679

Target 43 [top]

Target 43 ID

400

Target 43 Name

Tubulin beta-8 chain B

Target 43 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 43 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 43 Synonyms

Not Available

Target 43 Gene Name

Not Available

Target 43 Protein Sequence

>Tubulin beta-8 chain B

MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA

Target 43 Number of Residues

444

Target 43 Molecular Weight

49572.3

Target 43 Theoretical pI

4.49

Target 43 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 43 General Function

Cell cycle control, cell division, chromosome partitioning

Target 43 Pathways

Not Available

Target 43 Reactions

Not Available

Target 43 Signals

None

Target 43 Transmembrane Regions

None

Target 43 Essentiality

Non Essential

Target 43 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 43 GenBank ID Protein

Not Available

Target 43 UniProtKB ID

A6NNZ2

Target 43 Cellular Location

Cytoplasmic

Target 43 Gene Sequence

Not Available

Target 43 GenBank Gene ID

Not Available

Target 43 GeneCard ID

Not Available

Target 43 GenAtlas ID

Not Available

Target 43 HGNC ID

Not Available

Target 43 Chromosome Location

Not Available

Target 43 Locus

Not Available

Target 43 SNPs

Not Available

Target 43 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 43 General References

16177791; 19524510

Target 44 [top]

Target 44 ID

425

Target 44 Name

Putative tubulin beta chain-like protein ENSP00000290377

Target 44 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 44 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 44 Synonyms

Not Available

Target 44 Gene Name

Not Available

Target 44 Protein Sequence

>Putative tubulin beta chain-like protein ENSP00000290377

MDSVRSGPFGQVLRPDNFIFGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQG
FQLTHSLGGGTGSGMVTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQL
IENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRK
LAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMRAARDPRHGRYLT
AAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAICDIPPRGLKMSASFIGNNA
AIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAKE
EEDEEYAEEEVA

Target 44 Number of Residues

372

Target 44 Molecular Weight

41774.7

Target 44 Theoretical pI

4.50

Target 44 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 44 General Function

Cell cycle control, cell division, chromosome partitioning

Target 44 Pathways

Not Available

Target 44 Reactions

Not Available

Target 44 Signals

None

Target 44 Transmembrane Regions

None

Target 44 Essentiality

Non Essential

Target 44 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 44 GenBank ID Protein

Not Available

Target 44 UniProtKB ID

A6NKZ8

Target 44 Cellular Location

Cytoplasmic

Target 44 Gene Sequence

Not Available

Target 44 GenBank Gene ID

Not Available

Target 44 GeneCard ID

Not Available

Target 44 GenAtlas ID

Not Available

Target 44 HGNC ID

Not Available

Target 44 Chromosome Location

Not Available

Target 44 Locus

Not Available

Target 44 SNPs

Not Available

Target 44 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 44 General References

15164053

Target 45 [top]

Target 45 ID

426

Target 45 Name

Putative tubulin beta-4q chain

Target 45 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 45 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 45 Synonyms

Not Available

Target 45 Gene Name

TUBB4Q

Target 45 Protein Sequence

>Putative tubulin beta-4q chain

MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVRSGPFAEVFRPDNFISRQCGAGNNWAKGRYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATVSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSQGSQQYRALTVAELTQQMFDAKNMM
AARDPRHGCYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNIKTAVCDIPPWG
LKMSVTFTGNNTAVQELKRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSE
YQQYQDATAEGEGV

Target 45 Number of Residues

434

Target 45 Molecular Weight

48434.2

Target 45 Theoretical pI

4.91

Target 45 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 45 General Function

Cell cycle control, cell division, chromosome partitioning

Target 45 Pathways

Not Available

Target 45 Reactions

Not Available

Target 45 Signals

None

Target 45 Transmembrane Regions

None

Target 45 Essentiality

Non Essential

Target 45 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 45 GenBank ID Protein

Not Available

Target 45 UniProtKB ID

Q99867

Target 45 Cellular Location

Cytoplasmic

Target 45 Gene Sequence

Not Available

Target 45 GenBank Gene ID

Not Available

Target 45 GeneCard ID

TUBB4Q

Target 45 GenAtlas ID

TUBB4Q

Target 45 HGNC ID

HGNC:12413 Link Image

Target 45 Chromosome Location

Not Available

Target 45 Locus

4q35

Target 45 SNPs

SNPJam Report Link Image

Target 45 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 45 General References

10828619

Target 46 [top]

Target 46 ID

427

Target 46 Name

Putative tubulin-like protein alpha-4B

Target 46 Mechanism of Action

Direct binding of tubulin leads to protein damage. (R016)

Target 46 Description

Not Available

Target 46 Synonyms

Alpha-tubulin 4B

Target 46 Gene Name

TUBA4B

Target 46 Protein Sequence

>Putative tubulin-like protein alpha-4B

MRHQQTERQDPSQPLSRQHGTYRQIFHPEQLITGKEDAANNYAWGHYTIGKEFIDLLLDR
IRKLADQCTGLQGFLVFHSLGRGTGSDVTSFLMEWLSVNYGKKSKLGFSIYPAPQVSTAM
VQPYNSILTTHTTLEHSDCAFMVDNKAIYDICHCNLDIERPTYTNLNRLISQIVSSITAS
LRFDGALNVDLTEFQTNLVSYLTSTSPWPPMHQSSLQKRYTTSSCWWQRLPMPALSLPTR
W

Target 46 Number of Residues

241

Target 46 Molecular Weight

27551.0

Target 46 Theoretical pI

7.93

Target 46 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 46 General Function

Involved in GTP binding

Target 46 Pathways

Not Available

Target 46 Reactions

Not Available

Target 46 Signals

None

Target 46 Transmembrane Regions

None

Target 46 Essentiality

Non Essential

Target 46 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 46 GenBank ID Protein

Not Available

Target 46 UniProtKB ID

Q9H853

Target 46 Cellular Location

Cytoplasmic

Target 46 Gene Sequence

>726 bp

ATGCGGCACCAGCAGACAGAGAGACAAGACCCCAGCCAGCCCCTGTCCAGGCAGCATGGC
ACATACCGCCAGATCTTCCATCCAGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAAT
AACTATGCCTGGGGCCACTACACCATTGGGAAGGAGTTCATCGACCTGCTACTGGACCGG
ATTCGGAAGCTGGCTGACCAGTGCACAGGACTTCAGGGCTTCCTGGTGTTCCACAGCCTT
GGTCGGGGCACTGGCTCTGACGTCACCTCATTCCTGATGGAGTGGCTTTCTGTTAACTAT
GGCAAGAAATCCAAGCTGGGATTCTCCATCTACCCAGCCCCCCAGGTGTCTACAGCCATG
GTCCAGCCCTACAACTCTATCCTGACCACCCACACCACCCTGGAGCACTCAGACTGTGCC
TTCATGGTGGACAACAAAGCAATCTATGACATCTGCCACCGCAACCTAGACATTGAGCGC
CCAACCTACACCAACCTCAATCGCCTCATTAGCCAAATTGTCTCCTCCATCACAGCTTCT
CTGCGCTTTGACGGGGCCCTCAATGTGGACCTGACAGAGTTCCAGACCAACCTGGTGTCC
TACCTCACATCCACTTCCCCCTGGCCACCTATGCACCAGTCATCTCTGCAGAAAAAGTAT
ACCACGAGCAGCTGTCGGTGGCAGAGATTACCAATGCCTGCTTTGAGCCTGCCAACCAGA
TGGTGA

Target 46 GenBank Gene ID

Not Available

Target 46 GeneCard ID

TUBA4B

Target 46 GenAtlas ID

TUBA4B

Target 46 HGNC ID

HGNC:18637 Link Image

Target 46 Chromosome Location

Not Available

Target 46 Locus

Not Available

Target 46 SNPs

SNPJam Report Link Image

Target 46 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 46 General References

14702039; 15815621

Target 47 [top]

Target 47 ID

486

Target 47 Name

Histone H1.0

Target 47 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 47 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division

Target 47 Synonyms

Histone H1(0); Histone H1'

Target 47 Gene Name

H1F0

Target 47 Protein Sequence

>Histone H1.0

MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKV
GENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATP
KKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVK
PKAKSSAKRAGKKK

Target 47 Number of Residues

194

Target 47 Molecular Weight

20862.8

Target 47 Theoretical pI

11.60

Target 47 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 47 General Function

Cell wall/membrane/envelope biogenesis

Target 47 Pathways

Not Available

Target 47 Reactions

Not Available

Target 47 Signals

None

Target 47 Transmembrane Regions

None

Target 47 Essentiality

Non Essential

Target 47 Domain Function

PF00538:Linker_histone

Target 47 GenBank ID Protein

Not Available

Target 47 UniProtKB ID

P07305

Target 47 Cellular Location

Nucleus

Target 47 Gene Sequence

>585 bp

ATGACCGAGAATTCCACGTCCGCCCCTGCGGCCAAGCCCAAGCGGGCCAAGGCCTCCAAG
AAGTCCACAGACCACCCCAAGTATTCAGACATGATCGTGGCTGCCATCCAGGCCGAGAAG
AACCGCGCTGGCTCCTCGCGCCAGTCCATTCAGAAGTATATCAAGAGCCACTACAAGGTG
GGTGAGAACGCTGACTCGCAGATCAAGTTGTCCATCAAGCGCCTGGTCACCACCGGTGTC
CTCAAGCAGACCAAAGGGGTGGGGGCCTCGGGGTCCTTCCGGCTAGCCAAGAGCGACGAA
CCCAAGAAGTCAGTGGCCTTCAAGAAGACCAAGAAGGAAATCAAGAAGGTAGCCACGCCA
AAGAAGGCATCCAAGCCCAAGAAGGCTGCCTCCAAAGCCCCAACCAAGAAACCCAAAGCC
ACCCCGGTCAAGAAGGCCAAGAAGAAGCTGGCTGCCACGCCCAAGAAAGCCAAAAAACCC
AAGACTGTCAAAGCCAAGCCGGTCAAGGCATCCAAGCCCAAAAAGGCCAAACCAGTGAAA
CCCAAAGCAAAGTCCAGTGCCAAGAGGGCCGGCAAGAAGAAGTGA

Target 47 GenBank Gene ID

Not Available

Target 47 GeneCard ID

H1F0

Target 47 GenAtlas ID

H1F0

Target 47 HGNC ID

HGNC:4714

Target 47 Chromosome Location

Chromosome:22

Target 47 Locus

22q13.1

Target 47 SNPs

SNPJam Report Link Image

Target 47 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 47 General References

3084796; 15461802; 10591208; 15489334; 18993075; 9582379; 17081983; 17525332; 19007248

Target 48 [top]

Target 48 ID

493

Target 48 Name

Histone H1.1

Target 48 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 48 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures

Target 48 Synonyms

Not Available

Target 48 Gene Name

HIST1H1A

Target 48 Protein Sequence

>Histone H1.1

MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVSELIVQAASSSKERGGV
SLAALKKALAAAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVETK
PGASKVATKTKATGASKKLKKATGASKKSVKTPKKAKKPAATRKSSKNPKKPKTVKPKKV
AKSPAKAKAVKPKAAKARVTKPKTAKPKKAAPKKK

Target 48 Number of Residues

215

Target 48 Molecular Weight

21841.9

Target 48 Theoretical pI

11.76

Target 48 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 48 General Function

Lipid transport and metabolism

Target 48 Pathways

Not Available

Target 48 Reactions

Not Available

Target 48 Signals

None

Target 48 Transmembrane Regions

None

Target 48 Essentiality

Non Essential

Target 48 Domain Function

PF00538:Linker_histone

Target 48 GenBank ID Protein

Not Available

Target 48 UniProtKB ID

Q02539

Target 48 Cellular Location

Nucleus

Target 48 Gene Sequence

>648 bp

ATGTCTGAAACAGTGCCTCCCGCCCCCGCCGCTTCTGCTGCTCCTGAGAAACCTTTAGCT
GGCAAGAAGGCAAAGAAACCTGCTAAGGCTGCAGCAGCCTCCAAGAAAAAACCCGCTGGC
CCTTCCGTGTCAGAGCTGATCGTGCAGGCTGCTTCCTCCTCTAAGGAGCGTGGTGGTGTG
TCGTTGGCAGCTCTTAAAAAGGCGCTGGCGGCCGCAGGCTACGACGTGGAGAAGAACAAC
AGCCGCATTAAGCTGGGCATTAAGAGCCTGGTAAGCAAGGGAACGTTGGTGCAGACAAAG
GGTACCGGAGCCTCGGGTTCCTTCAAGCTCAACAAGAAGGCGTCCTCCGTGGAAACCAAG
CCCGGCGCCTCAAAGGTGGCTACAAAAACTAAGGCAACGGGTGCATCTAAAAAGCTCAAA
AAGGCCACGGGGGCTAGCAAAAAGAGCGTCAAGACTCCGAAAAAGGCTAAAAAGCCTGCG
GCAACAAGGAAATCCTCCAAGAATCCAAAAAAACCCAAAACTGTAAAGCCCAAGAAAGTA
GCTAAAAGCCCTGCTAAAGCTAAGGCTGTAAAACCCAAGGCGGCCAAGGCTAGGGTGACG
AAGCCAAAGACTGCCAAACCCAAGAAAGCGGCACCCAAGAAAAAGTAA

Target 48 GenBank Gene ID

Not Available

Target 48 GeneCard ID

HIST1H1A

Target 48 GenAtlas ID

HIST1H1A

Target 48 HGNC ID

HGNC:4715

Target 48 Chromosome Location

Not Available

Target 48 Locus

6p21.3

Target 48 SNPs

SNPJam Report Link Image

Target 48 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 48 General References

2759094; 12408966; 15489334; 17287340

Target 49 [top]

Target 49 ID

487

Target 49 Name

Histone H1.2

Target 49 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 49 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures

Target 49 Synonyms

Histone H1d

Target 49 Gene Name

HIST1H1C

Target 49 Protein Sequence

>Histone H1.2

MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLA
ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKV
KKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVA
KPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK

Target 49 Number of Residues

213

Target 49 Molecular Weight

21364.6

Target 49 Theoretical pI

11.71

Target 49 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 49 General Function

Lipid transport and metabolism

Target 49 Pathways

Not Available

Target 49 Reactions

Not Available

Target 49 Signals

None

Target 49 Transmembrane Regions

None

Target 49 Essentiality

Non Essential

Target 49 Domain Function

PF00538:Linker_histone

Target 49 GenBank ID Protein

Not Available

Target 49 UniProtKB ID

P16403

Target 49 Cellular Location

Nucleus

Target 49 Gene Sequence

Not Available

Target 49 GenBank Gene ID

Not Available

Target 49 GeneCard ID

HIST1H1C

Target 49 GenAtlas ID

HIST1H1C

Target 49 HGNC ID

HGNC:4716

Target 49 Chromosome Location

Not Available

Target 49 Locus

6p21.3

Target 49 SNPs

SNPJam Report Link Image

Target 49 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 49 General References

2759094; 12408966; 15489334; 2613692; 17081983; 17924679; 17287340; 17370265

Target 50 [top]

Target 50 ID

490

Target 50 Name

Histone H1.3

Target 50 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 50 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures

Target 50 Synonyms

Histone H1c

Target 50 Gene Name

HIST1H1D

Target 50 Protein Sequence

>Histone H1.3

MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSL
AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPK
AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT
PQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK

Target 50 Number of Residues

221

Target 50 Molecular Weight

22349.7

Target 50 Theoretical pI

11.79

Target 50 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 50 General Function

Lipid transport and metabolism

Target 50 Pathways

Not Available

Target 50 Reactions

Not Available

Target 50 Signals

None

Target 50 Transmembrane Regions

None

Target 50 Essentiality

Non Essential

Target 50 Domain Function

PF00538:Linker_histone

Target 50 GenBank ID Protein

Not Available

Target 50 UniProtKB ID

P16402

Target 50 Cellular Location

Nucleus

Target 50 Gene Sequence

>666 bp

ATGTCGGAGACTGCTCCACTTGCTCCTACCATTCCTGCACCCGCAGAAAAAACACCTGTG
AAGAAAAAGGCGAAGAAGGCAGGCGCAACTGCTGGGAAACGCAAAGCATCCGGACCCCCA
GTATCTGAGCTTATCACCAAGGCAGTGGCAGCTTCTAAGGAGCGCAGCGGCGTTTCTCTG
GCCGCGCTTAAGAAAGCGCTTGCGGCTGCCGGCTACGATGTAGAAAAAAACAACAGCCGT
ATCAAGCTTGGCCTCAAGAGCTTGGTGAGCAAAGGTACCCTGGTGCAGACCAAAGGTACC
GGTGCTTCTGGCTCCTTCAAACTCAACAAGAAAGCGGCTTCCGGGGAAGGCAAACCCAAG
GCCAAAAAGGCTGGCGCAGCCAAGCCTAGGAAGCCTGCTGGGGCAGCCAAGAAGCCCAAG
AAGGTGGCTGGCGCCGCTACCCCGAAGAAAAGCATCAAAAAGACTCCTAAGAAGGTAAAG
AAGCCAGCAACCGCTGCTGGGACCAAGAAAGTGGCCAAGAGTGCGAAAAAGGTGAAAACA
CCTCAGCCAAAAAAAGCTGCCAAGAGTCCAGCTAAGGCCAAAGCCCCTAAGCCCAAGGCG
GCCAAGCCTAAGTCGGGGAAGCCGAAGGTTACAAAGGCAAAGAAGGCAGCTCCGAAGAAA
AAGTGA

Target 50 GenBank Gene ID

Not Available

Target 50 GeneCard ID

HIST1H1D

Target 50 GenAtlas ID

HIST1H1D

Target 50 HGNC ID

HGNC:4717

Target 50 Chromosome Location

Not Available

Target 50 Locus

6p21.3

Target 50 SNPs

SNPJam Report Link Image

Target 50 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 50 General References

1916825; 12408966; 14574404; 15489334; 2613692; 17081983; 17287340; 19367720; 18669648

Target 51 [top]

Target 51 ID

488

Target 51 Name

Histone H1.4

Target 51 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 51 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures

Target 51 Synonyms

Histone H1b

Target 51 Gene Name

HIST1H1E

Target 51 Protein Sequence

>Histone H1.4

MSETAPAAPAAPAPAEKTPVKKKARKSAGAAKRKASGPPVSELITKAVAASKERSGVSLA
ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKA
KKAGAAKAKKPAGAAKKPKKATGAATPKKSAKKTPKKAKKPAAAAGAKKAKSPKKAKAAK
PKKAPKSPAKAKAVKPKAAKPKTAKPKAAKPKKAAAKKK

Target 51 Number of Residues

219

Target 51 Molecular Weight

21865.0

Target 51 Theoretical pI

11.80

Target 51 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 51 General Function

Lipid transport and metabolism

Target 51 Pathways

Not Available

Target 51 Reactions

Not Available

Target 51 Signals

None

Target 51 Transmembrane Regions

None

Target 51 Essentiality

Non Essential

Target 51 Domain Function

PF00538:Linker_histone

Target 51 GenBank ID Protein

Not Available

Target 51 UniProtKB ID

P10412

Target 51 Cellular Location

Nucleus

Target 51 Gene Sequence

>660 bp

ATGTCCGAGACTGCGCCTGCCGCGCCCGCTGCTCCGGCCCCTGCCGAGAAGACTCCCGTG
AAGAAGAAGGCCCGCAAGTCTGCAGGTGCGGCCAAGCGCAAAGCGTCTGGGCCCCCGGTG
TCCGAGCTCATTACTAAAGCTGTTGCCGCCTCCAAGGAGCGCAGCGGCGTATCTTTGGCC
GCTCTCAAGAAAGCGCTGGCAGCCGCTGGCTATGACGTGGAGAAGAACAACAGCCGCATC
AAGCTGGGTCTCAAGAGCCTGGTGAGCAAGGGCACCCTGGTGCAGACCAAGGGCACCGGC
GCGTCGGGTTCCTTCAAACTCAACAAGAAGGCGGCCTCTGGGGAAGCCAAGCCTAAGGCT
AAAAAGGCAGGCGCGGCCAAGGCCAAGAAGCCAGCAGGAGCGGCGAAGAAGCCCAAGAAG
GCGACGGGGGCGGCCACCCCCAAGAAGAGCGCCAAGAAGACCCCAAAGAAGGCGAAGAAG
CCGGCTGCAGCTGCTGGAGCCAAAAAAGCGAAAAGCCCGAAAAAGGCGAAAGCAGCCAAG
CCAAAAAAGGCGCCCAAGAGCCCAGCGAAGGCCAAAGCAGTTAAACCCAAGGCGGCTAAA
CCAAAGACCGCCAAGCCCAAGGCAGCCAAGCCAAAGAAGGCGGCAGCCAAGAAAAAGTAG

Target 51 GenBank Gene ID

Not Available

Target 51 GeneCard ID

HIST1H1E

Target 51 GenAtlas ID

HIST1H1E

Target 51 HGNC ID

HGNC:4718

Target 51 Chromosome Location

Not Available

Target 51 Locus

Not Available

Target 51 SNPs

SNPJam Report Link Image

Target 51 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 51 General References

1916825; 12408966; 14574404; 15489334; 3782055; 17081983; 17924679; 17287340; 19007248; 18691976

Target 52 [top]

Target 52 ID

489

Target 52 Name

Histone H1.5

Target 52 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 52 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures

Target 52 Synonyms

Histone H1a

Target 52 Gene Name

HIST1H1B

Target 52 Protein Sequence

>Histone H1.5

MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL
SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK
PKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAA
AKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK

Target 52 Number of Residues

226

Target 52 Molecular Weight

22579.9

Target 52 Theoretical pI

11.69

Target 52 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 52 General Function

Lipid transport and metabolism

Target 52 Pathways

Not Available

Target 52 Reactions

Not Available

Target 52 Signals

None

Target 52 Transmembrane Regions

None

Target 52 Essentiality

Non Essential

Target 52 Domain Function

PF00538:Linker_histone

Target 52 GenBank ID Protein

Not Available

Target 52 UniProtKB ID

P16401

Target 52 Cellular Location

Nucleus

Target 52 Gene Sequence

>681 bp

ATGTCGGAAACCGCTCCTGCCGAGACAGCCACCCCGGCGCCGGTGGAGAAATCCCCGGCT
AAGAAGAAGGCAACTAAGAAGGCTGCCGGCGCCGGCGCTGCTAAGCGCAAAGCGACGGGG
CCCCCAGTCTCAGAGCTGATCACCAAGGCTGTGGCTGCTTCTAAGGAGCGCAATGGGCTT
TCTTTGGCAGCCCTTAAGAAGGCCTTAGCGGCCGGTGGCTACGACGTGGAGAAGAATAAC
AGCCGCATTAAGCTGGGCCTCAAGAGCTTGGTGAGCAAGGGCACCCTGGTGCAGACCAAG
GGCACTGGTGCTTCTGGCTCCTTTAAACTCAACAAGAAGGCGGCCTCCGGGGAAGCCAAG
CCCAAAGCCAAGAAGGCAGGCGCCGCTAAAGCTAAGAAGCCCGCGGGGGCCACGCCTAAG
AAGGCCAAGAAGGCTGCAGGGGCGAAAAAGGCAGTGAAGAAGACTCCGAAGAAGGCGAAG
AAGCCCGCGGCGGCTGGCGTCAAAAAGGTGGCGAAGAGCCCTAAGAAGGCCAAGGCCGCT
GCCAAACCGAAAAAGGCAACCAAGAGTCCTGCCAAGCCCAAGGCAGTTAAGCCGAAGGCG
GCAAAGCCCAAAGCCGCTAAGCCCAAAGCAGCAAAACCTAAAGCTGCAAAGGCCAAGAAG
GCGGCTGCCAAAAAGAAGTAG

Target 52 GenBank Gene ID

Not Available

Target 52 GeneCard ID

HIST1H1B

Target 52 GenAtlas ID

HIST1H1B

Target 52 HGNC ID

HGNC:4719

Target 52 Chromosome Location

Not Available

Target 52 Locus

6p22-p21.3

Target 52 SNPs

SNPJam Report Link Image

Target 52 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 52 General References

9031620; 12408966; 14574404; 15489334; 2613692; 16083285; 17081983; 17287340; 19007248

Target 53 [top]

Target 53 ID

495

Target 53 Name

Histone H1oo

Target 53 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 53 Description

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity)

Target 53 Synonyms

Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1

Target 53 Gene Name

H1FOO

Target 53 Protein Sequence

>Histone H1oo

MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHSSLPVGRRHPPVLRMVL
EALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLARPLNSKARG
ATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKPSEAKEDPPNVGKVKKAAKRP
AKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVPPKPDKAMRAPSSAGGLSRKAKA
KGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKKKVVAKAKAPKAGQGPNTKAA
APAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA

Target 53 Number of Residues

346

Target 53 Molecular Weight

35813.2

Target 53 Theoretical pI

11.90

Target 53 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 53 General Function

Lipid transport and metabolism

Target 53 Pathways

Not Available

Target 53 Reactions

Not Available

Target 53 Signals

None

Target 53 Transmembrane Regions

None

Target 53 Essentiality

Non Essential

Target 53 Domain Function

PF00538:Linker_histone

Target 53 GenBank ID Protein

Not Available

Target 53 UniProtKB ID

Q8IZA3

Target 53 Cellular Location

Cytoplasm (By similarity). Nucleus (By similarity)

Target 53 Gene Sequence

>1041 bp

ATGGCTCCTGGGAGCGTCACCAGCGACATCTCACCCTCCTCGACTTCCACAGCAGGATCA
TCCAGGTCTCCTGAATCTGAAAAGCCAGGCCCGAGCCACGGCGGTGTCCCACCAGGAGGC
CCGAGCCACAGCAGCCTCCCGGTGGGACGCCGCCACCCCCCGGTGCTACGCATGGTGCTG
GAGGCGCTGCAGGCTGGGGAGCAGCGCCGGGGCACGTCGGTGGCAGCTATCAAGCTCTAC
ATCCTGCACAAGTACCCAACAGTGGACGTCCTCCGCTTCAAGTACCTGCTGAAGCAGGCG
CTGGCCACTGGCATGCGCCGTGGCCTCCTCGCCAGGCCCCTCAACTCCAAAGCCAGGGGG
GCCACTGGCAGCTTCAAATTAGTTCCCAAGCACAAGAAGAAAATCCAGCCCAGGAAGATG
GCCCCCGCGACGGCTCCCAGGAGAGCGGGTGAGGCCAAGGGGAAGGGCCCCAAGAAACCA
AGTGAGGCCAAGGAGGACCCTCCCAACGTGGGCAAGGTGAAAAAGGCAGCCAAGAGGCCA
GCAAAGGTGCAGAAGCCTCCTCCCAAGCCAGGCGCAGCCACAGAGAAGGCTCGCAAGCAA
GGCGGCGCGGCCAAGGACACCAGGGCACAGTCGGGAGAGGCTAGGAAGGTGCCCCCCAAG
CCAGACAAGGCCATGCGGGCACCTTCCAGTGCTGGTGGGCTCAGCAGGAAGGCAAAGGCC
AAAGGCAGCAGGAGCAGCCAAGGAGATGCTGAGGCCTACAGGAAAACCAAAGCTGAGAGT
AAGAGTTCAAAACCCACGGCCAGCAAGGTCAAGAATGGTGCTGCTTCCCCGACCAAAAAG
AAGGTGGTGGCCAAGGCCAAGGCCCCTAAAGCTGGGCAGGGGCCAAACACCAAGGCTGCT
GCTCCTGCTAAGGGCAGTGGGTCCAAGGTGGTACCTGCACATTTGTCCAGGAAGACAGAG
GCCCCCAAGGGCCCTAGAAAGGCTGGGCTGCCCATCAAGGCCTCATCATCCAAAGTGTCC
AGCCAGAGGGCTGAAGCTTAG

Target 53 GenBank Gene ID

Not Available

Target 53 GeneCard ID

H1FOO

Target 53 GenAtlas ID

H1FOO

Target 53 HGNC ID

HGNC:18463 Link Image

Target 53 Chromosome Location

Not Available

Target 53 Locus

3q21.3

Target 53 SNPs

SNPJam Report Link Image

Target 53 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 53 General References

12711322; 15489334

Target 54 [top]

Target 54 ID

491

Target 54 Name

Histone H1t

Target 54 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 54 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures

Target 54 Synonyms

Testicular H1 histone

Target 54 Gene Name

HIST1H1T

Target 54 Protein Sequence

>Histone H1t

MSETVPAASASAGVAAMEKLPTKKRGRKPAGLISASRKVPNLSVSKLITEALSVSQERVG
MSLVALKKALAAAGYDVEKNNSRIKLSLKSLVNKGILVQTRGTGASGSFKLSKKVIPKST
RSKAKKSVSAKTKKLVLSRDSKSPKTAKTNKRAKKPRATTPKTVRSGRKAKGAKGKQQQK
SPVKARASKSKLTQHHEVNVRKATSKK

Target 54 Number of Residues

207

Target 54 Molecular Weight

22018.8

Target 54 Theoretical pI

12.28

Target 54 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 54 General Function

Involved in DNA binding

Target 54 Pathways

Not Available

Target 54 Reactions

Not Available

Target 54 Signals

None

Target 54 Transmembrane Regions

None

Target 54 Essentiality

Non Essential

Target 54 Domain Function

PF00538:Linker_histone

Target 54 GenBank ID Protein

Not Available

Target 54 UniProtKB ID

P22492

Target 54 Cellular Location

Nucleus

Target 54 Gene Sequence

>624 bp

ATGTCTGAAACCGTGCCTGCAGCTTCTGCCAGTGCTGGTGTAGCCGCTATGGAGAAACTT
CCAACCAAGAAGCGAGGGAGGAAGCCGGCTGGCTTGATAAGTGCAAGTCGCAAAGTGCCG
AACCTCTCTGTGTCCAAGTTGATCACCGAGGCCCTTTCAGTGTCACAGGAACGAGTAGGT
ATGTCTTTGGTTGCGCTCAAGAAGGCATTGGCCGCTGCTGGCTACGACGTAGAGAAGAAT
AACAGCCGCATCAAACTGTCCCTCAAGAGCTTAGTGAACAAGGGAATCCTGGTGCAAACC
AGGGGTACTGGTGCTTCCGGTTCCTTTAAGCTTAGTAAGAAGGTGATTCCTAAATCTACC
AGAAGCAAGGCTAAAAAGTCAGTTTCTGCCAAGACCAAGAAGCTGGTTTTATCCAGGGAC
TCCAAGTCACCAAAGACTGCTAAAACCAATAAGAGAGCCAAGAAGCCGAGAGCGACAACT
CCTAAAACTGTTAGGAGCGGGAGAAAGGCTAAAGGAGCCAAGGGTAAGCAACAGCAGAAG
AGCCCAGTGAAGGCAAGGGCTTCGAAGTCAAAATTGACCCAACATCATGAAGTTAATGTT
AGAAAGGCCACATCTAAGAAGTAA

Target 54 GenBank Gene ID

Not Available

Target 54 GeneCard ID

HIST1H1T

Target 54 GenAtlas ID

HIST1H1T

Target 54 HGNC ID

HGNC:4720

Target 54 Chromosome Location

Not Available

Target 54 Locus

6p21.3

Target 54 SNPs

SNPJam Report Link Image

Target 54 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 54 General References

1889752; 8175896; 12408966; 15489334; 17081983

Target 55 [top]

Target 55 ID

492

Target 55 Name

Histone H1x

Target 55 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 55 Description

Histones H1 are necessary for the condensation of nucleosome chains into higher order structures

Target 55 Synonyms

Not Available

Target 55 Gene Name

H1FX

Target 55 Protein Sequence

>Histone H1x

MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLG
ERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKK
LEGGGERRGAPAAATAPAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKK
DKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK

Target 55 Number of Residues

213

Target 55 Molecular Weight

22487.0

Target 55 Theoretical pI

11.49

Target 55 GO Classification

Function
binding nucleic acid binding DNA binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 55 General Function

Involved in DNA binding

Target 55 Pathways

Not Available

Target 55 Reactions

Not Available

Target 55 Signals

None

Target 55 Transmembrane Regions

None

Target 55 Essentiality

Non Essential

Target 55 Domain Function

PF00538:Linker_histone

Target 55 GenBank ID Protein

Not Available

Target 55 UniProtKB ID

Q92522

Target 55 Cellular Location

Nucleus

Target 55 Gene Sequence

>642 bp

ATGTCCGTGGAGCTCGAGGAGGCCCTGCCAGTGACGACCGCCGAGGGAATGGCCAAGAAG
GTGACCAAGGCTGGCGGCTCGGCGGCGTTGTCCCCATCTAAGAAGAGGAAGAATAGCAAG
AAGAAGAACCAGCCGGGCAAGTACAGCCAGCTGGTGGTGGAGACCATCCGTAGGCTGGGC
GAGCGCAACGGCTCGTCGCTGGCCAAGATCTACACCGAGGCCAAGAAGGTTCCGTGGTTC
GACCAGCAGAATGGGCGCACCTACCTCAAGTACTCGATCAAGGCGCTGGTGCAGAACGAC
ACGCTTCTGCAGGTGAAGGGCACCGGCGCCAACGGTTCCTTCAAGCTCAACCGCAAGAAG
CTGGAGGGCGGCGGGGAGCGGCGCGGAGCCCCGGCGGCCGCCACCGCCCCGGCCCCCACC
GCGCACAAAGCGAAGAAGGCAGCCCCGGGCGCGGCCGGCTCCCGGCGCGCGGACAAGAAG
CCCGCCAGGGGCCAGAAGCCGGAGCAGCGCTCGCACAAGAAGGGCGCTGGCGCCAAGAAG
GACAAAGGCGGCAAGGCCAAGAAGACGGCGGCCGCCGGGGGCAAGAAGGTGAAGAAGGCG
GCCAAGCCCAGCGTCCCCAAAGTGCCCAAGGGCCGCAAGTGA

Target 55 GenBank Gene ID

Not Available

Target 55 GeneCard ID

H1FX

Target 55 GenAtlas ID

H1FX

Target 55 HGNC ID

HGNC:4722

Target 55 Chromosome Location

Not Available

Target 55 Locus

3q21.3

Target 55 SNPs

SNPJam Report Link Image

Target 55 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 55 General References

8964515; 15489334; 15302935; 17081983; 17924679; 17287340; 19007248; 18669648

Target 56 [top]

Target 56 ID

500

Target 56 Name

Histone H2A type 1

Target 56 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 56 Description

Target 56 Synonyms

H2A.1; H2A/p

Target 56 Gene Name

HIST1H2AG

Target 56 Protein Sequence

>Histone H2A type 1

MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK

Target 56 Number of Residues

130

Target 56 Molecular Weight

14091.4

Target 56 Theoretical pI

11.55

Target 56 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 56 General Function

Involved in DNA binding

Target 56 Pathways

Not Available

Target 56 Reactions

Not Available

Target 56 Signals

None

Target 56 Transmembrane Regions

None

Target 56 Essentiality

Non Essential

Target 56 Domain Function

PF00125:Histone

Target 56 GenBank ID Protein

Not Available

Target 56 UniProtKB ID

P0C0S8

Target 56 Cellular Location

Nucleus

Target 56 Gene Sequence

>393 bp

ATGTCTGGACGTGGCAAGCAGGGAGGCAAAGCCCGCGCTAAGGCCAAGACTCGCTCTTCT
AGGGCCGGTCTCCAGTTCCCCGTGGGCCGAGTGCACCGCCTGCTCCGCAAAGGCAACTAT
GCCGAGCGGGTCGGGGCCGGCGCGCCGGTGTATCTGGCAGCGGTGCTGGAGTACCTGACC
GCCGAGATCCTGGAACTGGCGGGCAACGCGGCCCGCGACAACAAGAAGACCCGCATCATC
CCGCGTCATCTCCAACTGGCCATCCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCAAA
GTCACCATCGCACAGGGCGGTGTCCTGCCCAACATTCAGGCCGTGCTACTGCCCAAAAAG
ACTGAGAGCCACCACAAGGCGAAGGGCAAGTAA

Target 56 GenBank Gene ID

Not Available

Target 56 GeneCard ID

HIST1H2AG

Target 56 GenAtlas ID

HIST1H2AG

Target 56 HGNC ID

HGNC:4737

Target 56 Chromosome Location

Not Available

Target 56 Locus

Not Available

Target 56 SNPs

SNPJam Report Link Image

Target 56 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 56 General References

9439656; 10064132; 1768865; 8179821; 12408966; 14574404; 15489334; 7410338; 11709551; 15078818

Target 57 [top]

Target 57 ID

504

Target 57 Name

Histone H2A type 1-A

Target 57 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 57 Description

Target 57 Synonyms

H2A/r

Target 57 Gene Name

HIST1H2AA

Target 57 Protein Sequence

>Histone H2A type 1-A

MSGRGKQGGKARAKSKSRSSRAGLQFPVGRIHRLLRKGNYAERIGAGAPVYLAAVLEYLT
AEILELAGNASRDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK
TESHHHKAQSK

Target 57 Number of Residues

131

Target 57 Molecular Weight

14233.4

Target 57 Theoretical pI

11.50

Target 57 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 57 General Function

Involved in DNA binding

Target 57 Pathways

Not Available

Target 57 Reactions

Not Available

Target 57 Signals

None

Target 57 Transmembrane Regions

None

Target 57 Essentiality

Non Essential

Target 57 Domain Function

PF00125:Histone

Target 57 GenBank ID Protein

Not Available

Target 57 UniProtKB ID

Q96QV6

Target 57 Cellular Location

Nucleus

Target 57 Gene Sequence

>396 bp

ATGTCTGGACGAGGGAAGCAGGGAGGAAAAGCACGCGCCAAGTCTAAGTCTCGCTCTTCT
AGAGCGGGTTTGCAGTTTCCCGTAGGCCGGATCCATCGTCTGCTTCGTAAGGGAAACTAT
GCAGAGCGGATAGGGGCAGGCGCACCAGTGTATTTGGCGGCAGTGTTAGAGTATCTCACA
GCAGAAATCCTTGAGCTGGCAGGCAATGCGTCTCGCGATAACAAAAAAACTCGCATTATT
CCCCGCCACCTGCAGCTAGCGATCCGCAATGATGAGGAACTCAATAAGCTTTTGGGCGGC
GTGACCATTGCCCAGGGCGGAGTCCTGCCTAACATTCAGGCAGTGCTGCTGCCCAAGAAG
ACTGAGAGTCACCACCATAAAGCCCAAAGCAAGTAA

Target 57 GenBank Gene ID

Not Available

Target 57 GeneCard ID

HIST1H2AA

Target 57 GenAtlas ID

HIST1H2AA

Target 57 HGNC ID

HGNC:18729 Link Image

Target 57 Chromosome Location

Not Available

Target 57 Locus

Not Available

Target 57 SNPs

SNPJam Report Link Image

Target 57 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 57 General References

12408966; 14574404; 15489334; 15078818; 15010469; 15386022; 15823041; 16359901; 16702407; 18001824

Target 58 [top]

Target 58 ID

496

Target 58 Name

Histone H2A type 1-B/E

Target 58 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 58 Description

Target 58 Synonyms

H2A/m; H2A.2; H2A/a

Target 58 Gene Name

HIST1H2AB

Target 58 Protein Sequence

>Histone H2A type 1-B/E

MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK

Target 58 Number of Residues

130

Target 58 Molecular Weight

14135.4

Target 58 Theoretical pI

11.66

Target 58 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 58 General Function

Involved in DNA binding

Target 58 Pathways

Not Available

Target 58 Reactions

Not Available

Target 58 Signals

None

Target 58 Transmembrane Regions

None

Target 58 Essentiality

Non Essential

Target 58 Domain Function

PF00125:Histone

Target 58 GenBank ID Protein

Not Available

Target 58 UniProtKB ID

P04908

Target 58 Cellular Location

Nucleus

Target 58 Gene Sequence

>393 bp

ATGTCTGGACGTGGAAAGCAAGGCGGCAAAGCTCGGGCAAAAGCTAAAACGCGTTCTTCC
AGGGCCGGTCTTCAGTTTCCAGTTGGCCGTGTGCACCGCCTCCTCCGCAAAGGCAACTAC
TCCGAACGAGTCGGGGCCGGCGCTCCAGTGTACCTGGCAGCGGTGCTGGAATATCTGACG
GCCGAGATCTTAGAGCTAGCTGGCAACGCGGCTCGCGACAATAAGAAGACCCGCATCATC
CCGCGCCACCTGCAGCTAGCCATCCGCAACGACGAGGAGCTAAATAAGCTTCTAGGTCGC
GTGACCATCGCGCAGGGCGGTGTCCTGCCCAACATCCAGGCCGTATTGCTGCCTAAGAAG
ACGGAGAGCCACCATAAGGCCAAGGGCAAGTGA

Target 58 GenBank Gene ID

Not Available

Target 58 GeneCard ID

HIST1H2AB

Target 58 GenAtlas ID

HIST1H2AB

Target 58 HGNC ID

HGNC:4734

Target 58 Chromosome Location

Not Available

Target 58 Locus

Not Available

Target 58 SNPs

SNPJam Report Link Image

Target 58 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 58 General References

6647026; 1916825; 9439656; 12408966; 14574404; 15489334; 15078818; 15010469; 15386022; 11709551

Target 59 [top]

Target 59 ID

497

Target 59 Name

Histone H2A type 1-C

Target 59 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 59 Description

Target 59 Synonyms

H2A/l

Target 59 Gene Name

HIST1H2AC

Target 59 Protein Sequence

>Histone H2A type 1-C

MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK

Target 59 Number of Residues

130

Target 59 Molecular Weight

14105.4

Target 59 Theoretical pI

11.66

Target 59 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 59 General Function

Involved in DNA binding

Target 59 Pathways

Not Available

Target 59 Reactions

Not Available

Target 59 Signals

None

Target 59 Transmembrane Regions

None

Target 59 Essentiality

Non Essential

Target 59 Domain Function

PF00125:Histone

Target 59 GenBank ID Protein

Not Available

Target 59 UniProtKB ID

Q93077

Target 59 Cellular Location

Nucleus

Target 59 Gene Sequence

>393 bp

ATGTCTGGACGTGGTAAGCAAGGAGGCAAAGCTCGCGCCAAAGCGAAATCCCGCTCTTCT
CGCGCTGGTCTCCAGTTCCCGGTGGGCCGAGTGCACCGCCTGCTCCGTAAAGGCAACTAC
GCAGAGCGGGTTGGGGCAGGCGCGCCGGTGTACCTGGCGGCGGTGTTAGAGTACCTGACC
GCCGAGATCCTGGAGCTGGCCGGCAACGCGGCTCGCGACAACAAGAAGACTCGCATCATC
CCGCGCCACTTGCAGCTGGCCATCCGCAACGACGAGGAGCTCAACAAACTGCTAGGCCGG
GTGACCATTGCTCAGGGCGGCGTCCTTCCTAACATCCAGGCCGTGCTTCTGCCTAAGAAG
ACCGAGAGTCACCACAAGGCCAAGGGCAAGTGA

Target 59 GenBank Gene ID

Not Available

Target 59 GeneCard ID

HIST1H2AC

Target 59 GenAtlas ID

HIST1H2AC

Target 59 HGNC ID

HGNC:4733

Target 59 Chromosome Location

Not Available

Target 59 Locus

Not Available

Target 59 SNPs

SNPJam Report Link Image

Target 59 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 59 General References

9119399; 9149941; 12408966; 15489334; 15078818; 15010469; 15386022; 15823041; 16359901; 16702407

Target 60 [top]

Target 60 ID

498

Target 60 Name

Histone H2A type 1-D

Target 60 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 60 Description

Target 60 Synonyms

H2A.3; H2A/g

Target 60 Gene Name

HIST1H2AD

Target 60 Protein Sequence

>Histone H2A type 1-D

MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK

Target 60 Number of Residues

130

Target 60 Molecular Weight

14107.4

Target 60 Theoretical pI

11.55

Target 60 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 60 General Function

Involved in DNA binding

Target 60 Pathways

Not Available

Target 60 Reactions

Not Available

Target 60 Signals

None

Target 60 Transmembrane Regions

None

Target 60 Essentiality

Non Essential

Target 60 Domain Function

PF00125:Histone

Target 60 GenBank ID Protein

Not Available

Target 60 UniProtKB ID

P20671

Target 60 Cellular Location

Nucleus

Target 60 Gene Sequence

Not Available

Target 60 GenBank Gene ID

Not Available

Target 60 GeneCard ID

HIST1H2AD

Target 60 GenAtlas ID

HIST1H2AD

Target 60 HGNC ID

HGNC:4729

Target 60 Chromosome Location

Not Available

Target 60 Locus

Not Available

Target 60 SNPs

SNPJam Report Link Image

Target 60 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 60 General References

2587222; 9119399; 12408966; 14574404; 15489334; 15078818; 15010469; 15386022; 15823041

Target 61 [top]

Target 61 ID

505

Target 61 Name

Histone H2A type 1-H

Target 61 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 61 Description

Target 61 Synonyms

H2A/s

Target 61 Gene Name

HIST1H2AH

Target 61 Protein Sequence

>Histone H2A type 1-H

MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKAK

Target 61 Number of Residues

128

Target 61 Molecular Weight

13906.1

Target 61 Theoretical pI

11.53

Target 61 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 61 General Function

Involved in DNA binding

Target 61 Pathways

Not Available

Target 61 Reactions

Not Available

Target 61 Signals

None

Target 61 Transmembrane Regions

None

Target 61 Essentiality

Non Essential

Target 61 Domain Function

PF00125:Histone

Target 61 GenBank ID Protein

Not Available

Target 61 UniProtKB ID

Q96KK5

Target 61 Cellular Location

Nucleus

Target 61 Gene Sequence

>387 bp

ATGTCTGGACGTGGCAAGCAAGGCGGTAAAGCTCGCGCCAAGGCCAAGACCCGCTCTTCT
CGGGCTGGGCTTCAGTTCCCCGTGGGCCGAGTGCACCGCCTGCTCCGCAAGGGTAATTAT
GCCGAGCGGGTTGGAGCCGGCGCGCCAGTGTACCTGGCTGCGGTGCTGGAGTACCTGACC
GCTGAGATCCTGGAGCTGGCTGGCAATGCGGCCCGCGACAACAAGAAGACCCGTATCATC
CCGCGTCACCTCCAACTGGCCATCCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCAAA
GTCACCATCGCGCAGGGTGGTGTCTTGCCCAATATCCAGGCCGTGCTGCTGCCTAAGAAG
ACTGAGAGCCACCATAAGGCCAAATAA

Target 61 GenBank Gene ID

Not Available

Target 61 GeneCard ID

HIST1H2AH

Target 61 GenAtlas ID

HIST1H2AH

Target 61 HGNC ID

HGNC:13671 Link Image

Target 61 Chromosome Location

Not Available

Target 61 Locus

Not Available

Target 61 SNPs

SNPJam Report Link Image

Target 61 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 61 General References

12408966; 14574404; 15489334; 15078818; 15010469; 15386022; 15823041; 16359901; 16702407; 16319397

Target 62 [top]

Target 62 ID

499

Target 62 Name

Histone H2A type 1-J

Target 62 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 62 Description

Target 62 Synonyms

H2A/e

Target 62 Gene Name

HIST1H2AJ

Target 62 Protein Sequence

>Histone H2A type 1-J

MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKTK

Target 62 Number of Residues

128

Target 62 Molecular Weight

13936.2

Target 62 Theoretical pI

11.53

Target 62 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 62 General Function

Involved in DNA binding

Target 62 Pathways

Not Available

Target 62 Reactions

Not Available

Target 62 Signals

None

Target 62 Transmembrane Regions

None

Target 62 Essentiality

Non Essential

Target 62 Domain Function

PF00125:Histone

Target 62 GenBank ID Protein

Not Available

Target 62 UniProtKB ID

Q99878

Target 62 Cellular Location

Nucleus

Target 62 Gene Sequence

Not Available

Target 62 GenBank Gene ID

Not Available

Target 62 GeneCard ID

HIST1H2AJ

Target 62 GenAtlas ID

HIST1H2AJ

Target 62 HGNC ID

HGNC:4727

Target 62 Chromosome Location

Not Available

Target 62 Locus

Not Available

Target 62 SNPs

SNPJam Report Link Image

Target 62 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 62 General References

9439656; 12408966; 14574404; 15489334; 15078818; 15010469; 15386022; 15823041; 16359901; 16702407

Target 63 [top]

Target 63 ID

516

Target 63 Name

Histone H2B type 1-K

Target 63 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 63 Description

Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Target 63 Synonyms

H2B K; HIRA-interacting protein 1

Target 63 Gene Name

HIST1H2BK

Target 63 Protein Sequence

>Histone H2B type 1-K

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSAK

Target 63 Number of Residues

126

Target 63 Molecular Weight

13890.0

Target 63 Theoretical pI

11.00

Target 63 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 63 General Function

Involved in DNA binding

Target 63 Pathways

Not Available

Target 63 Reactions

Not Available

Target 63 Signals

None

Target 63 Transmembrane Regions

None

Target 63 Essentiality

Non Essential

Target 63 Domain Function

PF00125:Histone

Target 63 GenBank ID Protein

Not Available

Target 63 UniProtKB ID

O60814

Target 63 Cellular Location

Nucleus

Target 63 Gene Sequence

>381 bp

ATGCCGGAACCAGCGAAGTCCGCTCCCGCGCCCAAGAAGGGCTCGAAGAAAGCCGTGACT
AAGGCGCAGAAGAAGGACGGTAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTACTCCGTA
TACGTGTACAAGGTGCTGAAGCAGGTCCACCCCGACACCGGCATCTCCTCTAAGGCCATG
GGAATCATGAACTCCTTCGTCAACGACATCTTCGAACGCATCGCGGGTGAGGCTTCCCGC
CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC
CTGCTGCTGCCCGGGGAGTTGGCCAAGCACGCCGTGTCCGAGGGCACCAAGGCCGTCACC
AAGTACACCAGCGCTAAGTAA

Target 63 GenBank Gene ID

Not Available

Target 63 GeneCard ID

HIST1H2BK

Target 63 GenAtlas ID

HIST1H2BK

Target 63 HGNC ID

HGNC:13954 Link Image

Target 63 Chromosome Location

Not Available

Target 63 Locus

6p21.33

Target 63 SNPs

SNPJam Report Link Image

Target 63 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 63 General References

9710638; 12408966; 14574404; 15489334; 11859126; 8620898; 12860195; 15019208; 16627869; 12757711

Target 64 [top]

Target 64 ID

501

Target 64 Name

Histone H2A type 2-A

Target 64 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 64 Description

Target 64 Synonyms

H2A.2; H2A/o

Target 64 Gene Name

HIST2H2AA3

Target 64 Protein Sequence

>Histone H2A type 2-A

MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK

Target 64 Number of Residues

130

Target 64 Molecular Weight

14095.4

Target 64 Theoretical pI

11.55

Target 64 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 64 General Function

Involved in DNA binding

Target 64 Pathways

Not Available

Target 64 Reactions

Not Available

Target 64 Signals

None

Target 64 Transmembrane Regions

None

Target 64 Essentiality

Non Essential

Target 64 Domain Function

PF00125:Histone

Target 64 GenBank ID Protein

Not Available

Target 64 UniProtKB ID

Q6FI13

Target 64 Cellular Location

Nucleus

Target 64 Gene Sequence

>393 bp

ATGTCTGGTCGTGGCAAGCAAGGAGGCAAGGCCCGCGCCAAGGCCAAGTCGCGCTCGTCC
CGCGCTGGCCTTCAGTTCCCGGTAGGGCGAGTGCATCGCTTGCTGCGCAAAGGCAACTAC
GCGGAGCGAGTGGGGGCCGGCGCGCCCGTCTACATGGCTGCGGTCCTCGAGTATCTGACC
GCCGAGATCCTGGAGCTGGCGGGCAACGCGGCTCGGGACAACAAGAAGACGCGCATCATC
CCTCGTCACCTCCAGCTGGCCATCCGCAACGACGAGGAACTGAACAAGCTGCTGGGCAAA
GTCACCATCGCCCAGGGCGGCGTCTTGCCTAACATCCAGGCCGTACTGCTCCCTAAGAAG
ACGGAGAGTCACCACAAGGCAAAGGGCAAGTGA

Target 64 GenBank Gene ID

Not Available

Target 64 GeneCard ID

HIST2H2AA3 Link Image

Target 64 GenAtlas ID

HIST2H2AA3 Link Image

Target 64 HGNC ID

HGNC:4736

Target 64 Chromosome Location

Not Available

Target 64 Locus

Not Available

Target 64 SNPs

SNPJam Report Link Image

Target 64 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 64 General References

8179821; 12408966; 14702039; 16710414; 15489334; 15078818; 15010469; 15386022

Target 65 [top]

Target 65 ID

506

Target 65 Name

Histone H2A type 2-B

Target 65 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 65 Description

Target 65 Synonyms

Not Available

Target 65 Gene Name

HIST2H2AB

Target 65 Protein Sequence

>Histone H2A type 2-B

MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK
TESHKPGKNK

Target 65 Number of Residues

130

Target 65 Molecular Weight

13995.2

Target 65 Theoretical pI

11.53

Target 65 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 65 General Function

Involved in DNA binding

Target 65 Pathways

Not Available

Target 65 Reactions

Not Available

Target 65 Signals

None

Target 65 Transmembrane Regions

None

Target 65 Essentiality

Non Essential

Target 65 Domain Function

PF00125:Histone

Target 65 GenBank ID Protein

Not Available

Target 65 UniProtKB ID

Q8IUE6

Target 65 Cellular Location

Nucleus

Target 65 Gene Sequence

>393 bp

ATGTCAGGACGCGGAAAGCAGGGAGGCAAGGCCCGCGCTAAGGCCAAGTCGCGCTCGTCC
CGCGCTGGTCTCCAGTTCCCGGTGGGGCGAGTGCACCGCTTGCTGCGCAAAGGCAACTAC
GCGGAGCGGGTCGGGGCAGGCGCCCCGGTGTACCTGGCGGCGGTCCTCGAGTACCTGACC
GCGGAAATTCTGGAGCTGGCGGGCAACGCGGCTCGGGACAACAAGAAGACGCGCATCATC
CCTCGCCATCTGCAACTAGCCGTGAGGAATGACGAAGAGCTCAACAAGTTACTCGGGGGT
GTCACCATTGCCCAGGGCGGCGTCTTGCCCAATATCCAGGCTGTCCTGTTGCCCAAGAAA
ACGGAGAGTCACAAGCCTGGCAAGAACAAGTAA

Target 65 GenBank Gene ID

Not Available

Target 65 GeneCard ID

HIST2H2AB

Target 65 GenAtlas ID

HIST2H2AB

Target 65 HGNC ID

HGNC:20508 Link Image

Target 65 Chromosome Location

Not Available

Target 65 Locus

Not Available

Target 65 SNPs

SNPJam Report Link Image

Target 65 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 65 General References

12408966; 16710414; 15078818; 15010469; 15386022; 15823041; 16359901; 16702407; 18001824; 18001825

Target 66 [top]

Target 66 ID

502

Target 66 Name

Histone H2A type 2-C

Target 66 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 66 Description

Target 66 Synonyms

H2A-GL101; H2A/q

Target 66 Gene Name

HIST2H2AC

Target 66 Protein Sequence

>Histone H2A type 2-C

MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHKAKSK

Target 66 Number of Residues

129

Target 66 Molecular Weight

13988.3

Target 66 Theoretical pI

11.55

Target 66 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 66 General Function

Involved in DNA binding

Target 66 Pathways

Not Available

Target 66 Reactions

Not Available

Target 66 Signals

None

Target 66 Transmembrane Regions

None

Target 66 Essentiality

Non Essential

Target 66 Domain Function

PF00125:Histone

Target 66 GenBank ID Protein

Not Available

Target 66 UniProtKB ID

Q16777

Target 66 Cellular Location

Nucleus

Target 66 Gene Sequence

>390 bp

ATGTCTGGTCGTGGCAAACAAGGAGGCAAGGCCCGCGCCAAGGCCAAGTCGCGCTCGTCC
CGCGCTGGCCTCCAGTTCCCGGTAGGGCGAGTGCACCGCTTGCTGCGCAAAGGCAACTAC
GCGGAGCGGGTGGGGGCCGGCGCGCCCGTCTACATGGCGGCGGTCCTCGAGTACCTGACC
GCCGAGATCCTGGAGCTGGCGGGCAACGCGGCTCGGGACAACAAGAAGACGCGCATCATC
CCTCGTCACCTCCAGCTGGCCATCCGCAACGACGAGGAACTGAACAAGCTGCTGGGCAAA
GTCACCATCGCCCAGGGCGGCGTTTTGCCTAACATCCAGGCCGTTCTGTTACCAAAGAAA
ACCGAAAGCCACAAAGCCAAAAGCAAATAA

Target 66 GenBank Gene ID

Not Available

Target 66 GeneCard ID

HIST2H2AC

Target 66 GenAtlas ID

HIST2H2AC

Target 66 HGNC ID

HGNC:4738

Target 66 Chromosome Location

Not Available

Target 66 Locus

Not Available

Target 66 SNPs

SNPJam Report Link Image

Target 66 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 66 General References

12408966; 15527963; 16710414; 15489334; 1469070; 15078818; 15010469; 15386022; 15823041; 16359901

Target 67 [top]

Target 67 ID

507

Target 67 Name

Histone H2A type 3

Target 67 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 67 Description

Target 67 Synonyms

Not Available

Target 67 Gene Name

HIST3H2A

Target 67 Protein Sequence

>Histone H2A type 3

MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK

Target 67 Number of Residues

130

Target 67 Molecular Weight

14121.4

Target 67 Theoretical pI

11.66

Target 67 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 67 General Function

Involved in DNA binding

Target 67 Pathways

Not Available

Target 67 Reactions

Not Available

Target 67 Signals

None

Target 67 Transmembrane Regions

None

Target 67 Essentiality

Non Essential

Target 67 Domain Function

PF00125:Histone

Target 67 GenBank ID Protein

Not Available

Target 67 UniProtKB ID

Q7L7L0

Target 67 Cellular Location

Nucleus

Target 67 Gene Sequence

Not Available

Target 67 GenBank Gene ID

Not Available

Target 67 GeneCard ID

HIST3H2A

Target 67 GenAtlas ID

HIST3H2A

Target 67 HGNC ID

HGNC:20507 Link Image

Target 67 Chromosome Location

Not Available

Target 67 Locus

1q42.13

Target 67 SNPs

SNPJam Report Link Image

Target 67 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 67 General References

12408966; 14702039; 16710414; 15489334; 15078818; 15010469; 15386022; 15823041; 16359901

Target 68 [top]

Target 68 ID

510

Target 68 Name

Histone H2A-Bbd type 1

Target 68 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 68 Description

Atypical histone H2A which can replace conventional H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Nucleosomes containing this histone are less rigid and organize only 118 base pair of DNA instead of 147 in classical nucleosomes. They are associated with transcriptionally active chromatin and excluded form Barr bodies

Target 68 Synonyms

H2A Barr body-deficient; H2A.Bbd

Target 68 Gene Name

H2AFB1

Target 68 Protein Sequence

>Histone H2A-Bbd type 1

MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVI
EYLTAKVPELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED

Target 68 Number of Residues

115

Target 68 Molecular Weight

12697.2

Target 68 Theoretical pI

11.10

Target 68 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 68 General Function

Involved in DNA binding

Target 68 Pathways

Not Available

Target 68 Reactions

Not Available

Target 68 Signals

None

Target 68 Transmembrane Regions

None

Target 68 Essentiality

Non Essential

Target 68 Domain Function

PF00125:Histone

Target 68 GenBank ID Protein

Not Available

Target 68 UniProtKB ID

P0C5Y9

Target 68 Cellular Location

Nucleus

Target 68 Gene Sequence

Not Available

Target 68 GenBank Gene ID

Not Available

Target 68 GeneCard ID

H2AFB1

Target 68 GenAtlas ID

H2AFB1

Target 68 HGNC ID

HGNC:22516 Link Image

Target 68 Chromosome Location

Not Available

Target 68 Locus

Not Available

Target 68 SNPs

SNPJam Report Link Image

Target 68 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 68 General References

8528212; 15772651; 15257289; 16287874

Target 69 [top]

Target 69 ID

509

Target 69 Name

Histone H2A-Bbd type 2/3

Target 69 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 69 Description

Target 69 Synonyms

H2A Barr body-deficient; H2A.Bbd

Target 69 Gene Name

H2AFB2

Target 69 Protein Sequence

>Histone H2A-Bbd type 2/3

MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVI
EYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED

Target 69 Number of Residues

115

Target 69 Molecular Weight

12713.2

Target 69 Theoretical pI

11.10

Target 69 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 69 General Function

Involved in DNA binding

Target 69 Pathways

Not Available

Target 69 Reactions

Not Available

Target 69 Signals

None

Target 69 Transmembrane Regions

None

Target 69 Essentiality

Non Essential

Target 69 Domain Function

PF00125:Histone

Target 69 GenBank ID Protein

Not Available

Target 69 UniProtKB ID

P0C5Z0

Target 69 Cellular Location

Nucleus

Target 69 Gene Sequence

>348 bp

ATGCCGAGGAGGAGGAGACGCCGAGGGTCCTCCGGTGCTGGCGGCCGGGGGCGGACCTGC
TCTCGCACCGTCCGAGCGGAGCTTTCGTTTTCAGTGAGCCAGGTGGAGCGCAGTCTACGG
GAGGGCCACTACGCTCAGCGCCTGAGTCGCACGGCGCCGGTCTACCTCGCTGCGGTTATT
GAGTACCTGACGGCCAAGGTCCTGGAGCTGGCGGGCAACGAGGCCCAGAACAGCGGAGAG
CGGAACATCACTCCCCTGCTGCTGGACATGGTGGTTCACAACGACAGGCTACTGAGCACC
CTTTTCAACACGACCACCATCTCTCAAGTGGCCCCTGGCGAGGACTAG

Target 69 GenBank Gene ID

Not Available

Target 69 GeneCard ID

H2AFB2

Target 69 GenAtlas ID

H2AFB2

Target 69 HGNC ID

HGNC:18298 Link Image

Target 69 Chromosome Location

Not Available

Target 69 Locus

Not Available

Target 69 SNPs

SNPJam Report Link Image

Target 69 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 69 General References

11266453; 15772651; 15489334; 15257289; 16287874

Target 70 [top]

Target 70 ID

512

Target 70 Name

Histone H2A.J

Target 70 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 70 Description

Target 70 Synonyms

H2a/j

Target 70 Gene Name

H2AFJ

Target 70 Protein Sequence

>Histone H2A.J

MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESQKTKSK

Target 70 Number of Residues

129

Target 70 Molecular Weight

14019.3

Target 70 Theoretical pI

11.55

Target 70 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 70 General Function

Involved in DNA binding

Target 70 Pathways

Not Available

Target 70 Reactions

Not Available

Target 70 Signals

None

Target 70 Transmembrane Regions

None

Target 70 Essentiality

Non Essential

Target 70 Domain Function

PF00125:Histone

Target 70 GenBank ID Protein

Not Available

Target 70 UniProtKB ID

Q9BTM1

Target 70 Cellular Location

Nucleus (By similarity)

Target 70 Gene Sequence

>456 bp

ATGTCCGGTCGCGGGAAACAGGGCGGCAAAGTGCGAGCAAAGGCCAAATCCCGCTCCTCC
CGCGCGGGCCTGCAGTTCCCGGTGGGCCGAGTGCACAGACTGCTGCGCAAAGGGAACTAC
GCGGAGCGAGTGGGCGCCGGGGCGCCGGTGTACCTGGCGGCGGTGTTGGAGTACCTTACG
GCGGAGATCCTGGAGCTGGCTGGCAACGCCGCGCGTGACAACAAGAAGACCAGGATAATT
CCCCGCCACCTGCAGCTCGCCATCCGCAACGACGAGGAGTTAAACAAGCTGCTGGGCAAA
GTGACCATCGCTCAGGGCGGCGTCCTGCCCAACATCCAGGCCGTGCTGCTGCCAGTTTGT
GAGCACTCAGGACCAAGTTCTGGGAAGATACCGTCGGATCGAGCTGAGCTCGGGGCAGGA
AGTGTCTGCGGCCATATTTTTCAAAAAGTGGAGTAA

Target 70 GenBank Gene ID

Not Available

Target 70 GeneCard ID

H2AFJ

Target 70 GenAtlas ID

H2AFJ

Target 70 HGNC ID

HGNC:14456 Link Image

Target 70 Chromosome Location

Chromosome:12

Target 70 Locus

12p12

Target 70 SNPs

SNPJam Report Link Image

Target 70 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 70 General References

14702039; 15489334

Target 71 [top]

Target 71 ID

511

Target 71 Name

Histone H2A.V

Target 71 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 71 Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)

Target 71 Synonyms

H2A.F/Z

Target 71 Gene Name

H2AFV

Target 71 Protein Sequence

>Histone H2A.V

MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILE
YLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIG
KKGQQKTA

Target 71 Number of Residues

128

Target 71 Molecular Weight

13508.6

Target 71 Theoretical pI

11.29

Target 71 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 71 General Function

Involved in DNA binding

Target 71 Pathways

Not Available

Target 71 Reactions

Not Available

Target 71 Signals

None

Target 71 Transmembrane Regions

None

Target 71 Essentiality

Non Essential

Target 71 Domain Function

PF00125:Histone

Target 71 GenBank ID Protein

Not Available

Target 71 UniProtKB ID

Q71UI9

Target 71 Cellular Location

Nucleus (By similarity)

Target 71 Gene Sequence

>387 bp

ATGGCTGGAGGCAAAGCTGGAAAGGACAGTGGGAAGGCCAAGGCTAAGGCAGTATCTCGC
TCACAGAGAGCTGGGCTACAGTTTCCTGTGGGCCGCATCCACAGACACTTGAAGACTCGC
ACCACAAGCCATGGAAGGGTGGGTGCCACTGCTGCCGTGTACAGTGCTGCGATTCTGGAG
TACCTCACTGCAGAGGTGCTGGAGCTGGCAGGTAATGCTTCTAAGGATCTCAAAGTAAAG
CGTATCACTCCGCGTCACTTGCAGCTTGCAATCCGTGGTGATGAAGAGTTGGATTCTCTT
ATCAAGGCTACCATAGCTGGGGGTGGTGTGATCCCTCACATCCACAAATCTCTGATTGGA
AAGAAGGGACAGCAGAAAACTGCTTAG

Target 71 GenBank Gene ID

Not Available

Target 71 GeneCard ID

H2AFV

Target 71 GenAtlas ID

H2AFV

Target 71 HGNC ID

HGNC:20664 Link Image

Target 71 Chromosome Location

Not Available

Target 71 Locus

7p13

Target 71 SNPs

SNPJam Report Link Image

Target 71 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 71 General References

12853948; 15489334; 16457589; 16916647

Target 72 [top]

Target 72 ID

503

Target 72 Name

Histone H2A.x

Target 72 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 72 Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation

Target 72 Synonyms

H2a/x

Target 72 Gene Name

H2AFX

Target 72 Protein Sequence

>Histone H2A.x

MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK
TSATVGPKAPSGGKKATQASQEY

Target 72 Number of Residues

143

Target 72 Molecular Weight

15144.4

Target 72 Theoretical pI

11.39

Target 72 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 72 General Function

Involved in enzyme binding

Target 72 Pathways

Not Available

Target 72 Reactions

Not Available

Target 72 Signals

None

Target 72 Transmembrane Regions

None

Target 72 Essentiality

Non Essential

Target 72 Domain Function

PF00125:Histone

Target 72 GenBank ID Protein

Not Available

Target 72 UniProtKB ID

P16104

Target 72 Cellular Location

Nucleus

Target 72 Gene Sequence

>432 bp

ATGTCGGGCCGCGGCAAGACTGGCGGCAAGGCCCGCGCCAAGGCCAAGTCGCGCTCGTCG
CGCGCCGGCCTCCAGTTCCCAGTGGGCCGTGTACACCGGCTGCTGCGGAAGGGCCACTAC
GCCGAGCGCGTTGGCGCCGGCGCGCCAGTGTACCTGGCGGCAGTGCTGGAGTACCTCACC
GCTGAGATCCTGGAGCTGGCGGGCAATGCGGCCCGCGACAACAAGAAGACGCGAATCATC
CCCCGCCACCTGCAGCTGGCCATCCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCGGC
GTGACGATCGCCCAGGGAGGCGTCCTGCCCAACATCCAGGCCGTGCTGCTGCCCAAGAAG
ACCAGCGCCACCGTGGGGCCGAAGGCGCCCTCGGGCGGCAAGAAGGCCACCCAGGCCTCC
CAGGAGTACTAA

Target 72 GenBank Gene ID

Not Available

Target 72 GeneCard ID

H2AFX

Target 72 GenAtlas ID

H2AFX

Target 72 HGNC ID

HGNC:4739

Target 72 Chromosome Location

Chromosome:11

Target 72 Locus

11q23.2-q23.3

Target 72 SNPs

SNPJam Report Link Image

Target 72 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 72 General References

2587254; 15489334; 9488723; 10477747; 10959836; 10734083; 11673449; 12419185

Target 73 [top]

Target 73 ID

508

Target 73 Name

Histone H2A.Z

Target 73 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 73 Description

Target 73 Synonyms

H2A/z

Target 73 Gene Name

H2AFZ

Target 73 Protein Sequence

>Histone H2A.Z

MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILE
YLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIG
KKGQQKTV

Target 73 Number of Residues

128

Target 73 Molecular Weight

13552.6

Target 73 Theoretical pI

11.29

Target 73 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 73 General Function

Involved in DNA binding

Target 73 Pathways

Not Available

Target 73 Reactions

Not Available

Target 73 Signals

None

Target 73 Transmembrane Regions

None

Target 73 Essentiality

Non Essential

Target 73 Domain Function

PF00125:Histone

Target 73 GenBank ID Protein

Not Available

Target 73 UniProtKB ID

P0C0S5

Target 73 Cellular Location

Nucleus

Target 73 Gene Sequence

>387 bp

ATGGCTGGCGGTAAGGCTGGAAAGGACTCCGGAAAGGCCAAGACAAAGGCGGTTTCCCGC
TCGCAGAGAGCCGGCTTGCAGTTCCCAGTGGGCCGTATTCATCGACACCTAAAATCTAGG
ACGACCAGTCATGGACGTGTGGGCGCGACTGCCGCTGTGTACAGCGCAGCCATCCTGGAG
TACCTCACCGCAGAGGTACTTGAACTGGCAGGAAATGCATCAAAAGACTTAAAGGTAAAG
CGTATTACCCCTCGTCACTTGCAACTTGCTATTCGTGGAGATGAAGAATTGGATTCTCTC
ATCAAGGCTACAATTGCTGGTGGTGGTGTCATTCCACACATCCACAAATCTCTGATTGGG
AAGAAAGGACAACAGAAGACTGTCTAA

Target 73 GenBank Gene ID

Not Available

Target 73 GeneCard ID

H2AFZ

Target 73 GenAtlas ID

H2AFZ

Target 73 HGNC ID

HGNC:4741

Target 73 Chromosome Location

Not Available

Target 73 Locus

4q24

Target 73 SNPs

SNPJam Report Link Image

Target 73 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 73 General References

3344202; 1697587; 15815621; 15489334; 11835281; 15878876; 16457589; 16916647; 16319397

Target 74 [top]

Target 74 ID

518

Target 74 Name

Histone H2B type 1-A

Target 74 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 74 Description

Target 74 Synonyms

Histone H2B, testis; Testis-specific histone H2B

Target 74 Gene Name

HIST1H2BA

Target 74 Protein Sequence

>Histone H2B type 1-A

MPEVSSKGATISKKGFKKAVVKTQKKEGKKRKRTRKESYSIYIYKVLKQVHPDTGISSKA
MSIMNSFVTDIFERIASEASRLAHYSKRSTISSREIQTAVRLLLPGELAKHAVSEGTKAV
TKYTSSK

Target 74 Number of Residues

127

Target 74 Molecular Weight

14167.4

Target 74 Theoretical pI

11.00

Target 74 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 74 General Function

Involved in DNA binding

Target 74 Pathways

Not Available

Target 74 Reactions

Not Available

Target 74 Signals

None

Target 74 Transmembrane Regions

None

Target 74 Essentiality

Non Essential

Target 74 Domain Function

PF00125:Histone

Target 74 GenBank ID Protein

Not Available

Target 74 UniProtKB ID

Q96A08

Target 74 Cellular Location

Nucleus

Target 74 Gene Sequence

>384 bp

ATGCCGGAGGTGTCATCTAAAGGTGCTACCATTTCCAAGAAGGGCTTTAAGAAAGCTGTC
GTTAAGACCCAGAAAAAGGAAGGCAAAAAGCGCAAGAGGACCCGTAAGGAGAGTTATTCT
ATTTACATTTACAAAGTGCTAAAGCAGGTCCATCCGGACACTGGCATCTCTTCGAAAGCT
ATGAGCATTATGAATTCTTTCGTCACTGATATCTTTGAGCGTATAGCGAGCGAGGCATCA
CGTTTGGCTCACTACAGCAAGCGCTCCACCATTTCTTCCAGAGAGATTCAGACAGCAGTG
CGCTTGCTACTGCCGGGAGAGCTGGCTAAACATGCTGTGTCTGAGGGCACCAAGGCTGTC
ACTAAGTACACCAGCTCCAAATAA

Target 74 GenBank Gene ID

Not Available

Target 74 GeneCard ID

HIST1H2BA

Target 74 GenAtlas ID

HIST1H2BA

Target 74 HGNC ID

HGNC:18730 Link Image

Target 74 Chromosome Location

Not Available

Target 74 Locus

6p22.2

Target 74 SNPs

SNPJam Report Link Image

Target 74 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 74 General References

12213818; 12408966; 14574404; 15489334; 16307923; 16283522; 16713563; 16916647

Target 75 [top]

Target 75 ID

519

Target 75 Name

Histone H2B type 1-B

Target 75 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 75 Description

Target 75 Synonyms

H2B.f; H2B/f; H2B.1

Target 75 Gene Name

HIST1H2BB

Target 75 Protein Sequence

>Histone H2B type 1-B

MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 75 Number of Residues

126

Target 75 Molecular Weight

13950.1

Target 75 Theoretical pI

11.00

Target 75 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 75 General Function

Involved in DNA binding

Target 75 Pathways

Not Available

Target 75 Reactions

Not Available

Target 75 Signals

None

Target 75 Transmembrane Regions

None

Target 75 Essentiality

Non Essential

Target 75 Domain Function

PF00125:Histone

Target 75 GenBank ID Protein

Not Available

Target 75 UniProtKB ID

P33778

Target 75 Cellular Location

Nucleus

Target 75 Gene Sequence

>381 bp

ATGCCTGAACCCTCTAAGTCTGCTCCAGCCCCTAAAAAGGGTTCTAAGAAGGCTATCACT
AAGGCGCAGAAGAAGGATGGTAAGAAGCGTAAGCGCAGCCGCAAGGAGAGCTATTCTATC
TATGTGTACAAGGTTCTGAAGCAGGTCCACCCCGACACCGGCATCTCATCCAAGGCCATG
GGGATCATGAATTCCTTCGTCAACGACATCTTCGAGCGCATCGCGGGCGAGGCTTCTCGC
CTGGCTCACTACAATAAGCGCTCGACCATCACCTCCAGGGAGATTCAGACGGCTGTGCGC
CTGCTGCTGCCTGGGGAGCTGGCTAAGCATGCTGTGTCCGAGGGCACTAAGGCAGTTACC
AAGTACACTAGCTCTAAATAA

Target 75 GenBank Gene ID

Not Available

Target 75 GeneCard ID

HIST1H2BB

Target 75 GenAtlas ID

HIST1H2BB

Target 75 HGNC ID

HGNC:4751

Target 75 Chromosome Location

Not Available

Target 75 Locus

6p21.3

Target 75 SNPs

SNPJam Report Link Image

Target 75 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 75 General References

1916825; 12408966; 15489334; 11709551; 12757711; 16307923; 16283522; 16713563; 16916647; 16319397

Target 76 [top]

Target 76 ID

513

Target 76 Name

Histone H2B type 1-C/E/F/G/I

Target 76 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 76 Description

Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Target 76 Synonyms

H2B.a/g/h/k/l; H2B.1 A; H2B/a; H2B/g; H2B/h; H2B/k; H2B/l

Target 76 Gene Name

HIST1H2BC

Target 76 Protein Sequence

>Histone H2B type 1-C/E/F/G/I

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSK

Target 76 Number of Residues

125

Target 76 Molecular Weight

13819.0

Target 76 Theoretical pI

11.00

Target 76 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 76 General Function

Involved in DNA binding

Target 76 Pathways

Not Available

Target 76 Reactions

Not Available

Target 76 Signals

None

Target 76 Transmembrane Regions

None

Target 76 Essentiality

Non Essential

Target 76 Domain Function

PF00125:Histone

Target 76 GenBank ID Protein

Not Available

Target 76 UniProtKB ID

P62807

Target 76 Cellular Location

Nucleus

Target 76 Gene Sequence

Not Available

Target 76 GenBank Gene ID

Not Available

Target 76 GeneCard ID

HIST1H2BC

Target 76 GenAtlas ID

HIST1H2BC

Target 76 HGNC ID

HGNC:4757

Target 76 Chromosome Location

Not Available

Target 76 Locus

Not Available

Target 76 SNPs

SNPJam Report Link Image

Target 76 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 76 General References

1916825; 9119399; 12408966; 14574404; 15489334; 422550; 16319397; 11859126; 8620898; 12860195

Target 77 [top]

Target 77 ID

514

Target 77 Name

Histone H2B type 1-D

Target 77 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 77 Description

Target 77 Synonyms

H2B.b; H2B/b; H2B.1 B; HIRA-interacting protein 2

Target 77 Gene Name

HIST1H2BD

Target 77 Protein Sequence

>Histone H2B type 1-D

MPEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 77 Number of Residues

126

Target 77 Molecular Weight

13936.1

Target 77 Theoretical pI

11.00

Target 77 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 77 General Function

Involved in DNA binding

Target 77 Pathways

Not Available

Target 77 Reactions

Not Available

Target 77 Signals

None

Target 77 Transmembrane Regions

None

Target 77 Essentiality

Non Essential

Target 77 Domain Function

PF00125:Histone

Target 77 GenBank ID Protein

Not Available

Target 77 UniProtKB ID

P58876

Target 77 Cellular Location

Nucleus

Target 77 Gene Sequence

>381 bp

ATGCCTGAACCTACCAAGTCTGCTCCTGCCCCAAAGAAGGGCTCCAAGAAGGCGGTGACT
AAGGCTCAGAAGAAGGACGGGAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTATTCAGTG
TATGTGTACAAGGTGCTGAAGCAGGTCCATCCCGACACCGGCATCTCTTCCAAGGCAATG
GGGATCATGAATTCCTTCGTCAACGACATCTTCGAGCGCATCGCAGGCGAGGCTTCCCGC
CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC
CTGCTGCTTCCGGGGGAGCTGGCCAAGCACGCCGTGTCGGAGGGCACCAAGGCCGTCACC
AAGTACACCAGTTCCAAGTAA

Target 77 GenBank Gene ID

Not Available

Target 77 GeneCard ID

HIST1H2BD

Target 77 GenAtlas ID

HIST1H2BD

Target 77 HGNC ID

HGNC:4747

Target 77 Chromosome Location

Not Available

Target 77 Locus

6p21.3

Target 77 SNPs

SNPJam Report Link Image

Target 77 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 77 General References

9710638; 1916825; 12408966; 14574404; 15489334; 16627869; 12757711; 16307923; 16283522; 16713563

Target 78 [top]

Target 78 ID

520

Target 78 Name

Histone H2B type 1-H

Target 78 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 78 Description

Target 78 Synonyms

H2B.j; H2B/j

Target 78 Gene Name

HIST1H2BH

Target 78 Protein Sequence

>Histone H2B type 1-H

MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 78 Number of Residues

126

Target 78 Molecular Weight

13892.0

Target 78 Theoretical pI

11.00

Target 78 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 78 General Function

Involved in DNA binding

Target 78 Pathways

Not Available

Target 78 Reactions

Not Available

Target 78 Signals

None

Target 78 Transmembrane Regions

None

Target 78 Essentiality

Non Essential

Target 78 Domain Function

PF00125:Histone

Target 78 GenBank ID Protein

Not Available

Target 78 UniProtKB ID

Q93079

Target 78 Cellular Location

Nucleus

Target 78 Gene Sequence

>381 bp

ATGCCTGATCCAGCTAAGTCCGCTCCCGCCCCGAAGAAGGGCTCCAAGAAGGCGGTGACC
AAGGCGCAGAAGAAGGATGGCAAGAAGCGTAAACGCAGCCGCAAGGAGAGCTACTCCGTA
TACGTTTACAAGGTGCTGAAGCAAGTCCACCCCGACACCGGCATCTCCTCCAAAGCCATG
GGGATCATGAATTCCTTTGTCAACGATATCTTCGAGCGCATCGCCGGCGAGGCTTCCCGC
CTGGCTCATTACAACAAGCGTTCGACCATCACCTCCAGGGAGATCCAGACAGCCGTGCGC
CTGCTGCTGCCTGGGGAACTGGCCAAGCACGCCGTGTCCGAGGGCACTAAGGCCGTCACC
AAGTACACCAGCTCCAAATAA

Target 78 GenBank Gene ID

Not Available

Target 78 GeneCard ID

HIST1H2BH

Target 78 GenAtlas ID

HIST1H2BH

Target 78 HGNC ID

HGNC:4755

Target 78 Chromosome Location

Not Available

Target 78 Locus

Not Available

Target 78 SNPs

SNPJam Report Link Image

Target 78 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 78 General References

9119399; 12408966; 14574404; 16627869; 12757711; 16307923; 16283522; 16713563; 16457587; 16916647

Target 79 [top]

Target 79 ID

515

Target 79 Name

Histone H2B type 1-J

Target 79 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 79 Description

Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Target 79 Synonyms

H2B.r; H2B/r; H2B.1

Target 79 Gene Name

HIST1H2BJ

Target 79 Protein Sequence

>Histone H2B type 1-J

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSAK

Target 79 Number of Residues

126

Target 79 Molecular Weight

13904.1

Target 79 Theoretical pI

11.00

Target 79 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 79 General Function

Involved in DNA binding

Target 79 Pathways

Not Available

Target 79 Reactions

Not Available

Target 79 Signals

None

Target 79 Transmembrane Regions

None

Target 79 Essentiality

Non Essential

Target 79 Domain Function

PF00125:Histone

Target 79 GenBank ID Protein

Not Available

Target 79 UniProtKB ID

P06899

Target 79 Cellular Location

Nucleus

Target 79 Gene Sequence

>378 bp

ATGCCAGAGCCAGCGAAGTCTGCTCCCGCCCCGAAAAAGGGCTCCAAGAAGGCGGTGACT
AAGGCGCAGAAGAAAGACGGCAAGAGCGCAGCGCACCGCAAGGAGAGCTATTCCATCTAT
GTGTACAAGGTTCTGAAGCAGGTCCACCCTGACACCGGCATTTCGTCCAAGGCCATGGGC
ATCATGAATTCGTTTGTGAACGACATTTTCGAGCGCATCGCAGGTGAGGCTTCCCGCCTT
GCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGCCTG
CTGCTGCCTGGGGAGTTGGCCAAGCACGCCGTGTCCGAGGGTACTAAGGCCGTCACCAAG
TACACCAGCGCTAAGTAA

Target 79 GenBank Gene ID

Not Available

Target 79 GeneCard ID

HIST1H2BJ

Target 79 GenAtlas ID

HIST1H2BJ

Target 79 HGNC ID

HGNC:4761

Target 79 Chromosome Location

Not Available

Target 79 Locus

Not Available

Target 79 SNPs

SNPJam Report Link Image

Target 79 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 79 General References

6647026; 12408966; 14574404; 2917990; 11859126; 8620898; 12860195; 15019208; 16627869; 11709551

Target 80 [top]

Target 80 ID

521

Target 80 Name

Histone H2B type 1-L

Target 80 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 80 Description

Target 80 Synonyms

H2B.c; H2B/c

Target 80 Gene Name

HIST1H2BL

Target 80 Protein Sequence

>Histone H2B type 1-L

MPELAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIASEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 80 Number of Residues

126

Target 80 Molecular Weight

13952.1

Target 80 Theoretical pI

11.00

Target 80 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 80 General Function

Involved in DNA binding

Target 80 Pathways

Not Available

Target 80 Reactions

Not Available

Target 80 Signals

None

Target 80 Transmembrane Regions

None

Target 80 Essentiality

Non Essential

Target 80 Domain Function

PF00125:Histone

Target 80 GenBank ID Protein

Not Available

Target 80 UniProtKB ID

Q99880

Target 80 Cellular Location

Nucleus

Target 80 Gene Sequence

Not Available

Target 80 GenBank Gene ID

Not Available

Target 80 GeneCard ID

HIST1H2BL

Target 80 GenAtlas ID

HIST1H2BL

Target 80 HGNC ID

HGNC:4748

Target 80 Chromosome Location

Not Available

Target 80 Locus

Not Available

Target 80 SNPs

SNPJam Report Link Image

Target 80 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 80 General References

9439656; 12408966; 14702039; 14574404; 15489334; 16627869; 12757711; 16307923; 16283522; 16713563

Target 81 [top]

Target 81 ID

522

Target 81 Name

Histone H2B type 1-M

Target 81 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 81 Description

Target 81 Synonyms

H2B.e; H2B/e

Target 81 Gene Name

HIST1H2BM

Target 81 Protein Sequence

>Histone H2B type 1-M

MPEPVKSAPVPKKGSKKAINKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 81 Number of Residues

126

Target 81 Molecular Weight

13989.2

Target 81 Theoretical pI

11.00

Target 81 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 81 General Function

Involved in DNA binding

Target 81 Pathways

Not Available

Target 81 Reactions

Not Available

Target 81 Signals

None

Target 81 Transmembrane Regions

None

Target 81 Essentiality

Non Essential

Target 81 Domain Function

PF00125:Histone

Target 81 GenBank ID Protein

Not Available

Target 81 UniProtKB ID

Q99879

Target 81 Cellular Location

Nucleus

Target 81 Gene Sequence

>381 bp

ATGCCTGAACCAGTCAAATCTGCTCCAGTCCCTAAAAAAGGCTCCAAGAAGGCCATTAAC
AAGGCTCAGAAGAAGGATGGAAAGAAGCGCAAACGCAGCCGCAAGGAGAGCTACTCTGTG
TATGTGTACAAGGTGCTGAAGCAGGTCCACCCCGACACCGGCATCTCTTCCAAGGCTATG
GGAATCATGAACTCCTTCGTCAACGACATCTTTGAGCGTATCGCCGGAGAAGCGTCACGC
CTGGCGCATTACAACAAGCGCTCGACCATCACTTCGAGGGAGATCCAGACGGCCGTGCGC
CTACTGCTACCCGGGGAATTGGCCAAGCACGCCGTGTCCGAGGGCACCAAGGCCGTCACC
AAGTATACCAGCTCCAAATGA

Target 81 GenBank Gene ID

Not Available

Target 81 GeneCard ID

HIST1H2BM

Target 81 GenAtlas ID

HIST1H2BM

Target 81 HGNC ID

HGNC:4750

Target 81 Chromosome Location

Not Available

Target 81 Locus

Not Available

Target 81 SNPs

SNPJam Report Link Image

Target 81 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 81 General References

9439656; 12408966; 14574404; 15489334; 12757711; 16307923; 16283522; 16713563; 16457587

Target 82 [top]

Target 82 ID

523

Target 82 Name

Histone H2B type 1-N

Target 82 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 82 Description

Target 82 Synonyms

H2B.d; H2B/d

Target 82 Gene Name

HIST1H2BN

Target 82 Protein Sequence

>Histone H2B type 1-N

MPEPSKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 82 Number of Residues

126

Target 82 Molecular Weight

13922.0

Target 82 Theoretical pI

11.00

Target 82 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 82 General Function

Involved in DNA binding

Target 82 Pathways

Not Available

Target 82 Reactions

Not Available

Target 82 Signals

None

Target 82 Transmembrane Regions

None

Target 82 Essentiality

Non Essential

Target 82 Domain Function

PF00125:Histone

Target 82 GenBank ID Protein

Not Available

Target 82 UniProtKB ID

Q99877

Target 82 Cellular Location

Nucleus

Target 82 Gene Sequence

Not Available

Target 82 GenBank Gene ID

Not Available

Target 82 GeneCard ID

HIST1H2BN

Target 82 GenAtlas ID

HIST1H2BN

Target 82 HGNC ID

HGNC:4749

Target 82 Chromosome Location

Not Available

Target 82 Locus

Not Available

Target 82 SNPs

SNPJam Report Link Image

Target 82 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 82 General References

9439656; 12408966; 14574404; 15489334; 16627869; 12757711; 16307923; 16283522; 16713563; 16916647

Target 83 [top]

Target 83 ID

524

Target 83 Name

Histone H2B type 1-O

Target 83 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 83 Description

Target 83 Synonyms

H2B.n; H2B/n; H2B.2

Target 83 Gene Name

HIST1H2BO

Target 83 Protein Sequence

>Histone H2B type 1-O

MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 83 Number of Residues

126

Target 83 Molecular Weight

13906.0

Target 83 Theoretical pI

11.00

Target 83 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 83 General Function

Involved in DNA binding

Target 83 Pathways

Not Available

Target 83 Reactions

Not Available

Target 83 Signals

None

Target 83 Transmembrane Regions

None

Target 83 Essentiality

Non Essential

Target 83 Domain Function

PF00125:Histone

Target 83 GenBank ID Protein

Not Available

Target 83 UniProtKB ID

P23527

Target 83 Cellular Location

Nucleus

Target 83 Gene Sequence

>381 bp

ATGCCCGACCCGGCTAAATCTGCTCCTGCCCCCAAAAAGGGCTCCAAGAAAGCCGTAACC
AAGGCCCAGAAAAAGGACGGCAAGAAGCGCAAGCGCAGCCGCAAAGAGAGTTACTCTATC
TACGTGTACAAGGTGCTGAAGCAAGTCCACCCCGACACCGGCATCTCATCGAAGGCCATG
GGCATCATGAACTCCTTCGTCAATGACATCTTTGAGCGCATCGCTGGCGAGGCTTCCCGC
CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC
CTGCTGCTGCCCGGGGAGCTGGCCAAGCACGCCGTGTCCGAGGGCACAAAGGCCGTCACC
AAGTACACCAGCTCCAAGTGA

Target 83 GenBank Gene ID

Not Available

Target 83 GeneCard ID

HIST1H2BO

Target 83 GenAtlas ID

HIST1H2BO

Target 83 HGNC ID

HGNC:4758

Target 83 Chromosome Location

Not Available

Target 83 Locus

Not Available

Target 83 SNPs

SNPJam Report Link Image

Target 83 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 83 General References

1768865; 12408966; 14574404; 15489334; 16627869; 12757711; 16307923; 16283522; 16713563; 16916647

Target 84 [top]

Target 84 ID

517

Target 84 Name

Histone H2B type 2-E

Target 84 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 84 Description

Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Target 84 Synonyms

H2B.q; H2B/q; H2B-GL105

Target 84 Gene Name

HIST2H2BE

Target 84 Protein Sequence

>Histone H2B type 2-E

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 84 Number of Residues

126

Target 84 Molecular Weight

13920.1

Target 84 Theoretical pI

11.00

Target 84 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 84 General Function

Involved in DNA binding

Target 84 Pathways

Not Available

Target 84 Reactions

Not Available

Target 84 Signals

None

Target 84 Transmembrane Regions

None

Target 84 Essentiality

Non Essential

Target 84 Domain Function

PF00125:Histone

Target 84 GenBank ID Protein

Not Available

Target 84 UniProtKB ID

Q16778

Target 84 Cellular Location

Nucleus

Target 84 Gene Sequence

Not Available

Target 84 GenBank Gene ID

Not Available

Target 84 GeneCard ID

HIST2H2BE

Target 84 GenAtlas ID

HIST2H2BE

Target 84 HGNC ID

HGNC:4760

Target 84 Chromosome Location

Not Available

Target 84 Locus

1q21-q23

Target 84 SNPs

SNPJam Report Link Image

Target 84 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 84 General References

1469070; 12408966; 16710414; 15489334; 11859126; 8620898; 12860195; 15019208; 16627869

Target 85 [top]

Target 85 ID

525

Target 85 Name

Histone H2B type 2-F

Target 85 Mechanism of Action

Direct binding of histone leads to protein damage. (R016)

Target 85 Description

Target 85 Synonyms

Not Available

Target 85 Gene Name

HIST2H2BF

Target 85 Protein Sequence

>Histone H2B type 2-F

MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK

Target 85 Number of Residues

126

Target 85 Molecular Weight

13920.1

Target 85 Theoretical pI

11.00

Target 85 GO Classification

Function
binding nucleic acid binding DNA binding
Process
cellular physiological process cell organization and biogenesis organelle organization and biogenesis chromosome organization and biogenesis chromosome organization and biogenesis (sensu Eukaryota) physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism protein complex assembly nucleosome assembly
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus protein complex nucleosome

Target 85 General Function

Involved in DNA binding

Target 85 Pathways

Not Available

Target 85 Reactions

Not Available

Target 85 Signals

None

Target 85 Transmembrane Regions

None

Target 85 Essentiality

Non Essential

Target 85 Domain Function

PF00125:Histone

Target 85 GenBank ID Protein

Not Available

Target 85 UniProtKB ID

Q5QNW6

Target 85 Cellular Location

Nucleus

Target 85 Gene Sequence

>381 bp

ATGCCGGATCCAGCGAAATCCGCTCCTGCTCCCAAGAAGGGCTCCAAAAAGGCTGTTACG
AAAGTGCAGAAGAAGGACGGCAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTACTCCGTT
TACGTGTACAAGGTGCTGAAGCAGGTCCACCCCGACACCGGCATCTCGTCCAAGGCCATG
GGCATCATGAACTCCTTCGTCAACGACATCTTCGAGCGCATCGCGGGAGAGGCGTCCCGC
CTGGCGCACTACAACAAGCGCTCCACCATCACATCCCGCGAGATCCAGACGGCCGTGCGC
CTGCTGCTGCCCGGCGAGCTGGCCAAGCACGCCGTGTCCGAGGGCACCAAGGCGGTCACC
AAGTACACCAGCTCGAAGTAA

Target 85 GenBank Gene ID

Not Available

Target 85 GeneCard ID

HIST2H2BF

Target 85 GenAtlas ID

HIST2H2BF

Target 85 HGNC ID

HGNC:24700 Link Image

Target 85 Chromosome Location

Not Available

Target 85 Locus

1q21.2

Target 85 SNPs

SNPJam Report Link Image

Target 85 Toxin References

R016 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for benzene. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 85 General References

14702039; 16710414; 15489334; 12757711; 16307923; 16283522; 16713563; 16916647; 16319397