| Version |
1.0 |
| Creation Date |
2009-03-06 18:57:54 |
| Update Date |
2010-05-18 20:48:27 |
| Accession Number |
T3D0009 |
| Name |
Benzo[a]pyrene |
| Compound Type |
- Aromatic Hydrocarbon
- Industrial By-product/Pollutant
- Organic Compound
- Polycyclic Aromatic Hydrocarbon
|
| Description |
Benzo[a]pyrene is one of over 100 different polycyclic aromatic hydrocarbons (PAHs). PAHs are chemicals that are formed during the incomplete burning organic substances, such as fossil fuels. They are usually found as a mixture containing two or more of these compounds. (R028) |
| Synonyms |
- 1,2-Benzpyrene
- 3,4 Benzopyrene
- 3,4 Benzpyrene
- 3,4-Benz(a)pyrene
- 3,4-Benzo(a)pyrene
- 3,4-Benzopirene [Italian]
- 3,4-Benzopyrene (carcinogen)
- 3,4-Benzpyren [German]
- 3,4-Benzpyrene
- 3,4-Benzypyrene
- 3,4-benzylpyrene
- 4,5-Benzpyrene
- 6,7-Benzopyrene
- Benz(a)pyrene
- Benzo(a)pyrene
- Benzo(a)pyrene [polycyclic aromatic compounds]
- Benzo(a)pyrene [polycyclic aromatic hydrocarbons]
- Benzo(d,e,f)chrysene
- Benzo(def)chrysene
- Benzo[PQR]tetraphene
- Benzo[a]pyrene
- Benzo[a]pyrene solution
- Benzo[d,e,f]chrysene
- Benzo[def]chrysene
- Benzopyrene
- Benzpyrene
- benzo[def]chrysene
|
| Chemical IUPAC Name |
pentacyclo[10.6.2.0^{2,7}.0^{9,19}.0^{16,20}]icosa-1(19),2,4,6,8,10,12(20),13,15,17-decaene |
| Chemical Formula |
C20H12 |
| Chemical Structure |
 |
| CAS Registry Number |
50-32-8 |
| InChI Identifier |
InChI=1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H |
| InChI Key |
InChIKey=FMMWHPNWAFZXNH-UHFFFAOYSA-N |
| PubChem Compound ID |
2336  |
| KEGG ID |
C07535  |
| UniProt ID |
Not Available |
| OMIM ID |
Not Available |
| ChEBI ID |
29865  |
| BioCyc ID |
Not Available |
| SuperToxic ID |
Not Available |
| CTD ID |
D001564  |
| Stitch ID |
Benzo[a]pyrene  |
| DrugBank ID |
Not Available |
| PDB ID |
Not Available |
| ACToR ID |
141 |
| Wikipedia Link |
http://en.wikipedia.org/wiki/Benzo(a)pyrene  |
| Monoisotopic Mass |
252.0939 |
| MOL File |
Show |
| PDB File |
Show |
| SDF File |
Show |
| SMILES |
C1=CC=C2C(=C1)C=C1C=CC3=C4C(C=CC2=C14)=CC=C3 |
| Appearance |
Pale yellow solid. |
| Melting Point |
176.5 °C |
| Solubility |
1.62e-06 mg/mL at 25 °C [MAY,WE et al. (1983)] |
| Predicted LogP |
5.2734 |
| Route of Exposure |
Oral (R028) ; inhalation (R028 ; dermal (R028) |
| Mechanism of Action |
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. The main carcinogenic metabolite of benzo(a)pyrene is the diol-epoxide trans-9,10-epoxy-7,8-dihydrodiol. (R028, R060, R068, R073) |
| Metabolism |
PAH metabolism occurs in all tissues, usually by cytochrome P-450 and its associated enzymes. PAHs are metabolized into reactive intermediates, which include epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations. The phenols, quinones, and dihydrodiols can all be conjugated to glucuronides and sulfate esters; the quinones also form glutathione conjugates. (R028) |
| Toxicity Values |
LD50: 250 mg/kg (Intraperitoneal, Mouse) (R270) |
| Lethal Dose |
Not Available |
| Carcinogenicity (IARC Classification) |
1, carcinogenic to humans. (R264) |
| Uses/Sources |
PAHs are released into the environment via the combustion of fossil fuels, coke oven emissions and vehicle exhausts, as well as naturally from forest fires and volcanic eruptions. PAHs from these sources may contaminate nearly water systems. They are also found in coal tar and charbroiled food. (R028) |
| Minimum Risk Level |
Not Available |
| Health Effects |
PAHs are carcinogens and have been associated with the increased risk of skin, respiratory tract, bladder, stomach, and kidney cancers. They may also cause reproductive effects and depress the immune system. (R028) |
| Symptoms |
Acute exposure to PAHs causes irritation and inflammation of the skin and lung tissue. (R034)
|
| Treatment |
There is no known antidote for PAHs. Exposure is usually handled with symptomatic treatment. (R028) |
| General References |
- R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
- R270 - HSDB: Hazardous Substances Data Bank. National Library of Medicine (2001).
- R060 - Wikipedia. Benzopyrene. Last Updated 22 January 2009.
- R028 - ATSDR - Agency for Toxic Substances and Disease Registry (1995). Toxicological profile for PAHs. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
- R034 - Santodonato J, Howard P, Basu D: Health and ecological assessment of polynuclear aromatic hydrocarbons. J Environ Pathol Toxicol. 1981 Sep;5(1):1-364. [PubMed
]
- R073 - Padros J, Pelletier E: In vivo formation of (+)-anti-benzo[a]pyrene diol-epoxide-plasma albumin adducts in fish. Mar Environ Res. 2000 Jul-Dec;50(1-5):347-51. [PubMed
]
- R068 - Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW: Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med. 2008 Feb 15;44(4):570-83. Epub 2007 Nov 12. [PubMed
]
|
| Targets |
- Aryl hydrocarbon receptor
- Glycine N-methyltransferase
- DNA
|
|
Target 1
[top]
|
| Target 1 ID |
201 |
| Target 1 Name |
Aryl hydrocarbon receptor |
| Target 1 Mechanism of Action |
Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073) |
| Target 1 Description |
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues |
| Target 1 Synonyms |
- Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76
|
| Target 1 Gene Name |
AHR |
| Target 1 Protein Sequence |
>Aryl hydrocarbon receptor
MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDV
INKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQ
ALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP
SQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQ
GKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGC
DAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRW
TWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF
PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAP
FENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLY
SIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQ
QQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFV
PFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYP
MGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQH
THVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP
DLTSSGFL
|
| Target 1 Number of Residues |
848 |
| Target 1 Molecular Weight |
96146.7 |
| Target 1 Theoretical pI |
6.34 |
| Target 1 GO Classification |
|
Function
|
signal transducer activity
transcription regulator activity |
|
Process
|
cellular process
cell communication
signal transduction
regulation of transcription, DNA-dependent
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus |
|
| Target 1 General Function |
Involved in Hsp90 protein binding |
| Target 1 Pathways |
Not Available |
| Target 1 Reactions |
Not Available |
| Target 1 Signals |
|
| Target 1 Transmembrane Regions |
|
| Target 1 Essentiality |
Non Essential |
| Target 1 Domain Function |
PF00010:HLH
PF00989:PAS
PF08447:PAS_3 |
| Target 1 GenBank ID Protein |
Not Available |
| Target 1 UniProtKB ID |
P35869  |
| Target 1 Cellular Location |
Cytoplasm. Nucleus |
| Target 1 Gene Sequence |
>2427 bp
ATGAACAGCAGCAGCGCCAACATCACCTACGCCAGTCGCAAGCGGCGGAAGCCGGTGCAG
AAAACAGTAAAGCCAATCCCAGCTGAAGGAATCAAGTCAAATCCTTCCAAGCGGCATAGA
GACCGACTTAATACAGAGTTGGACCGTTTGGCTAGCCTGCTGCCTTTCCCACAAGATGTT
ATTAATAAGTTGGACAAACTTTCAGTTCTTAGGCTCAGCGTCAGTTACCTGAGAGCCAAG
AGCTTCTTTGATGTTGCATTAAAATCCTCCCCTACTGAAAGAAACGGAGGCCAGGATAAC
TGTAGAGCAGCAAATTTCAGAGAAGGCCTGAACTTACAAGAAGGAGAATTCTTATTACAG
GCTCTGAATGGCTTTGTATTAGTTGTCACTACAGATGCTTTGGTCTTTTATGCTTCTTCT
ACTATACAAGATTATCTAGGGTTTCAGCAGTCTGATGTCATACATCAGAGTGTATATGAA
CTTATCCATACCGAAGACCGAGCTGAATTTCAGCGTCAGCTACACTGGGCATTAAATCCT
TCTCAGTGTACAGAGTCTGGACAAGGAATTGAAGAAGCCACTGGTCTCCCCCAGACAGTA
GTCTGTTATAACCCAGACCAGATTCCTCCAGAAAACTCTCCTTTAATGGAGAGGTGCTTC
ATATGTCGTCTAAGGTGTCTGCTGGATAATTCATCTGGTTTTCTGGCAATGAATTTCCAA
GGGAAGTTAAAGTATCTTCATGGACAGAAAAAGAAAGGGAAAGATGGATCAATACTTCCA
CCTCAGTTGGCTTTGTTTGCGATAGCTACTCCACTTCAGCCACCATCCATACTTGAAATC
CGGACCAAAAATTTTATCTTTAGAACCAAACACAAACTAGACTTCACACCTATTGGTTGT
GATGCCAAAGGAAGAATTGTTTTAGGATATACTGAAGCAGAGCTGTGCACGAGAGGCTCA
GGTTATCAGTTTATTCATGCAGCTGATATGCTTTATTGTGCCGAGTCCCATATCCGAATG
ATTAAGACTGGAGAAAGTGGCATGATAGTTTTCCGGCTTCTTACAAAAAACAACCGATGG
ACTTGGGTCCAGTCTAATGCACGCCTGCTTTATAAAAATGGAAGACCAGATTATATCATT
GTAACTCAGAGACCACTAACAGATGAGGAAGGAACAGAGCATTTACGAAAACGAAATACG
AAGTTGCCTTTTATGTTTACCACTGGAGAAGCTGTGTTGTATGAGGCAACCAACCCTTTT
CCTGCCATAATGGATCCCTTACCACTAAGGACTAAAAATGGCACTAGTGGAAAAGACTCT
GCTACCACATCCACTCTAAGCAAGGACTCTCTCAATCCTAGTTCCCTCCTGGCTGCCATG
ATGCAACAAGATGAGTCTATTTATCTCTATCCTGCTTCAAGTACTTCAAGTACTGCACCT
TTTGAAAACAACTTTTTCAACGAATCTATGAATGAATGCAGAAATTGGCAAGATAATACT
GCACCGATGGGAAATGATACTATCCTGAAACATGAGCAAATTGACCAGCCTCAGGATGTG
AACTCATTTGCTGGAGGTCACCCAGGGCTCTTTCAAGATAGTAAAAACAGTGACTTGTAC
AGCATAATGAAAAACCTAGGCATTGATTTTGAAGACATCAGACACATGCAGAATGAAAAA
TTTTTCAGAAATGATTTTTCTGGTGAGGTTGACTTCAGAGACATTGACTTAACGGATGAA
ATCCTGACGTATGTCCAAGATTCTTTAAGTAAGTCTCCCTTCATACCTTCAGATTATCAA
CAGCAACAGTCCTTGGCTCTGAACTCAAGCTGTATGGTACAGGAACACCTACATCTAGAA
CAGCAACAGCAACATCACCAAAAGCAAGTAGTAGTGGAGCCACAGCAACAGCTGTGTCAG
AAGATGAAGCACATGCAAGTTAATGGCATGTTTGAAAATTGGAACTCTAACCAATTCGTG
CCTTTCAATTGTCCACAGCAAGACCCACAACAATATAATGTCTTTACAGACTTACATGGG
ATCAGTCAAGAGTTCCCCTACAAATCTGAAATGGATTCTATGCCTTATACACAGAACTTT
ATTTCCTGTAATCAGCCTGTATTACCACAACATTCCAAATGTACAGAGCTGGACTACCCT
ATGGGGAGTTTTGAACCATCCCCATACCCCACTACTTCTAGTTTAGAAGATTTTGTCACT
TGTTTACAACTTCCTGAAAACCAAAAGCATGGATTAAATCCACAGTCAGCCATAATAACT
CCTCAGACATGTTATGCTGGGGCCGTGTCGATGTATCAGTGCCAGCCAGAACCTCAGCAC
ACCCACGTGGGTCAGATGCAGTACAATCCAGTACTGCCAGGCCAACAGGCATTTTTAAAC
AAGTTTCAGAATGGAGTTTTTAAATGA
|
| Target 1 GenBank Gene ID |
Not Available |
| Target 1 GeneCard ID |
AHR  |
| Target 1 GenAtlas ID |
AHR  |
| Target 1 HGNC ID |
HGNC:348  |
| Target 1 Chromosome Location |
Not Available |
| Target 1 Locus |
7p15 |
| Target 1 SNPs |
SNPJam Report  |
| Target 1 Toxin References |
- R060 - Wikipedia. Benzopyrene. Last Updated 22 January 2009.
- R028 - ATSDR - Agency for Toxic Substances and Disease Registry (1995). Toxicological profile for PAHs. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
- R073 - Padros J, Pelletier E: In vivo formation of (+)-anti-benzo[a]pyrene diol-epoxide-plasma albumin adducts in fish. Mar Environ Res. 2000 Jul-Dec;50(1-5):347-51. [PubMed
]
- R068 - Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW: Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med. 2008 Feb 15;44(4):570-83. Epub 2007 Nov 12. [PubMed
]
|
| Target 1 General References |
8393992; 8246913; 7883760; 12853948; 15489334; 16696038; 7515333; 7961644; 10395741; 11259615 |
|
Target 2
[top]
|
| Target 2 ID |
140 |
| Target 2 Name |
Glycine N-methyltransferase |
| Target 2 Mechanism of Action |
Many PAH's induce the expression of cytochrome P450 enzymes, especially CYP1A1, CYP1A2, and CYP1B1, by binding to the aryl hydrocarbon receptor or glycine N-methyltransferase protein. These enzymes metabolize PAH's into their toxic intermediates. The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073) |
| Target 2 Description |
Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine |
| Target 2 Synonyms |
Not Available |
| Target 2 Gene Name |
GNMT |
| Target 2 Protein Sequence |
>Glycine N-methyltransferase
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQR
VLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMT
LDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNY
DHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSK
FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
|
| Target 2 Number of Residues |
295 |
| Target 2 Molecular Weight |
32742.0 |
| Target 2 Theoretical pI |
7.03 |
| Target 2 GO Classification |
|
Function
|
| Not Available |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 2 General Function |
Secondary metabolites biosynthesis, transport and catabolism |
| Target 2 Pathways |
Not Available |
| Target 2 Reactions |
Not Available |
| Target 2 Signals |
|
| Target 2 Transmembrane Regions |
|
| Target 2 Essentiality |
Non Essential |
| Target 2 Domain Function |
PF08242:Methyltransf_12 |
| Target 2 GenBank ID Protein |
Not Available |
| Target 2 UniProtKB ID |
Q14749  |
| Target 2 Cellular Location |
Cytoplasm |
| Target 2 Gene Sequence |
>888 bp
ATGGTGGACAGCGTGTACCGGACCCGCTCCCTGGGGGTGGCGGCCGAAGGGCTCCCGGAC
CAGTACGCGGACGGGGAGGCGGCGCGCGTGTGGCAGCTGTATATCGGAGACACCCGCAGC
CGCACCGCCGAGTACAAGGCATGGCTGCTTGGGCTGCTGCGCCAGCACGGCTGCCAGCGG
GTGCTCGACGTAGCCTGTGGCACTGGGGTGGACTCCATTATGCTGGTGGAAGAGGGCTTC
AGTGTGACGAGTGTGGATGCCAGTGACAAGATGCTGAAGTATGCACTTAAGGAGCGCTGG
AACCGGCGGCACGAGCCCGCCTTCGACAAGTGGGTCATCGAAGAAGCCAACTGGATGACT
CTGGACAAAGATGTGCCCCAGTCAGCAGAGGGTGGCTTTGATGCTGTCATCTGCCTTGGA
AACAGTTTCGCTCACTTGCCAGACTGCAAAGGGGACCAGAGTGAGCACCGGCTGGCGCTG
AAAAACATTGCGAGCATGGTGCGGGCAGGGGGCCTACTGGTCATTGATCATCGCAACTAC
GACCACATCCTCAGTACAGGCTGTGCACCCCCAGGGAAGAACATCTACTATAAGAGTGAC
TTGACCAAGGACGTCACAACATCAGTGCTGATAGTGAACAACAAGGCCCACATGGTGACC
CTGGACTATACGGTGCAGGTGCCGGGGGCTGGCCAGGATGGCTCTCCTGGCTTGAGTAAG
TTCCGGCTCTCCTACTACCCACACTGTCTGGCATCCTTCACGGAGCTGCTCCAAGCAGCC
TTCGGAGGTAAGTGCCAGCACAGCGTCCTGGGCGACTTCAAGCCTTACAAGCCAGGCCAA
ACCTACATTCCCTGCTACTTCATCCACGTGCTCAAGAGGACAGACTGA
|
| Target 2 GenBank Gene ID |
Not Available |
| Target 2 GeneCard ID |
GNMT  |
| Target 2 GenAtlas ID |
GNMT  |
| Target 2 HGNC ID |
HGNC:4415  |
| Target 2 Chromosome Location |
Not Available |
| Target 2 Locus |
6p12 |
| Target 2 SNPs |
SNPJam Report  |
| Target 2 Toxin References |
- R060 - Wikipedia. Benzopyrene. Last Updated 22 January 2009.
- R028 - ATSDR - Agency for Toxic Substances and Disease Registry (1995). Toxicological profile for PAHs. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
- R073 - Padros J, Pelletier E: In vivo formation of (+)-anti-benzo[a]pyrene diol-epoxide-plasma albumin adducts in fish. Mar Environ Res. 2000 Jul-Dec;50(1-5):347-51. [PubMed
]
- R068 - Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW: Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med. 2008 Feb 15;44(4):570-83. Epub 2007 Nov 12. [PubMed
]
|
| Target 2 General References |
9495250; 10843803; 14574404; 15489334; 8281755; 15340920; 17660255; 11810299; 14651980 |
|
Target 3
[top]
|
| Target 3 ID |
632 |
| Target 3 Name |
DNA |
| Target 3 Mechanism of Action |
The reactive metabolites of PAHs (epoxide intermediates, dihydrodiols, phenols, quinones, and their various combinations) covalently bind to DNA and other cellular macromolecules, initiating mutagenesis and carcinogenesis. (R028, R060, R068, R073) |
| Target 3 Description |
Not Available |
| Target 3 Synonyms |
Not Available |
| Target 3 Gene Name |
Not Available |
| Target 3 Protein Sequence |
Not Available |
| Target 3 Number of Residues |
Not Available |
| Target 3 Molecular Weight |
Not Available |
| Target 3 Theoretical pI |
Not Available |
| Target 3 GO Classification |
|
Function
|
| Not Available |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 3 General Function |
Not Available |
| Target 3 Pathways |
Not Available |
| Target 3 Reactions |
Not Available |
| Target 3 Signals |
Not Available |
| Target 3 Transmembrane Regions |
Not Available |
| Target 3 Essentiality |
Not Available |
| Target 3 Domain Function |
Not Available |
| Target 3 GenBank ID Protein |
Not Available |
| Target 3 UniProtKB ID |
DNA  |
| Target 3 Cellular Location |
Not Available |
| Target 3 Gene Sequence |
Not Available |
| Target 3 GenBank Gene ID |
Not Available |
| Target 3 GeneCard ID |
Not Available |
| Target 3 GenAtlas ID |
Not Available |
| Target 3 HGNC ID |
Not Available |
| Target 3 Chromosome Location |
Not Available |
| Target 3 Locus |
Not Available |
| Target 3 SNPs |
Not Available |
| Target 3 Toxin References |
- R060 - Wikipedia. Benzopyrene. Last Updated 22 January 2009.
- R028 - ATSDR - Agency for Toxic Substances and Disease Registry (1995). Toxicological profile for PAHs. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
- R073 - Padros J, Pelletier E: In vivo formation of (+)-anti-benzo[a]pyrene diol-epoxide-plasma albumin adducts in fish. Mar Environ Res. 2000 Jul-Dec;50(1-5):347-51. [PubMed
]
- R068 - Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW: Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med. 2008 Feb 15;44(4):570-83. Epub 2007 Nov 12. [PubMed
]
|
| Target 3 General References |
Not Available |