|
Target 1
[top]
|
| Target 1 ID |
2 |
| Target 1 Name |
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial |
| Target 1 Mechanism of Action |
Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001) |
| Target 1 Description |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) |
| Target 1 Synonyms |
- PDHE1-A type II
|
| Target 1 Gene Name |
PDHA2 |
| Target 1 Protein Sequence |
>Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGL
KYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHG
VCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACK
YKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDY
YKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYR
TREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEPHLE
ELGHHIYSSDSSFEVRGANPWIKFKSVS
|
| Target 1 Number of Residues |
388 |
| Target 1 Molecular Weight |
42932.9 |
| Target 1 Theoretical pI |
8.56 |
| Target 1 GO Classification |
|
Function
|
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
|
Process
|
physiological process
metabolism |
|
Component
|
| Not Available |
|
| Target 1 General Function |
Energy production and conversion |
| Target 1 Pathways |
Not Available |
| Target 1 Reactions |
Not Available |
| Target 1 Signals |
|
| Target 1 Transmembrane Regions |
|
| Target 1 Essentiality |
Non Essential |
| Target 1 Domain Function |
PF00676:E1_dh |
| Target 1 GenBank ID Protein |
Not Available |
| Target 1 UniProtKB ID |
P29803  |
| Target 1 Cellular Location |
Mitochondrion matrix |
| Target 1 Gene Sequence |
Not Available |
| Target 1 GenBank Gene ID |
Not Available |
| Target 1 GeneCard ID |
PDHA2 |
| Target 1 GenAtlas ID |
PDHA2 |
| Target 1 HGNC ID |
HGNC:8807 |
| Target 1 Chromosome Location |
Not Available |
| Target 1 Locus |
4q22-q23 |
| Target 1 SNPs |
SNPJam Report |
| Target 1 Toxin References |
- R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.
|
| Target 1 General References |
2249846; 14702039; 15489334; 17081983; 18083107; 18088087; 18669648 |
|
Target 2
[top]
|
| Target 2 ID |
3 |
| Target 2 Name |
Hemoglobin subunit beta |
| Target 2 Mechanism of Action |
Arsenic binds to hemoglobin. (R052) |
| Target 2 Description |
LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure |
| Target 2 Synonyms |
- Hemoglobin beta chain; Beta-globin; LVV-hemorphin-7
|
| Target 2 Gene Name |
HBB |
| Target 2 Protein Sequence |
>Hemoglobin subunit beta
MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG
KEFTPPVQAAYQKVVAGVANALAHKYH
|
| Target 2 Number of Residues |
147 |
| Target 2 Molecular Weight |
15998.3 |
| Target 2 Theoretical pI |
7.32 |
| Target 2 GO Classification |
|
Function
|
oxygen binding
binding
tetrapyrrole binding
heme binding |
|
Process
|
physiological process
cellular physiological process
transport
gas transport
oxygen transport |
|
Component
|
protein complex
hemoglobin complex |
|
| Target 2 General Function |
Involved in heme binding |
| Target 2 Pathways |
Not Available |
| Target 2 Reactions |
Not Available |
| Target 2 Signals |
|
| Target 2 Transmembrane Regions |
|
| Target 2 Essentiality |
Non Essential |
| Target 2 Domain Function |
PF00042:Globin |
| Target 2 GenBank ID Protein |
Not Available |
| Target 2 UniProtKB ID |
P68871 |
| Target 2 Cellular Location |
Not Available |
| Target 2 Gene Sequence |
>444 bp
ATGGTNCAYYTNACNCCNGTGGAGAAGTCYGCYGTNACNGCNCTNTGGGGYAAGGTNAAY
GTGGATGAAGYYGGYGGYGAGGCCCTGGGCAGNCTGCTNGTGGTCTACCCTTGGACCCAG
AGGTTCTTNGANTCNTTYGGGGATCTGNNNACNCCNGANGCAGTTATGGGCAACCCTAAG
GTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGAC
AACCTCAAGGGCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTNCAYGTGGAT
CCTGAGAACTTCAGGCTNCTNGGCAACGTGYTNGTCTGYGTGCTGGCCCATCACTTTGGC
AAAGAATTCACCCCACCAGTGCANGCNGCCTATCAGAAAGTGGTNGCTGGTGTNGCTAAT
GCCCTGGCCCACAAGTATCACTAA
|
| Target 2 GenBank Gene ID |
Not Available |
| Target 2 GeneCard ID |
HBB |
| Target 2 GenAtlas ID |
HBB |
| Target 2 HGNC ID |
HGNC:4827 |
| Target 2 Chromosome Location |
Chromosome:11 |
| Target 2 Locus |
11p15.5 |
| Target 2 SNPs |
SNPJam Report |
| Target 2 Toxin References |
- R052 - Naranmandura H, Suzuki KT: Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex. Chem Res Toxicol. 2008 Mar;21(3):678-85. Epub 2008 Feb 2. [PubMed ]
|
| Target 2 General References |
1019344; 6254664; 16175509 |
|
Target 3
[top]
|
| Target 3 ID |
4 |
| Target 3 Name |
Hemoglobin subunit alpha |
| Target 3 Mechanism of Action |
Arsenic binds to hemoglobin. (R052) |
| Target 3 Description |
Involved in oxygen transport from the lung to the various peripheral tissues |
| Target 3 Synonyms |
- Hemoglobin alpha chain; Alpha-globin
|
| Target 3 Gene Name |
HBA1 |
| Target 3 Protein Sequence |
>Hemoglobin subunit alpha
MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG
KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP
AVHASLDKFLASVSTVLTSKYR
|
| Target 3 Number of Residues |
142 |
| Target 3 Molecular Weight |
15257.4 |
| Target 3 Theoretical pI |
9.09 |
| Target 3 GO Classification |
|
Function
|
oxygen binding
binding |
|
Process
|
gas transport
oxygen transport
physiological process
cellular physiological process
transport |
|
Component
|
protein complex
hemoglobin complex |
|
| Target 3 General Function |
Involved in heme binding |
| Target 3 Pathways |
Not Available |
| Target 3 Reactions |
Not Available |
| Target 3 Signals |
|
| Target 3 Transmembrane Regions |
|
| Target 3 Essentiality |
Non Essential |
| Target 3 Domain Function |
PF00042:Globin |
| Target 3 GenBank ID Protein |
Not Available |
| Target 3 UniProtKB ID |
P69905 |
| Target 3 Cellular Location |
Not Available |
| Target 3 Gene Sequence |
>429 bp
ATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGGCAAGGTTGGCGCG
CACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCCTGTCCTTCCCCACCACC
AAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTGCCCAGGTTAAGGGCCACGGC
AAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCGCACGTGGACGACATGCCCAACGCG
CTGTCCGCCCTGAGCGACCTGCACGCGCACAAGCTTCGGGTGGACCCGGTCAACTTCAAG
CTCCTAAGCCACTGCCTGCTGGTGACCCTGGCCGCCCACCTCCCCGCCGAGTTCACCCCT
GCGGTGCACGCCTCCCTGGACAAGTTCCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAA
TACCGTTAA
|
| Target 3 GenBank Gene ID |
Not Available |
| Target 3 GeneCard ID |
HBA1 |
| Target 3 GenAtlas ID |
HBA1 |
| Target 3 HGNC ID |
HGNC:4823 |
| Target 3 Chromosome Location |
Chromosome:16 |
| Target 3 Locus |
16p13.3 |
| Target 3 SNPs |
SNPJam Report |
| Target 3 Toxin References |
- R052 - Naranmandura H, Suzuki KT: Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex. Chem Res Toxicol. 2008 Mar;21(3):678-85. Epub 2008 Feb 2. [PubMed ]
|
| Target 3 General References |
7448866; 6244294; 6452630; 6946451; 11410421; 11402454; 16728641 |
|
Target 4
[top]
|
| Target 4 ID |
222 |
| Target 4 Name |
Haptoglobin |
| Target 4 Mechanism of Action |
Arsenic binds to haptoglobin. (R052) |
| Target 4 Description |
Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes |
| Target 4 Synonyms |
- Haptoglobin alpha chain; Haptoglobin beta chain
|
| Target 4 Gene Name |
HP |
| Target 4 Protein Sequence |
>Haptoglobin
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
|
| Target 4 Number of Residues |
406 |
| Target 4 Molecular Weight |
45205.1 |
| Target 4 Theoretical pI |
6.56 |
| Target 4 GO Classification |
|
Function
|
catalytic activity
hydrolase activity
peptidase activity
endopeptidase activity
serine-type endopeptidase activity
binding
protein binding
hemoglobin binding |
|
Process
|
physiological process
metabolism
macromolecule metabolism
protein metabolism
cellular protein metabolism
proteolysis |
|
Component
|
| extracellular region |
|
| Target 4 General Function |
Involved in hemoglobin binding |
| Target 4 Pathways |
Not Available |
| Target 4 Reactions |
Not Available |
| Target 4 Signals |
|
| Target 4 Transmembrane Regions |
|
| Target 4 Essentiality |
Non Essential |
| Target 4 Domain Function |
PF00089:Trypsin |
| Target 4 GenBank ID Protein |
Not Available |
| Target 4 UniProtKB ID |
P00738 |
| Target 4 Cellular Location |
Secreted |
| Target 4 Gene Sequence |
>1221 bp
DDEISITE.AGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGG
GGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGC
CCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAG
AACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATAATAAGAAGCAG
TGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCG
AAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTCCGCTACCAGTGTAAGAAC
TACTACAAACTGCGCACAGAAGGAGATGGAGTGTACACCTTAAACAATGAGAAGCAGTGG
ATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAG
AATCCGGCAAACCCAGTGCAGCGGATCCTAGGTGGACACCTTGATGCCAAAGGCAGCTTT
CCCTGGCAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAAT
GAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACA
GCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATT
GAGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAA
CAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCA
GAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACT
GACCATCTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTAT
GAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATA
CTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGC
GATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGG
ATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACT
TCCATCCAGGACTGGGTTCAG
|
| Target 4 GenBank Gene ID |
Not Available |
| Target 4 GeneCard ID |
HP |
| Target 4 GenAtlas ID |
HP |
| Target 4 HGNC ID |
HGNC:5141 |
| Target 4 Chromosome Location |
Chromosome:16 |
| Target 4 Locus |
16q22.1 |
| Target 4 SNPs |
SNPJam Report |
| Target 4 Toxin References |
- R052 - Naranmandura H, Suzuki KT: Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex. Chem Res Toxicol. 2008 Mar;21(3):678-85. Epub 2008 Feb 2. [PubMed ]
|
| Target 4 General References |
6688992; 6310599; 6546723; 6330675; 4018023; 2987228; 1478675; 14702039; 15489334 |
|
Target 5
[top]
|
| Target 5 ID |
5 |
| Target 5 Name |
Estrogen receptor |
| Target 5 Mechanism of Action |
Arsenic binds to the estrogen receptor. (R054) |
| Target 5 Description |
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues |
| Target 5 Synonyms |
- ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
|
| Target 5 Gene Name |
ESR1 |
| Target 5 Protein Sequence |
>Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
| Target 5 Number of Residues |
595 |
| Target 5 Molecular Weight |
66215.4 |
| Target 5 Theoretical pI |
8.14 |
| Target 5 GO Classification |
|
Function
|
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity |
|
Process
|
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus |
|
| Target 5 General Function |
Involved in estrogen receptor activity |
| Target 5 Pathways |
Not Available |
| Target 5 Reactions |
Not Available |
| Target 5 Signals |
|
| Target 5 Transmembrane Regions |
|
| Target 5 Essentiality |
Non Essential |
| Target 5 Domain Function |
PF00104:Hormone_recep
PF02159:Oest_recep
PF00105:zf-C4 |
| Target 5 GenBank ID Protein |
Not Available |
| Target 5 UniProtKB ID |
P03372 |
| Target 5 Cellular Location |
Nucleus |
| Target 5 Gene Sequence |
>63 bp
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
|
| Target 5 GenBank Gene ID |
Not Available |
| Target 5 GeneCard ID |
ESR1 |
| Target 5 GenAtlas ID |
ESR1 |
| Target 5 HGNC ID |
HGNC:3467 |
| Target 5 Chromosome Location |
Not Available |
| Target 5 Locus |
6q25.1 |
| Target 5 SNPs |
SNPJam Report |
| Target 5 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 5 General References |
3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106 |
|
Target 6
[top]
|
| Target 6 ID |
6 |
| Target 6 Name |
Glucocorticoid receptor |
| Target 6 Mechanism of Action |
Arsenic binds to the glucocorticoid receptor. (R054) |
| Target 6 Description |
Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity) |
| Target 6 Synonyms |
- GR; Nuclear receptor subfamily 3 group C member 1
|
| Target 6 Gene Name |
NR3C1 |
| Target 6 Protein Sequence |
>Glucocorticoid receptor
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
|
| Target 6 Number of Residues |
777 |
| Target 6 Molecular Weight |
85658.6 |
| Target 6 Theoretical pI |
6.31 |
| Target 6 GO Classification |
|
Function
|
transcription factor activity
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
glucocorticoid receptor activity
binding
nucleic acid binding
DNA binding |
|
Process
|
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus |
|
| Target 6 General Function |
Involved in glucocorticoid receptor activity |
| Target 6 Pathways |
Not Available |
| Target 6 Reactions |
Not Available |
| Target 6 Signals |
|
| Target 6 Transmembrane Regions |
|
| Target 6 Essentiality |
Non Essential |
| Target 6 Domain Function |
PF02155:GCR
PF00104:Hormone_recep
PF00105:zf-C4 |
| Target 6 GenBank ID Protein |
Not Available |
| Target 6 UniProtKB ID |
P04150 |
| Target 6 Cellular Location |
Cytoplasm. Nucleus |
| Target 6 Gene Sequence |
>2334 bp
ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA
|
| Target 6 GenBank Gene ID |
Not Available |
| Target 6 GeneCard ID |
NR3C1 |
| Target 6 GenAtlas ID |
NR3C1 |
| Target 6 HGNC ID |
HGNC:7978 |
| Target 6 Chromosome Location |
Not Available |
| Target 6 Locus |
5q31.3 |
| Target 6 SNPs |
SNPJam Report |
| Target 6 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 6 General References |
2867473; 1707881; 17974005; 15372022; 15489334; 2026589; 1958537 |
|
Target 7
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|
| Target 7 ID |
7 |
| Target 7 Name |
Glutathione reductase, mitochondrial |
| Target 7 Mechanism of Action |
Arsenic binds glutathione reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009) |
| Target 7 Description |
Maintains high levels of reduced glutathione in the cytosol |
| Target 7 Synonyms |
- GRase; GR
|
| Target 7 Gene Name |
GSR |
| Target 7 Protein Sequence |
>Glutathione reductase, mitochondrial
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
|
| Target 7 Number of Residues |
522 |
| Target 7 Molecular Weight |
56256.6 |
| Target 7 Theoretical pI |
8.66 |
| Target 7 GO Classification |
|
Function
|
disulfide oxidoreductase activity
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
FAD binding
catalytic activity
oxidoreductase activity
transporter activity
electron transporter activity
glutathione-disulfide reductase activity |
|
Process
|
generation of precursor metabolites and energy
electron transport
physiological process
metabolism
cellular metabolism
cofactor metabolism
coenzyme metabolism
glutathione metabolism |
|
Component
|
cell
intracellular
cytoplasm |
|
| Target 7 General Function |
RNA processing and modification |
| Target 7 Pathways |
Not Available |
| Target 7 Reactions |
Not Available |
| Target 7 Signals |
|
| Target 7 Transmembrane Regions |
|
| Target 7 Essentiality |
Non Essential |
| Target 7 Domain Function |
PF00070:Pyr_redox
PF07992:Pyr_redox_2
PF02852:Pyr_redox_dim |
| Target 7 GenBank ID Protein |
Not Available |
| Target 7 UniProtKB ID |
P00390 |
| Target 7 Cellular Location |
Mitochondrion. Cytoplasm |
| Target 7 Gene Sequence |
>1440 bp
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCC
TCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCG
GCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATG
CATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATT
AAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACA
ATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATG
CCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCT
GTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCAT
GATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGTCAAGGAGGTTAAAAAGACTTTGTCG
GGCTTGGAAGTCAGCATGGTTACTGCAGTTCCCGGTAGGCTACCAGTCATGACCATGATT
CCAGATGTTGACTGCCTGCTCTGGGCCATTGGGCGGGTCCCGAATACCAAGGACCTGAGT
TTAAACAAACTGGGGATTCAAACCGATGACAAGGGTCATATCATCGTAGACGAATTCCAG
AATACCAACGTCAAAGGCATCTATGCAGTTGGGGATGTATGTGGAAAAGCTCTTCTTACT
CCAGTTGCAATAGCTGCTGGCCGAAAACTTGCCCATCGACTTTTTGAATATAAGGAAGAT
TCCAAATTAGATTATAACAACATCCCAACTGTGGTCTTCAGCCACCCCCCTATTGGGACA
GTGGGACTCACGGAAGATGAAGCCATTCATAAATATGGAATAGAAAATGTGAAGACCTAT
TCAACGAGCTTTACCCCGATGTATCACGCAGTTACCAAAAGGAAAACAAAATGTGTGATG
AAAATGGTCTGTGCTAACAAGGAAGAAAAGGTGGTTGGGATCCATATGCAGGGACTTGGG
TGTGATGAAATGCTGCAGGGTTTTGCTGTTGCAGTGAAGATGGGAGCAACGAAGGCAGAC
TTTGACAACACAGTCGCCATTCACCCTACCTCTTCAGAAGAGCTGGTCACACTTCGTTGA
|
| Target 7 GenBank Gene ID |
Not Available |
| Target 7 GeneCard ID |
GSR |
| Target 7 GenAtlas ID |
GSR |
| Target 7 HGNC ID |
HGNC:4623 |
| Target 7 Chromosome Location |
Not Available |
| Target 7 Locus |
8p21.1 |
| Target 7 SNPs |
SNPJam Report |
| Target 7 Toxin References |
- R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
|
| Target 7 General References |
2185014; 10708558; 16421571; 15489334; 7060551; 923580; 15592455; 7334521 |
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Target 8
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| Target 8 ID |
8 |
| Target 8 Name |
Kelch-like ECH-associated protein 1 |
| Target 8 Mechanism of Action |
Arsenic binds to kelch-like ECH-associated protein 1. (R054) |
| Target 8 Description |
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome |
| Target 8 Synonyms |
- Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19
|
| Target 8 Gene Name |
KEAP1 |
| Target 8 Protein Sequence |
>Kelch-like ECH-associated protein 1
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
|
| Target 8 Number of Residues |
624 |
| Target 8 Molecular Weight |
69665.8 |
| Target 8 Theoretical pI |
6.42 |
| Target 8 GO Classification |
|
Function
|
binding
protein binding |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 8 General Function |
Involved in regulation of transcription |
| Target 8 Pathways |
Not Available |
| Target 8 Reactions |
Not Available |
| Target 8 Signals |
|
| Target 8 Transmembrane Regions |
|
| Target 8 Essentiality |
Non Essential |
| Target 8 Domain Function |
PF07707:BACK
PF00651:BTB
PF01344:Kelch_1 |
| Target 8 GenBank ID Protein |
Not Available |
| Target 8 UniProtKB ID |
Q14145 |
| Target 8 Cellular Location |
Cytoplasm. Nucleus |
| Target 8 Gene Sequence |
>1875 bp
ATGCAGCCAGATCCCAGGCCTAGCGGGGCTGGGGCCTGCTGCCGATTCCTGCCCCTGCAG
TCACAGTGCCCTGAGGGGGCAGGGGACGCGGTGATGTACGCCTCCACTGAGTGCAAGGCG
GAGGTGACGCCCTCCCAGCATGGCAACCGCACCTTCAGCTACACCCTGGAGGATCATACC
AAGCAGGCCTTTGGCATCATGAACGAGCTGCGGCTCAGCCAGCAGCTGTGTGACGTCACA
CTGCAGGTCAAGTACCAGGATGCACCGGCCGCCCAGTTCATGGCCCACAAGGTGGTGCTG
GCCTCATCCAGCCCTGTCTTCAAGGCCATGTTCACCAACGGGCTGCGGGAGCAGGGCATG
GAGGTGGTGTCCATTGAGGGTATCCACCCCAAGGTCATGGAGCGCCTCATTGAATTCGCC
TACACGGCCTCCATCTCCATGGGCGAGAAGTGTGTCCTCCACGTCATGAACGGTGCTGTC
ATGTACCAGATCGACAGCGTTGTCCGTGCCTGCAGTGACTTCCTGGTGCAGCAGCTGGAC
CCCAGCAATGCCATCGGCATCGCCAACTTCGCTGAGCAGATTGGCTGTGTGGAGTTGCAC
CAGCGTGCCCGGGAGTACATCTACATGCATTTTGGGGAGGTGGCCAAGCAAGAGGAGTTC
TTCAACCTGTCCCACTGCCAACTGGTGACCCTCATCAGCCGGGACGACCTGAACGTGCGC
TGCGAGTCCGAGGTCTTCCACGCCTGCATCAACTGGGTCAAGTACGACTGCGAACAGCGA
CGGTTCTACGTCCAGGCGCTGCTGCGGGCCGTGCGCTGCCACTCGTTGACGCCGAACTTC
CTGCAGATGCAGCTGCAGAAGTGCGAGATCCTGCAGTCCGACTCCCGCTGCAAGGACTAC
CTGGTCAAGATCTTCGAGGAGCTCACCCTGCACAAGCCCACGCAGGTGATGCCCTGCCGG
GCGCCCAAGGTGGGCCGCCTGATCTACACCGCGGGCGGCTACTTCCGACAGTCGCTCAGC
TACCTGGAGGCTTACAACCCCAGTGACGGCACCTGGCTCCGGTTGGCGGACCTGCAGGTG
CCGCGGAGCGGCCTGGCCGGCTGCGTGGTGGGCGGGCTGTTGTACGCCGTGGGCGGCAGG
AACAACTCGCCCGACGGCAACACCGACTCCAGCGCCCTGGACTGTTACAACCCCATGACC
AATCAGTGGTCGCCCTGCGCCCCCATGAGCGTGCCCCGTAACCGCATCGGGGTGGGGGTC
ATCGATGGCCACATCTATGCCGTCGGCGGCTCCCACGGCTGCATCCACCACAACAGTGTG
GAGAGGTATGAGCCAGAGCGGGATGAGTGGCACTTGGTGGCCCCAATGCTGACACGAAGG
ATCGGGGTGGGCGTGGCTGTCCTCAATCGTCTCCTTTATGCCGTGGGGGGCTTTGACGGG
ACAAACCGCCTTAATTCAGCTGAGTGTTACTACCCAGAGAGGAACGAGTGGCGAATGATC
ACAGCAATGAACACCATCCGAAGCGGGGCAGGCGTCTGCGTCCTGCACAACTGTATCTAT
GCTGCTGGGGGCTATGATGGTCAGGACCAGCTGAACAGCGTGGAGCGCTACGATGTGGAA
ACAGAGACGTGGACTTTCGTAGCCCCCATGAAGCACCGGCGAAGTGCCCTGGGGATCACT
GTCCACCAGGGGAGAATCTACGTCCTTGGAGGCTATGATGGTCACACGTTCCTGGACAGT
GTGGAGTGTTACGACCCAGATACAGACACCTGGAGCGAGGTGACCCGAATGACATCGGGC
CGGAGTGGGGTGGGCGTGGCTGTCACCATGGAGCCCTGCCGGAAGCAGATTGACCAGCAG
AACTGTACCTGTTGA
|
| Target 8 GenBank Gene ID |
Not Available |
| Target 8 GeneCard ID |
KEAP1 |
| Target 8 GenAtlas ID |
KEAP1 |
| Target 8 HGNC ID |
HGNC:23177 |
| Target 8 Chromosome Location |
Chromosome:19 |
| Target 8 Locus |
19p13.2 |
| Target 8 SNPs |
SNPJam Report |
| Target 8 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 8 General References |
8590280; 15489334; 14585973; 15379550; 15572695; 15657435; 17046835; 18691976 |
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Target 9
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| Target 9 ID |
9 |
| Target 9 Name |
Poly [ADP-ribose] polymerase 1 |
| Target 9 Mechanism of Action |
Arsenic binding of PARP-1 is believed to induce carcinogenesis by affecting DNA repair. (R054) |
| Target 9 Description |
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR |
| Target 9 Synonyms |
- PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1
|
| Target 9 Gene Name |
PARP1 |
| Target 9 Protein Sequence |
>Poly [ADP-ribose] polymerase 1
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS
NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA
QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG
QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT
GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP
WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK
LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG
TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV
SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG
GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE
REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA
NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
|
| Target 9 Number of Residues |
1014 |
| Target 9 Molecular Weight |
113082.9 |
| Target 9 Theoretical pI |
9.34 |
| Target 9 GO Classification |
|
Function
|
NAD+ ADP-ribosyltransferase activity
NAD+ ADP-ribosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
NAD+ ADP-ribosyltransferase activity
binding
nucleic acid binding
DNA binding |
|
Process
|
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid ADP-ribosylation
physiological process
metabolism
cellular metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
DNA metabolism |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
cell
intracellular |
|
| Target 9 General Function |
Involved in DNA binding |
| Target 9 Pathways |
Not Available |
| Target 9 Reactions |
Not Available |
| Target 9 Signals |
|
| Target 9 Transmembrane Regions |
|
| Target 9 Essentiality |
Non Essential |
| Target 9 Domain Function |
PF00533:BRCT
PF08063:PADR1
PF00644:PARP
PF02877:PARP_reg
PF05406:WGR
PF00645:zf-PARP |
| Target 9 GenBank ID Protein |
Not Available |
| Target 9 UniProtKB ID |
P09874 |
| Target 9 Cellular Location |
Nucleus |
| Target 9 Gene Sequence |
>3045 bp
TGCGGCAGCTAGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAGTACGCCA
AGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGA
TGGCCATCATGGTGCAGTCGCCCATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCT
CCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTCAGGTGGATGGGTTCT
CTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGA
CAGGCAAAGGCCAGGATGGAATTGGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAG
CAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATAGAAAAGG
GCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTG
ACCGCTGGTACCATCCAGGCTGCTTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCG
AGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAAGAAGCCC
TGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATG
GAGTGGATGAAGTGGCGAAGAAGAAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTG
AAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTAAAGAAAG
TGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTG
GGGAGTCGGCGATCTTGGACCGAGTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCT
GCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACTGGGGACG
TCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAA
CCCCAAAGGAATTCCGAGAAATCTCTTACCTCAAGAAATTGAAGGTTAAAAAGCAGGACC
GTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCCACAGCCT
CGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGA
TCCTGACTCTCGGGAAGCTGTCCCGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAAC
TCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACCAAAAAGG
AGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGT
CTGAGGACTTCCTCCAGGACGTCTCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAG
CGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTTGTGGCCC
CAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAG
GTATCAACAAATCTGAAAAGAGAATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATC
CTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTCTTCAGTG
CCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTC
TGGAGGACGACAAGGAAAACAGGTATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGG
TGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAGCACTTCA
TGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATC
CCAAAAAGTTCTACCCCCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGC
TGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTCATCAAGA
TGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGATCGACCTTCAGA
AGATGCCCTTGGGGAAGCTGAGCAAAAGGCAGATCCAGGCCGCATACTCCATCCTCAGTG
AGGTCCAGCAGGCGGTGTCTCAGGGCAGCAGCGACTCTCAGATCCTGGATCTCTCAAATC
GCTTTTACACCCTGATCCCCCACGACTTTGGGATGAAGAAGCCTCCGCTCCTGAACAATG
CAGACAGTGTGCAGGCCAAGGTGGAAATGCTTGACAACCTGCTGGACATCGAGGTGGCCT
ACAGTCTGCTCAGGGGAGGGTCTGATGATAGCAGCAAGGATCCCATCGATGTCAACTATG
AGAAGCTCAAAACTGACATTAAGGTGGTTGACAGAGATTCTGAAGAAGCCGAGATCATCA
GGAAGTATGTTAAGAACACTCATGCAACCACACACAATGCGTATGACTTGGAAGTCATCG
ATATCTTTAAGATAGAGCGTGAAGGCGAATGCCAGCGTTACAAGCCCTTTAAGCAGCTTC
ATAACCGAAGATTGCTGTGGCACGGGTCCAGGACCACCAACTTTGCTGGGATCCTGTCCC
AGGGTCTTCGGATAGCCCCGCCTGAAGCGCCCGTGACAGGCTACATGTTTGGTAAAGGGA
TCTATTTCGCTGACATGGTCTCCAAGAGTGCCAACTACTGCCATACGTCTCAGGGAGACC
CAATAGGCTTAATCCTGTTGGGAGAAGTTGCCCTTGGAAACATGTATGAACTGAAGCACG
CTTCACATATCAGCAAGTTACCCAAGGGCAAGCACAGTGTCAAAGGTTTGGGCAAAACTA
CCCCTGATCCTTCAGCTAACATTAGTCTGGATGGTGTAGACGTTCCTCTTGGGACCGGGA
TTTCATCTGGTGTGAATGACACCTCTCTACTATATAACGAGTACATTGTCTATGATATTG
CTCAGGTAAATCTGAAGTATCTGCTGAAACTGAAATTCAATTTTA
|
| Target 9 GenBank Gene ID |
Not Available |
| Target 9 GeneCard ID |
PARP1 |
| Target 9 GenAtlas ID |
PARP1 |
| Target 9 HGNC ID |
HGNC:270 |
| Target 9 Chromosome Location |
Not Available |
| Target 9 Locus |
1q41-q42 |
| Target 9 SNPs |
SNPJam Report |
| Target 9 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 9 General References |
3120710; 2824474; 2891139; 2513174; 15489334; 2125269; 2108670 |
|
Target 10
[top]
|
| Target 10 ID |
11 |
| Target 10 Name |
Tubulin beta chain |
| Target 10 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 10 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 10 Synonyms |
- Tubulin beta-5 chain
|
| Target 10 Gene Name |
TUBB |
| Target 10 Protein Sequence |
>Tubulin beta chain
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA
|
| Target 10 Number of Residues |
444 |
| Target 10 Molecular Weight |
49670.5 |
| Target 10 Theoretical pI |
4.52 |
| Target 10 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 10 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 10 Pathways |
Not Available |
| Target 10 Reactions |
Not Available |
| Target 10 Signals |
|
| Target 10 Transmembrane Regions |
|
| Target 10 Essentiality |
Non Essential |
| Target 10 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 10 GenBank ID Protein |
Not Available |
| Target 10 UniProtKB ID |
P07437 |
| Target 10 Cellular Location |
Cytoplasmic |
| Target 10 Gene Sequence |
>1335 bp
ATGAGGGAAATCGTGCACATCCAGGCTGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTC
TGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGACCGCATCTCTGTGTACTACAATGAAGCCACAGGTGGCAAATATGTT
CCTCGTGCCATCCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCT
TTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAAC
TGGGCCAAAGGCCACTACACAGAGGGCGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTA
CGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGC
GGGGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAATACCCT
GATCGCATCATGAATACCTTCAGTGTGGTGCCTTCACCCAAAGTGTCTGACACCGTGGTC
GAGCCCTACAATGCCACCCTCTCCGTCCATCAGTTGGTAGAGAATACTGATGAGACCTAT
TGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGCACTCTGAAGCTGACCACACCA
ACCTACGGGGATCTGAACCACCTTGTCTCAGCCACCATGAGTGGTGTCACCACCTGCCTC
CGTTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAGTTGGCAGTCAACATGGTCCCCTTC
CCACGTCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAG
TATCGAGCTCTCACAGTGCCGGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATG
GCTGCCTGTGACCCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGG
ATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAGAACAGCAGCTAC
TTTGTGGAATGGATCCCCAACAATGTCAAGACAGCCGTCTGTGACATCCCACCTCGTGGC
CTCAAGATGGCAGTCACCTTCATTGGCAATAGCACAGCCATCCAGGAGCTCTTCAAGCGC
ATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCTGAGAGCAACATGAACGACCTCGTCTCT
GAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCC
GAAGAGGAGGCCTAA
|
| Target 10 GenBank Gene ID |
Not Available |
| Target 10 GeneCard ID |
TUBB |
| Target 10 GenAtlas ID |
TUBB |
| Target 10 HGNC ID |
HGNC:20778 |
| Target 10 Chromosome Location |
Chromosome:6
Entrez Gene cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33 |
| Target 10 Locus |
6p21.33 |
| Target 10 SNPs |
SNPJam Report |
| Target 10 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 10 General References |
6688039; 6865944; 11504633; 15489334 |
|
Target 11
[top]
|
| Target 11 ID |
171 |
| Target 11 Name |
Thioredoxin reductase 1, cytoplasmic |
| Target 11 Mechanism of Action |
Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009) |
| Target 11 Description |
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid |
| Target 11 Synonyms |
- TR; Thioredoxin reductase TR1; KM-102-derived reductase-like factor; Gene associated with retinoid-IFN-induced mortality 12 protein; GRIM-12
|
| Target 11 Gene Name |
TXNRD1 |
| Target 11 Protein Sequence |
>Thioredoxin reductase 1, cytoplasmic
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
|
| Target 11 Number of Residues |
649 |
| Target 11 Molecular Weight |
70905.6 |
| Target 11 Theoretical pI |
7.42 |
| Target 11 GO Classification |
|
Function
|
oxidoreductase activity, acting on NADH or NADPH
oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
disulfide oxidoreductase activity
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
FAD binding
catalytic activity
oxidoreductase activity
transporter activity
electron transporter activity |
|
Process
|
homeostasis
cell homeostasis
cell redox homeostasis
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport |
|
Component
|
cell
intracellular
cytoplasm |
|
| Target 11 General Function |
Energy production and conversion |
| Target 11 Pathways |
Not Available |
| Target 11 Reactions |
Not Available |
| Target 11 Signals |
|
| Target 11 Transmembrane Regions |
|
| Target 11 Essentiality |
Non Essential |
| Target 11 Domain Function |
PF00462:Glutaredoxin
PF00070:Pyr_redox
PF07992:Pyr_redox_2
PF02852:Pyr_redox_dim |
| Target 11 GenBank ID Protein |
Not Available |
| Target 11 UniProtKB ID |
Q16881 |
| Target 11 Cellular Location |
Isoform 5:Cytoplasm |
| Target 11 Gene Sequence |
Not Available |
| Target 11 GenBank Gene ID |
Not Available |
| Target 11 GeneCard ID |
TXNRD1 |
| Target 11 GenAtlas ID |
TXNRD1 |
| Target 11 HGNC ID |
HGNC:12437 |
| Target 11 Chromosome Location |
Chromosome:12 |
| Target 11 Locus |
12q23-q24.1 |
| Target 11 SNPs |
SNPJam Report |
| Target 11 Toxin References |
- R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
|
| Target 11 General References |
7589432; 8999974; 9774665; 14980707; 15489334 |
|
Target 12
[top]
|
| Target 12 ID |
229 |
| Target 12 Name |
Thioredoxin reductase 2, mitochondrial |
| Target 12 Mechanism of Action |
Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009) |
| Target 12 Description |
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling |
| Target 12 Synonyms |
- Thioredoxin reductase TR3; TR-beta; Selenoprotein Z; SelZ
|
| Target 12 Gene Name |
TXNRD2 |
| Target 12 Protein Sequence |
>Thioredoxin reductase 2, mitochondrial
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQ
LGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGI
GLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST
TGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDV
VEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHG
QEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALG
IKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCUG
|
| Target 12 Number of Residues |
524 |
| Target 12 Molecular Weight |
56506.3 |
| Target 12 Theoretical pI |
7.55 |
| Target 12 GO Classification |
|
Function
|
oxidoreductase activity, acting on NADH or NADPH
oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
disulfide oxidoreductase activity
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
FAD binding
catalytic activity
oxidoreductase activity |
|
Process
|
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport |
|
Component
|
cell
intracellular
cytoplasm |
|
| Target 12 General Function |
Energy production and conversion |
| Target 12 Pathways |
Not Available |
| Target 12 Reactions |
Not Available |
| Target 12 Signals |
|
| Target 12 Transmembrane Regions |
|
| Target 12 Essentiality |
Non Essential |
| Target 12 Domain Function |
PF00070:Pyr_redox
PF07992:Pyr_redox_2
PF02852:Pyr_redox_dim |
| Target 12 GenBank ID Protein |
Not Available |
| Target 12 UniProtKB ID |
Q9NNW7 |
| Target 12 Cellular Location |
Mitochondrion |
| Target 12 Gene Sequence |
>1575 bp
ATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAG
GCCGTGGCGGGCGGGGTGCGGGGCGCGGCGCGGGGCGCAGCAGCAGGTCAGCGGGACTAT
GATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAG
CTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGG
GGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCG
GCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCC
GTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAAC
TGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGC
TTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCA
GCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGT
GCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAA
ACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATT
GGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATG
TCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCC
CCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACC
ACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCA
GACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGCCCCGACACTCAGAAG
ATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTG
GTGGAGGGGCGGCCTGAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAG
CGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTTCCCACGACCGTCTTC
ACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGG
CAGGAGCATGTTGAGGTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGA
CGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAGCCCCCACAGCTGGTG
CTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGG
ATCAAGTGTGGGGCTTCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGC
TCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTGGACCCCACGGTGACA
GGCTGCTGAGGGTAA
|
| Target 12 GenBank Gene ID |
Not Available |
| Target 12 GeneCard ID |
TXNRD2 |
| Target 12 GenAtlas ID |
TXNRD2 |
| Target 12 HGNC ID |
HGNC:18155 |
| Target 12 Chromosome Location |
Chromosome:22 |
| Target 12 Locus |
22q11.21 |
| Target 12 SNPs |
SNPJam Report |
| Target 12 Toxin References |
- R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
|
| Target 12 General References |
10455115; 9923614; 10215850; 10608886; 10591208; 15489334; 11060283 |
|
Target 13
[top]
|
| Target 13 ID |
86 |
| Target 13 Name |
Thioredoxin reductase 3 |
| Target 13 Mechanism of Action |
Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009) |
| Target 13 Description |
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity) |
| Target 13 Synonyms |
- Thioredoxin reductase TR2; Thioredoxin and glutathione reductase
|
| Target 13 Gene Name |
TXNRD3 |
| Target 13 Protein Sequence |
>Thioredoxin reductase 3
MGHVHRLVSGKRRMHLTSRPVASTHSPLILDMCPHLNNGPMTGCGRAGDPISHARGGAGG
RGERLPRGFARVVRVASEGSVRRPSGPVPAPQPPAFRFVSRPGRARSESETLERSPPQSP
GPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVV
IFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVH
VGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVV
PSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAI
QNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERP
RYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILL
RGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYN
TVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPV
AIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTL
FWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLL
DDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG
|
| Target 13 Number of Residues |
754 |
| Target 13 Molecular Weight |
82463.9 |
| Target 13 Theoretical pI |
8.80 |
| Target 13 GO Classification |
|
Function
|
oxidoreductase activity, acting on NADH or NADPH
oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
disulfide oxidoreductase activity
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
FAD binding
catalytic activity
oxidoreductase activity
transporter activity
electron transporter activity |
|
Process
|
homeostasis
cell homeostasis
cell redox homeostasis
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport |
|
Component
|
cell
intracellular
cytoplasm |
|
| Target 13 General Function |
Energy production and conversion |
| Target 13 Pathways |
Not Available |
| Target 13 Reactions |
Not Available |
| Target 13 Signals |
|
| Target 13 Transmembrane Regions |
|
| Target 13 Essentiality |
Non Essential |
| Target 13 Domain Function |
PF00462:Glutaredoxin
PF00070:Pyr_redox
PF07992:Pyr_redox_2
PF02852:Pyr_redox_dim |
| Target 13 GenBank ID Protein |
Not Available |
| Target 13 UniProtKB ID |
Q86VQ6 |
| Target 13 Cellular Location |
Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity) |
| Target 13 Gene Sequence |
Not Available |
| Target 13 GenBank Gene ID |
Not Available |
| Target 13 GeneCard ID |
TXNRD3 |
| Target 13 GenAtlas ID |
TXNRD3 |
| Target 13 HGNC ID |
HGNC:20667 |
| Target 13 Chromosome Location |
Not Available |
| Target 13 Locus |
3q21.3 |
| Target 13 SNPs |
SNPJam Report |
| Target 13 Toxin References |
- R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
|
| Target 13 General References |
16641997; 15489334; 10455115; 18669648 |
|
Target 14
[top]
|
| Target 14 ID |
271 |
| Target 14 Name |
DNA repair protein complementing XP-A cells |
| Target 14 Mechanism of Action |
Arsenic binding of XPA is believed to induce carcinogenesis by affecting DNA repair. (R054) |
| Target 14 Description |
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation |
| Target 14 Synonyms |
- Xeroderma pigmentosum group A-complementing protein
|
| Target 14 Gene Name |
XPA |
| Target 14 Protein Sequence |
>DNA repair protein complementing XP-A cells
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
|
| Target 14 Number of Residues |
273 |
| Target 14 Molecular Weight |
31367.7 |
| Target 14 Theoretical pI |
6.72 |
| Target 14 GO Classification |
|
Function
|
binding
nucleic acid binding
DNA binding
damaged DNA binding |
|
Process
|
physiological process
metabolism
cellular metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
DNA metabolism
DNA repair
nucleotide-excision repair |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus |
|
| Target 14 General Function |
Involved in damaged DNA binding |
| Target 14 Pathways |
Not Available |
| Target 14 Reactions |
Not Available |
| Target 14 Signals |
|
| Target 14 Transmembrane Regions |
|
| Target 14 Essentiality |
Non Essential |
| Target 14 Domain Function |
PF05181:XPA_C
PF01286:XPA_N |
| Target 14 GenBank ID Protein |
Not Available |
| Target 14 UniProtKB ID |
P23025 |
| Target 14 Cellular Location |
Nucleus |
| Target 14 Gene Sequence |
>822 bp
ATGGCGGCGGCCGACGGGGCTTTGCCGGAGGCGGCGGCTTTAGAGCAACCCGCGGAGCTG
CCTGCCTCGGTGCGGGCGAGTATCGAGCGGAAGCGGCAGCGGGCACTGATGCTGCGCCAG
GCCCGGCTGGCTGCCCGGCCCTACTCGGCGACGGCGGCTGCGGCTACTGGAGGCATGGCT
AATGTAAAAGCAGCCCCAAAGATAATTGACACAGGAGGAGGCTTCATTTTAGAAGAGGAA
GAAGAAGAAGAACAGAAAATTGGAAAAGTTGTTCATCAACCAGGACCTGTTATGGAATTT
GATTATGTAATATGCGAAGAATGTGGGAAAGAATTTATGGATTCTTATCTTATGAACCAC
TTTGATTTGCCAACTTGTGATAACTGCAGAGATGCTGATGATAAACACAAGCTTATAACC
AAAACAGAGGCAAAACAAGAATATCTTCTGAAAGACTGTGATTTAGAAAAAAGAGAGCCA
CCTCTTAAATTTATTGTGAAGAAGAATCCACATCATTCACAATGGGGTGATATGAAACTC
TACTTAAAGTTACAGATTGTGAAGAGGTCTCTTGAAGTTTGGGGTAGTCAAGAAGCATTA
GAAGAAGCAAAGGAAGTCCGACAGGAAAACCGAGAAAAAATGAAACAGAAGAAATTTGAT
AAAAAAGTAAAAGAATTGCGGCGAGCAGTAAGAAGCAGCGTGTGGAAAAGGGAGACGATT
GTTCATCAACATGAGTATGGACCAGAAGAAAACCTAGAAGATGACATGTACCGTAAGACT
TGTACTATGTGTGGCCATGAACTGACATATGAAAAAATGTGA
|
| Target 14 GenBank Gene ID |
Not Available |
| Target 14 GeneCard ID |
XPA |
| Target 14 GenAtlas ID |
XPA |
| Target 14 HGNC ID |
HGNC:12814 |
| Target 14 Chromosome Location |
Not Available |
| Target 14 Locus |
9q22.3 |
| Target 14 SNPs |
SNPJam Report |
| Target 14 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 14 General References |
2234061; 15164053; 15489334; 8294029; 8543191; 1918083; 1601884 |
|
Target 15
[top]
|
| Target 15 ID |
37 |
| Target 15 Name |
Tubulin alpha-1A chain |
| Target 15 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 15 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 15 Synonyms |
- Tubulin B-alpha-1; Tubulin alpha-3 chain; Alpha-tubulin 3
|
| Target 15 Gene Name |
TUBA1A |
| Target 15 Protein Sequence |
>Tubulin alpha-1A chain
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
|
| Target 15 Number of Residues |
451 |
| Target 15 Molecular Weight |
50135.2 |
| Target 15 Theoretical pI |
4.70 |
| Target 15 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 15 General Function |
Involved in GTP binding |
| Target 15 Pathways |
Not Available |
| Target 15 Reactions |
Not Available |
| Target 15 Signals |
|
| Target 15 Transmembrane Regions |
|
| Target 15 Essentiality |
Non Essential |
| Target 15 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 15 GenBank ID Protein |
Not Available |
| Target 15 UniProtKB ID |
Q71U36 |
| Target 15 Cellular Location |
Cytoplasmic |
| Target 15 Gene Sequence |
>1356 bp
ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGGGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAACTTATCACAGGCAAAGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCCGACCAGTGCACGGGTCTCCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATTGAG
CGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTATCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAACGTGCCTTTGTTCACTGGTACGTTGGGGAGGGGATGGAGGAAGGTGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA
|
| Target 15 GenBank Gene ID |
Not Available |
| Target 15 GeneCard ID |
TUBA1A |
| Target 15 GenAtlas ID |
TUBA1A |
| Target 15 HGNC ID |
HGNC:20766 |
| Target 15 Chromosome Location |
Chromosome:12 |
| Target 15 Locus |
12q12-q14.3 |
| Target 15 SNPs |
SNPJam Report |
| Target 15 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 15 General References |
3839072; 11504633; 15489334; 6646120; 17081983; 17584854; 18669648; 19524510 |
|
Target 16
[top]
|
| Target 16 ID |
223 |
| Target 16 Name |
Tubulin alpha-1B chain |
| Target 16 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 16 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 16 Synonyms |
- Tubulin alpha-ubiquitous chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1
|
| Target 16 Gene Name |
TUBA1B |
| Target 16 Protein Sequence |
>Tubulin alpha-1B chain
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
|
| Target 16 Number of Residues |
451 |
| Target 16 Molecular Weight |
50151.2 |
| Target 16 Theoretical pI |
4.70 |
| Target 16 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 16 General Function |
Involved in GTP binding |
| Target 16 Pathways |
Not Available |
| Target 16 Reactions |
Not Available |
| Target 16 Signals |
|
| Target 16 Transmembrane Regions |
|
| Target 16 Essentiality |
Non Essential |
| Target 16 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 16 GenBank ID Protein |
Not Available |
| Target 16 UniProtKB ID |
P68363 |
| Target 16 Cellular Location |
Cytoplasmic |
| Target 16 Gene Sequence |
>1356 bp
ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAG
CACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCCGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGCCTGTCAGTTGAT
TATGGCAAGAAATCCAAGCTGGAGTTCTCCATTTACCCGGCACCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTC
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGACATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTGGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCACG
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA
|
| Target 16 GenBank Gene ID |
Not Available |
| Target 16 GeneCard ID |
TUBA1B |
| Target 16 GenAtlas ID |
TUBA1B |
| Target 16 HGNC ID |
HGNC:18809 |
| Target 16 Chromosome Location |
Chromosome:12 |
| Target 16 Locus |
12q13.12 |
| Target 16 SNPs |
SNPJam Report |
| Target 16 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 16 General References |
6646120; 15489334; 8619814; 15592455; 19007248; 18781797 |
|
Target 17
[top]
|
| Target 17 ID |
145 |
| Target 17 Name |
Tubulin alpha-1C chain |
| Target 17 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 17 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 17 Synonyms |
- Tubulin alpha-6 chain; Alpha-tubulin 6
|
| Target 17 Gene Name |
TUBA1C |
| Target 17 Protein Sequence |
>Tubulin alpha-1C chain
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSADGEDEGEEY
|
| Target 17 Number of Residues |
449 |
| Target 17 Molecular Weight |
49894.9 |
| Target 17 Theoretical pI |
4.73 |
| Target 17 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 17 General Function |
Involved in GTP binding |
| Target 17 Pathways |
Not Available |
| Target 17 Reactions |
Not Available |
| Target 17 Signals |
|
| Target 17 Transmembrane Regions |
|
| Target 17 Essentiality |
Non Essential |
| Target 17 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 17 GenBank ID Protein |
Not Available |
| Target 17 UniProtKB ID |
Q9BQE3 |
| Target 17 Cellular Location |
Cytoplasmic |
| Target 17 Gene Sequence |
>1350 bp
ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAAACGGGTGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTACTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTATACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATTAATTACCAGCCTCCC
ACTGTGGTGCCTGGCGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAT
ACCACAGCTGTTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGAGCAGATAGTGCT
GACGGAGAGGATGAGGGTGAAGAGTATTAA
|
| Target 17 GenBank Gene ID |
Not Available |
| Target 17 GeneCard ID |
TUBA1C |
| Target 17 GenAtlas ID |
TUBA1C |
| Target 17 HGNC ID |
HGNC:20768 |
| Target 17 Chromosome Location |
Chromosome:12 |
| Target 17 Locus |
12q12-q14 |
| Target 17 SNPs |
SNPJam Report |
| Target 17 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 17 General References |
15489334; 15592455; 17081983; 19007248; 18691976; 18669648; 19524510 |
|
Target 18
[top]
|
| Target 18 ID |
147 |
| Target 18 Name |
Tubulin alpha-3C/D chain |
| Target 18 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 18 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 18 Synonyms |
- Alpha-tubulin 3C/D; Tubulin alpha-2 chain; Alpha-tubulin 2
|
| Target 18 Gene Name |
TUBA3C |
| Target 18 Protein Sequence |
>Tubulin alpha-3C/D chain
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY
|
| Target 18 Number of Residues |
450 |
| Target 18 Molecular Weight |
49959.1 |
| Target 18 Theoretical pI |
4.74 |
| Target 18 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 18 General Function |
Involved in GTP binding |
| Target 18 Pathways |
Not Available |
| Target 18 Reactions |
Not Available |
| Target 18 Signals |
|
| Target 18 Transmembrane Regions |
|
| Target 18 Essentiality |
Non Essential |
| Target 18 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 18 GenBank ID Protein |
Not Available |
| Target 18 UniProtKB ID |
Q13748 |
| Target 18 Cellular Location |
Cytoplasmic |
| Target 18 Gene Sequence |
>1257 bp
ATGCGTGAGTGTATCTCTATCCACGTGGGGCAGGCAGGAGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTGGAACATGGAATTCAGCCCGATGGTCAGATGCCAAGTGATAAA
ACCATTGGTGGTGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGAACCTATAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCGGCC
AATAATTACGCCAGAGGCCATTACACCATCGGCAAGGAGATCGTCGACCTGGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACGGGACTGCAGGGCTTCCTCATCTTCCACAGT
TTTGGGGGTGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACGGCAAGAAGTCCAAGCTAGAATTTGCCATTTACCCAGCCCCCCAGGTCTCCACGGCC
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATCGAG
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGACGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTAGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCGGTCATCTCAGCCGAGAAG
GCCTACCACGAGCAGCTGTCCGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCACGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGATGTGGTCCCGAAAGATGTCAACGCGGCCATCGCCACCATCAAGACCAAGCGCACC
ATCCAGTTTGTAGATTGGTGCCCAACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACGGTGGTCCCTGGGGGAGACCTGGCCAAGGTGCAGCGGGCTGTGTGCATGCTGAGCAAC
ACCACGGCCATCGCGGAGGCCTGGGCTCGCCTGGACCTGGCAGCTCTGGAGAAGGATTAT
GAAGAGGTGGGCGTGGATTCCGTGGAAGCCGAGGCTGAAGAAGGTGAAGAATACTGA
|
| Target 18 GenBank Gene ID |
Not Available |
| Target 18 GeneCard ID |
TUBA3C |
| Target 18 GenAtlas ID |
TUBA3C |
| Target 18 HGNC ID |
HGNC:12408 |
| Target 18 Chromosome Location |
Chromosome:13 |
| Target 18 Locus |
13q11 |
| Target 18 SNPs |
SNPJam Report |
| Target 18 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 18 General References |
9465305; 15057823; 15489334; 17924679; 19524510 |
|
Target 19
[top]
|
| Target 19 ID |
39 |
| Target 19 Name |
Tubulin alpha-3E chain |
| Target 19 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 19 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 19 Synonyms |
- Alpha-tubulin 3E
|
| Target 19 Gene Name |
TUBA3E |
| Target 19 Protein Sequence |
>Tubulin alpha-3E chain
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAASNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYSKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGMEEGEFSE
AREDLAALEKDCEEVGVDSVEAEAEEGEAY
|
| Target 19 Number of Residues |
450 |
| Target 19 Molecular Weight |
49858.1 |
| Target 19 Theoretical pI |
4.77 |
| Target 19 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 19 General Function |
Involved in GTP binding |
| Target 19 Pathways |
Not Available |
| Target 19 Reactions |
Not Available |
| Target 19 Signals |
|
| Target 19 Transmembrane Regions |
|
| Target 19 Essentiality |
Non Essential |
| Target 19 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 19 GenBank ID Protein |
Not Available |
| Target 19 UniProtKB ID |
Q6PEY2 |
| Target 19 Cellular Location |
Cytoplasmic |
| Target 19 Gene Sequence |
>1353 bp
ATGCGCGAGTGTATCTCTATCCACGTGGGGCAGGCGGGTGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTTGAACATGGAATTCAGCCCGATGGTCAAATGCCAAGTGATAAA
ACCATTGGTGGCGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGGACCTACAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCAGCC
AGTAATTACGCCAGGGGCCATTACACCATCGGCAAGGAGATTGTTGACCTAGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACAGGACTGCAGGGCTTCCTCATCTTCCACAGC
TTTGGGGGCGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACAGCAAGAAGTCCAAGCTAGAGTTTGCCATTTACCCAGCCCCCCAGGTCTCCACAGCC
GTGGTGGAGCCCTACAACTCCATCCTAACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATTGAA
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGATGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTCGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCAGTCATCTCAGCTGAGAAG
GCCTACCATGAGCAGCTGTCTGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCATGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGACGTGGTCCCCAAAGACGTCAATGCGGCCATCGCCACCATCAAGACCAAGCGCACT
ATCCAGTTTGTGGATTGGTGCCCGACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACAGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTGTGCATGCTGAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTGGTCCATAAGTTCGATCTCATGTATGCC
AAGTGGGCCTTTGTGCACTGGTACGTGGGCGAAGGCATGGAAGAGGGAGAGTTCTCTGAG
GCCCGCGAGGACCTGGCAGCTCTAGAGAAGGATTGTGAAGAGGTGGGCGTGGATTCCGTG
GAAGCTGAGGCTGAAGAAGGCGAAGAATACTGA
|
| Target 19 GenBank Gene ID |
Not Available |
| Target 19 GeneCard ID |
TUBA3E |
| Target 19 GenAtlas ID |
TUBA3E |
| Target 19 HGNC ID |
HGNC:20765 |
| Target 19 Chromosome Location |
Not Available |
| Target 19 Locus |
2q21.1 |
| Target 19 SNPs |
SNPJam Report |
| Target 19 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 19 General References |
15815621; 15489334; 16565220; 19524510 |
|
Target 20
[top]
|
| Target 20 ID |
40 |
| Target 20 Name |
Tubulin alpha-4A chain |
| Target 20 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 20 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 20 Synonyms |
- Tubulin alpha-1 chain; Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha
|
| Target 20 Gene Name |
TUBA4A |
| Target 20 Protein Sequence |
>Tubulin alpha-4A chain
MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK
HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD
RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGIDSYEDEDEGEE
|
| Target 20 Number of Residues |
448 |
| Target 20 Molecular Weight |
49924.0 |
| Target 20 Theoretical pI |
4.69 |
| Target 20 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 20 General Function |
Involved in GTP binding |
| Target 20 Pathways |
Not Available |
| Target 20 Reactions |
Not Available |
| Target 20 Signals |
|
| Target 20 Transmembrane Regions |
|
| Target 20 Essentiality |
Non Essential |
| Target 20 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 20 GenBank ID Protein |
Not Available |
| Target 20 UniProtKB ID |
P68366 |
| Target 20 Cellular Location |
Cytoplasmic |
| Target 20 Gene Sequence |
Not Available |
| Target 20 GenBank Gene ID |
Not Available |
| Target 20 GeneCard ID |
TUBA4A |
| Target 20 GenAtlas ID |
TUBA4A |
| Target 20 HGNC ID |
HGNC:12407 |
| Target 20 Chromosome Location |
Not Available |
| Target 20 Locus |
2q35 |
| Target 20 SNPs |
SNPJam Report |
| Target 20 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 20 General References |
3029670; 15489334; 15592455; 17924679; 18088087; 18691976; 18669648 |
|
Target 21
[top]
|
| Target 21 ID |
134 |
| Target 21 Name |
Tubulin alpha-8 chain |
| Target 21 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 21 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 21 Synonyms |
- Alpha-tubulin 8; Tubulin alpha chain-like 2
|
| Target 21 Gene Name |
TUBA8 |
| Target 21 Protein Sequence |
>Tubulin alpha-8 chain
MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGK
HVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLD
RIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNS
QMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGTDSFEEENEGEEF
|
| Target 21 Number of Residues |
449 |
| Target 21 Molecular Weight |
50093.1 |
| Target 21 Theoretical pI |
4.70 |
| Target 21 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 21 General Function |
Involved in GTP binding |
| Target 21 Pathways |
Not Available |
| Target 21 Reactions |
Not Available |
| Target 21 Signals |
|
| Target 21 Transmembrane Regions |
|
| Target 21 Essentiality |
Non Essential |
| Target 21 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 21 GenBank ID Protein |
Not Available |
| Target 21 UniProtKB ID |
Q9NY65 |
| Target 21 Cellular Location |
Cytoplasmic |
| Target 21 Gene Sequence |
>1350 bp
ATGCGGGAATGCATATCAGTCCACGTGGGCCAAGCGGGAGTTCAGATTGGCAATGCCTGC
TGGGAGCTCTTCTGCCTGGAACACGGCATCCAGGCAGACGGCACTTTTGATGCTCAAGCT
AGCAAGATCAACGATGATGACTCCTTCACCACCTTTTTCAGCGAGACTGGCAATGGGAAG
CATGTGCCCCGGGCCGTCATGATAGATCTGGAGCCTACTGTAGTGGATGAGGTTCGGGCA
GGAACCTACCGCCAGCTCTTCCATCCAGAGCAGCTGATCACAGGAAAGGAGGATGCAGCC
AACAACTATGCCCGGGGCCACTACACGGTGGGCAAGGAGAGCATTGACCTGGTGCTGGAC
CGCATACGGAAGCTGACAGATGCTTGCTCTGGCCTGCAGGGCTTCCTGATTTTCCACAGT
TTTGGTGGGGGCACTGGCTCCGGCTTCACTTCTCTGCTGATGGAACGCCTCTCCCTGGAT
TATGGCAAGAAATCCAAGCTGGAGTTTGCCATCTACCCAGCCCCCCAGGTCTCTACTGCA
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACCACACTGGAACATTCAGATTGT
GCTTTCATGGTGGACAACGAAGCCATCTATGACATCTGCCGCAGGAACCTTGACATTGAG
CGCCCTACCTATACCAACCTCAACCGCCTCATCAGTCAGATTGTGTCCTCAATCACTGCT
TCTCTCCGCTTTGACGGGGCCCTCAATGTGGACCTCACTGAGTTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCGCTGGTCACCTACGCGCCCATCATCTCTGCCGAGAAA
GCCTATCACGAACAGCTCTCTGTGGCCGAGATAACCAGCTCCTGCTTTGAGCCCAACAGC
CAGATGGTGAAGTGCGACCCGAGACATGGCAAGTACATGGCCTGCTGCATGCTCTACCGG
GGCGACGTGGTGCCCAAGGATGTGAATGTCGCTATTGCTGCCATCAAGACCAAGAGGACC
ATCCAGTTTGTAGACTGGTGTCCCACAGGCTTCAAGGTGGGCATCAACTACCAGCCCCCG
ACCGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTCTGCATGCTCAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTCGACCACAAGTTCGACCTCATGTACGCC
AAGCGGGCCTTTGTGCATTGGTATGTGGGAGAGGGGATGGAAGAAGGAGAATTTTCTGAG
GCCAGGGAAGACTTAGCTGCCCTGGAGAAGGATTATGAAGAAGTGGGGACTGATTCGTTT
GAAGAAGAAAATGAAGGGGAGGAATTTTAA
|
| Target 21 GenBank Gene ID |
Not Available |
| Target 21 GeneCard ID |
TUBA8 |
| Target 21 GenAtlas ID |
TUBA8 |
| Target 21 HGNC ID |
HGNC:12410 |
| Target 21 Chromosome Location |
Chromosome:22 |
| Target 21 Locus |
22q11.1 |
| Target 21 SNPs |
SNPJam Report |
| Target 21 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 21 General References |
10772959; 15461802; 15489334; 19524510 |
|
Target 22
[top]
|
| Target 22 ID |
93 |
| Target 22 Name |
Tubulin beta-1 chain |
| Target 22 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 22 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 22 Synonyms |
Not Available |
| Target 22 Gene Name |
TUBB1 |
| Target 22 Protein Sequence |
>Tubulin beta-1 chain
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
|
| Target 22 Number of Residues |
451 |
| Target 22 Molecular Weight |
50326.6 |
| Target 22 Theoretical pI |
4.82 |
| Target 22 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 22 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 22 Pathways |
Not Available |
| Target 22 Reactions |
Not Available |
| Target 22 Signals |
|
| Target 22 Transmembrane Regions |
|
| Target 22 Essentiality |
Non Essential |
| Target 22 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 22 GenBank ID Protein |
Not Available |
| Target 22 UniProtKB ID |
Q9H4B7 |
| Target 22 Cellular Location |
Cytoplasmic |
| Target 22 Gene Sequence |
>1356 bp
ATGCGTGAAATTGTCCATATTCAGATTGGCCAGTGTGGCAACCAGATCGGAGCCAAGTTC
TGGGAGATGATTGGTGAGGAACACGGGATCGACTTGGCTGGGAGCGACCGCGGGGCCTCG
GCCTTGCAGCTGGAGAGAATCAGCGTGTACTACAACGAAGCCTACGGTAGGAAATATGTG
CCCCGAGCAGTCTTGGTGGACCTAGAACCTGGGACGATGGACAGCATTCGATCTAGCAAA
TTAGGAGCTCTCTTTCAACCCGACAGTTTTGTCCATGGTAACTCTGGGGCTGGCAACAAC
TGGGCCAAAGGCCACTACACGGAGGGAGCCGAGCTGATCGAGAATGTCCTAGAGGTGGTG
AGGCACGAGAGTGAGAGCTGTGACTGCCTGCAGGGCTTCCAGATCGTCCACTCCCTGGGC
GGGGGCACAGGCTCCGGGATGGGCACTCTGCTCATGAACAAGATTAGAGAGGAGTACCCG
GACCGGATCATGAATTCCTTCAGCGTCATGCCTTCTCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAACGCGGTTCTGTCTATCCACCAGCTGATTGAGAATGCAGATGCCTGTTTC
TGCATTGACAATGAGGCCCTCTATGACATCTGCTTCCGTACCCTGAAGCTGACGACACCC
ACCTATGGGGATCTCAACCACCTAGTGTCCTTGACCATGAGCGGCATAACCACCTCCCTC
CGGTTCCCGGGTCAGCTCAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTCCCCTTC
CCCCGCCTGCACTTCTTTATGCCCGGCTTTGCCCCACTCACGGCCCAGGGCAGCCAGCAG
TACCGAGCCCTCTCCGTGGCCGAGCTCACCCAGCAGATGTTCGATGCCCGCAATACCATG
GCTGCCTGTGACCTCCGCCGTGGCCGCTACCTCACAGTGGCCTGCATTTTCCGGGGCAAG
ATGTCCACCAAGGAAGTGGACCAGCAACTGCTCTCCGTGCAGACCAGGAACAGCAGCTGC
TTTGTGGAGTGGATTCCCAACAACGTCAAGGTGGCTGTCTGCGACATCCCGCCCCGGGGG
CTGAGCATGGCCGCCACCTTCATTGGCAACAACACGGCCATCCAAGAGATCTTTAATAGG
GTCTCTGAGCATTTCTCAGCCATGTTCAAAAGGAAAGCTTTTGTGCACTGGTACACCAGC
GAAGGGATGGACATAAACGAATTTGGGGAAGCTGAAAATAACATCCATGATTTGGTATCC
GAGTACCAACAATTTCAAGATGCCAAAGCAGTTCTAGAGGAAGATGAAGAGGTCACGGAG
GAGGCAGAAATGGAGCCAGAAGATAAGGGACATTAA
|
| Target 22 GenBank Gene ID |
Not Available |
| Target 22 GeneCard ID |
TUBB1 |
| Target 22 GenAtlas ID |
TUBB1 |
| Target 22 HGNC ID |
HGNC:16257 |
| Target 22 Chromosome Location |
Chromosome:20 |
| Target 22 Locus |
20q13.32 |
| Target 22 SNPs |
SNPJam Report |
| Target 22 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 22 General References |
11780052; 15489334; 12665801; 19524510 |
|
Target 23
[top]
|
| Target 23 ID |
219 |
| Target 23 Name |
Tubulin beta-2A chain |
| Target 23 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 23 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 23 Synonyms |
Not Available |
| Target 23 Gene Name |
TUBB2A |
| Target 23 Protein Sequence |
>Tubulin beta-2A chain
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
|
| Target 23 Number of Residues |
445 |
| Target 23 Molecular Weight |
49906.7 |
| Target 23 Theoretical pI |
4.52 |
| Target 23 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 23 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 23 Pathways |
Not Available |
| Target 23 Reactions |
Not Available |
| Target 23 Signals |
|
| Target 23 Transmembrane Regions |
|
| Target 23 Essentiality |
Non Essential |
| Target 23 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 23 GenBank ID Protein |
Not Available |
| Target 23 UniProtKB ID |
Q13885 |
| Target 23 Cellular Location |
Cytoplasmic |
| Target 23 Gene Sequence |
>1338 bp
ATGCGCGAGATCGTGCACATCCAGGCGGGCCAGTGCGGCAACCAGATCGGCGCCAAGTTT
TGGGAGGTCATCAGCGATGAGCATGGGATCGACCCCACAGGCAGTTACCATGGAGACAGT
GACTTGCAGCTGGAGAGAATCAACGTGTACTACAATGAGGCTGCTGGTAACAAATATGTA
CCTCGGGCCATCCTGGTGGATCTGGAGCCTGGCACCATGGACTCTGTCAGGTCTGGACCC
TTCGGCCAGATCTTCAGACCAGACAACTTCGTGTTCGGCCAGAGTGGAGCCGGGAATAAC
TGGGCCAAGGGCCACTACACAGAGGGAGCCGAGCTGGTCGACTCGGTCCTGGATGTGGTG
AGGAAGGAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCTCTGGGG
GGCGGCACGGGGTCCGGGATGGGCACCCTGCTCATCAGCAAGATCCGGGAAGAGTACCCA
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACCCTCTCGGTCCACCAGCTGGTGGAAAACACAGATGAAACCTAC
TCCATTGATAACGAGGCCCTGTATGACATCTGCTTCCGCACCCTGAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCGCCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTCACGGTGCCCGAGCTCACCCAGCAGATGTTCGACTCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCTGCCATCTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTCAACGTGCAGAACAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGTCGGCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGACGAACAAGGGGAGTTCGAGGAGGAGGAG
GGCGAGGACGAGGCTTAA
|
| Target 23 GenBank Gene ID |
Not Available |
| Target 23 GeneCard ID |
TUBB2A |
| Target 23 GenAtlas ID |
TUBB2A |
| Target 23 HGNC ID |
HGNC:12412 |
| Target 23 Chromosome Location |
Not Available |
| Target 23 Locus |
6p25 |
| Target 23 SNPs |
SNPJam Report |
| Target 23 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 23 General References |
14574404; 15489334; 19524510; 16959974 |
|
Target 24
[top]
|
| Target 24 ID |
247 |
| Target 24 Name |
Tubulin beta-2B chain |
| Target 24 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 24 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 24 Synonyms |
Not Available |
| Target 24 Gene Name |
TUBB2B |
| Target 24 Protein Sequence |
>Tubulin beta-2B chain
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
|
| Target 24 Number of Residues |
445 |
| Target 24 Molecular Weight |
49952.8 |
| Target 24 Theoretical pI |
4.52 |
| Target 24 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 24 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 24 Pathways |
Not Available |
| Target 24 Reactions |
Not Available |
| Target 24 Signals |
|
| Target 24 Transmembrane Regions |
|
| Target 24 Essentiality |
Non Essential |
| Target 24 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 24 GenBank ID Protein |
Not Available |
| Target 24 UniProtKB ID |
Q9BVA1 |
| Target 24 Cellular Location |
Cytoplasmic |
| Target 24 Gene Sequence |
Not Available |
| Target 24 GenBank Gene ID |
Not Available |
| Target 24 GeneCard ID |
TUBB2B |
| Target 24 GenAtlas ID |
TUBB2B |
| Target 24 HGNC ID |
HGNC:30829 |
| Target 24 Chromosome Location |
Not Available |
| Target 24 Locus |
6p25 |
| Target 24 SNPs |
SNPJam Report |
| Target 24 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 24 General References |
14574404; 15489334; 19524510 |
|
Target 25
[top]
|
| Target 25 ID |
45 |
| Target 25 Name |
Tubulin beta-2C chain |
| Target 25 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 25 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 25 Synonyms |
- Tubulin beta-2 chain
|
| Target 25 Gene Name |
TUBB2C |
| Target 25 Protein Sequence |
>Tubulin beta-2C chain
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA
|
| Target 25 Number of Residues |
445 |
| Target 25 Molecular Weight |
49830.7 |
| Target 25 Theoretical pI |
4.52 |
| Target 25 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 25 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 25 Pathways |
Not Available |
| Target 25 Reactions |
Not Available |
| Target 25 Signals |
|
| Target 25 Transmembrane Regions |
|
| Target 25 Essentiality |
Non Essential |
| Target 25 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 25 GenBank ID Protein |
Not Available |
| Target 25 UniProtKB ID |
P68371 |
| Target 25 Cellular Location |
Cytoplasmic |
| Target 25 Gene Sequence |
>1338 bp
ATGAGGGAAATCGTGCACTTGCAGGCCGGGCAGTGCGGCAACCAAATCGGCGCCAAGTTT
TGGGAGGTGATCAGCGATGAGCACGGCATCGACCCCACGGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGAACGCATCAACGTGTACTACAATGAGGCCACCGGCGGCAAGTACGTG
CCCCGCGCCGTGCTCGTGGATCTGGAGCCCGGCACCATGGACTCCGTGCGCTCGGGGCCC
TTCGGGCAGATCTTCCGGCCGGACAACTTCGTTTTCGGTCAGAGTGGTGCTGGGAACAAC
TGGGCCAAGGGGCACTACACAGAAGGCGCGGAGCTGGTGGACTCGGTGCTGGATGTTGTG
AGAAAGGAGGCTGAGAGCTGTGACTGCCTGCAGGGTTTCCAGCTGACCCACTCCCTGGGT
GGGGGGACTGGGTCTGGGATGGGTACCCTCCTCATCAGCAAGATCCGGGAGGAGTACCCA
GACAGGATCATGAACACGTTTAGTGTGGTGCCTTCGCCCAAAGTGTCAGACACAGTGGTG
GAGCCCTACAACGCCACCCTCTCAGTCCACCAGCTCGTAGAAAACACAGACGAGACCTAC
TGCATTGATAACGAAGCTCTCTACGACATTTGCTTCAGAACCCTAAAGCTGACCACGCCC
ACCTATGGTGACCTGAACCACCTGGTGTCTGCTACCATGAGTGGGGTCACCACCTGCCTG
CGCTTCCCAGGCCAGCTCAATGCTGACCTGCGGAAGCTGGCTGTGAACATGGTCCCGTTT
CCCCGGCTGCACTTCTTCATGCCCGGCTTTGCCCCACTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTGACCGTGCCCGAGCTCACCCAGCAGATGTTTGATGCCAAGAACATGATG
GCTGCCTGCGACCCCCGCCATGGCCGCTACCTGACGGTTGCCGCCGTGTTCAGGGGCCGC
ATGTCCATGAAGGAGGTGGATGAGCAAATGCTTAATGTCCAAAACAAAAACAGCAGCTAT
TTTGTTGAGTGGATCCCCAACAATGTGAAAACGGCTGTCTGTGACATCCCACCTCGGGGG
CTAAAAATGTCCGCCACCTTCATTGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTGTCC
GAGTACCAGCAGTACCAGGATGCCACAGCCGAGGAGGAGGGCGAGTTCGAGGAGGAGGCT
GAGGAGGAGGTGGCCTAG
|
| Target 25 GenBank Gene ID |
Not Available |
| Target 25 GeneCard ID |
TUBB2C |
| Target 25 GenAtlas ID |
TUBB2C |
| Target 25 HGNC ID |
HGNC:20771 |
| Target 25 Chromosome Location |
Not Available |
| Target 25 Locus |
9q34 |
| Target 25 SNPs |
SNPJam Report |
| Target 25 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 25 General References |
3999141; 15164053; 15489334; 17081983; 19007248; 18691976; 18669648; 19524510 |
|
Target 26
[top]
|
| Target 26 ID |
242 |
| Target 26 Name |
Tubulin beta-3 chain |
| Target 26 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 26 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 26 Synonyms |
- Tubulin beta-III; Tubulin beta-4
|
| Target 26 Gene Name |
TUBB3 |
| Target 26 Protein Sequence |
>Tubulin beta-3 chain
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK
|
| Target 26 Number of Residues |
450 |
| Target 26 Molecular Weight |
50432.4 |
| Target 26 Theoretical pI |
4.57 |
| Target 26 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 26 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 26 Pathways |
Not Available |
| Target 26 Reactions |
Not Available |
| Target 26 Signals |
|
| Target 26 Transmembrane Regions |
|
| Target 26 Essentiality |
Non Essential |
| Target 26 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 26 GenBank ID Protein |
Not Available |
| Target 26 UniProtKB ID |
Q13509 |
| Target 26 Cellular Location |
Cytoplasmic |
| Target 26 Gene Sequence |
>1353 bp
ATGCGGGAGATCGTGCACATCCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTC
TGGGAAGTCATCAGTGATGAGCATGGCATCGACCCCAGCGGCAACTACGTGGGCGACTCG
GACTTGCAGCTGGAGCGGATCAGCGTCTACTACAACGAGGCCTCTTCTCACAAGTACGTG
CCTCGAGCCATTCTGGTGGACCTGGAACCCGGAACCATGGACAGTGTCCGCTCAGGGGCC
TTTGGACATCTCTTCAGGCCTGACAATTTCATCTTTGGTCAGAGTGGGGCCGGCAACAAC
TGGGCCAAGGGTCACTACACGGAGGGGGCGGAGCTGGTGGATTCGGTCCTGGATGTGGTG
CGGAAGGAGTGTGAAAACTGCGACTGCCTGCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGGGGGACGGGCTCCGGCATGGGCACGTTGCTCATCAGCAAGGTGCGTGAGGAGTATCCC
GACCGCATCATGAACACCTTCAGCGTCGTGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAACCCTACAACGCCACGCTGTCCATCCACCAGCTGGTGGAAAACACGGATGAAACCTAC
TGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGGCCACGCCC
ACCTACGGGGACCTCAACCACCTGGTATCGGCCACCATGAGCGGAGTCACCACCTCCTTG
CGCTTCCCGGGCCAGCTCAACGCTGACCTGCGCAAGCTGGCCGTCAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCCGGCTTCGCCCCCCTCACCAGGCGGGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCCACCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGGTGGCCGTGTGTGACATCCCGCCCCGCGGC
CTCAAGATGTCCTCCACCTTCATCGGGAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAAGAGGGCGAGATGTACGAAGACGAC
GAGGAGGAGTCGGAGGCCCAGGGCCCCAAGTGA
|
| Target 26 GenBank Gene ID |
Not Available |
| Target 26 GeneCard ID |
TUBB3 |
| Target 26 GenAtlas ID |
TUBB3 |
| Target 26 HGNC ID |
HGNC:20772 |
| Target 26 Chromosome Location |
Chromosome:16 |
| Target 26 Locus |
16q24.3 |
| Target 26 SNPs |
SNPJam Report |
| Target 26 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 26 General References |
9473684; 15489334; 19524510 |
|
Target 27
[top]
|
| Target 27 ID |
136 |
| Target 27 Name |
Tubulin beta-4 chain |
| Target 27 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 27 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain |
| Target 27 Synonyms |
- Tubulin 5 beta
|
| Target 27 Gene Name |
TUBB4 |
| Target 27 Protein Sequence |
>Tubulin beta-4 chain
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA
|
| Target 27 Number of Residues |
444 |
| Target 27 Molecular Weight |
49585.5 |
| Target 27 Theoretical pI |
4.51 |
| Target 27 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 27 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 27 Pathways |
Not Available |
| Target 27 Reactions |
Not Available |
| Target 27 Signals |
|
| Target 27 Transmembrane Regions |
|
| Target 27 Essentiality |
Non Essential |
| Target 27 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 27 GenBank ID Protein |
Not Available |
| Target 27 UniProtKB ID |
P04350 |
| Target 27 Cellular Location |
Cytoplasmic |
| Target 27 Gene Sequence |
>1335 bp
ATGCGGGAGATCGTGCACCTGCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTT
TGGGAGGTTATCAGTGACGAACATGGCATCGACCCCACAGGCACATACCATGGGGACAGT
GACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCCACAGGAGGAAATTATGTC
CCCAGAGCGGTGCTGGTGGACCTGGAACCCGGCACCATGGACTCTGTCCGTTCTGGCCCC
TTCGGTCAGATCTTTCGGCCGGACAACTTCGTGTTTGGCCAATCCGGAGCCGGCAACAAC
TGGGCAAAGGGGCACTACACGGAGGGCGCAGAGCTGGTGGACGCTGTCCTGGACGTAGTC
CGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGTGGCACGGGGTCCGGAATGGGCACGCTGCTCATCAGTAAGATCCGCGAGGAGTTCCCA
GACCGCATCATGAACACCTTCAGCGTGGTGCCCTCGCCCAAAGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACGCTGTCTGTGCACCAGCTGGTGGAGAATACGGATGAGACCTAC
TGCATCGACAACGAGGCACTCTACGACATCTGTTTCCGCACCCTCAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCCGTCAACATGGTCCCCTTT
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCACCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCCCTGACGGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCGGCGTGCGACCCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCGCGACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCTTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTATCT
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAGGGCGAGTTCGAGGAGGAGGCGGAG
GAGGAGGTGGCCTAG
|
| Target 27 GenBank Gene ID |
Not Available |
| Target 27 GeneCard ID |
TUBB4 |
| Target 27 GenAtlas ID |
TUBB4 |
| Target 27 HGNC ID |
HGNC:20774 |
| Target 27 Chromosome Location |
Chromosome:19 |
| Target 27 Locus |
19p13.3 |
| Target 27 SNPs |
SNPJam Report |
| Target 27 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 27 General References |
6462917; 15489334; 8619814; 16565220; 19524510 |
|
Target 28
[top]
|
| Target 28 ID |
74 |
| Target 28 Name |
Tubulin beta-6 chain |
| Target 28 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 28 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 28 Synonyms |
Not Available |
| Target 28 Gene Name |
TUBB6 |
| Target 28 Protein Sequence |
>Tubulin beta-6 chain
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYV
PRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVV
RKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMM
AACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATANDGEEAFEDEEEEIDG
|
| Target 28 Number of Residues |
446 |
| Target 28 Molecular Weight |
49856.8 |
| Target 28 Theoretical pI |
4.51 |
| Target 28 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 28 General Function |
Involved in GTP binding |
| Target 28 Pathways |
Not Available |
| Target 28 Reactions |
Not Available |
| Target 28 Signals |
|
| Target 28 Transmembrane Regions |
|
| Target 28 Essentiality |
Non Essential |
| Target 28 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 28 GenBank ID Protein |
Not Available |
| Target 28 UniProtKB ID |
Q9BUF5 |
| Target 28 Cellular Location |
Cytoplasmic |
| Target 28 Gene Sequence |
>1341 bp
ATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGGCACCAAGTTT
TGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCG
GCGCTGCAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTG
CCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCGGTCTGGGCCT
TTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGGCCAGACGGGTGCAGGGAACAAC
TGGGCGAAAGGGCACTACACGGAGGGCGCGGAGCTGGTGGACGCAGTGCTGGACGTGGTG
CGGAAGGAGTGCGAGCACTGCGACTGCCTGCAGGGCTTCCAGCTCACGCACTCGCTGGGC
GGCGGCACGGGCTCAGGCATGGGCACGCTGCTCATCAGCAAGATCCGTGAGGAGTTCCCG
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCGCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAATGCCACACTGTCGGTGCACCAGCTGGTGGAGAATACAGACGAGACCTAC
TGCATCGACAACGAGGCGCTCTATGACATCTGCTTCCGCACTCTGAAGCTGACAACGCCC
ACCTACGGGGACCTCAACCACCTGGTGTCCGCCACCATGAGTGGGGTCACCACCTCGCTG
CGCTTCCCGGGCCAGCTCAATGCTGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCTGGCTTCGCGCCGCTCACCAGCCGCGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGACGCCAGGAACATGATG
GCCGCCTGCGATCCGCGCCATGGCCGCTACCTGACCGTGGCCACCGTGTTCCGCGGGCCC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGTAAGAACAGCAGCTAC
TTCGTGGAGTGGATTCCCAACAACGTGAAGGTGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCTCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCTCAGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTTCACGGGT
GAGGGCATGGATGAAATGGAGTTCACCGAGGCGGAGAGCAACATGAACGACCTGGTATCC
GAGTACCAGCAGTACCAGGATGCCACCGCCAATGACGGGGAGGAAGCTTTTGAGGATGAG
GAAGAGGAGATCGATGGATAG
|
| Target 28 GenBank Gene ID |
Not Available |
| Target 28 GeneCard ID |
TUBB6 |
| Target 28 GenAtlas ID |
TUBB6 |
| Target 28 HGNC ID |
HGNC:20776 |
| Target 28 Chromosome Location |
Chromosome:18 |
| Target 28 Locus |
18p11.21 |
| Target 28 SNPs |
SNPJam Report |
| Target 28 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 28 General References |
14702039; 15489334; 17525332; 19524510 |
|
Target 29
[top]
|
| Target 29 ID |
228 |
| Target 29 Name |
Tubulin beta-8 chain |
| Target 29 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 29 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 29 Synonyms |
Not Available |
| Target 29 Gene Name |
TUBB8 |
| Target 29 Protein Sequence |
>Tubulin beta-8 chain
MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
|
| Target 29 Number of Residues |
444 |
| Target 29 Molecular Weight |
49775.7 |
| Target 29 Theoretical pI |
4.52 |
| Target 29 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 29 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 29 Pathways |
Not Available |
| Target 29 Reactions |
Not Available |
| Target 29 Signals |
|
| Target 29 Transmembrane Regions |
|
| Target 29 Essentiality |
Non Essential |
| Target 29 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 29 GenBank ID Protein |
Not Available |
| Target 29 UniProtKB ID |
Q3ZCM7 |
| Target 29 Cellular Location |
Cytoplasmic |
| Target 29 Gene Sequence |
Not Available |
| Target 29 GenBank Gene ID |
Not Available |
| Target 29 GeneCard ID |
TUBB8 |
| Target 29 GenAtlas ID |
Not Available |
| Target 29 HGNC ID |
Not Available |
| Target 29 Chromosome Location |
Not Available |
| Target 29 Locus |
Not Available |
| Target 29 SNPs |
SNPJam Report |
| Target 29 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 29 General References |
11731935; 15164054; 15489334; 19524510 |
|
Target 30
[top]
|
| Target 30 ID |
276 |
| Target 30 Name |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| Target 30 Mechanism of Action |
Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001) |
| Target 30 Description |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) |
| Target 30 Synonyms |
- Pyruvate dehydrogenase complex E2 subunit; PDC-E2; PDCE2; E2; Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; M2 antigen complex 70 kDa subunit
|
| Target 30 Gene Name |
DLAT |
| Target 30 Protein Sequence |
>Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
MWRVCARRAQNVAPWAGLEARWTALQEVPGTPRVTSRSGPAPARRNSVTTGYGGVRALCG
WTPSSGATPRNRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGDKIN
EGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYT
LDSSAAPTPQAAPAPTPAATASPPTPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEK
KVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADI
SAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSAPCPATPAGPKGRVFVSPL
AKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVF
TDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFI
IKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIAND
VVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPA
DNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPITMLL
|
| Target 30 Number of Residues |
647 |
| Target 30 Molecular Weight |
68996.0 |
| Target 30 Theoretical pI |
7.94 |
| Target 30 GO Classification |
|
Function
|
binding
protein binding
acetyltransferase activity
S-acetyltransferase activity
dihydrolipoyllysine-residue acetyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring groups other than amino-acyl groups
acyltransferase activity |
|
Process
|
cellular metabolism
alcohol metabolism
monosaccharide metabolism
hexose metabolism
glucose metabolism
glucose catabolism
glycolysis
physiological process
metabolism |
|
Component
|
protein complex
pyruvate dehydrogenase complex |
|
| Target 30 General Function |
Energy production and conversion |
| Target 30 Pathways |
Not Available |
| Target 30 Reactions |
Not Available |
| Target 30 Signals |
|
| Target 30 Transmembrane Regions |
|
| Target 30 Essentiality |
Non Essential |
| Target 30 Domain Function |
PF00198:2-oxoacid_dh
PF00364:Biotin_lipoyl
PF02817:E3_binding |
| Target 30 GenBank ID Protein |
Not Available |
| Target 30 UniProtKB ID |
P10515 |
| Target 30 Cellular Location |
Mitochondrion matrix |
| Target 30 Gene Sequence |
Not Available |
| Target 30 GenBank Gene ID |
Not Available |
| Target 30 GeneCard ID |
DLAT |
| Target 30 GenAtlas ID |
DLAT |
| Target 30 HGNC ID |
HGNC:2896 |
| Target 30 Chromosome Location |
Chromosome:11 |
| Target 30 Locus |
11q23.1 |
| Target 30 SNPs |
SNPJam Report |
| Target 30 Toxin References |
- R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.
|
| Target 30 General References |
16554811; 3174635; 3191998; 9649469; 16049940 |
|
Target 31
[top]
|
| Target 31 ID |
273 |
| Target 31 Name |
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial |
| Target 31 Mechanism of Action |
Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001) |
| Target 31 Description |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) |
| Target 31 Synonyms |
- PDHE1-A type I
|
| Target 31 Gene Name |
PDHA1 |
| Target 31 Protein Sequence |
>Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
|
| Target 31 Number of Residues |
390 |
| Target 31 Molecular Weight |
43295.3 |
| Target 31 Theoretical pI |
8.14 |
| Target 31 GO Classification |
|
Function
|
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
|
Process
|
physiological process
metabolism |
|
Component
|
| Not Available |
|
| Target 31 General Function |
Energy production and conversion |
| Target 31 Pathways |
Not Available |
| Target 31 Reactions |
Not Available |
| Target 31 Signals |
|
| Target 31 Transmembrane Regions |
|
| Target 31 Essentiality |
Non Essential |
| Target 31 Domain Function |
PF00676:E1_dh |
| Target 31 GenBank ID Protein |
Not Available |
| Target 31 UniProtKB ID |
P08559 |
| Target 31 Cellular Location |
Mitochondrion matrix |
| Target 31 Gene Sequence |
>1173 bp
GCCTGTGCTTCATGAGGAAGATGCTCGCCGCCGTCTCCCGCGTGCTGTCTGGCGCTTCTC
AGAAGCCGGCAAGCAGAGTGCTGGTAGCATCCCGTAATTTTGCAAATGATGCTACATTTG
AAATTAAGAAATGTGACCTTCACCGGCTGGAAGAAGGCCCTCCTGTCACAACAGTGCTCA
CCAGGGAGGATGGGCTCAAATACTACAGGATGATGCAGACTGTACGCCGAATGGAGTTGA
AAGCAGATCAGCTGTATAAACAGAAAATTATTCGTGGTTTCTGTCACTTGTGTGATGGTC
AGGAAGCTTGCTGTGTGGGCCTGGAGGCCGGCATCAACCCCACAGACCATCTCATCACAG
CCTACCGGGCTCACGGCTTTACTTTCACCCGGGGCCTTTCCGTCCGAGAAATTCTCGCAG
AGCTTACAGGACGAAAAGGAGGTTGTGCTAAAGGGAAAGGAGGATCGATGCACATGTATG
CCAAGAACTTCTACGGGGGCAATGGCATCGTGGGAGCGCAGGTGCCCCTGGGCGCTGGGA
TTGCTCTAGCCTGTAAGTATAATGGAAAAGATGAGGTCTGCCTGACTTTATATGGCGATG
GTGCTGCTAACCAGGGCCAGATATTCGAAGCTTACAACATGGCAGCTTTGTGGAAATTAC
CTTGTATTTTCATCTGTGAGAATAATCGCTATGGAATGGGAACGTCTGTTGAGAGAGCGG
CAGCCAGCACTGATTACTACAAGAGAGGCGATTTCATTCCTGGGCTGAGAGTGGATGGAA
TGGATATCCTGTGCGTCCGAGAGGCAACAAGGTTTGCTGCTGCCTATTGTAGATCTGGGA
AGGGGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACC
CTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGGAAGTAAGAAGTAAGAGTGACCCTA
TTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGG
AAATTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATC
CTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCTACTCCAGCGACCCACCTTTTGAAG
TTCGTGGTGCCAATCAGTGGATCAAGTTTAAGT
|
| Target 31 GenBank Gene ID |
Not Available |
| Target 31 GeneCard ID |
PDHA1 |
| Target 31 GenAtlas ID |
PDHA1 |
| Target 31 HGNC ID |
HGNC:8806 |
| Target 31 Chromosome Location |
Not Available |
| Target 31 Locus |
Xp22.2-p22.1 |
| Target 31 SNPs |
SNPJam Report |
| Target 31 Toxin References |
- R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.
|
| Target 31 General References |
2227443; 2748588; 3034892; 2745444; 2828359; 3422424; 15489334; 10077682 |
|
Target 32
[top]
|
| Target 32 ID |
275 |
| Target 32 Name |
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial |
| Target 32 Mechanism of Action |
Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001) |
| Target 32 Description |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) |
| Target 32 Synonyms |
- PDHE1-B
|
| Target 32 Gene Name |
PDHB |
| Target 32 Protein Sequence |
>Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV
AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI
DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS
EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV
SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG
VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
|
| Target 32 Number of Residues |
359 |
| Target 32 Molecular Weight |
39233.1 |
| Target 32 Theoretical pI |
6.63 |
| Target 32 GO Classification |
|
Function
|
| Not Available |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 32 General Function |
Energy production and conversion |
| Target 32 Pathways |
Not Available |
| Target 32 Reactions |
Not Available |
| Target 32 Signals |
|
| Target 32 Transmembrane Regions |
|
| Target 32 Essentiality |
Non Essential |
| Target 32 Domain Function |
PF02779:Transket_pyr
PF02780:Transketolase_C |
| Target 32 GenBank ID Protein |
Not Available |
| Target 32 UniProtKB ID |
P11177 |
| Target 32 Cellular Location |
Mitochondrion matrix |
| Target 32 Gene Sequence |
>1080 bp
ATGGCGGCGGTGTCTGGCTTGGTGCGGAGACCCCTTCGGGAGGTCTCCGGGCTGCTGAAG
AGGCGCTTTCACTGGACCGCGCCGGCTGCGCTGCAGGTGACAGTTCGTGATGCTATAAAT
CAGGGTATGGATGAGGAGCTGGAAAGAGATGAGAAGGTATTTCTGCTTGGAGAAGAAGTT
GCCCAGTATGATGGGGCATACAAGGTTAGTCGAGGGCTGTGGAAGAAATATGGAGACAAG
AGGATTATTGACACTCCCATATCAGAGATGGGCTTTGCTGGAATTGCTGTAGGTGCAGCT
ATGGCTGGGTTGCGGCCCATTTGTGAATTTATGACCTTCAATTTCTCCATGCAAGCCATT
GACCAGGTTATAAACTCAGCTGCCAAGACCTACTACATGTCTGGTGGCCTTCAGCCTGTG
CCTATAGTCTTCAGGGGACCCAATGGTGCCTCAGCAGGTGTAGCTGCCCAGCACTCACAG
TGCTTTGCTGCCTGGTATGGGCACTGCCCAGGCTTAAAGGTGGTCAGTCCCTGGAATTCA
GAGGATGCTAAAGGACTTATTAAATCAGCCATTCGGGATAACAATCCAGTGGTGGTGCTA
GAGAATGAATTGATGTATGGGGTTCCTTTTGAATTTCCTCCGGAAGCTCAGTCAAAAGAT
TTTCTGATTCCTATTGGAAAAGCCAAAATAGAAAGGCAAGGAACACATATAACTGTGGTT
TCCCATTCAAGACCTGTGGGCCACTGCTTAGAAGCTGCAGCAGTGCTATCTAAAGAAGGA
GTTGAATGTGAGGTGATAAATATGCGTACCATTAGACCAATGGACATGGAAACCATAGAA
GCCAGTGTCATGAAGACAAATCATCTTGTAACTGTGGAAGGAGGCTGGCCACAGTTTGGA
GTAGGAGCTGAAATCTGTGCCAGGATCATGGAAGGTCCTGCGTTCAATTTCCTGGATGCT
CCTGCTGTTCGTGTCACTGGTGCTGATGTCCCTATGCCTTATGCAAAGATTCTAGAGGAC
AACTCTATACCTCAGGTCAAAGACATCATATTTGCAATAAAGAAAACATTAAATATTTAG
|
| Target 32 GenBank Gene ID |
Not Available |
| Target 32 GeneCard ID |
PDHB |
| Target 32 GenAtlas ID |
PDHB |
| Target 32 HGNC ID |
HGNC:8808 |
| Target 32 Chromosome Location |
Not Available |
| Target 32 Locus |
3p21.1-p14.2 |
| Target 32 SNPs |
SNPJam Report |
| Target 32 Toxin References |
- R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.
|
| Target 32 General References |
2323578; 1702713; 2376596; 2377599; 3422424; 11230166; 15489334; 2829898; 7895732 |
|
Target 33
[top]
|
| Target 33 ID |
274 |
| Target 33 Name |
Pyruvate dehydrogenase protein X component, mitochondrial |
| Target 33 Mechanism of Action |
Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001) |
| Target 33 Description |
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex |
| Target 33 Synonyms |
- Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Lipoyl-containing pyruvate dehydrogenase complex component X; E3-binding protein; E3BP; proX
|
| Target 33 Gene Name |
PDHX |
| Target 33 Protein Sequence |
>Pyruvate dehydrogenase protein X component, mitochondrial
MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSK
NIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTL
RFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTAT
PTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPH
AYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF
IDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDD
ELATRFLKSFKANLENPIRLA
|
| Target 33 Number of Residues |
501 |
| Target 33 Molecular Weight |
54121.8 |
| Target 33 Theoretical pI |
9.09 |
| Target 33 GO Classification |
|
Function
|
binding
protein binding
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring groups other than amino-acyl groups
acyltransferase activity |
|
Process
|
physiological process
metabolism |
|
Component
|
| Not Available |
|
| Target 33 General Function |
Energy production and conversion |
| Target 33 Pathways |
Not Available |
| Target 33 Reactions |
Not Available |
| Target 33 Signals |
|
| Target 33 Transmembrane Regions |
|
| Target 33 Essentiality |
Non Essential |
| Target 33 Domain Function |
PF00198:2-oxoacid_dh
PF00364:Biotin_lipoyl
PF02817:E3_binding |
| Target 33 GenBank ID Protein |
Not Available |
| Target 33 UniProtKB ID |
O00330 |
| Target 33 Cellular Location |
Mitochondrion matrix |
| Target 33 Gene Sequence |
>1506 bp
ATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTC
CCTGGCTGCCGAAGCGTAGGGCTGGTGAAGGGGGCTCTTGGGTGGTCCGTAAGCCGCGGA
GCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTA
ATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAA
GGTGAAGCGGTGAGTGCTGGAGATGCATTATGTGAAATTGAGACTGACAAAGCTGTGGTT
ACCTTAGATGCAAGTGATGATGGAATCTTGGCCAAAATCGTGGTTGAAGAAGGAAGTAAA
AATATACGGCTAGGTTCACTAATTGGTTTGATAGTAGAAGAAGGAGAAGATTGGAAACAT
GTTGAAATTCCCAAAGACGTAGGTCCTCCACCACCAGTTTCAAAACCTTCAGAGCCTCGC
CCCTCACCAGAACCACAGATTTCCATCCCTGTCAAGAAGGAACACATACCCGGGACACTA
CGGTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAACACTCACTGGATGCTAGC
CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGAGGATGCTCTCAAACTTGTC
CAGTTGAAACAAACGGGCAAGATTACCGAGTCCAGACCAACTCCAGCCCCCACAGCCACT
CCCACAGCACCTTCGCCCCTACAGGCCACATCTGGACCATCTTATCCCCGGCCTGTGATC
CCACCAGTATCAACTCCCGGACAACCCAATGCAGTGGGCACATTCACTGAAATCCCCGCC
AGCAATATTCGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGTACTGTACCTCAT
GCATATGCTACTGCTGACTGTGACCTTGGAGCTGTTTTAAAAGTTAGGCAAGATCTGGTC
AAAGATGACATTAAAGTATCAGTAAATGATTTTATCATCAAGGCAGCAGCTGTTACCCTT
AAACAAATGCCAGATGTTAATGTAAGCTGGGATGGAGAGGGCCCAAAGCAACTGCCATTT
ATTGACATTTCAGTGGCTGTGGCAACAGATAAAGGCTTACTTACTCCAATCATAAAAGAT
GCTGCTGCTAAAGGTATCCAGGAAATTGCTGACTCTGTAAAGGCTCTATCAAAGAAAGCA
AGAGATGGAAAATTGTTGCCTGAAGAATACCAAGGAGGATCTTTTAGTATTTCCAACTTG
GGGATGTTTGGCATCGACGAATTTACTGCAGTGATTAACCCTCCTCAGGCCTGCATTTTG
GCGGTTGGGAGGTTCCGACCTGTGCTGAAGCTCACTGAGGATGAAGAGGGAAATGCCAAA
CTGCAGCAGCGCCAGCTCATAACAGTCACAATGTCAAGTGACAGTCGAGTGGTTGATGAC
GAACTGGCAACCAGGTTTCTTAAAAGTTTTAAAGCAAACCTAGAGAATCCTATCCGACTT
GCCTAG
|
| Target 33 GenBank Gene ID |
Not Available |
| Target 33 GeneCard ID |
PDHX |
| Target 33 GenAtlas ID |
PDHX |
| Target 33 HGNC ID |
HGNC:21350 |
| Target 33 Chromosome Location |
Chromosome:11 |
| Target 33 Locus |
11p13 |
| Target 33 SNPs |
SNPJam Report |
| Target 33 Toxin References |
- R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.
|
| Target 33 General References |
9242632; 9399911; 9467010; 15489334; 9110174; 16263718; 16442803 |
|
Target 34
[top]
|
| Target 34 ID |
12 |
| Target 34 Name |
Actin, cytoplasmic 1 |
| Target 34 Mechanism of Action |
Arsenic binds to actin. (R053) |
| Target 34 Description |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| Target 34 Synonyms |
- Beta-actin; Actin, cytoplasmic 1, N-terminally processed
|
| Target 34 Gene Name |
ACTB |
| Target 34 Protein Sequence |
>Actin, cytoplasmic 1
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
|
| Target 34 Number of Residues |
375 |
| Target 34 Molecular Weight |
41736.4 |
| Target 34 Theoretical pI |
5.15 |
| Target 34 GO Classification |
|
Function
|
structural molecule activity
structural constituent of cytoskeleton
motor activity
binding
protein binding |
|
Process
|
| Not Available |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
actin cytoskeleton
actin filament |
|
| Target 34 General Function |
Cytoskeleton |
| Target 34 Pathways |
Not Available |
| Target 34 Reactions |
Not Available |
| Target 34 Signals |
|
| Target 34 Transmembrane Regions |
|
| Target 34 Essentiality |
Non Essential |
| Target 34 Domain Function |
PF00022:Actin |
| Target 34 GenBank ID Protein |
Not Available |
| Target 34 UniProtKB ID |
P60709 |
| Target 34 Cellular Location |
Cytoplasm, cytoskeleton |
| Target 34 Gene Sequence |
>1128 bp
ATGGATGATGATATCGCCGCGCTCGTCGTCGACAACGGCTCCGGCATGTGCAAGGCCGGC
TTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCAC
CAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCCTATGTGGGCGACGAGGCCCAGAGC
AAGAGAGGCATCCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGAC
GACATGGAGAAAATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCCGAGGAG
CACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACC
CAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTTGCTATCCAGGCTGTGCTA
TCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACC
CACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTG
GCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGCGGCTACAGCTTC
ACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTACGTCGCC
CTGGACTTCGAGCAAGAGATGGCCACGGCTGCTTCCAGCTCCTCCCTGGAGAAGAGCTAC
GAGCTGCCTGACGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGCTGCCCTGAGGCA
CTCTTCCAGCCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAAC
TCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACAGTGCTGTCT
GGCGGCACCACCATGTACCCTGGCATTGCCGACAGGATGCAGAAGGAGATCACTGCCCTG
GCACCCAGCACAATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCCGTGTGG
ATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAG
GAGTATGACGAGTCCGGCCCCTCCATCGTCCACCGCAAATGCTTCTAG
|
| Target 34 GenBank Gene ID |
Not Available |
| Target 34 GeneCard ID |
ACTB |
| Target 34 GenAtlas ID |
ACTB |
| Target 34 HGNC ID |
HGNC:132 |
| Target 34 Chromosome Location |
Not Available |
| Target 34 Locus |
7p15-p12 |
| Target 34 SNPs |
SNPJam Report |
| Target 34 Toxin References |
- R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]
|
| Target 34 General References |
6322116; 2994062; 1734024; 12853948; 15489334; 12665801; 6842590 |
|
Target 35
[top]
|
| Target 35 ID |
151 |
| Target 35 Name |
Actin, cytoplasmic 2 |
| Target 35 Mechanism of Action |
Arsenic binds to actin. (R053) |
| Target 35 Description |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| Target 35 Synonyms |
- Gamma-actin; Actin, cytoplasmic 2, N-terminally processed
|
| Target 35 Gene Name |
ACTG1 |
| Target 35 Protein Sequence |
>Actin, cytoplasmic 2
MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
|
| Target 35 Number of Residues |
375 |
| Target 35 Molecular Weight |
41792.5 |
| Target 35 Theoretical pI |
5.16 |
| Target 35 GO Classification |
|
Function
|
structural molecule activity
structural constituent of cytoskeleton
motor activity
binding
protein binding |
|
Process
|
| Not Available |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
actin cytoskeleton
actin filament |
|
| Target 35 General Function |
Cytoskeleton |
| Target 35 Pathways |
Not Available |
| Target 35 Reactions |
Not Available |
| Target 35 Signals |
|
| Target 35 Transmembrane Regions |
|
| Target 35 Essentiality |
Non Essential |
| Target 35 Domain Function |
PF00022:Actin |
| Target 35 GenBank ID Protein |
Not Available |
| Target 35 UniProtKB ID |
P63261 |
| Target 35 Cellular Location |
Cytoplasm, cytoskeleton |
| Target 35 Gene Sequence |
>1128 bp
ATGGAAGAAGAGATCGCCGCGCTGGTCATTGACAATGGCTCCGGCATGTGCAAAGCTGGT
TTTGCTGGGGACGACGCTCCCCGAGCCGTGTTTCCTTCCATCGTCGGGCGCCCCAGACAC
CAGGGCGTCATGGTGGGCATGGGCCAGAAGGACTCCTACGTGGGCGACGAGGCCCAGAGC
AAGCGTGGCATCCTGACCCTGAAGTACCCCATTGAGCATGGCATCGTCACCAACTGGGAC
GACATGGAGAAGATCTGGCACCACACCTTCTACAACGAGCTGCGCGTGGCCCCGGAGGAG
CACCCAGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACAGAGAGAAGATGACT
CAGATTATGTTTGAGACCTTCAACACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTG
TCCCTCTACGCCTCTGGGCGCACCACTGGCATTGTCATGGACTCTGGAGACGGGGTCACC
CACACGGTGCCCATCTACGAGGGCTACGCCCTCCCCCACGCCATCCTGCGTCTGGACCTG
GCTGGCCGGGACCTGACCGACTACCTCATGAAGATCCTCACTGAGCGAGGCTACAGCTTC
ACCACCACGGCCGAGCGGGAAATCGTGCGCGACATCAAGGAGAAGCTGTGCTACGTCGCC
CTGGACTTCGAGCAGGAGATGGCCACCGCCGCATCCTCCTCTTCTCTGGAGAAGAGCTAC
GAGCTGCCCGATGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGGTGTCCGGAGGCG
CTGTTCCAGCCTTCCTTCCTGGGTATGGAATCTTGCGGCATCCACGAGACCACCTTCAAC
TCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACGGTGCTGTCG
GGCGGCACCACCATGTACCCGGGCATTGCCGACAGGATGCAGAAGGAGATCACCGCCCTG
GCGCCCAGCACCATGAAGATCAAGATCATCGCACCCCCAGAGCGCAAGTACTCGGTGTGG
ATCGGTGGCTCCATCCTGGCCTCACTGTCCACCTTCCAGCAGATGTGGATTAGCAAGCAG
GAGTACGACGAGTCGGGCCCCTCCATCGTCCACCGCAAATGCTTCTAA
|
| Target 35 GenBank Gene ID |
Not Available |
| Target 35 GeneCard ID |
ACTG1 |
| Target 35 GenAtlas ID |
ACTG1 |
| Target 35 HGNC ID |
HGNC:144 |
| Target 35 Chromosome Location |
Chromosome:17 |
| Target 35 Locus |
17q25 |
| Target 35 SNPs |
SNPJam Report |
| Target 35 Toxin References |
- R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]
|
| Target 35 General References |
3737401; 2837653; 14702039; 15489334; 12665801; 3472224 |
|
Target 36
[top]
|
| Target 36 ID |
378 |
| Target 36 Name |
Actin, alpha cardiac muscle 1 |
| Target 36 Mechanism of Action |
Arsenic binds to actin. (R053) |
| Target 36 Description |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| Target 36 Synonyms |
- Alpha-cardiac actin
|
| Target 36 Gene Name |
ACTC1 |
| Target 36 Protein Sequence |
>Actin, alpha cardiac muscle 1
MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
KQEYDEAGPSIVHRKCF
|
| Target 36 Number of Residues |
377 |
| Target 36 Molecular Weight |
42018.6 |
| Target 36 Theoretical pI |
5.05 |
| Target 36 GO Classification |
|
Function
|
structural molecule activity
structural constituent of cytoskeleton
motor activity
binding
protein binding |
|
Process
|
| Not Available |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
actin cytoskeleton
actin filament |
|
| Target 36 General Function |
Cytoskeleton |
| Target 36 Pathways |
Not Available |
| Target 36 Reactions |
Not Available |
| Target 36 Signals |
|
| Target 36 Transmembrane Regions |
|
| Target 36 Essentiality |
Non Essential |
| Target 36 Domain Function |
PF00022:Actin |
| Target 36 GenBank ID Protein |
Not Available |
| Target 36 UniProtKB ID |
P68032 |
| Target 36 Cellular Location |
Cytoplasm, cytoskeleton |
| Target 36 Gene Sequence |
Not Available |
| Target 36 GenBank Gene ID |
Not Available |
| Target 36 GeneCard ID |
ACTC1 |
| Target 36 GenAtlas ID |
ACTC1 |
| Target 36 HGNC ID |
HGNC:143 |
| Target 36 Chromosome Location |
Chromosome:15 |
| Target 36 Locus |
15q11-q14 |
| Target 36 SNPs |
SNPJam Report |
| Target 36 Toxin References |
- R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]
|
| Target 36 General References |
6310553; 15489334; 9563954; 10330430; 10966831; 14729850; 17947298; 18403758 |
|
Target 37
[top]
|
| Target 37 ID |
379 |
| Target 37 Name |
Actin, alpha skeletal muscle |
| Target 37 Mechanism of Action |
Arsenic binds to actin. (R053) |
| Target 37 Description |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| Target 37 Synonyms |
- Alpha-actin-1
|
| Target 37 Gene Name |
ACTA1 |
| Target 37 Protein Sequence |
>Actin, alpha skeletal muscle
MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
MSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIT
KQEYDEAGPSIVHRKCF
|
| Target 37 Number of Residues |
377 |
| Target 37 Molecular Weight |
42050.7 |
| Target 37 Theoretical pI |
5.05 |
| Target 37 GO Classification |
|
Function
|
structural molecule activity
structural constituent of cytoskeleton
motor activity
binding
protein binding |
|
Process
|
| Not Available |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
actin cytoskeleton
actin filament |
|
| Target 37 General Function |
Cytoskeleton |
| Target 37 Pathways |
Not Available |
| Target 37 Reactions |
Not Available |
| Target 37 Signals |
|
| Target 37 Transmembrane Regions |
|
| Target 37 Essentiality |
Non Essential |
| Target 37 Domain Function |
PF00022:Actin |
| Target 37 GenBank ID Protein |
Not Available |
| Target 37 UniProtKB ID |
P68133 |
| Target 37 Cellular Location |
Cytoplasm, cytoskeleton |
| Target 37 Gene Sequence |
>1134 bp
CCCGCCCAGAAACTAGACACAATGTGCGACGAAGACGAGACCACCGCCCTCGTGTGCGAC
AATGGCTCCGGCCTGGTGAAAGCCGGCTTCGCCGGGGATGACGCCCCTAGGGCCGTGTTC
CCGTCCATCGTGGGCCGCCCCCGACACCAGGGCGTCATGGTCGGTATGGGTCAGAAAGAT
TCCTACGTGGGCGACGAGGCTCAGAGCAAGAGAGGTATCCTGACCCTGAAGTACCCTATC
GAGCACGGCATCATCACCAACTGGGATGACATGGAGAAGATCTGGCACCACACCTTCTAC
AACGAGCTTCGCGTGGCTCCCGAGGAGCACCCCACCCTGCTCACCGAAGCCCCCCTCAAT
CCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACGTGCCCGCC
ATGTACGTGGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCCGGCAGGACCACCGGCATC
GTGCTGGACTCCGGCGACGGCGTCACCCACAACGTGCCCATTTATGAGGGCTACGCGCTG
CCGCACGCCATCATGCGCCTGGACCTGGCGGGCCGCGATCTTACCGACTACCTGATGAAG
ATCCTCACTGAGCGTGGCTACTCCTTCGTGACCACAGCTGAGCGCGAGATCGTGCGCGAC
ATCAAGGAGAAGCTGTGCTACGTGGCCCTGGACTTCGAGAACGAGATGGCGACGGCCGCC
TCCTCCTCCTCCCTGGAAAAGAGCTACGAGCTGCCAGACGGGCAGGTCATCACCATCGGC
AACGAGCGCTTCCGCTGCCCGGAGACGCTCTTCCAGCCCTCCTTCATCGGTATGGAGTCG
GCGGGCATTCACGAGACCACCTACAACAGCATCATGAAGTGTGACATCGACATCAGGAAG
GACCTGTATGCCAACAACGTCATGTCGGGGGGCACCACGATGTACCCTGGGATCGCTGAC
CGCATGCAGAAAGAGATCACCGCGCTGGCACCCAGCACCATGAAGATCAAGATCATCGCC
CCGCCGGAGCGCAAATACTCGGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACC
TTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTCCATC
|
| Target 37 GenBank Gene ID |
Not Available |
| Target 37 GeneCard ID |
ACTA1 |
| Target 37 GenAtlas ID |
ACTA1 |
| Target 37 HGNC ID |
HGNC:129 |
| Target 37 Chromosome Location |
Not Available |
| Target 37 Locus |
1q42.13 |
| Target 37 SNPs |
SNPJam Report |
| Target 37 Toxin References |
- R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]
|
| Target 37 General References |
6190133; 2907503; 10508519; 15489334; 10958653; 16916647; 18083107; 11333380; 11166164 |
|
Target 38
[top]
|
| Target 38 ID |
377 |
| Target 38 Name |
Actin, aortic smooth muscle |
| Target 38 Mechanism of Action |
Arsenic binds to actin. (R053) |
| Target 38 Description |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| Target 38 Synonyms |
- Alpha-actin-2; Cell growth-inhibiting gene 46 protein
|
| Target 38 Gene Name |
ACTA2 |
| Target 38 Protein Sequence |
>Actin, aortic smooth muscle
MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
KQEYDEAGPSIVHRKCF
|
| Target 38 Number of Residues |
377 |
| Target 38 Molecular Weight |
42008.6 |
| Target 38 Theoretical pI |
5.05 |
| Target 38 GO Classification |
|
Function
|
structural molecule activity
structural constituent of cytoskeleton
motor activity
binding
protein binding |
|
Process
|
| Not Available |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
actin cytoskeleton
actin filament |
|
| Target 38 General Function |
Cytoskeleton |
| Target 38 Pathways |
Not Available |
| Target 38 Reactions |
Not Available |
| Target 38 Signals |
|
| Target 38 Transmembrane Regions |
|
| Target 38 Essentiality |
Non Essential |
| Target 38 Domain Function |
PF00022:Actin |
| Target 38 GenBank ID Protein |
Not Available |
| Target 38 UniProtKB ID |
P62736 |
| Target 38 Cellular Location |
Cytoplasm, cytoskeleton |
| Target 38 Gene Sequence |
>1134 bp
ATGTGTGAAGAAGAGGACAGCACTGCCTTGGTGTGTGACAATGGCTCTGGGCTCTGTAAG
GCCGGCTTTGCTGGGGACGATGCTCCCAGGGCTGTTTTCCCATCCATTGTGGGACGTCCC
AGACATCAGGGGGTGATGGTGGGAATGGGACAAAAAGACAGCTACGTGGGTGACGAAGCA
CAGAGCAAAAGAGGAATCCTGACCCTGAAGTACCCGATAGAACATGGCATCATCACCAAC
TGGGACGACATGGAAAAGATCTGGCACCACTCTTTCTACAATGAGCTTCGTGTTGCCCCT
GAAGAGCATCCCACCCTGCTCACGGAGGCACCCCTGAACCCCAAGGCCAACCGGGAGAAA
ATGACTCAAATTATGTTTGAGACTTTCAATGTCCCAGCCATGTATGTGGCTATCCAGGCG
GTGCTGTCTCTCTATGCCTCTGGACGCACAACTGGCATCGTGCTGGACTCTGGAGATGGT
GTCACCCACAATGTCCCCATCTATGAGGGCTATGCCTTGCCCCATGCCATCATGCGTCTG
GATCTGGCTGGCCGAGATCTCACTGACTACCTCATGAAGATCCTGACTGAGCGTGGCTAT
TCCTTCGTTACTACTGCTGAGCGTGAGATTGTCCGGGACATCAAGGAGAAACTGTGTTAT
GTAGCTCTGGACTTTGAAAATGAGATGGCCACTGCCGCATCCTCATCCTCCCTTGAGAAG
AGTTACGAGTTGCCTGATGGGCAAGTGATCACCATCGGAAATGAACGTTTCCGCTGCCCA
GAGACCCTGTTCCAGCCATCCTTCATCGGGATGGAGTCTGCTGGCATCCATGAAACCACC
TACAACAGCATCATGAAGTGTGATATTGACATCAGGAAGGACCTCTATGCTAACAATGTC
CTATCAGGGGGCACCACTATGTACCCTGGCATTGCCGACCGAATGCAGAAGGAGATCACG
GCCCTAGCACCCAGCACCATGAAGATCAAGATCATTGCCCCTCCGGAGCGCAAATACTCT
GTCTGGATCGGTGGCTCCATCCTGGCCTCTCTGTCCACCTTCCAGCAGATGTGGATCAGC
AAACAGGAATACGATGAAGCCGGGCCTTCCATTGTCCACCGCAAATGCTTCTAA
|
| Target 38 GenBank Gene ID |
Not Available |
| Target 38 GeneCard ID |
ACTA2 |
| Target 38 GenAtlas ID |
ACTA2 |
| Target 38 HGNC ID |
HGNC:130 |
| Target 38 Chromosome Location |
Chromosome:10 |
| Target 38 Locus |
10q23.3 |
| Target 38 SNPs |
SNPJam Report |
| Target 38 Toxin References |
- R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]
|
| Target 38 General References |
2701935; 2295650; 15164054; 15489334; 6330528; 2612915; 15555551; 17994018 |
|
Target 39
[top]
|
| Target 39 ID |
380 |
| Target 39 Name |
Actin, gamma-enteric smooth muscle |
| Target 39 Mechanism of Action |
Arsenic binds to actin. (R053) |
| Target 39 Description |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| Target 39 Synonyms |
- Smooth muscle gamma-actin; Gamma-2-actin; Alpha-actin-3
|
| Target 39 Gene Name |
ACTG2 |
| Target 39 Protein Sequence |
>Actin, gamma-enteric smooth muscle
MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQ
SKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKM
TQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLD
LAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKS
YELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVL
SGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISK
PEYDEAGPSIVHRKCF
|
| Target 39 Number of Residues |
376 |
| Target 39 Molecular Weight |
41876.5 |
| Target 39 Theoretical pI |
5.16 |
| Target 39 GO Classification |
|
Function
|
structural molecule activity
structural constituent of cytoskeleton
motor activity
binding
protein binding |
|
Process
|
| Not Available |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
actin cytoskeleton
actin filament |
|
| Target 39 General Function |
Cytoskeleton |
| Target 39 Pathways |
Not Available |
| Target 39 Reactions |
Not Available |
| Target 39 Signals |
|
| Target 39 Transmembrane Regions |
|
| Target 39 Essentiality |
Non Essential |
| Target 39 Domain Function |
PF00022:Actin |
| Target 39 GenBank ID Protein |
Not Available |
| Target 39 UniProtKB ID |
P63267 |
| Target 39 Cellular Location |
Cytoplasm, cytoskeleton |
| Target 39 Gene Sequence |
>1131 bp
ATGTGTGAAGAGGAGACCACCGCGCTCGTGTGTGACAATGGCTCTGGCCTGTGCAAGGCA
GGCTTCGCAGGAGATGATGCCCCCCGGGCTGTCTTCCCCTCCATTGTGGGCCGCCCTCGC
CACCAGGGTGTGATGGTGGGAATGGGCCAGAAAGACAGCTATGTGGGGGATGAGGCTCAG
AGCAAGCGAGGGATCCTAACTCTCAAATACCCCATTGAACACGGCATCATCACCAACTGG
GATGACATGGAGAAGATCTGGCACCACTCCTTCTACAATGAGCTGCGTGTAGCACCTGAA
GAGCACCCCACCCTGCTCACAGAGGCTCCCCTAAATCCCAAGGCCAACAGGGAAAAGATG
ACCCAGATCATGTTTGAAACCTTCAATGTCCCTGCCATGTACGTCGCCATTCAAGCTGTG
CTCTCCCTCTATGCCTCTGGCCGCACGACAGGCATCGTCCTGGATTCAGGTGATGGCGTC
ACCCACAATGTCCCCATCTATGAAGGCTATGCCCTGCCCCATGCCATCATGCGCCTGGAC
TTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCC
TTTGTGACCACAGCTGAGAGAGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTG
GCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCTTCCTCTTCCTCCCTGGAGAAGAGC
TATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAG
ACCCTCTTCCAGCCTTCCTTTATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTAC
AATTCCATCATGAAGTGTGACATTGACATCCGTAAGGACTTATATGCCAACAATGTCCTC
TCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCC
CTGGCCCCCAGCACCATGAAGATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTC
TGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACCTTCCAGCAGATGTGGATCAGCAAG
CCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAA
|
| Target 39 GenBank Gene ID |
Not Available |
| Target 39 GeneCard ID |
ACTG2 |
| Target 39 GenAtlas ID |
ACTG2 |
| Target 39 HGNC ID |
HGNC:145 |
| Target 39 Chromosome Location |
Not Available |
| Target 39 Locus |
2p13.1 |
| Target 39 SNPs |
SNPJam Report |
| Target 39 Toxin References |
- R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]
|
| Target 39 General References |
2377475; 1710027; 14702039; 15815621; 15489334 |
|
Target 40
[top]
|
| Target 40 ID |
399 |
| Target 40 Name |
Tubulin alpha chain-like 3 |
| Target 40 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 40 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 40 Synonyms |
Not Available |
| Target 40 Gene Name |
TUBAL3 |
| Target 40 Protein Sequence |
>Tubulin alpha chain-like 3
MRECLSIHIGQAGIQIGDACWELYCLEHGIQPNGVVLDTQQDQLENAKMEHTNASFDTFF
CETRAGKHVPRALFVDLEPTVIDGIRTGQHRSLFHPEQLLSGKEDAANNYARGRYSVGSE
VIDLVLERTRKLAEQCGGLQGFLIFRSFGGGTGSGFTSLLMERLTGEYSRKTKLEFSVYP
APRISTAVVEPYNSVLTTHSTTEHTDCTFMVDNEAVYDICHRKLGVECPSHASINRLVVQ
VVSSITASLRFEGPLNVDLIEFQTNLVPYPRIHFPMTAFAPIVSADKAYHEQFSVSDITT
ACFESSNQLVKCDPRLGKYMACCLLYRGDVVPKEVNAAIAATKSRHSVQFVDWCPTGFKV
GINNRPPTVMPGGDLAKVHRSICMLSNTTAIVEAWARLDHKFDLMYAKRAFLHWYLREGM
EEAEFLEAREDLAALERDYEEVAQSF
|
| Target 40 Number of Residues |
446 |
| Target 40 Molecular Weight |
49908.3 |
| Target 40 Theoretical pI |
5.96 |
| Target 40 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 40 General Function |
Involved in GTP binding |
| Target 40 Pathways |
Not Available |
| Target 40 Reactions |
Not Available |
| Target 40 Signals |
|
| Target 40 Transmembrane Regions |
|
| Target 40 Essentiality |
Non Essential |
| Target 40 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 40 GenBank ID Protein |
Not Available |
| Target 40 UniProtKB ID |
A6NHL2 |
| Target 40 Cellular Location |
Cytoplasmic |
| Target 40 Gene Sequence |
>1341 bp
ATGAGGGAGTGCCTTTCCATCCACATCGGTCAAGCTGGCATCCAGATTGGGGACGCCTGC
TGGGAACTCTATTGCCTGGAACATGGAATCCAGCCAAATGGCGTTGTTCTTGACACTCAA
CAGGATCAGCTGGAAAATGCAAAAATGGAGCACACAAATGCATCTTTCGATACCTTCTTC
TGTGAGACAAGAGCTGGGAAGCATGTGCCTAGAGCACTCTTCGTGGACTTGGAGCCAACT
GTTATAGATGGGATCCGGACGGGCCAGCACCGTTCACTCTTCCACCCCGAGCAGCTCCTT
AGCGGAAAGGAGGATGCTGCCAACAATTACGCGCGAGGCCGTTACTCTGTGGGGTCGGAG
GTCATCGACCTTGTGCTGGAGAGGACCCGGAAGCTGGCAGAACAGTGTGGTGGACTTCAG
GGATTTTTGATTTTCCGAAGCTTTGGAGGAGGCACTGGTTCAGGGTTTACGTCTCTCTTA
ATGGAGAGGCTCACAGGAGAATATAGCAGAAAGACTAAGCTGGAGTTCTCGGTCTACCCA
GCCCCCAGGATCTCCACTGCCGTGGTAGAGCCTTATAACTCTGTCCTCACCACCCACTCC
ACCACAGAGCACACGGACTGTACCTTCATGGTGGACAACGAGGCCGTCTATGATATATGC
CATCGTAAACTCGGTGTTGAATGCCCCTCTCATGCCAGCATCAATAGATTGGTGGTTCAG
GTGGTATCTTCCATCACTGCCTCCCTCCGGTTTGAAGGGCCCTTGAATGTAGACCTAATT
GAATTCCAGACCAACCTGGTACCTTATCCGAGAATACATTTCCCCATGACAGCCTTCGCC
CCCATCGTCTCTGCTGACAAAGCCTACCATGAGCAGTTCTCTGTGTCAGACATCACCACT
GCTTGCTTTGAGTCCTCCAACCAGCTGGTCAAGTGTGATCCTCGGCTTGGGAAGTACATG
GCCTGCTGCCTACTCTATAGAGGGGATGTGGTCCCCAAGGAAGTGAATGCAGCAATCGCA
GCCACGAAGTCGAGGCACTCTGTTCAGTTTGTAGATTGGTGTCCAACTGGTTTCAAGGTG
GGCATCAACAATCGGCCGCCCACGGTGATGCCGGGTGGGGACCTGGCCAAAGTCCACCGG
TCCATCTGCATGCTGAGCAACACCACGGCGATTGTGGAGGCCTGGGCCCGCCTGGACCAC
AAGTTTGACCTCATGTACGCCAAGAGAGCATTTCTGCACTGGTACCTCAGAGAAGGCATG
GAAGAAGCAGAGTTCTTGGAGGCCAGGGAAGATCTGGCAGCCCTGGAGAGGGACTATGAG
GAAGTGGCGCAAAGTTTCTGA
|
| Target 40 GenBank Gene ID |
Not Available |
| Target 40 GeneCard ID |
TUBAL3 |
| Target 40 GenAtlas ID |
TUBAL3 |
| Target 40 HGNC ID |
HGNC:23534 |
| Target 40 Chromosome Location |
Chromosome:10 |
| Target 40 Locus |
10p15.1 |
| Target 40 SNPs |
SNPJam Report |
| Target 40 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 40 General References |
14702039; 15164054; 15489334; 17924679 |
|
Target 41
[top]
|
| Target 41 ID |
400 |
| Target 41 Name |
Tubulin beta-8 chain B |
| Target 41 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 41 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 41 Synonyms |
Not Available |
| Target 41 Gene Name |
Not Available |
| Target 41 Protein Sequence |
>Tubulin beta-8 chain B
MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
|
| Target 41 Number of Residues |
444 |
| Target 41 Molecular Weight |
49572.3 |
| Target 41 Theoretical pI |
4.49 |
| Target 41 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 41 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 41 Pathways |
Not Available |
| Target 41 Reactions |
Not Available |
| Target 41 Signals |
|
| Target 41 Transmembrane Regions |
|
| Target 41 Essentiality |
Non Essential |
| Target 41 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 41 GenBank ID Protein |
Not Available |
| Target 41 UniProtKB ID |
A6NNZ2 |
| Target 41 Cellular Location |
Cytoplasmic |
| Target 41 Gene Sequence |
Not Available |
| Target 41 GenBank Gene ID |
Not Available |
| Target 41 GeneCard ID |
Not Available |
| Target 41 GenAtlas ID |
Not Available |
| Target 41 HGNC ID |
Not Available |
| Target 41 Chromosome Location |
Not Available |
| Target 41 Locus |
Not Available |
| Target 41 SNPs |
Not Available |
| Target 41 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 41 General References |
16177791; 19524510 |
|
Target 42
[top]
|
| Target 42 ID |
425 |
| Target 42 Name |
Putative tubulin beta chain-like protein ENSP00000290377 |
| Target 42 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 42 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 42 Synonyms |
Not Available |
| Target 42 Gene Name |
Not Available |
| Target 42 Protein Sequence |
>Putative tubulin beta chain-like protein ENSP00000290377
MDSVRSGPFGQVLRPDNFIFGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQG
FQLTHSLGGGTGSGMVTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQL
IENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRK
LAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMRAARDPRHGRYLT
AAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAICDIPPRGLKMSASFIGNNA
AIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAKE
EEDEEYAEEEVA
|
| Target 42 Number of Residues |
372 |
| Target 42 Molecular Weight |
41774.7 |
| Target 42 Theoretical pI |
4.50 |
| Target 42 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 42 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 42 Pathways |
Not Available |
| Target 42 Reactions |
Not Available |
| Target 42 Signals |
|
| Target 42 Transmembrane Regions |
|
| Target 42 Essentiality |
Non Essential |
| Target 42 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 42 GenBank ID Protein |
Not Available |
| Target 42 UniProtKB ID |
A6NKZ8 |
| Target 42 Cellular Location |
Cytoplasmic |
| Target 42 Gene Sequence |
Not Available |
| Target 42 GenBank Gene ID |
Not Available |
| Target 42 GeneCard ID |
Not Available |
| Target 42 GenAtlas ID |
Not Available |
| Target 42 HGNC ID |
Not Available |
| Target 42 Chromosome Location |
Not Available |
| Target 42 Locus |
Not Available |
| Target 42 SNPs |
Not Available |
| Target 42 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 42 General References |
15164053 |
|
Target 43
[top]
|
| Target 43 ID |
426 |
| Target 43 Name |
Putative tubulin beta-4q chain |
| Target 43 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 43 Description |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity) |
| Target 43 Synonyms |
Not Available |
| Target 43 Gene Name |
TUBB4Q |
| Target 43 Protein Sequence |
>Putative tubulin beta-4q chain
MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVRSGPFAEVFRPDNFISRQCGAGNNWAKGRYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATVSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSQGSQQYRALTVAELTQQMFDAKNMM
AARDPRHGCYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNIKTAVCDIPPWG
LKMSVTFTGNNTAVQELKRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSE
YQQYQDATAEGEGV
|
| Target 43 Number of Residues |
434 |
| Target 43 Molecular Weight |
48434.2 |
| Target 43 Theoretical pI |
4.91 |
| Target 43 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 43 General Function |
Cell cycle control, cell division, chromosome partitioning |
| Target 43 Pathways |
Not Available |
| Target 43 Reactions |
Not Available |
| Target 43 Signals |
|
| Target 43 Transmembrane Regions |
|
| Target 43 Essentiality |
Non Essential |
| Target 43 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 43 GenBank ID Protein |
Not Available |
| Target 43 UniProtKB ID |
Q99867 |
| Target 43 Cellular Location |
Cytoplasmic |
| Target 43 Gene Sequence |
Not Available |
| Target 43 GenBank Gene ID |
Not Available |
| Target 43 GeneCard ID |
TUBB4Q |
| Target 43 GenAtlas ID |
TUBB4Q |
| Target 43 HGNC ID |
HGNC:12413 |
| Target 43 Chromosome Location |
Not Available |
| Target 43 Locus |
4q35 |
| Target 43 SNPs |
SNPJam Report |
| Target 43 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 43 General References |
10828619 |
|
Target 44
[top]
|
| Target 44 ID |
427 |
| Target 44 Name |
Putative tubulin-like protein alpha-4B |
| Target 44 Mechanism of Action |
Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054) |
| Target 44 Description |
Not Available |
| Target 44 Synonyms |
- Alpha-tubulin 4B
|
| Target 44 Gene Name |
TUBA4B |
| Target 44 Protein Sequence |
>Putative tubulin-like protein alpha-4B
MRHQQTERQDPSQPLSRQHGTYRQIFHPEQLITGKEDAANNYAWGHYTIGKEFIDLLLDR
IRKLADQCTGLQGFLVFHSLGRGTGSDVTSFLMEWLSVNYGKKSKLGFSIYPAPQVSTAM
VQPYNSILTTHTTLEHSDCAFMVDNKAIYDICHCNLDIERPTYTNLNRLISQIVSSITAS
LRFDGALNVDLTEFQTNLVSYLTSTSPWPPMHQSSLQKRYTTSSCWWQRLPMPALSLPTR
W
|
| Target 44 Number of Residues |
241 |
| Target 44 Molecular Weight |
27551.0 |
| Target 44 Theoretical pI |
7.93 |
| Target 44 GO Classification |
|
Function
|
| structural molecule activity |
|
Process
|
physiological process
cellular physiological process
cell organization and biogenesis
organelle organization and biogenesis
cytoskeleton organization and biogenesis
microtubule-based process
microtubule-based movement |
|
Component
|
organelle
non-membrane-bound organelle
intracellular non-membrane-bound organelle
cytoskeleton
microtubule cytoskeleton
microtubule |
|
| Target 44 General Function |
Involved in GTP binding |
| Target 44 Pathways |
Not Available |
| Target 44 Reactions |
Not Available |
| Target 44 Signals |
|
| Target 44 Transmembrane Regions |
|
| Target 44 Essentiality |
Non Essential |
| Target 44 Domain Function |
PF00091:Tubulin
PF03953:Tubulin_C |
| Target 44 GenBank ID Protein |
Not Available |
| Target 44 UniProtKB ID |
Q9H853 |
| Target 44 Cellular Location |
Cytoplasmic |
| Target 44 Gene Sequence |
>726 bp
ATGCGGCACCAGCAGACAGAGAGACAAGACCCCAGCCAGCCCCTGTCCAGGCAGCATGGC
ACATACCGCCAGATCTTCCATCCAGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAAT
AACTATGCCTGGGGCCACTACACCATTGGGAAGGAGTTCATCGACCTGCTACTGGACCGG
ATTCGGAAGCTGGCTGACCAGTGCACAGGACTTCAGGGCTTCCTGGTGTTCCACAGCCTT
GGTCGGGGCACTGGCTCTGACGTCACCTCATTCCTGATGGAGTGGCTTTCTGTTAACTAT
GGCAAGAAATCCAAGCTGGGATTCTCCATCTACCCAGCCCCCCAGGTGTCTACAGCCATG
GTCCAGCCCTACAACTCTATCCTGACCACCCACACCACCCTGGAGCACTCAGACTGTGCC
TTCATGGTGGACAACAAAGCAATCTATGACATCTGCCACCGCAACCTAGACATTGAGCGC
CCAACCTACACCAACCTCAATCGCCTCATTAGCCAAATTGTCTCCTCCATCACAGCTTCT
CTGCGCTTTGACGGGGCCCTCAATGTGGACCTGACAGAGTTCCAGACCAACCTGGTGTCC
TACCTCACATCCACTTCCCCCTGGCCACCTATGCACCAGTCATCTCTGCAGAAAAAGTAT
ACCACGAGCAGCTGTCGGTGGCAGAGATTACCAATGCCTGCTTTGAGCCTGCCAACCAGA
TGGTGA
|
| Target 44 GenBank Gene ID |
Not Available |
| Target 44 GeneCard ID |
TUBA4B |
| Target 44 GenAtlas ID |
TUBA4B |
| Target 44 HGNC ID |
HGNC:18637 |
| Target 44 Chromosome Location |
Not Available |
| Target 44 Locus |
Not Available |
| Target 44 SNPs |
SNPJam Report |
| Target 44 Toxin References |
- R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]
|
| Target 44 General References |
14702039; 15815621 |
