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Showing toxin card for Cadmium (T3D0007)

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Version 1.0
Creation Date 2009-03-06 18:57:54
Update Date 2010-03-18 21:52:14
Accession Number T3D0007
Name Cadmium
Compound Type
  • Cadmium Compound
  • Inorganic Compound
  • Metal
Description Cadmium is a transition metal and chemical element with the symbol Cd and atomic number 48. Cadmium is found naturally in the earth's crust, though rarely on it's own. It is usually extracted as a byproduct from mining, smelting, and refining sulfide ores of zinc, lead, and copper. (R019)
Synonyms
  1. Cadmio
  2. Cadmium Metallicum 6x - Tab
  3. Cadmium compounds
  4. Cadmium elemental
  5. Cadmium metallicum
  6. Cadmium muriaticum
  7. Elemental Cadmium
  8. Colloidal cadmium
  9. Kadmium [german]
Chemical IUPAC Name cadmium(2+) ion
Chemical Formula Cd
Chemical Structure Structure
CAS Registry Number 7440-43-9
InChI Identifier InChI=1S/Cd/q+2
InChI Key InChIKey=WLZRMCYVCSSEQC-UHFFFAOYSA-N
PubChem Compound ID 23973 Link Image
KEGG ID C01413 Link Image
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID 22977 Link Image
BioCyc ID CD%2b2 Link Image
SuperToxic ID Not Available
CTD ID D002104 Link Image
Stitch ID Cadmium Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID 6393
Wikipedia Link http://en.wikipedia.org/wiki/Cadmium Link Image
Monoisotopic Mass 113.903358
MOL File Show
PDB File Show
SDF File Show
SMILES [Cd++]
Appearance Bluish-white metallic solid.
Melting Point 594.22?K (321.07?°C, 609.93?°F)
Solubility Not Available
Predicted LogP -0.07
Route of Exposure Oral (R019) ; inhalation (R019) ; dermal (R019)
Mechanism of Action Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Accumulation of cadmium in the kidney results in increased excretion of vital low and high molecular weight proteins. Cadmium is a high affinity zinc analog and can interfere in its biological processes. It also binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R026, R058, R059, R069)
Metabolism Cadmium is absorbed from oral, inhalation, and dermal routes. Cadmium initially binds to metallothionein and albumin and is transported mainly to the kidney and liver. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Cadmium is not known to undergo any direct metabolic conversion and is excreted unchanged, mainly in the urine. (R019)
Toxicity Values LD50: 225 mg/kg (Oral, Rat) (R263) LD50: 5700 ug/kg (Intraperitoneal, Mouse) (R263)
Lethal Dose 150 mg (oral) or 39 mg/m3 over 20 minutes (inhalation) for an adult human. (R263, R271)
Carcinogenicity (IARC Classification) 1, carcinogenic to humans. (R264)
Uses/Sources Cadmium is used mainly in the electroplating of other metals and the production of metal alloys. It can be found in batteries, pigments, metal coatings, and plastics. Exposure usually occurs in an industrial setting, but can also result from breathing cigarette smoke and eating contaminated foods. (R019)
Minimum Risk Level Acute Inhalation: 0.00003 mg/m3 (R260) Chronic Inhalation: 0.00001 mg/m3 (R260) Intermediate Oral: 0.0005 mg/kg/day (R260) Chronic Oral: 0.0001 mg/kg/day (R260)
Health Effects Chronic exposure to cadmium fumes can cause chemical pneumonitis, pulmonary edema, and lung diseases such as bronchitis and emphysema. Cadmium also accumulates in the kidneys, causing permanent damage. Loss of bone density also occurs. (R019)
Symptoms Acute inhalation of cadmium fumes results in metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Ingestion of cadmium causes vomiting and diarrhea. (R019)
Treatment Cadmium poisoning is treated by removal from exposure and supportive care. If ingested, induced vomiting or gastric lavage may be performed. (R272)
General References
  • R019 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for cadmium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
  • R058 - Tsuruoka S, Swenson ER, Fujimura A, Imai M: Mechanism of Cd-induced inhibition of Na-glucose cotransporter in rabbit proximal tubule cells: roles of luminal pH and membrane-bound carbonic anhydrase. Nephron Physiol. 2008;110(2):p11-20. Epub 2008 Oct 13. [PubMed Link Image]
  • R164 - Wikipedia. Metallothionein. Last Updated 20 December 2008.
  • R271 - Buckler HM, Smith WDF, & Rees WDW: Self poisoning with oral cadmium chloride. Br Med J 1986; 292:1559-1560. [PubMed Link Image]
  • R263 - Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
  • R026 - OSHA (2005). Safety and Health Topics: Cadmium. Occupational Safety & Health Administrations.
  • R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R272 - International Programme on Chemical Safety (IPCS) INCHEM (1992). Poison Information Monograph for Cadmium.
  • R059 - Zang Y, Odwin-Dacosta S, Yager JD: Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells. Toxicol Lett. 2009 Jan 30;184(2):134-8. Epub 2008 Nov 11. [PubMed Link Image]
Targets
  1. Estrogen receptor
  2. Estrogen receptor beta
  3. Mitogen-activated protein kinase 1
  4. Mitogen-activated protein kinase 3
  5. Mitogen-activated protein kinase 4
  6. Mitogen-activated protein kinase 6
  7. Mitogen-activated protein kinase 7
  8. Mitogen-activated protein kinase 8
  9. Mitogen-activated protein kinase 9
  10. Mitogen-activated protein kinase 10
  11. Mitogen-activated protein kinase 11
  12. Mitogen-activated protein kinase 12
  13. Mitogen-activated protein kinase 13
  14. Mitogen-activated protein kinase 14
  15. C-jun-amino-terminal kinase-interacting protein 2
  16. C-jun-amino-terminal kinase-interacting protein 4
  17. C-jun-amino-terminal kinase-interacting protein 1
  18. C-jun-amino-terminal kinase-interacting protein 3
  19. Mitogen-activated protein kinase 15
Target 1 [top]
Target 1 ID 5
Target 1 Name Estrogen receptor
Target 1 Mechanism of Action Cadmium binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. (R059)
Target 1 Description Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues
Target 1 Synonyms
  1. ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
Target 1 Gene Name ESR1
Target 1 Protein Sequence >Estrogen receptor 
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Target 1 Number of Residues 595
Target 1 Molecular Weight 66215.4
Target 1 Theoretical pI 8.14
Target 1 GO Classification
Function
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 1 General Function Involved in estrogen receptor activity
Target 1 Pathways Not Available
Target 1 Reactions Not Available
Target 1 Signals
  • None
Target 1 Transmembrane Regions
  • None
Target 1 Essentiality Non Essential
Target 1 Domain Function PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4
Target 1 GenBank ID Protein Not Available
Target 1 UniProtKB ID P03372 Link Image
Target 1 Cellular Location Nucleus
Target 1 Gene Sequence >63 bp 
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
Target 1 GenBank Gene ID Not Available
Target 1 GeneCard ID ESR1 Link Image
Target 1 GenAtlas ID ESR1 Link Image
Target 1 HGNC ID HGNC:3467 Link Image
Target 1 Chromosome Location Not Available
Target 1 Locus 6q25.1
Target 1 SNPs SNPJam Report Link Image
Target 1 Toxin References
  • R059 - Zang Y, Odwin-Dacosta S, Yager JD: Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells. Toxicol Lett. 2009 Jan 30;184(2):134-8. Epub 2008 Nov 11. [PubMed Link Image]
Target 1 General References 3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106
Target 2 [top]
Target 2 ID 208
Target 2 Name Estrogen receptor beta
Target 2 Mechanism of Action Cadmium binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. (R059)
Target 2 Description Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
Target 2 Synonyms
  1. ER-beta; Nuclear receptor subfamily 3 group A member 2
Target 2 Gene Name ESR2
Target 2 Protein Sequence >Estrogen receptor beta 
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Target 2 Number of Residues 530
Target 2 Molecular Weight 59215.8
Target 2 Theoretical pI 8.55
Target 2 GO Classification
Function
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 2 General Function Involved in estrogen receptor activity
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Signals
  • None
Target 2 Transmembrane Regions
  • None
Target 2 Essentiality Non Essential
Target 2 Domain Function PF00104:Hormone_recep PF00105:zf-C4
Target 2 GenBank ID Protein Not Available
Target 2 UniProtKB ID Q92731 Link Image
Target 2 Cellular Location Nucleus
Target 2 Gene Sequence >1593 bp 
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA
Target 2 GenBank Gene ID Not Available
Target 2 GeneCard ID ESR2 Link Image
Target 2 GenAtlas ID ESR2 Link Image
Target 2 HGNC ID HGNC:3468 Link Image
Target 2 Chromosome Location Chromosome:14
Target 2 Locus 14q23.2
Target 2 SNPs SNPJam Report Link Image
Target 2 Toxin References
  • R059 - Zang Y, Odwin-Dacosta S, Yager JD: Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells. Toxicol Lett. 2009 Jan 30;184(2):134-8. Epub 2008 Nov 11. [PubMed Link Image]
Target 2 General References 9473491; 9636657; 9685228; 9671811; 16938840; 15489334; 10964723; 8769313
Target 3 [top]
Target 3 ID 197
Target 3 Name Mitogen-activated protein kinase 1
Target 3 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 3 Description Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2
Target 3 Synonyms
  1. Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1
Target 3 Gene Name MAPK1
Target 3 Protein Sequence >Mitogen-activated protein kinase 1 
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Target 3 Number of Residues 360
Target 3 Molecular Weight 41389.3
Target 3 Theoretical pI 6.99
Target 3 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 3 General Function Involved in ATP binding
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • None
Target 3 Essentiality Non Essential
Target 3 Domain Function PF00069:Pkinase
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB ID P28482 Link Image
Target 3 Cellular Location Not Available
Target 3 Gene Sequence >1083 bp 
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGAC
GTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGC
TCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAG
CACCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACAT
GAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCATCGAGCAAATGAAAGAT
GTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACAC
CTCAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATC
CATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACCTGCTGCTCAACACCACC
TGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCAC
ACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTG
AATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAA
ATGCTTTCCAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAATCACATT
TTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCT
AGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCA
AATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAG
AGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGT
GACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAG
GAAAAGCTAAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCT
TAA
Target 3 GenBank Gene ID Not Available
Target 3 GeneCard ID MAPK1 Link Image
Target 3 GenAtlas ID MAPK1 Link Image
Target 3 HGNC ID HGNC:6871 Link Image
Target 3 Chromosome Location Chromosome:22
Target 3 Locus 22q11.2|22q11.21
Target 3 SNPs SNPJam Report Link Image
Target 3 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 3 General References 1540184; 1319925; 15489334; 12665801; 8794306; 11912194; 18083107; 18211802; 15951569; 15592455
Target 4 [top]
Target 4 ID 98
Target 4 Name Mitogen-activated protein kinase 3
Target 4 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 4 Description Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4)
Target 4 Synonyms
  1. Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule-associated protein 2 kinase
Target 4 Gene Name MAPK3
Target 4 Protein Sequence >Mitogen-activated protein kinase 3 
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
Target 4 Number of Residues 379
Target 4 Molecular Weight 43135.2
Target 4 Theoretical pI 6.74
Target 4 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 4 General Function Involved in ATP binding
Target 4 Pathways REACT_1788-Transcription;
Target 4 Reactions Not Available
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Non Essential
Target 4 Domain Function PF00069:Pkinase
Target 4 GenBank ID Protein Not Available
Target 4 UniProtKB ID P27361 Link Image
Target 4 Cellular Location Not Available
Target 4 Gene Sequence >1140 bp 
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG
Target 4 GenBank Gene ID Not Available
Target 4 GeneCard ID MAPK3 Link Image
Target 4 GenAtlas ID MAPK3 Link Image
Target 4 HGNC ID HGNC:6877 Link Image
Target 4 Chromosome Location Chromosome:16
Target 4 Locus 16p11.2
Target 4 SNPs SNPJam Report Link Image
Target 4 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 4 General References 7687743; 15489334; 1540184; 1319925; 8794306; 11912194; 15951569; 17081983; 16581800
Target 5 [top]
Target 5 ID 166
Target 5 Name Mitogen-activated protein kinase 4
Target 5 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 5 Description Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle
Target 5 Synonyms
  1. Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK
Target 5 Gene Name MAPK4
Target 5 Protein Sequence >Mitogen-activated protein kinase 4 
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK
HALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT
LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYS
HKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQL
ILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDR
LTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVS
LSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF
EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTG
AREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLD
VFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
Target 5 Number of Residues 587
Target 5 Molecular Weight 65921.0
Target 5 Theoretical pI 5.11
Target 5 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 5 General Function Involved in ATP binding
Target 5 Pathways Not Available
Target 5 Reactions Not Available
Target 5 Signals
  • None
Target 5 Transmembrane Regions
  • None
Target 5 Essentiality Non Essential
Target 5 Domain Function PF00069:Pkinase
Target 5 GenBank ID Protein Not Available
Target 5 UniProtKB ID P31152 Link Image
Target 5 Cellular Location Not Available
Target 5 Gene Sequence >1674 bp 
ATGGCTGAGAAGGGTGACTGCATCGCCAGTGTCTATGGGTATGACCTCGGTGGGCGCTTT
GTTGACTTCCAACCCCTGGGCTTCGGTGTCAATGGTTTGGTGCTGTCGGCCGTGGACAGC
CGGGCCTGCCGGAAGGTCGCTGTGAAGAAGATTGCCCTGAGCGATGCCCGCAGCATGAAG
CACGCGCTCCGAGAGATCAAGATCATTCGGCGCCTGGACCACGACAACATCGTCAAAGTG
TACGAGGTGCTCGGTCCCAAGGGCACTGACCTGCAGGGTGAGCTGTTCAAGTTCAGCGTG
GCGTACATCGTCCAGGAGTACATGGAGACCGACCTGGCACGCCTGCTGGAGCAGGGCACG
CTGGCAGAAGAGCATGCCAAGCTGTTCATGTACCAGCTGCTCCGCGGGCTCAAGTACATC
CACTCCGCCAACGTGCTGCACAGGGACCTGAAGCCCGCCAACATCTTCATCAGCACAGAG
GACCTCGTGCTCAAGATTGGGGATTTCGGGTTGGCAAGGATCGTTGATCAGCATTACTCC
CACAAGGGTTATCTGTCAGAAGGGTTGGTAACAAAGTGGTACCGTTCCCCACGACTGCTC
CTTTCCCCCAATAACTACACCAAAGCCATCGACATGTGGGCCGCCGGCTGCATCCTGGCT
GAGATGCTTACGGGGAGAATGCTCTTTGCTGGGGCCCATGAGCTGGAGCAGATGCAACTC
ATCCTGGAGACCATCCCTGTAATCCGGGAGGAAGACAAGGACGAGCTGCTCAGGGTGATG
CCTTCCTTTGTCAGCAGCACCTGGGAGGTGAAGAGGCCTCTGCGCAAGCTGCTCCCTGAA
GTGAACAGTGAAGCCATCGACTTTCTGGAGAAGATCCTGACCTTTAACCCCATGGATCGC
CTAACAGCTGAGATGGGGCTGCAACACCCCTACATGAGCCCATACTCGTGCCCTGAGGAC
GAGCCCACCTCACAACACCCCTTCCGCATTGAGGATGAGATCGACGACATCGTGCTGATG
GCCGCTAACCAGAGCCAGCTGTCCAACTGGGACACGTGCAGTTCCAGGTACCCTGTGAGC
CTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGC
GACCCGCGCGGGTTCGGCGCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCG
CACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAG
GCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTG
CTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCG
CACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCG
CGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAG
GGCGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGC
CCCCCGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTT
CATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAA
Target 5 GenBank Gene ID Not Available
Target 5 GeneCard ID MAPK4 Link Image
Target 5 GenAtlas ID MAPK4 Link Image
Target 5 HGNC ID HGNC:6878 Link Image
Target 5 Chromosome Location Chromosome:18
Target 5 Locus 18q12-q21
Target 5 SNPs SNPJam Report Link Image
Target 5 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 5 General References 1319925; 14702039; 16177791; 18669648; 17344846
Target 6 [top]
Target 6 ID 30
Target 6 Name Mitogen-activated protein kinase 6
Target 6 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 6 Description Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity)
Target 6 Synonyms
  1. Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK
Target 6 Gene Name MAPK6
Target 6 Protein Sequence >Mitogen-activated protein kinase 6 
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK
HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE
QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP
HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ
MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS
PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC
QFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS
TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK
EQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQ
HEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSG
GEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEG
FLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHL
N
Target 6 Number of Residues 721
Target 6 Molecular Weight 82680.1
Target 6 Theoretical pI 4.67
Target 6 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 6 General Function Involved in ATP binding
Target 6 Pathways Not Available
Target 6 Reactions Not Available
Target 6 Signals
  • None
Target 6 Transmembrane Regions
  • None
Target 6 Essentiality Non Essential
Target 6 Domain Function PF00069:Pkinase
Target 6 GenBank ID Protein Not Available
Target 6 UniProtKB ID Q16659 Link Image
Target 6 Cellular Location Not Available
Target 6 Gene Sequence >2166 bp 
ATGGCAGAGAAATTTGAAAGTCTCATGAACATTCATGGTTTTGATCTGGGTTCTAGGTAT
ATGGACTTAAAACCATTGGGTTGTGGAGGCAATGGCTTGGTTTTTTCTGCTGTAGACAAT
GACTGTGACAAAAGAGTAGCCATCAAGAAAATTGTCCTTACTGATCCCCAGAGTGTCAAA
CATGCTCTACGTGAAATCAAAATTATTAGAAGACTTGACCATGATAACATTGTGAAAGTG
TTTGAGATTCTTGGTCCCAGTGGAAGCCAATTAACAGACGATGTGGGCTCTCTTACGGAA
CTGAACAGTGTTTACATTGTTCAGGAGTACATGGAGACAGACTTGGCTAATGTGCTGGAG
CAGGGCCCTTTACTGGAAGAGCATGCCAGGCTTTTCATGTATCAGCTGCTACGGGGGCTC
AAGTATATTCACTCTGCAAATGTACTGCACAGAGATCTCAAACCAGCTAATCTTTTCATT
AATACGGAAGACTTGGTGCTGAAGATAGGTGACTTTGGTCTTGCACGGATCATGGATCCT
CATTATTCCCATAAGGGTCATCTTTCTGAAGGATTGGTTACTAAATGGTACAGATCTCCA
CGTCTTTTACTTTCTCCTAATAATTATACTAAAGCCATTGACATGTGGGCTGCAGGCTGC
ATCTTTGCTGAAATGCTGACTGGTAAAACCCTTTTTGCAGGTGCACATGAACTTGAACAG
ATGCAGCTGATTTTAGAATCTATTCCTGTTGTACATGAGGAAGATCGTCAGGAGCTTCTC
AGCGTAATTCCAGTTTACATTAGAAATGACATGACTGAGCCACACAAACCTTTAACTCAG
CTGCTTCCAGGAATTAGTCGAGAAGCACTGGATTTCCTGGAACAAATTTTGACATTTAGC
CCCATGGATCGGTTAACAGCAGAAGAAGCACTCTCCCATCCTTACATGAGCATATATTCT
TTTCCAATGGATGAGCCAATTTCAAGCCATCCTTTTCATATTGAAGATGAAGTTGATGAT
ATTTTGCTTATGGATGAAACTCACAGTCACATTTATAACTGGGAAAGGTATCATGATTGT
CAGTTTTCAGAGCATGATTGGCCTGTACATAACAACTTTGATATTGATGAAGTTCAGCTT
GATCCAAGAGCTCTGTCCGATGTCACTGATGAAGAAGAAGTACAAGTTGATCCCCGAAAA
TATTTGGATGGAGATCGGGAAAAGTATCTGGAGGATCCTGCTTTTGATACCAATTACTCT
ACTGAGCCTTGTTGGCAATACTCAGATCATCATGAAAACAAATATTGTGATCTGGAGTGT
AGCCATACTTGTAACTACAAAACGAGGTCATCATCATATTTAGATAACTTAGTTTGGAGA
GAGAGTGAAGTTAACCATTACTATGAACCCAAGCTTATTATAGATCTTTCCAATTGGAAA
GAACAAAGCAAAGAAAAATCTGATAAGAAAGGCAAATCAAAATGTGAAAGGAATGGATTG
GTTAAAGCCCAGATAGCGCTAGAGGAAGCATCACAGCAACTGGCTGGAAAAGAAAGGGAA
AAGAATCAGGGATTTGATTTTGATTCCTTTATTGCAGGAACTATTCAGCTTAGTTCCCAG
CATGAGCCTACTGATGTTGTTGATAAATTAAATGACTTGAATAGCTCAGTGTCCCAACTA
GAATTGAAAAGTTTGATATCAAAGTCAGTAAGCCAAGAAAAACAGGAAAAAGGAATGGCA
AATCTGGCTCAATTAGAAGCCTTGTACCAGTCTTCTTGGGACAGCCAGTTTGTGAGTGGT
GGGGAGGACTGTTTTTTCATAAATCAGTTTTGTGAGGTAAGGAAGGATGAACAAGTTGAG
AAGGAAAACACTTACACTAGTTACTTGGACAAGTTCTTTAGCAGGAAAGAAGATACTGAA
ATGCTAGAAACTGAGCCAGTAGAGGATGGGAAGCTTGGGGAGAGAGGACATGAGGAAGGA
TTTCTGAACAACAGTGGGGAGTTCCTCTTTAACAAGCAGCTCGAGTCCATAGGCATCCCA
CAGTTTCACAGTCCAGTTGGGTCACCACTTAAGTCAATACAGGCCACATTAACACCTTCT
GCTATGAAATCTTCCCCTCAAATTCCTCATCAAACATACAGCAGCATTCTGAAACATCTG
AACTAA
Target 6 GenBank Gene ID Not Available
Target 6 GeneCard ID MAPK6 Link Image
Target 6 GenAtlas ID MAPK6 Link Image
Target 6 HGNC ID HGNC:6879 Link Image
Target 6 Chromosome Location Chromosome:15
Target 6 Locus 15q21
Target 6 SNPs SNPJam Report Link Image
Target 6 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 6 General References 7969157; 8875998; 17974005; 15489334; 18669648; 17344846
Target 7 [top]
Target 7 ID 225
Target 7 Name Mitogen-activated protein kinase 7
Target 7 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 7 Description Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways
Target 7 Synonyms
  1. Extracellular signal-regulated kinase 5; ERK-5; ERK4; Big MAP kinase 1; BMK1 kinase
Target 7 Gene Name MAPK7
Target 7 Protein Sequence >Mitogen-activated protein kinase 7 
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
Target 7 Number of Residues 816
Target 7 Molecular Weight 88385.5
Target 7 Theoretical pI 5.68
Target 7 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 7 General Function Involved in ATP binding
Target 7 Pathways Not Available
Target 7 Reactions Not Available
Target 7 Signals
  • None
Target 7 Transmembrane Regions
  • None
Target 7 Essentiality Non Essential
Target 7 Domain Function PF00069:Pkinase
Target 7 GenBank ID Protein Not Available
Target 7 UniProtKB ID Q13164 Link Image
Target 7 Cellular Location Cytoplasm. Nucleus
Target 7 Gene Sequence >2451 bp 
ATGGCCGAGCCTCTGAAGGAGGAAGACGGCGAGGACGGCTCTGCGGAGCCCCCCGGGCCC
GTGAAGGTCGAACCCGCCCACACCGCTGCCTCTGTAGCGGCCAAGAACCTGGCCCTGCTT
AAAGCCCGCTCCTTCGATGTGACCTTTGACGTGGGCGACGAGTACGAGATCATCGAGACC
ATAGGCAACGGGGCCTATGGAGTGGTGTCCTCCGCCCGCCGCCGCCTCACCGGCCAGCAG
GTGGCCATCAAGAAGATCCCTAATGCTTTCGATGTGGTGACCAATGCCAAGCGGACCCTC
AGGGAGCTGAAGATCCTCAAGCACTTTAAACACGACAACATCATCGCCATCAAGGACATC
CTGAGGCCCACCGTGCCCTATGGCGAATTCAAATCTGTCTACGTGGTCCTGGACCTGATG
GAAAGCGACCTGCACCAGATCATCCACTCCTCACAGCCCCTCACACTGGAACACGTGCGC
TACTTCCTGTACCAACTGCTGCGGGGCCTGAAGTACATGCACTCGGCTCAGGTCATCCAC
CGTGACCTGAAGCCCTCCAACCTATTGGTGAATGAGAACTGTGAGCTCAAGATTGGTGAC
TTTGGTATGGCTCGTGGCCTGTGCACCTCGCCCGCTGAACATCAGTACTTCATGACTGAG
TATGTGGCCACGCGCTGGTACCGTGCGCCCGAGCTCATGCTCTCTTTGCATGAGTATACA
CAGGCTATTGACCTCTGGTCTGTGGGCTGCATCTTTGGTGAGATGCTGGCCCGGCGCCAG
CTCTTCCCAGGCAAAAACTATGTACACCAGCTACAGCTCATCATGATGGTGCTGGGTACC
CCATCACCAGCCGTGATTCAGGCTGTGGGGGCTGAGAGGGTGCGGGCCTATATCCAGAGC
TTGCCACCACGCCAGCCTGTGCCCTGGGAGACAGTGTACCCAGGTGCCGACCGCCAGGCC
CTATCACTGCTGGGTCGCATGCTGCGTTTTGAGCCCAGCGCTCGCATCTCAGCAGCTGCT
GCCCTTCGCCACCCTTTCCTGGCCAAGTACCATGATCCTGATGATGAGCCTGACTGTGCC
CCGCCCTTTGACTTTGCCTTTGACCGCGAAGCCCTCACTCGGGAGCGCATTAAGGAGGCC
ATTGTGGCTGAAATTGAGGACTTCCATGCAAGGCGTGAGGGCATCCGCCAACAGATCCGC
TTCCAGCCTTCTCTACAGCCTGTGGCTAGTGAGCCTGGCTGTCCAGATGTTGAAATGCCC
AGTCCCTGGGCTCCCAGTGGGGACTGTGCCATGGAGTCTCCACCACCAGCCCCGCCACCA
TGCCCCGGCCCTGCACCTGACACCATTGATCTGACCCTGCAGCCACCTCCACCAGTCAGT
GAGCCTGCCCCACCAAAGAAAGATGGTGCCATCTCAGACAATACTAAGGCTGCCCTTAAA
GCTGCCCTGCTCAAGTCTTTGAGGAGCCGGCTCAGAGATGGCCCCAGCGCACCCCTGGAG
GCTCCTGAGCCTCGGAAGCCGGTGACAGCCCAGGAGCGCCAGCGGGAGCGGGAGGAGAAG
CGGCGGAGGCGGCAAGAACGAGCCAAGGAGCGGGAGAAACGGCGGCAGGAGCGGGAGCGA
AAGGAACGGGGGGCTGGGGCCTCTGGGGGCCCCTCCACTGACCCCTTGGCTGGACTAGTG
CTCAGTGACAATGACAGAAGCCTGTTGGAACGCTGGACTCGAATGGCCCGGCCCGCAGCC
CCAGCCCTCACCTCTGTGCCGGCCCCTGCCCCAGCGCCAACGCCAACCCCAACCCCAGTC
CAACCTACCAGTCCTCCTCCTGGCCCTGTAGCCCAGCCCACTGGCCCGCAACCACAATCT
GCGGGCTCTACCTCTGGCCCTGTACCCCAGCCTGCCTGCCCACCCCCTGGCCCTGCACCC
CACCCCACTGGCCCTCCTGGGCCCATCCCTGTCCCCGCGCCACCCCAGATTGCCACCTCC
ACCAGCCTCCTGGCTGCCCAGTCACTTGTGCCACCCCCTGGGCTGCCTGGCTCCAGCACC
CCAGGAGTTTTGCCTTACTTCCCACCTGGCCTGCCGCCCCCAGACGCCGGGGGAGCCCCT
CAGTCTTCCATGTCAGAGTCACCTGATGTCAACCTTGTGACCCAGCAGCTATCTAAGTCA
CAGGTGGAGGACCCCCTGCCCCCTGTGTTCTCAGGCACACCAAAGGGCAGTGGGGCTGGC
TACGGTGTTGGCTTTGACCTGGAGGAATTCTTAAACCAGTCTTTCGACATGGGCGTGGCT
GATGGGCCACAGGATGGCCAGGCAGATTCAGCCTCTCTCTCAGCCTCCCTGCTTGCTGAC
TGGCTCGAAGGCCATGGCATGAACCCTGCCGATATTGAGTCCCTGCAGCGTGAGATCCAG
ATGGACTCCCCAATGCTGCTGGCTGACCTGCCTGACCTCCAGGACCCCTGA
Target 7 GenBank Gene ID Not Available
Target 7 GeneCard ID MAPK7 Link Image
Target 7 GenAtlas ID MAPK7 Link Image
Target 7 HGNC ID HGNC:6880 Link Image
Target 7 Chromosome Location Chromosome:17
Target 7 Locus 17p11.2
Target 7 SNPs SNPJam Report Link Image
Target 7 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 7 General References 7646528; 7759517; 15716121; 15489334; 9384584; 9790194; 11278431; 18083107
Target 8 [top]
Target 8 ID 15
Target 8 Name Mitogen-activated protein kinase 8
Target 8 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 8 Description JNK1 isoforms display different binding patterns:beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms
Target 8 Synonyms
  1. Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK-46
Target 8 Gene Name MAPK8
Target 8 Protein Sequence >Mitogen-activated protein kinase 8 
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
Target 8 Number of Residues 427
Target 8 Molecular Weight 48295.1
Target 8 Theoretical pI 6.89
Target 8 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 8 General Function Involved in ATP binding
Target 8 Pathways REACT_578-Apoptosis;
Target 8 Reactions Not Available
Target 8 Signals
  • None
Target 8 Transmembrane Regions
  • None
Target 8 Essentiality Non Essential
Target 8 Domain Function PF00069:Pkinase
Target 8 GenBank ID Protein Not Available
Target 8 UniProtKB ID P45983 Link Image
Target 8 Cellular Location Not Available
Target 8 Gene Sequence >1155 bp 
ATGAGCAGAAGCAAGCGTGACAACAATTTTTATAGTGTAGAGATTGGAGATTCTACATTC
ACAGTCCTGAAACGATATCAGAATTTAAAACCTATAGGCTCAGGAGCTCAAGGAATAGTA
TGCGCAGCTTATGATGCCATTCTTGAAAGAAATGTTGCAATCAAGAAGCTAAGCCGACCA
TTTCAGAATCAGACTCATGCCAAGCGGGCCTACAGAGAGCTAGTTCTTATGAAATGTGTT
AATCACAAAAATATAATTGGCCTTTTGAATGTTTTCACACCACAGAAATCCCTAGAAGAA
TTTCAAGATGTTTACATAGTCATGGAGCTCATGGATGCAAATCTTTGCCAAGTGATTCAG
ATGGAGCTAGATCATGAAAGAATGTCCTACCTTCTCTATCAGATGCTGTGTGGAATCAAG
CACCTTCATTCTGCTGGAATTATTCATCGGGACTTAAAGCCCAGTAATATAGTAGTAAAA
TCTGATTGCACTTTGAAGATTCTTGACTTCGGTCTGGCCAGGACTGCAGGAACGAGTTTT
ATGATGACGCCTTATGTAGTGACTCGCTACTACAGAGCACCCGAGGTCATCCTTGGCATG
GGCTACAAGGAAAACGTGGATTTATGGTCTGTGGGGTGCATTATGGGAGAAATGGTTTGC
CACAAAATCCTCTTTCCAGGAAGGGACTATATTGATCAGTGGAATAAAGTTATTGAACAG
CTTGGAACACCATGTCCTGAATTCATGAAGAAACTGCAACCAACAGTAAGGACTTACGTT
GAAAACAGACCTAAATATGCTGGATATAGCTTTGAGAAACTCTTCCCTGATGTCCTTTTC
CCAGCTGACTCAGAACACAACAAACTTAAAGCCAGTCAGGCAAGGGATTTGTTATCCAAA
ATGCTGGTAATAGATGCATCTAAAAGGATCTCTGTAGATGAAGCTCTCCAACACCCGTAC
ATCAATGTCTGGTATGATCCTTCTGAAGCAGAAGCTCCACCACCAAAGATCCCTGACAAG
CAGTTAGATGAAAGGGAACACACAATAGAAGAGTGGAAAGAATTGATATATAAGGAAGTT
ATGGACTTGGAGGAGAGAACCAAGAATGGAGTTATACGGGGGCAGCCCTCTCCTTTAGCA
CAGGTGCAGCAGTGA
Target 8 GenBank Gene ID Not Available
Target 8 GeneCard ID MAPK8 Link Image
Target 8 GenAtlas ID MAPK8 Link Image
Target 8 HGNC ID HGNC:6881 Link Image
Target 8 Chromosome Location Chromosome:10
Target 8 Locus 10q11.22
Target 8 SNPs SNPJam Report Link Image
Target 8 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 8 General References 8137421; 8654373; 7839144; 11062067; 12514174; 15693750; 16581800; 17875713; 18083107; 17924679
Target 9 [top]
Target 9 ID 19
Target 9 Name Mitogen-activated protein kinase 9
Target 9 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 9 Description JNK2 isoforms display different binding patterns:alpha- 1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it
Target 9 Synonyms
  1. Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2; JNK-55
Target 9 Gene Name MAPK9
Target 9 Protein Sequence >Mitogen-activated protein kinase 9 
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
Target 9 Number of Residues 424
Target 9 Molecular Weight 48138.7
Target 9 Theoretical pI 5.34
Target 9 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 9 General Function Involved in ATP binding
Target 9 Pathways Not Available
Target 9 Reactions Not Available
Target 9 Signals
  • None
Target 9 Transmembrane Regions
  • None
Target 9 Essentiality Non Essential
Target 9 Domain Function PF00069:Pkinase
Target 9 GenBank ID Protein Not Available
Target 9 UniProtKB ID P45984 Link Image
Target 9 Cellular Location Not Available
Target 9 Gene Sequence >1275 bp 
ATGAGCGACAGTAAATGTGACAGTCAGTTTTATAGTGTGCAAGTGGCAGACTCAACCTTC
ACTGTCCTAAAACGTTACCAGCAGCTGAAACCAATTGGCTCTGGGGCCCAAGGGATTGTT
TGTGCTGCATTTGATACAGTTCTTGGGATAAGTGTTGCAGTCAAGAAACTAAGCCGTCCT
TTTCAGAACCAAACTCATGCAAAGAGAGCTTATCGTGAACTTGTCCTCTTAAAATGTGTC
AATCATAAAAATATAATTAGTTTGTTAAATGTGTTTACACCACAAAAAACTCTAGAAGAA
TTTCAAGATGTGTATTTGGTTATGGAATTAATGGATGCTAACTTATGTCAGGTTATTCAC
ATGGAGCTGGATCATGAAAGAATGTCCTACCTTCTTTACCAGATGCTTTGTGGTATTAAA
CATCTGCATTCAGCTGGTATAATTCATAGAGATTTGAAGCCTAGCAACATTGTTGTGAAA
TCAGACTGCACCCTGAAGATCCTTGACTTTGGCCTGGCCCGGACAGCGTGCACTAACTTC
ATGATGACCCCTTACGTGGTGACACGGTACTACCGGGCGCCCGAAGTCATCCTGGGTATG
GGCTACAAAGAGAACGTTGATATCTGGTCAGTGGGTTGCATCATGGGAGAGCTGGTGAAA
GGTTGTGTGATATTCCAAGGCACTGACCATATTGATCAGTGGAATAAAGTTATTGAGCAG
CTGGGAACACCATCAGCAGAGTTCATGAAGAAACTTCAGCCAACTGTGAGGAATTATGTC
GAAAACAGACCAAAGTATCCTGGAATCAAATTTGAAGAACTCTTTCCAGATTGGATATTC
CCATCAGAATCTGAGCGAGACAAAATAAAAACAAGTCAAGCCAGAGATCTGTTATCAAAA
ATGTTAGTGATTGATCCTGACAAGCGGATCTCTGTAGACGAAGCTCTGCGTCACCCATAC
ATCACTGTTTGGTATGACCCCGCCGAAGCAGAAGCCCCACCACCTCAAATTTATGATGCC
CAGTTGGAAGAAAGAGAACATGCAATTGAAGAATGGAAAGAGCTAATTTACAAAGAAGTC
ATGGATTGGGAAGAAAGAAGCAAGAATGGTGTTGTAAAAGATCAGCCTTCAGATGCAGCA
GTAAGTAGCAACGCCACTCCTTCTCAGTCTTCATCGATCAATGACATTTCATCCATGTCC
ACTGAGCAGACGCTGGCCTCAGACACAGACAGCAGTCTTGATGCCTCGACGGGACCCCTT
GAAGGCTGTCGATGA
Target 9 GenBank Gene ID Not Available
Target 9 GeneCard ID MAPK9 Link Image
Target 9 GenAtlas ID MAPK9 Link Image
Target 9 HGNC ID HGNC:6886 Link Image
Target 9 Chromosome Location Not Available
Target 9 Locus 5q35
Target 9 SNPs SNPJam Report Link Image
Target 9 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 9 General References 7969172; 8001819; 8654373; 15489334; 11062067; 15693750; 17875713; 18083107
Target 10 [top]
Target 10 ID 198
Target 10 Name Mitogen-activated protein kinase 10
Target 10 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 10 Description Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity (By similarity)
Target 10 Synonyms
  1. Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12
Target 10 Gene Name MAPK10
Target 10 Protein Sequence >Mitogen-activated protein kinase 10 
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
Target 10 Number of Residues 464
Target 10 Molecular Weight 52585.0
Target 10 Theoretical pI 6.78
Target 10 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 10 General Function Involved in ATP binding
Target 10 Pathways Not Available
Target 10 Reactions Not Available
Target 10 Signals
  • None
Target 10 Transmembrane Regions
  • None
Target 10 Essentiality Non Essential
Target 10 Domain Function PF00069:Pkinase
Target 10 GenBank ID Protein Not Available
Target 10 UniProtKB ID P53779 Link Image
Target 10 Cellular Location Cytoplasm
Target 10 Gene Sequence >1269 bp 
ATGAGCCTCCATTTCTTATACTACTGCAGTGAACCAACATTGGATGTGAAAATTGCCTTT
TGTCAGGGATTCGATAAACAAGTGGATGTGTCATATATTGCCAAACATTACAACATGAGC
AAAAGCAAAGTTGACAACCAGTTCTACAGTGTGGAAGTGGGAGACTCAACCTTCACAGTT
CTCAAGCGCTACCAGAATCTAAAGCCTATTGGCTCTGGGGCTCAGGGCATAGTTTGTGCC
GCGTATGATGCTGTCCTTGACAGAAATGTGGCCATTAAGAAGCTCAGCAGACCCTTTCAG
AACCAAACACATGCCAAGAGAGCGTACCGGGAGCTGGTCCTCATGAAGTGTGTGAACCAT
AAAAACATTATTAGTTTATTAAATGTCTTCACACCCCAGAAAACGCTGGAGGAGTTCCAA
GATGTTTACTTAGTAATGGAACTGATGGATGCCAACTTATGTCAAGTGATTCAGATGGAA
TTAGACCATGAGCGAATGTCTTACCTGCTGTACCAAATGTTGTGTGGCATTAAGCACCTC
CATTCTGCTGGAATTATTCACAGGGATTTAAAACCAAGTAACATTGTAGTCAAGTCTGAT
TGCACATTGAAAATCCTGGACTTTGGACTGGCCAGGACAGCAGGCACAAGCTTCATGATG
ACTCCATATGTGGTGACACGTTATTACAGAGCCCCTGAGGTCATCCTGGGGATGGGCTAC
AAGGAGAACGTGGATATATGGTCTGTGGGATGCATTATGGGAGAAATGGTTCGCCACAAA
ATCCTCTTTCCAGGAAGGGACTATATTGACCAGTGGAATAAGGTAATTGAACAACTAGGA
ACACCATGTCCAGAATTCATGAAGAAATTGCAACCCACAGTAAGAAACTATGTGGAGAAT
CGGCCCAAGTATGCGGGACTCACCTTCCCCAAACTCTTCCCAGATTCCCTCTTCCCAGCG
GACTCCGAGCACAATAAACTCAAAGCCAGCCAAGCCAGGGACTTGTTGTCAAAGATGCTA
GTGATTGACCCAGCAAAAAGAATATCAGTGGACGACGCCTTACAGCATCCCTACATCAAC
GTCTGGTATGACCCAGCCGAAGTGGAGGCGCCTCCACCTCAGATATATGACAAGCAGTTG
GATGAAAGAGAACACACAATTGAAGAATGGAAAGAACTTATCTACAAGGAAGTAATGAAT
TCAGAAGAAAAGACTAAAAATGGTGTAGTAAAAGGACAGCCTTCTCCTTCAGCACAGGTG
CAGCAGTGA
Target 10 GenBank Gene ID Not Available
Target 10 GeneCard ID MAPK10 Link Image
Target 10 GenAtlas ID MAPK10 Link Image
Target 10 HGNC ID HGNC:6872 Link Image
Target 10 Chromosome Location Not Available
Target 10 Locus 4q22.1-q23
Target 10 SNPs SNPJam Report Link Image
Target 10 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 10 General References 7826642; 8654373; 15815621; 15489334; 10715136; 15693750; 16249883; 16611996; 18083107
Target 11 [top]
Target 11 ID 82
Target 11 Name Mitogen-activated protein kinase 11
Target 11 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 11 Description Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2
Target 11 Synonyms
  1. Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; p38-2; Stress-activated protein kinase 2
Target 11 Gene Name MAPK11
Target 11 Protein Sequence >Mitogen-activated protein kinase 11 
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
Target 11 Number of Residues 364
Target 11 Molecular Weight 41356.9
Target 11 Theoretical pI 5.64
Target 11 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 11 General Function Involved in ATP binding
Target 11 Pathways Not Available
Target 11 Reactions Not Available
Target 11 Signals
  • None
Target 11 Transmembrane Regions
  • None
Target 11 Essentiality Non Essential
Target 11 Domain Function PF00069:Pkinase
Target 11 GenBank ID Protein Not Available
Target 11 UniProtKB ID Q15759 Link Image
Target 11 Cellular Location Not Available
Target 11 Gene Sequence >1119 bp 
ATGTCGGGCCCTCGCGCCGGCTTCTACCGGCAGGAGCTGAACAAGACCGTGTGGGAGGTG
CCGCAGCGGCTGCAGGGGCTGCGCCCGGTGGGCTCCGGCGCCTACGGCTCCGTCTGTTCG
GCCTACGACGCCCGGCTGCGCCAGAAGGTGGCGGTGAAGAAGCTGTCGCGCCCCTTCCAG
TCGCTGATCCACGCGCGCAGAACGTACCGGGAGCTGCGGCTGCTCAAGCACCTGAAGCAC
GAGAACGTCATCGGGCTTCTGGACGTCTTCACGCCGGCCACGTCCATCGAGGACTTCAGC
GAAGTGTACTTGGTGACCACCCTGATGGGCGCCGACCTGAACAACATCGTCAAGTGCCAG
GCGGGCGCCCATCAGGGTGCCCGCCTGGCACTTGACGAGCACGTTCAATTCCTGGTTTAC
CAGCTGCTGCGCGGGCTGAAGTACATCCACTCGGCCGGGATCATCCACCGGGACCTGAAG
CCCAGCAACGTGGCTGTGAACGAGGACTGTGAGCTCAGGATCCTGGATTTCGGGCTGGCG
CGCCAGGCGGACGAGGAGATGACCGGCTATGTGGCCACGCGCTGGTACCGGGCACCTGAG
ATCATGCTCAACTGGATGCATTACAACCAAACAGTGGATATCTGGTCCGTGGGCTGCATC
ATGGCTGAGCTGCTCCAGGGCAAGGCCCTCTTCCCGGGAAGCGACTACATTGACCAGCTG
AAGCGCATCATGGAAGTGGTGGGCACACCCAGCCCTGAGGTTCTGGCAAAAATCTCCTCG
GAACACGCCCGGACATATATCCAGTCCCTGCCCCCCATGCCCCAGAAGGACCTGAGCAGC
ATCTTCCGTGGAGCCAACCCCCTGGCCATAGACCTCCTTGGAAGGATGCTGGTGCTGGAC
AGTGACCAGAGGGTCAGTGCAGCTGAGGCACTGGCCCACGCCTACTTCAGCCAGTACCAC
GACCCCGAGGATGAGCCAGAGGCCGAGCCATATGATGAGAGCGTTGAGGCCAAGGAGCGC
ACGCTGGAGGAGTGGAAGGAGCTCACTTACCAGGAAGTCCTTAGCTTCAAGCCCCCAGAG
CCACCGAAGCCACCTGGCAGCCTGGAGATTGAGCAGTGA
Target 11 GenBank Gene ID Not Available
Target 11 GeneCard ID MAPK11 Link Image
Target 11 GenAtlas ID MAPK11 Link Image
Target 11 HGNC ID HGNC:6873 Link Image
Target 11 Chromosome Location Chromosome:22
Target 11 Locus 22q13.33
Target 11 SNPs SNPJam Report Link Image
Target 11 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 11 General References 8663524; 9207191; 9430721; 9218798; 9235954; 15461802; 10591208; 15489334
Target 12 [top]
Target 12 ID 205
Target 12 Name Mitogen-activated protein kinase 12
Target 12 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 12 Description Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation
Target 12 Synonyms
  1. Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 gamma
Target 12 Gene Name MAPK12
Target 12 Protein Sequence >Mitogen-activated protein kinase 12 
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL
Target 12 Number of Residues 367
Target 12 Molecular Weight 41939.8
Target 12 Theoretical pI 6.33
Target 12 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 12 General Function Involved in ATP binding
Target 12 Pathways Not Available
Target 12 Reactions Not Available
Target 12 Signals
  • None
Target 12 Transmembrane Regions
  • None
Target 12 Essentiality Non Essential
Target 12 Domain Function PF00069:Pkinase
Target 12 GenBank ID Protein Not Available
Target 12 UniProtKB ID P53778 Link Image
Target 12 Cellular Location Cytoplasm. Mitochondrion
Target 12 Gene Sequence >1104 bp 
ATGAGCTCTCCGCCGCCCACCCGCAGTGGCTTTTACCGCCAGGAGGTGACCAAGACGGCC
TGGGAGGTGCGCGCCGTGTACCGGGACCTGCAGCCCGTGGGCTCGGGCGCCTACGGCGCG
GTGTGCTCGGCCGTGGACGGCCGCACCGGCGCTAAGGTTGCCATCAAGAAGCTGTATCGG
CCCTTCCAGTCCGAGCTGTTCGCCAAGCTCGCCTACCGCGAGCTGCGCCTGCTCAAGCAC
ATGCGCCACGAGAACGTGATCGGGCTGCTGGACGTATTCACTCCTGATGAGACCCTGGAT
GACTTCACGGACTTTTACCTGGTGATGCCGTTCATGGGCACCGACCTGGGCAAGCTCATG
AAACATGAGAAGCTAGGCGAGGACCGGATCCAGTTCCTCGTGTACCAGATGATGAAGGGG
CTGAGGTATATCCACGCTGCCGGCATCATCCACAGAGACCTGAAGCCCGGCAACCTGGCT
GTGAACGAAGACTGTGAGCTGAAGATCCTGGACTTCGGCCTGGCCAGGCAGGCAGACAGT
GAGATGACTGGGTACGTGGTGACCCGGTGGTACCGGGCTCCCGAGGTCATCTTGAATTGG
ATCGCGTACACGCAGACGGTGGACATCTGGTCTGTGGGCTGCATCATGGCGGAGATGATC
ACAGGCAAGACGCTGTTCAAGGGCAGCGACCACCTGGACCAGCTGAAGGAGATCATGAAG
GTGACGGGGACGCCTCCGGCTGAGTTTGTGCAGCGGCTGCAGAGCGATGAGGCCAAGAAC
TACATGAAGGGCCTCCCCGAATTGGAGAAGAAGGATTTTGCCTCTATCCTGACCAATGCA
AGCCCTCTGGCTGTGAACCTCCTGGAGAAGATGCTGGTGCTGGACGCGGACATCAGGTTG
ACTGCAGGCGAGTTTCTTTCCCATCCCTACTTCGAGTCCCTGCACGACACGGAAGATGAG
CCCCAGGTCCAGAAGTATGATGACTCCTTTGACTACTTTGACCGCACACTGGATGAATGG
AAGCGTGTTACTTACAAAGAGGTGCTCAGCTTCAAGCCTCCCCGGCAGCTGGGGGCCAGG
GTCTCCAAGGAGACGCCTCTGTGA
Target 12 GenBank Gene ID Not Available
Target 12 GeneCard ID MAPK12 Link Image
Target 12 GenAtlas ID MAPK12 Link Image
Target 12 HGNC ID HGNC:6874 Link Image
Target 12 Chromosome Location Chromosome:22
Target 12 Locus 22q13.33
Target 12 SNPs SNPJam Report Link Image
Target 12 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 12 General References 8633070; 9169156; 8920915; 10591208; 15489334; 10212242; 11991731; 12167088; 15284239; 17081983
Target 13 [top]
Target 13 ID 75
Target 13 Name Mitogen-activated protein kinase 13
Target 13 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 13 Description Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K
Target 13 Synonyms
  1. Stress-activated protein kinase 4; Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta
Target 13 Gene Name MAPK13
Target 13 Protein Sequence >Mitogen-activated protein kinase 13 
MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF
QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM
EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT
GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG
VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA
QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR
SGMKL
Target 13 Number of Residues 365
Target 13 Molecular Weight 42089.3
Target 13 Theoretical pI 8.66
Target 13 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 13 General Function Involved in ATP binding
Target 13 Pathways Not Available
Target 13 Reactions Not Available
Target 13 Signals
  • None
Target 13 Transmembrane Regions
  • None
Target 13 Essentiality Non Essential
Target 13 Domain Function PF00069:Pkinase
Target 13 GenBank ID Protein Not Available
Target 13 UniProtKB ID O15264 Link Image
Target 13 Cellular Location Not Available
Target 13 Gene Sequence >1098 bp 
ATGAGCCTCATCCGGAAAAAGGGCTTCTACAAGCAGGACGTCAACAAGACCGCCTGGGAG
CTGCCCAAGACCTACGTGTCCCCGACGCACGTCGGCAGCGGGGCCTATGGCTCCGTGTGC
TCGGCCATCGACAAGCGGTCAGGGGAGAAGGTGGCCATCAAGAAGCTGAGCCGACCCTTT
CAGTCCGAGATCTTCGCCAAGCGCGCCTACCGGGAGCTGCTGCTGCTGAAGCACATGCAG
CATGAGAACGTCATTGGGCTCCTGGATGTCTTCACCCCAGCCTCCTCCCTGCGCAACTTC
TATGACTTCTACCTGGTGATGCCCTTCATGCAGACGGATCTGCAGAAGATCATGGGGATG
GAGTTCAGTGAGGAGAAGATCCAGTACCTGGTGTATCAGATGCTCAAAGGCCTTAAGTAC
ATCCACTCTGCTGGGGTCGTGCACAGGGACCTGAAGCCAGGCAACCTGGCTGTGAATGAG
GACTGTGAACTGAAGATTCTGGATTTTGGGCTGGCGCGACATGCAGACGCCGAGATGACT
GGCTACGTGGTGACCCGCTGGTACCGAGCCCCCGAGGTGATCCTCAGCTGGATGCACTAC
AACCAGACAGTGGACATCTGGTCTGTGGGCTGTATCATGGCAGAGATGCTGACAGGGAAA
ACTCTGTTCAAGGGGAAAGATTACCTGGACCAGCTGACCCAGATCCTGAAAGTGACCGGG
GTGCCTGGCACGGAGTTTGTGCAGAAGCTGAACGACAAAGCGGCCAAATCCTACATCCAG
TCCCTGCCACAGACCCCCAGGAAGGATTTCACTCAGCTGTTCCCACGGGCCAGCCCCCAG
GCTGCGGACCTGCTGGAGAAGATGCTGGAGCTAGACGTGGACAAGCGCCTGACGGCCGCG
CAGGCCCTCACCCATCCCTTCTTTGAACCCTTCCGGGACCCTGAGGAAGAGACGGAGGCC
CAGCAGCCGTTTGATGATTCCTTAGAACACGAGAAACTCACAGTGGATGAATGGAAGCAG
CACATCTACAAGGAGATTGTGAACTTCAGCCCCATTGCCCGGAAGGACTCACGGCGCCGG
AGTGGCATGAAGCTGTAG
Target 13 GenBank Gene ID Not Available
Target 13 GeneCard ID MAPK13 Link Image
Target 13 GenAtlas ID MAPK13 Link Image
Target 13 HGNC ID HGNC:6875 Link Image
Target 13 Chromosome Location Not Available
Target 13 Locus 6p21.31
Target 13 SNPs SNPJam Report Link Image
Target 13 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 13 General References 9218798; 9374491; 9295308; 9207191; 10066767; 10727080; 14574404; 15489334; 10201954
Target 14 [top]
Target 14 ID 232
Target 14 Name Mitogen-activated protein kinase 14
Target 14 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 14 Description Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis
Target 14 Synonyms
  1. Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A
Target 14 Gene Name MAPK14
Target 14 Protein Sequence >Mitogen-activated protein kinase 14 
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Target 14 Number of Residues 360
Target 14 Molecular Weight 41292.9
Target 14 Theoretical pI 5.58
Target 14 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 14 General Function Involved in ATP binding
Target 14 Pathways Not Available
Target 14 Reactions Not Available
Target 14 Signals
  • None
Target 14 Transmembrane Regions
  • None
Target 14 Essentiality Non Essential
Target 14 Domain Function PF00069:Pkinase
Target 14 GenBank ID Protein Not Available
Target 14 UniProtKB ID Q16539 Link Image
Target 14 Cellular Location Cytoplasm (By similarity). Nucleus (By similarity)
Target 14 Gene Sequence >1083 bp 
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTG
CCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCT
GCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG
TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACAT
GAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAAT
GATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG
AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTAT
ATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAA
GACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA
GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTAC
AACCAGACAGTTGATATTTGGTCAGTGGGATGCATAATGGCCGAGCTGTTGACTGGAAGA
ACATTGTTTCCTGGTACAGACCATATTAACCAGCTTCAGCAGATTATGCGTCTGACAGGA
ACACCCCCCGCTTATCTCATTAACAGGATGCCAAGCCATGAGGCAAGAAACTATATTCAG
TCTTTGACTCAGATGCCGAAGATGAACTTTGCGAATGTATTTATTGGTGCCAATCCCCTG
GCTGTCGACTTGCTGGAGAAGATGCTTGTATTGGACTCAGATAAGAGAATTACAGCGGCC
CAAGCCCTTGCACATGCCTACTTTGCTCAGTACCACGATCCTGATGATGAACCAGTGGCC
GATCCTTATGATCAGTCCTTTGAAAGCAGGGACCTCCTTATAGATGAGTGGAAAAGCCTG
ACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCC
TGA
Target 14 GenBank Gene ID Not Available
Target 14 GeneCard ID MAPK14 Link Image
Target 14 GenAtlas ID MAPK14 Link Image
Target 14 HGNC ID HGNC:6876 Link Image
Target 14 Chromosome Location Not Available
Target 14 Locus 6p21.3-p21.2
Target 14 SNPs SNPJam Report Link Image
Target 14 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 14 General References 7997261; 7696354; 7479834; 10727080; 11866441; 14702039; 14574404
Target 15 [top]
Target 15 ID 226
Target 15 Name C-jun-amino-terminal kinase-interacting protein 2
Target 15 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 15 Description The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins (By similarity)
Target 15 Synonyms
  1. JNK-interacting protein 2; JIP-2; JNK MAP kinase scaffold protein 2; Islet-brain-2; IB-2; Mitogen-activated protein kinase 8-interacting protein 2
Target 15 Gene Name MAPK8IP2
Target 15 Protein Sequence >C-jun-amino-terminal kinase-interacting protein 2 
MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSL
SLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPA
PGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALR
ELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPGGTSPSSDPGIEADLRSRSSGGR
GGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSSGRSSHLTNSIEEA
SSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMIS
EGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP
APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEE
DAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDS
GGEASEEEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLV
NGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYA
HAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLR
PPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLS
RFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE
Target 15 Number of Residues 824
Target 15 Molecular Weight 87973.9
Target 15 Theoretical pI 4.08
Target 15 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 15 General Function Involved in beta-amyloid binding
Target 15 Pathways Not Available
Target 15 Reactions Not Available
Target 15 Signals
  • None
Target 15 Transmembrane Regions
  • None
Target 15 Essentiality Non Essential
Target 15 Domain Function PF00640:PID PF00018:SH3_1
Target 15 GenBank ID Protein Not Available
Target 15 UniProtKB ID Q13387 Link Image
Target 15 Cellular Location Cytoplasm
Target 15 Gene Sequence >2475 bp 
ATGGCGGATCGCGCGGAGATGTTTTCTCTCTCCACCTTCCACTCGCTGTCGCCGCCGGGC
TGCAGGCCTCCCCAGGACATAAGCCTGGAAGAATTTGACGACGAAGATCTGTCTGAGATC
ACTGATGACTGTGGCCTGGGCCTCAGCTACGACTCAGACCACTGTGAGAAGGACAGCCTC
TCCCTGGGGCGCTCGGAGCAGCCGCACCCCATCTGCTCCTTCCAGGATGACTTCCAGGAG
TTTGAGATGATCGATGACAATGAAGAGGAGGACGATGAGGACGAGGAAGAGGAGGAGGAG
GAGGAGGAGGGAGATGGGGAAGGCCAGGAGGGAGGAGACCCTGGCTCAGAGGCACCTGCC
CCCGGGCCCCTTATCCCCTCCCCTTCCGTGGAGGAGCCCCACAAGCACCGGCCCACCACC
CTCCGTCTGACCACACTGGGGGCCCAGGACTCCCTAAACAACAACGGAGGCTTTGACCTG
GTGCGTCCGGCCTCCTGGCAGGAGACAGCGCTATGCTCACCCGCCCCGGAGGCCCTCAGA
GAGCTCCCGGGCCCCCTCCCTGCCACGGACACCGGGCCCGGCGGGGCGCAGTCGCCAGTG
CGCCCGGGTTGCGACTGCGAAGGGAACCGGCCTGCGGAACCCCCTGCGCCAGGGGGGACT
TCGCCCTCCTCAGATCCCGGCATCGAGGCTGACCTGAGAAGCCGCTCGAGCGGCGGCCGC
GGGGGACGTCGCAGCAGCCAGGAGCTGTCCTCGCCCGGCTCCGACTCGGAGGACGCGGGC
GGCGCGCGCCTGGGGCGCATGATCTCGTCCATCTCGGAGACGGAGCTGGAGCTGAGCAGC
GATGGCGGAAGCAGCAGCAGCGGCCGCTCCTCGCACCTCACCAACTCCATCGAGGAGGCC
TCGTCGCCCGCCTCGGAGCCGGAGCCCCCGCGCGAACCCCCGCGCCGCCCCGCCTTCCTG
CCCGTGGGCCCCGACGACACCAACAGCGAGTACGAGTCGGGGTCGGAGTCGGAGCCGGAC
CTCAGCGAGGACGCGGACTCGCCCTGGCTGCTCAGCAACCTGGTGAGCCGCATGATCTCC
GAGGGCTCCTCGCCCATCCGCTGCCCCGGCCAGTGCCTGTCTCCTGCGCCGCGCCCGCCC
GGGGAGCCCGTGTCGCCGGCCGGCGGGGCCGCCCAGGACTCCCAGGACCCCGAGGCGGCC
GCGGGGCCCGGCGGCGTGGAGCTGGTGGACATGGAGACGCTGTGCGCGCCGCCGCCGCCC
GCGCCCGCCGCGCCTCGACCCGGCCCCGCGCAGCCCGGGCCCTGCCTATTCCTCAGCAAC
CCCACGCGTGACACCATCACGCCGCTGTGGGCCGCGCCCGGCCGCGCCGCCCGCCCGGGA
CGAGCCTGCTCCGCCGCCTGCTCCGAGGAGGAGGACGAAGAGGACGACGAGGAAGAGGAG
GATGCCGAGGACAGTGCGGGGTCCCCCGGGGGCAGGGGCACGGGCCCCTCGGCGCCGCGG
GACGCGTCGCTGGTGTACGACGCGGTCAAGTACACGCTGGTGGTGGATGAGCACACGCAG
CTGGAGCTGGTGAGCCTGCGGCGCTGTGCTGGGCTGGGCCACGACAGCGAAGAGGACAGC
GGCGGGGAGGCCAGCGAGGAGGAGGCGGGCGCGGCGCTGCTAGGCGGCGGTCAGGTCTCG
GGGGACACCTCGCCGGACAGCCCTGACCTCACTTTCTCCAAGAAGTTCCTCAATGTCTTC
GTCAACAGCACATCTCGGTCCTCCAGCACCGAGTCCTTTGGCCTTTTCTCCTGTCTGGTC
AACGGCGAGGAGCGAGAGCAGACTCACCGGGCTGTGTTCAGGTTCATCCCGCGGCATCCA
GACGAGCTGGAGCTGGATGTGGATGACCCTGTGTTGGTGGAGGCCGAGGAGGACGACTTC
TGGTTCCGTGGCTTCAACATGCGCACGGGGGAGCGCGGTGTGTTTCCTGCCTTCTACGCC
CATGCGGTGCCCGGCCCTGCCAAGGACCTGCTGGGGAGTAAGCGGAGCCCCTGCTGGGTG
GAGCGCTTTGACGTGCAGTTCCTGGGCTCCGTGGAGGTGCCCTGCCACCAGGGCAACGGC
ATCCTGTGTGCAGCCATGCAGAAGATTGCCACTGCCCGGAAACTGACCGTCCACCTGCGC
CCTCCTGCCTCCTGTGACCTCGAGATCTCTCTTCGGGGGGTCAAGCTGAGTCTGAGCGGA
GGAGGGCCCGAGTTCCAGCGCTGCAGCCATTTCTTCCAGATGAAGAACATCTCCTTCTGC
GGCTGCCATCCCCGCAACAGCTGCTATTTCGGCTTCATCACCAAACACCCCCTGCTGAGC
CGCTTCGCCTGCCACGTCTTTGTCTCCCAGGAGTCCATGAGGCCGGTGGCGCAGAGTGTG
GGCCGCGCCTTCCTGGAGTACTACCAAGAGCACCTGGCGTACGCCTGCCCCACGGAGGAC
ATCTACCTGGAGTAG
Target 15 GenBank Gene ID Not Available
Target 15 GeneCard ID MAPK8IP2 Link Image
Target 15 GenAtlas ID MAPK8IP2 Link Image
Target 15 HGNC ID HGNC:6883 Link Image
Target 15 Chromosome Location Chromosome:22
Target 15 Locus 22q13.33
Target 15 SNPs SNPJam Report Link Image
Target 15 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 15 General References 10490659; 10756100; 10591208; 15489334; 12529303
Target 16 [top]
Target 16 ID 62
Target 16 Name C-jun-amino-terminal kinase-interacting protein 4
Target 16 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 16 Description The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction
Target 16 Synonyms
  1. JNK-interacting protein 4; JIP-4; JNK-associated leucine-zipper protein; JLP; Sperm-associated antigen 9; Mitogen-activated protein kinase 8-interacting protein 4; Human lung cancer oncogene 6 protein; HLC-6; Proliferation-inducing protein 6; Sperm-specific protein; Sperm surface protein; Protein highly expressed in testis; PHET; Sunday driver 1; Cancer/testis antigen 89; CT89
Target 16 Gene Name SPAG9
Target 16 Protein Sequence >C-jun-amino-terminal kinase-interacting protein 4 
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN
LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR
VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP
RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG
FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY
KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL
LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA
EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE
NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP
GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG
QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD
TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN
ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG
GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG
SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE
EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG
TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK
SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK
LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK
VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP
GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN
E
Target 16 Number of Residues 1321
Target 16 Molecular Weight 146204.4
Target 16 Theoretical pI 4.79
Target 16 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 16 General Function Transcription
Target 16 Pathways Not Available
Target 16 Reactions Not Available
Target 16 Signals
  • None
Target 16 Transmembrane Regions
  • None
Target 16 Essentiality Non Essential
Target 16 Domain Function PF09744:Jnk-SapK_ap_N
Target 16 GenBank ID Protein Not Available
Target 16 UniProtKB ID O60271 Link Image
Target 16 Cellular Location Isoform 5:Cytoplasmic vesicle, secretory vesicle, acrosome
Target 16 Gene Sequence >3936 bp 
ATGGAGCTGGAGGACGGTGTGGTGTATCAGGAGGAGCCCGGCGGCTCCGGGGCCGTGATG
TCGGAGCGGGTGTCCGGCCTGGCCGGCTCCATCTACCGCGAGTTCGAGCGGCTTATCGGG
CGCTATGACGAGGAGGTGGTCAAAGAGCTGATGCCGCTGGTGGTGGCTGTGCTGGAGAAC
CTGGACTCGGTGTTCGCGCAGGACCAGGAGCACCAGGTGGAGCTGGAGCTGCTGCGGGAC
GACAACGAGCAGCTCATCACCCAGTACGAGCGGGAGAAGGCGCTGCGCAAGCACGCTGAG
GAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGA
GTGGAATCTTTAGAATCTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGAC
CAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAATATAATGCATTACAT
CAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCAT
CAGCTCTCAGGGAGTGATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGC
CCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGCTTACACCTGATGCT
CAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCA
CGTTCTCATACCAGCCTGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCT
ACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTACTGATACTCCCTTA
AAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGC
AAACACATTGAAGTACAGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAA
AATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTGAGCTGGATATGGAC
AAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCT
TTTGATCGCAATACAGAATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATA
GGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAGTTGAGAATCTTATA
TTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTG
ATAGCAAAAGTGGATGAACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCT
GTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGGAGGAAGAGCTTAGG
AAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGAT
ATTCCCACAGCCCAGAGGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAG
CGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTCGATGGACAGAGATG
ATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAG
TTTGTGCCAACTCGTTTCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCT
GAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCAAG
AAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTT
AGTGAAGAAACTGAAGCTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGT
CAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTCTG
CCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCT
GTGCCTGTCTATCTCAGACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCT
GTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAAGT
GTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCT
CAGAGTAGTTTAGATAAGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAAT
CAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAGTT
CTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCT
CATGTTCTGTGCATTGCAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAA
GATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCAAC
AGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAA
GGTGTGACGGGAGCTGCCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAA
CCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAGAA
GCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAA
ACTGGCGTCTACACAGAGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGAC
CTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAGTA
CTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCA
ACTATGTGGCTTGGAGCTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGG
AGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGAAG
GGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGAT
GGGCAGTGGGATTTGTCAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATC
CGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATGTG
GTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGC
CAAGTGCGACAGCTTGCGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCT
ACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGCCT
TATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCT
CTTATGGTGTCTTGTAATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATC
CCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAATC
CGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGT
TCAATGGCACATGCACAGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTG
GCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGGGT
GACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTT
GTCATCAGTGGAGGAGAGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCA
GAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAGTCAC
TTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGA
Target 16 GenBank Gene ID Not Available
Target 16 GeneCard ID SPAG9 Link Image
Target 16 GenAtlas ID SPAG9 Link Image
Target 16 HGNC ID HGNC:14524 Link Image
Target 16 Chromosome Location Chromosome:17
Target 16 Locus 17q21.33
Target 16 SNPs SNPJam Report Link Image
Target 16 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 16 General References 12391307; 16112646; 9628581; 12168954; 14702039; 16625196; 15489334; 9480848; 14662895; 15144186
Target 17 [top]
Target 17 ID 64
Target 17 Name C-jun-amino-terminal kinase-interacting protein 1
Target 17 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 17 Description The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response
Target 17 Synonyms
  1. JNK-interacting protein 1; JIP-1; JNK MAP kinase scaffold protein 1; Islet-brain 1; IB-1; Mitogen-activated protein kinase 8-interacting protein 1
Target 17 Gene Name MAPK8IP1
Target 17 Protein Sequence >C-jun-amino-terminal kinase-interacting protein 1 
MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISL
QCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAAR
RPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN
SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRS
TATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFL
PPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPP
PPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVS
SPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLF
SCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFP
AYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLT
VHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFI
TKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
Target 17 Number of Residues 711
Target 17 Molecular Weight 77523.6
Target 17 Theoretical pI 4.61
Target 17 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 17 General Function Involved in kinesin binding
Target 17 Pathways Not Available
Target 17 Reactions Not Available
Target 17 Signals
  • None
Target 17 Transmembrane Regions
  • None
Target 17 Essentiality Non Essential
Target 17 Domain Function PF00640:PID PF00018:SH3_1
Target 17 GenBank ID Protein Not Available
Target 17 UniProtKB ID Q9UQF2 Link Image
Target 17 Cellular Location Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity)
Target 17 Gene Sequence Not Available
Target 17 GenBank Gene ID Not Available
Target 17 GeneCard ID MAPK8IP1 Link Image
Target 17 GenAtlas ID MAPK8IP1 Link Image
Target 17 HGNC ID HGNC:6882 Link Image
Target 17 Chromosome Location Chromosome:11
Target 17 Locus 11p12-p11.2
Target 17 SNPs SNPJam Report Link Image
Target 17 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 17 General References 9933567; 10574993; 11238452; 11726277; 11912189; 12756254; 11147798; 14507925; 12937412
Target 18 [top]
Target 18 ID 132
Target 18 Name C-jun-amino-terminal kinase-interacting protein 3
Target 18 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 18 Description The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins (By similarity)
Target 18 Synonyms
  1. JNK-interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3
Target 18 Gene Name MAPK8IP3
Target 18 Protein Sequence >C-jun-amino-terminal kinase-interacting protein 3 
MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV
NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK
ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE
RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ
LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV
GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD
RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV
GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE
EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE
RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY
KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR
LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP
NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL
TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD
GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE
VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP
TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT
LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS
FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL
GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP
GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS
PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK
AERSHIIVWQVSYTPE
Target 18 Number of Residues 1336
Target 18 Molecular Weight 147455.9
Target 18 Theoretical pI 5.08
Target 18 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 18 General Function Transcription
Target 18 Pathways Not Available
Target 18 Reactions Not Available
Target 18 Signals
  • None
Target 18 Transmembrane Regions
  • None
Target 18 Essentiality Non Essential
Target 18 Domain Function PF09744:Jnk-SapK_ap_N
Target 18 GenBank ID Protein Not Available
Target 18 UniProtKB ID Q9UPT6 Link Image
Target 18 Cellular Location Cytoplasm (By similarity)
Target 18 Gene Sequence Not Available
Target 18 GenBank Gene ID Not Available
Target 18 GeneCard ID MAPK8IP3 Link Image
Target 18 GenAtlas ID MAPK8IP3 Link Image
Target 18 HGNC ID HGNC:6884 Link Image
Target 18 Chromosome Location Chromosome:16
Target 18 Locus 16p13.3
Target 18 SNPs SNPJam Report Link Image
Target 18 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 18 General References 10470851; 11214971; 11157797; 15616553; 15489334; 15302935
Target 19 [top]
Target 19 ID 119
Target 19 Name Mitogen-activated protein kinase 15
Target 19 Mechanism of Action Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (R069)
Target 19 Description In vitro, phosphorylates MBP
Target 19 Synonyms
  1. Extracellular signal-regulated kinase 8
Target 19 Gene Name MAPK15
Target 19 Protein Sequence >Mitogen-activated protein kinase 15 
MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFRE
ITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQ
LLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVAT
RWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEE
DLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQ
HPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEG
VSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQ
TALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVR
VASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLE
GHHV
Target 19 Number of Residues 544
Target 19 Molecular Weight 59831.6
Target 19 Theoretical pI 9.18
Target 19 GO Classification
Function
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
Process
physiological process
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
protein amino acid phosphorylation
Component
Not Available
Target 19 General Function Involved in ATP binding
Target 19 Pathways Not Available
Target 19 Reactions Not Available
Target 19 Signals
  • None
Target 19 Transmembrane Regions
  • None
Target 19 Essentiality Non Essential
Target 19 Domain Function PF00069:Pkinase
Target 19 GenBank ID Protein Not Available
Target 19 UniProtKB ID Q8TD08 Link Image
Target 19 Cellular Location Not Available
Target 19 Gene Sequence >1635 bp 
ATGTGCACCGTAGTGGACCCTCGCATTGTCCGGAGATACCTACTCAGGCGGCAGCTCGGG
CAGGGGGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCC
ATCAAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAA
ATCACGCTCCTCCAGGAGTTTGGGGACCATCCCAACATCATCAGCCTCCTTGACGTGATC
CGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAAC
GCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAG
CTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCG
TCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGC
TCCCTGGGCGACCTCCCTGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACA
CGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGAC
ATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGC
ACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAG
GACCTCCTGGCTCTCGGCTCAGGCTGCCGTGCCTCTGTGCTGCACCAGCTGGGGTCCCGG
CCACGACAGACGCTGGATGCCCTCCTACCGCCAGACACCTCCCCAGAGGCCTTGGACCTC
CTTAGGCGACTCCTGGTGTTCGCCCCGGACAAGCGGTTAAGCGCGACCCAGGCACTGCAG
CACCCCTACGTGCAGAGGTTCCACTGCCCCAGCGACGAGTGGGCACGAGAGGCAGATGTG
CGGCCCCGGGCACACGAAGGGGTCCAGCTCTCTGTGCCTGAGTACCGCAGCCGCGTCTAT
CAGATGATCCTGGAGTGTGGAGGCAGCAGCGGCACCTCGAGAGAGAAGGGCCCGGAGGGT
GTCTCCCCAAGCCAGGCACACCTGCACAAACCCAGAGCCGACCCTCAGCTGCCTTCTAGG
ACACCTGTGCAGGGTCCCAGACCCAGGCCCCAGAGCAGCCCAGGCCATGACCCTGCCGAG
CACGAGTCCCCCCGTGCAGCCAAGAACGTTCCCAGGCAGAACTCCGCTCCCCTGCTCCAA
ACTGCTCTCCTAGGGAATGGGGAAAGGCCCCCTGGGGCGAAGGAAGCGCCCCCCTTGACA
CTCTCGCTGGTGAAGCCAAGCGGGAGGGGAGCTGCGCCCTCCCTGACCTCCCAGGCTGCG
GCTCAGGTGGCCAACCAGGCCCTGATCCGGGGTGACTGGAACCGGGGCGGTGGGGTGAGG
GTGGCCAGCGTACAACAGGTCCCTCCCCGGCTTCCTCCGGAGGCCCGGCCCGGCCGGAGG
ATGTTCAGCACCTCTGCCTTGCAGGGTGCCCAGGGGGGTGCCAGGGCTTTGCTTGGAGGC
TACTCCCAAGCCTACGGGACTGTCTGCCACTCGGCACTGGGCCACCTGCCCCTGCTGGAG
GGGCACCATGTGTGA
Target 19 GenBank Gene ID Not Available
Target 19 GeneCard ID MAPK15 Link Image
Target 19 GenAtlas ID MAPK15 Link Image
Target 19 HGNC ID HGNC:24667 Link Image
Target 19 Chromosome Location Not Available
Target 19 Locus Not Available
Target 19 SNPs SNPJam Report Link Image
Target 19 Toxin References
  • R069 - Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 Apr;105(1):251-61. Epub 2007 Nov 16. [PubMed Link Image]
Target 19 General References 11875070; 16484222; 15489334; 16624805

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.