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Showing toxin card for Bisphenol A (T3D0637)

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Version 1.0
Creation Date 2009-03-19 21:46:58
Update Date 2010-05-18 20:50:35
Accession Number T3D0637
Name Bisphenol A
Compound Type
  • Aromatic Hydrocarbon
  • Organic Compound
Description Bisphenol A, commonly abbreviated as BPA, is an organic compound with two phenol functional groups. It is a difunctional building block of several important plastics and plastic additives. With an annual production of 2–3 million metric tonnes, it is an important monomer in the production of polycarbonate. Suspected of being hazardous to humans since the 1930s, concerns about the use of bisphenol A in consumer products were regularly reported in the news media in 2008 after several governments issued reports questioning its safety, and some retailers removed baby bottles and other children's products made from it from their shelves. (S292)
Synonyms
  1. beta.beta-Bis(p-hydroxyphenyl)propane
  2. beta-di-(p-hydroxyphenyl)propane
  3. 2, 2-Bis(4-hydroxyphenyl)propane
  4. 2, 2-Bis(hydroxyphenyl)propane
  5. 2, 2-Di(4-phenylol)propane
  6. 2,2-(4,4'-Dihydroxydiphenyl)propane
  7. 2,2-(4,4-Dihydroxydiphenyl)propane
  8. 2,2-Bis (4-hydroxyphenol) propane
  9. 2,2-Bis(4'-hydroxyphenyl)propane
  10. 2,2-Bis(4,4'-hydroxyphenyl)propane
  11. 2,2-Bis(4-hydroxyphenyl)propane
  12. 2,2-Bis(hydroxyphenyl)propane
  13. 2,2-Bis(p-hydroxyphenyl)propane
  14. 2,2-Bis-4'-hydroxyfenylpropan [Czech]
  15. 2,2-Di(4-hydroxyphenyl)propane
  16. 2,2-Di(4-phenylol)propane
  17. 2,2-di-(4'-Hydroxyphenyl)-propane
  18. 4, 4'-Bisphenol A
  19. 4, 4'-Dihydroxydiphenyl-2,2-propane
  20. 4, 4'-Dihydroxydiphenyldimethylmethane
  21. 4, 4'-Dihydroxydiphenylpropane
  22. 4,4' Isopropylidinediphenol
  23. 4,4'-(1-Methylethane-1,1-diyl)diphenol
  24. 4,4'-(1-Methylethylidene)bisphenol
  25. 4,4'-(propane-2,2-diyl)diphenol
  26. 4,4'-Bisphenol A
  27. 4,4'-Dihydroxdiphenylpropane
  28. 4,4'-Dihydroxy-2,2-diphenylpropane
  29. 4,4'-Dihydroxydiphenyl-2,2-propane
  30. 4,4'-Dihydroxydiphenyldimethylmethane
  31. 4,4'-Dihydroxydiphenylpropane
  32. 4,4'-Dimethylmethylenediphenol
  33. 4,4'-Isopropylidene diphenol
  34. 4,4'-Isopropylidenebis[phenol]
  35. 4,4'-Isopropylidenebisphenol
  36. 4,4'-Isopropylidenediphenol
  37. 4,4'-Isopropylidenediphenol B
  38. 4,4'-propane-2,2-diyldiphenol
  39. 4,4-Isopropylidenediphenol
  40. 4,4[-Isopropylidenediphenol
  41. 4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol
  42. Beta,beta'-bis(p-hydroxyphenyl)propane
  43. Beta,beta-di-(p-hydroxyphenyl)propane
  44. Beta-di-p-hydroxyphenylpropane
  45. Biphenol a
  46. Bis(4-hydroxyphenyl) dimethylmethane
  47. Bis(4-hydroxyphenyl) propane
  48. Bis(4-hydroxyphenyl)dimethylmethane
  49. Bis(p-hydroxyphenyl)propane
  50. Bisferol a [czech]
  51. Bisphenol
  52. Bisphenol a
  53. Dimethyl bis(p-hydroxyphenyl)methane
  54. Dimethylbis(p-hydroxyphenyl)methane
  55. Dimethylmethylene-p,p'-diphenol
  56. Diphenylolpropane
  57. Hydrogenated bisphenol a
  58. Isopropylidenebis(4-hydroxybenzene)
  59. P, p'-dihydroxydiphenyldimethylmethane
  60. P, p'-dihydroxydiphenylpropane
  61. P, p'-isopropylidenediphenol
  62. P,p'-bisphenol a
  63. P,p'-dihydroxydiphenyldimethylmethane
  64. P,p'-dihydroxydiphenylpropane
  65. P,p'-isopropylidenebisphenol
  66. P,p'-isopropylidenediphenol
  67. Phenol, 4,4'-dimethylmethylenedi-
  68. Poly(bisphenol a carbonate)
  69. Rikabanol
  70. b, b'-bis(p-hydroxyphenyl)propane
  71. b,b'-bis(p-hydroxyphenyl)propane
  72. b-di-(p-hydroxyphenyl)propane
  73. b-di-p-hydroxyphenylpropane
  74. bis(4-hyd roxyphenyl) dimethylmethane
  75. bis(4-hydroxyphenyl)propane
  76. di-2,2-(4-Hydroxyphenyl)propane
Chemical IUPAC Name 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
Chemical Formula C15H16O2
Chemical Structure Structure
CAS Registry Number 80-05-7
InChI Identifier InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
InChI Key InChIKey=IISBACLAFKSPIT-UHFFFAOYSA-N
PubChem Compound ID 6623 Link Image
KEGG ID C13624 Link Image
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID 33216 Link Image
BioCyc ID CPD-10489 Link Image
SuperToxic ID Not Available
CTD ID C006780 Link Image
Stitch ID Bisphenol A Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID 183
Wikipedia Link Not Available
Monoisotopic Mass 228.11503
MOL File Show
PDB File Show
SDF File Show
SMILES CC(C)(C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
Appearance Crystallizes as prisms from dil acetic acid and as needles from water (S316).
Melting Point 153 oC
Solubility 0.12 mg/mL at 25 oC [DORN,PB et al. (1987)]
Predicted LogP 4.045
Route of Exposure Oral (S292) ; inhalation (S292) ; dermal (S292)
Mechanism of Action Bisphenol is an endocrine disruptor. Low doses of bisphenol A can mimic the body's own hormones, possibly causing negative health effects. There is thus concern that long term low dose exposure to bisphenol A may induce chronic toxicity in humans (R1090).
Metabolism Bisphenol A (BPA) is rapidly absorbed from the gastrointestinal tract after ingestionand is then converted to a number of metabolites, mainly BPA glucuronide, in the liver . Metabloites of Bsiphenol A (BPA) include isopropyl-hydroxyphenol (produced by the cleavage of BPA), a bisphenol A glutathione conjugate, glutathionyl-phenol, glutathionyl 4-isopropylphenol, and BPA dimers. The monoglucuronide conjugate was the major urinary metabolite; unchanged BPA is the principal component excreted in feces (S314, S315).
Toxicity Values LD50: 2230 mg/kg (Oral, Rabbit) (V374)
Lethal Dose Not Available
Carcinogenicity (IARC Classification) Not Available
Uses/Sources Bisphenol A is used primarily to make plastics, and products containing bisphenol A-based plastics have been in commerce for more than 50 years. It is used in the synthesis of polyesters, polysulfones, and polyether ketones, as an antioxidant in some plasticizers, and as a polymerization inhibitor in PVC. It is a key monomer in production of polycarbonate plastic and epoxy resins. Polycarbonate plastic, which is clear and nearly shatter-proof, is used to make a variety of common products including baby and water bottles, sports equipment, medical and dental devices, dental fillings and sealants, eyeglass lenses, CDs and DVDs, and household electronics.[6] Epoxy resins containing bisphenol A are used as coatings on the inside of almost all food and beverage cans. Bisphenol A is also a precursor to the flame retardant, tetrabromobisphenol A, and was formerly used as a fungicide. (S292)
Minimum Risk Level Not Available
Health Effects Permanent changes to genital tract, changes in breast tissue that predispose cells to hormones and carcinogens, increased prostate weight 30%, lower bodyweight, increase of anogenital distance in both genders, signs of early puberty and longer estrus, decline in testicular testosterone, breast cells predisposed to cancer, prostate cells more sensitive to hormones and cancer, decreased maternal behaviors, reversed the normal sex differences in brain structure and behavior, U.S. human exposure limit (not a result from an animal study, but a guideline set by EPA). (S292)
Symptoms Bisphenol A has low acute toxicity, with an oral LD50 of 3250 mg/kg in rats, but it is an endocrine disruptor. Low doses of bisphenol A can mimic the body's own hormones, possibly causing negative health effects. There is thus concern that long term low dose exposure to bisphenol A may induce chronic toxicity in humans. (S292)
Treatment Consider dilution immediately after ingestion. Insertion of a specialized nasogastric tube after confirmation of a circumferential burn may prevent strictures. In case of inhalation, move patient to fresh air and monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. In case of eye contact, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Decontaminate skin or mucous membranes immediately with water and a soft sponge. (R383)
General References
  • S316 - Lide DR, Milne GWA (eds) (1994). Handbook of Data on Organic Compounds. Volume I. 3rd ed. Boca Raton, FL: CRC Press, Inc.
  • R383 - Rumack BH (2009). POISINDEX(R) Information System. Englewood, CO: Micromedex, Inc. CCIS Volume 141, edition expires Aug, 2009.
  • R1090 - Wikipedia. Tetrabromobisphenol A. Last Updated 30 April 2009.
  • S315 - Jaeg JP, Perdu E, Dolo L, Debrauwer L, Cravedi JP, Zalko D. Characterization of new bisphenol a metabolites produced by CD1 mice liver microsomes and S9 fractions. J Agric Food Chem. 2004 Jul 28;52(15):4935-42. [PubMed Link Image]
  • S292 - Wikipedia. Bisphenol A. Last Updated 25 June 2009.
  • S314 - Pottenger LH, Domoradzki JY, Markham DA, Hansen SC, Cagen SZ, Waechter JM Jr. The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Toxicol Sci. 2000 Mar;54(1):3-18. [PubMed Link Image]
Targets
  1. Protein disulfide-isomerase
  2. Estrogen receptor
  3. Estrogen receptor beta
  4. Androgen receptor
  5. Estrogen-related receptor gamma
Target 1 [top]
Target 1 ID 544
Target 1 Name Protein disulfide-isomerase
Target 1 Mechanism of Action The binding activity of L-T3 and 17beta-estradiol hormones to PDI was competitively inhibited by BPA. This in turn abolishes PDIs isomerase activities. (S291)
Target 1 Description This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP
Target 1 Synonyms
  1. PDI; Prolyl 4-hydroxylase subunit beta; Cellular thyroid hormone-binding protein; p55
Target 1 Gene Name P4HB
Target 1 Protein Sequence >Protein disulfide-isomerase 
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALA
PEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGR
EADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAID
DIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEF
TEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQR
ILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQEL
PEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENI
VIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGD
DDDLEDLEEAEEPDMEEDDDQKAVKDEL
Target 1 Number of Residues 508
Target 1 Molecular Weight 57115.8
Target 1 Theoretical pI 4.49
Target 1 GO Classification
Function
transporter activity
electron transporter activity
catalytic activity
isomerase activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
endoplasmic reticulum
Target 1 General Function Posttranslational modification, protein turnover, chaperones
Target 1 Pathways Not Available
Target 1 Reactions Not Available
Target 1 Signals
  • 1-17
Target 1 Transmembrane Regions
  • None
Target 1 Essentiality Non Essential
Target 1 Domain Function PF00085:Thioredoxin
Target 1 GenBank ID Protein Not Available
Target 1 UniProtKB ID P07237 Link Image
Target 1 Cellular Location Endoplasmic reticulum lumen. Melanosome. Cell membrane
Target 1 Gene Sequence >1527 bp 
ATGCTGCGCCGCGCTCTGCTGTGCCTGCCGTGGNCCGCCCTGGTGCGCGCCGACGCCCCC
GAGGAGGAGGACCACGTCTTGGTGCTGCGGAAAAGCAACTTCGCGGAGGCGCTGGCGGCC
CACAAGTACCCGCCGGTGGAGTTCCATGCCCCCTGGTGTGGCCACTGCAAGGCTCTGGCC
CCTGAGTATGCCAAAGCCGCTGGGAAGCTGAAGGCAGAAGGTTCCGAGATCAGGTTGGCC
AAGGTGGACGCCACGGAGGAGTCTGACCTAGCCCAGCAGTACGGCGTGCGCGGCTATCCC
ACCATCAAGTTCTTCAGGAATGGAGACACGGCTTCCCCCAAGGAATATACAGCTGGCAGA
GAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGCTGCCACCACCCTG
CCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCCGTCATCGGCTTC
TTCAAGGACGTGGAGTCGGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGAT
GACATACCATTTGGGATCACTTCCAACAGTGACGTGTTCTCCAAATACCAGCTCGACAAA
GATGGGGTTGTCCTCTTTAAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTC
ACCAAGGAGAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTC
ACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCACATCCTGCTGTTC
TTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAG
AGCTTCAAGGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGC
ATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCATCACCTTG
GAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACA
GAGTTCTGCCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTG
CCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTGAAGACGTG
GCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGC
AAACAGTTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATC
GTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTGCACGGCTTC
CCCACACTCGGGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAA
CGCACGCTGGATGGTTTTAAGAAATTCCTAGAGAGCGGTGGCCAAGATGGGGCAGGGGAT
GTTGACGACCTCGAGGACCTCGAAGAAGCAGAGGAGCCAGACATGGAGGAAGACGATGAC
CAGAAAGCTGTGAAAGATGAACTGTAA
Target 1 GenBank Gene ID Not Available
Target 1 GeneCard ID P4HB Link Image
Target 1 GenAtlas ID P4HB Link Image
Target 1 HGNC ID HGNC:8548 Link Image
Target 1 Chromosome Location Chromosome:17
Target 1 Locus 17q25
Target 1 SNPs SNPJam Report Link Image
Target 1 Toxin References
  • S291 - Hiroi T, Okada K, Imaoka S, Osada M, Funae Y: Bisphenol A binds to protein disulfide isomerase and inhibits its enzymatic and hormone-binding activities. Endocrinology. 2006 Jun;147(6):2773-80. Epub 2006 Mar 16. [PubMed Link Image]
Target 1 General References 3034602; 3611107; 2846539; 15489334; 1597478; 9150948; 12665801; 2079031; 1286669
Target 2 [top]
Target 2 ID 5
Target 2 Name Estrogen receptor
Target 2 Mechanism of Action Bisphenol-A (BPA) has been reported to bind to the estrogen receptor (ER) and also to act as a xenoestrogen on the reproductive system of many species. (S293)
Target 2 Description Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues
Target 2 Synonyms
  1. ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
Target 2 Gene Name ESR1
Target 2 Protein Sequence >Estrogen receptor 
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Target 2 Number of Residues 595
Target 2 Molecular Weight 66215.4
Target 2 Theoretical pI 8.14
Target 2 GO Classification
Function
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 2 General Function Involved in estrogen receptor activity
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Signals
  • None
Target 2 Transmembrane Regions
  • None
Target 2 Essentiality Non Essential
Target 2 Domain Function PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4
Target 2 GenBank ID Protein Not Available
Target 2 UniProtKB ID P03372 Link Image
Target 2 Cellular Location Nucleus
Target 2 Gene Sequence >63 bp 
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
Target 2 GenBank Gene ID Not Available
Target 2 GeneCard ID ESR1 Link Image
Target 2 GenAtlas ID ESR1 Link Image
Target 2 HGNC ID HGNC:3467 Link Image
Target 2 Chromosome Location Not Available
Target 2 Locus 6q25.1
Target 2 SNPs SNPJam Report Link Image
Target 2 Toxin References
  • S293 - Furuya M, Adachi K, Kuwahara S, Ogawa K, Tsukamoto Y: Inhibition of male chick phenotypes and spermatogenesis by Bisphenol-A. Life Sci. 2006 Mar 6;78(15):1767-76. Epub 2005 Nov 16. [PubMed Link Image]
Target 2 General References 3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106
Target 3 [top]
Target 3 ID 208
Target 3 Name Estrogen receptor beta
Target 3 Mechanism of Action Bisphenol-A (BPA) has been reported to bind to the estrogen receptor (ER) and also to act as a xenoestrogen on the reproductive system of many species. (S293)
Target 3 Description Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
Target 3 Synonyms
  1. ER-beta; Nuclear receptor subfamily 3 group A member 2
Target 3 Gene Name ESR2
Target 3 Protein Sequence >Estrogen receptor beta 
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Target 3 Number of Residues 530
Target 3 Molecular Weight 59215.8
Target 3 Theoretical pI 8.55
Target 3 GO Classification
Function
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 3 General Function Involved in estrogen receptor activity
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • None
Target 3 Essentiality Non Essential
Target 3 Domain Function PF00104:Hormone_recep PF00105:zf-C4
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB ID Q92731 Link Image
Target 3 Cellular Location Nucleus
Target 3 Gene Sequence >1593 bp 
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA
Target 3 GenBank Gene ID Not Available
Target 3 GeneCard ID ESR2 Link Image
Target 3 GenAtlas ID ESR2 Link Image
Target 3 HGNC ID HGNC:3468 Link Image
Target 3 Chromosome Location Chromosome:14
Target 3 Locus 14q23.2
Target 3 SNPs SNPJam Report Link Image
Target 3 Toxin References
  • S293 - Furuya M, Adachi K, Kuwahara S, Ogawa K, Tsukamoto Y: Inhibition of male chick phenotypes and spermatogenesis by Bisphenol-A. Life Sci. 2006 Mar 6;78(15):1767-76. Epub 2005 Nov 16. [PubMed Link Image]
Target 3 General References 9473491; 9636657; 9685228; 9671811; 16938840; 15489334; 10964723; 8769313
Target 4 [top]
Target 4 ID 34
Target 4 Name Androgen receptor
Target 4 Mechanism of Action Tumor-derived mutants of the androgen receptor are receptive to activation by bisphenol A (BPA). (S294)
Target 4 Description Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3
Target 4 Synonyms
  1. Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Target 4 Gene Name AR
Target 4 Protein Sequence >Androgen receptor 
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSA
LECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLK
DILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKA
VSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKS
TEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSR
DYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP
GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPY
GYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLE
TARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRND
CTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLT
VSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRM
YSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR
IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIIS
VQVPKILSGKVKPIYFHTQ
Target 4 Number of Residues 919
Target 4 Molecular Weight 98987.9
Target 4 Theoretical pI 6.38
Target 4 GO Classification
Function
transcription factor activity
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
androgen receptor activity
binding
nucleic acid binding
DNA binding
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 4 General Function Involved in androgen binding
Target 4 Pathways Not Available
Target 4 Reactions Not Available
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Non Essential
Target 4 Domain Function PF02166:Androgen_recep PF00104:Hormone_recep PF00105:zf-C4
Target 4 GenBank ID Protein Not Available
Target 4 UniProtKB ID P10275 Link Image
Target 4 Cellular Location Nucleus
Target 4 Gene Sequence >2760 bp 
ATGGAAGTGCAGTTAGGGCTGGGAAGGGTCTACCCTCGGCCGCCGTCCAAGACCTACCGA
GGAGCTTTCCAGAATCTGTTCCAGAGCGTGCGCGAAGTGATCCAGAACCCGGGCCCCAGG
CACCCAGAGGCCGCGAGCGCAGCACCTCCCGGCGCCAGTTTGCTGCTGCTGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGACT
AGCCCCAGGCAGCAGCAGCAGCAGCAGGGTGAGGATGGTTCTCCCCAAGCCCATCGTAGA
GGCCCCACAGGCTACCTGGTCCTGGATGAGGAACAGCAACCTTCACAGCCGCAGTCGGCC
CTGGAGTGCCACCCCGAGAGAGGTTGCGTCCCAGAGCCTGGAGCCGCCGTGGCCGCCAGC
AAGGGGCTGCCGCAGCAGCTGCCAGCACCTCCGGACGAGGATGACTCAGCTGCCCCATCC
ACGTTGTCCCTGCTGGGCCCCACTTTCCCCGGCTTAAGCAGCTGCTCCGCTGACCTTAAA
GACATCCTGAGCGAGGCCAGCACCATGCAACTCCTTCAGCAACAGCAGCAGGAAGCAGTA
TCCGAAGGCAGCAGCAGCGGGAGAGCGAGGGAGGCCTCGGGGGCTCCCACTTCCTCCAAG
GACAATTACTTAGGGGGCACTTCGACCATTTCTGACAACGCCAAGGAGTTGTGTAAGGCA
GTGTCGGTGTCCATGGGCCTGGGTGTGGAGGCGTTGGAGCATCTGAGTCCAGGGGAACAG
CTTCGGGGGGATTGCATGTACGCCCCACTTTTGGGAGTTCCACCCGCTGTGCGTCCCACT
CCTTGTGCCCCATTGGCCGAATGCAAAGGTTCTCTGCTAGACGACAGCGCAGGCAAGAGC
ACTGAAGATACTGCTGAGTATTCCCCTTTCAAGGGAGGTTACACCAAAGGGCTAGAAGGC
GAGAGCCTAGGCTGCTCTGGCAGCGCTGCAGCAGGGAGCTCCGGGACACTTGAACTGCCG
TCTACCCTGTCTCTCTACAAGTCCGGAGCACTGGACGAGGCAGCTGCGTACCAGAGTCGC
GACTACTACAACTTTCCACTGGCTCTGGCCGGACCGCCGCCCCCTCCGCCGCCTCCCCAT
CCCCACGCTCGCATCAAGCTGGAGAACCCGCTGGACTACGGCAGCGCCTGGGCGGCTGCG
GCGGCGCAGTGCCGCTATGGGGACCTGGCGAGCCTGCATGGCGCGGGTGCAGCGGGACCC
GGTTCTGGGTCACCCTCAGCCGCCGCTTCCTCATCCTGGCACACTCTCTTCACAGCCGAA
GAAGGCCAGTTGTATGGACCGTGTGGTGGTGGTGGGGGTGGTGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGAGGCGGGAGCTGTAGCCCCCTAC
GGCTACACTCGGCCCCCTCAGGGGCTGGCGGGCCAGGAAAGCGACTTCACCGCACCTGAT
GTGTGGTACCCTGGCGGCATGGTGAGCAGAGTGCCCTATCCCAGTCCCACTTGTGTCAAA
AGCGAAATGGGCCCCTGGATGGATAGCTACTCCGGACCTTACGGGGACATGCGTTTGGAG
ACTGCCAGGGACCATGTTTTGCCCATTGACTATTACTTTCCACCCCAGAAGACCTGCCTG
ATCTGTGGAGATGAAGCTTCTGGGTGTCACTATGGAGCTCTCACATGTGGAAGCTGCAAG
GTCTTCTTCAAAAGAGCCGCTGAAGGGAAACAGAAGTACCTGTGCGCCAGCAGAAATGAT
TGCACTATTGATAAATTCCGAAGGAAAAATTGTCCATCTTGTCGTCTTCGGAAATGTTAT
GAAGCAGGGATGACTCTGGGAGCCCGGAAGCTGAAGAAACTTGGTAATCTGAAACTACAG
GAGGAAGGAGAGGCTTCCAGCACCACCAGCCCCACTGAGGAGACAACCCAGAAGCTGACA
GTGTCACACATTGAAGGCTATGAATGTCAGCCCATCTTTCTGAATGTCCTGGAAGCCATT
GAGCCAGGTGTAGTGTGTGCTGGACACGACAACAACCAGCCCGACTCCTTTGCAGCCTTG
CTCTCTAGCCTCAATGAACTGGGAGAGAGACAGCTTGTACACGTGGTCAAGTGGGCCAAG
GCCTTGCCTGGCTTCCGCAACTTACACGTGGACGACCAGATGGCTGTCATTCAGTACTCC
TGGATGGGGCTCATGGTGTTTGCCATGGGCTGGCGATCCTTCACCAATGTCAACTCCAGG
ATGCTCTACTTCGCCCCTGATCTGGTTTTCAATGAGTACCGCATGCACAAGTCCCGGATG
TACAGCCAGTGTGTCCGAATGAGGCACCTCTCTCAAGAGTTTGGATGGCTCCAAATCACC
CCCCAGGAATTCCTGTGCATGAAAGCACTGCTACTCTTCAGCATTATTCCAGTGGATGGG
CTGAAAAATCAAAAATTCTTTGATGAACTTCGAATGAACTACATCAAGGAACTCGATCGT
ATCATTGCATGCAAAAGAAAAAATCCCACATCCTGCTCAAGACGCTTCTACCAGCTCACC
AAGCTCCTGGACTCCGTGCAGCCTATTGCGAGAGAGCTGCATCAGTTCACTTTTGACCTG
CTAATCAAGTCACACATGGTGAGCGTGGACTTTCCGGAAATGATGGCAGAGATCATCTCT
GTGCAAGTGCCCAAGATCCTTTCTGGGAAAGTCAAGCCCATCTATTTCCACACCCAGTGA
Target 4 GenBank Gene ID Not Available
Target 4 GeneCard ID AR Link Image
Target 4 GenAtlas ID AR Link Image
Target 4 HGNC ID HGNC:644 Link Image
Target 4 Chromosome Location Not Available
Target 4 Locus Xq11.2-q12
Target 4 SNPs SNPJam Report Link Image
Target 4 Toxin References
  • S294 - Wetherill YB, Hess-Wilson JK, Comstock CE, Shah SA, Buncher CR, Sallans L, Limbach PA, Schwemberger S, Babcock GF, Knudsen KE: Bisphenol A facilitates bypass of androgen ablation therapy in prostate cancer. Mol Cancer Ther. 2006 Dec;5(12):3181-90. [PubMed Link Image]
Target 4 General References 3216866; 2594783; 2342476; 3174628; 2911578; 2293020; 15634333; 15772651; 15489334
Target 5 [top]
Target 5 ID 67
Target 5 Name Estrogen-related receptor gamma
Target 5 Mechanism of Action Bisphenol A (BPA) functions at very low doses as an endocrine disruptor. The human estrogen-related receptor gamma (ERR gamma) behaves as a constitutive activator of transcription, although the endogenous ligand is unknown. (S295)
Target 5 Description Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity)
Target 5 Synonyms
  1. Estrogen receptor-related protein 3; ERR gamma-2; Nuclear receptor subfamily 3 group B member 3
Target 5 Gene Name ESRRG
Target 5 Protein Sequence >Estrogen-related receptor gamma 
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG
SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML
NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC
QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH
LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK
LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT
LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
Target 5 Number of Residues 458
Target 5 Molecular Weight 51305.5
Target 5 Theoretical pI 6.44
Target 5 GO Classification
Function
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 5 General Function Involved in AF-2 domain binding
Target 5 Pathways Not Available
Target 5 Reactions Not Available
Target 5 Signals
  • None
Target 5 Transmembrane Regions
  • None
Target 5 Essentiality Non Essential
Target 5 Domain Function PF00104:Hormone_recep PF00105:zf-C4
Target 5 GenBank ID Protein Not Available
Target 5 UniProtKB ID P62508 Link Image
Target 5 Cellular Location Nucleus (Probable)
Target 5 Gene Sequence >1377 bp 
ATGGATTCGGTAGAACTTTGCCTTCCTGAATCTTTTTCCCTGCACTACGAGGAAGAGCTT
CTCTGCAGAATGTCAAACAAAGATCGACACATTGATTCCAGCTGTTCGTCCTTCATCAAG
ACGGAACCTTCCAGCCCAGCCTCCCTGACGGACAGCGTCAACCACCACAGCCCTGGTGGC
TCTTCAGACGCCAGTGGGAGCTACAGTTCAACCATGAATGGCCATCAGAACGGACTTGAC
TCGCCACCTCTCTACCCTTCTGCTCCTATCCTGGGAGGTAGTGGGCCTGTCAGGAAACTG
TATGATGACTGCTCCAGCACCATTGTTGAAGATCCCCAGACCAAGTGTGAATACATGCTC
AACTCGATGCCCAAGAGACTGTGTTTAGTGTGTGGTGACATCGCTTCTGGGTACCACTAT
GGGGTAGCATCATGTGAAGCCTGCAAGGCATTCTTCAAGAGGACAATTCAAGGCAATATA
GAATACAGCTGCCCTGCCACGAATGAATGTGAAATCACAAAGCGCAGACGTAAATCCTGC
CAGGCTTGCCGCTTCATGAAGTGTTTAAAAGTGGGCATGCTGAAAGAAGGGGTGCGTCTT
GACAGAGTACGTGGAGGTCGGCAGAAGTACAAGCGCAGGATAGATGCGGAGAACAGCCCA
TACCTGAACCCTCAGCTGGTTCAGCCAGCCAAAAAGCCATATAACAAGATTGTCTCACAT
TTGTTGGTGGCTGAACCGGAGAAGATCTATGCCATGCCTGACCCTACTGTCCCCGACAGT
GACATCAAAGCCCTCACTACACTGTGTGACTTGGCCGACCGAGAGTTGGTGGTTATCATT
GGATGGGCGAAGCATATTCCAGGCTTCTCCACGCTGTCCCTGGCGGACCAGATGAGCCTT
CTGCAGAGTGCTTGGATGGAAATTTTGATCCTTGGTGTCGTATACCGGTCTCTTTCATTT
GAGGATGAACTTGTCTATGCAGACGATTATATAATGGACGAAGACCAGTCCAAATTAGCA
GGCCTTCTTGATCTAAATAATGCTATCCTGCAGCTGGTAAAGAAATACAAGAGCATGAAG
CTGGAAAAAGAAGAATTTGTCACCCTCAAAGCTATAGCTCTTGCTAATTCAGACTCCATG
CACATAGAAGATGTTGAAGCCGTTCAGAAGCTTCAGGATGTCTTACATGAAGCGCTGCAG
GATTATGAAGCTGGCCAGCACATGGAAGACCCTCGTCGAGCTGGCAAGATGCTGATGACA
CTGCCACTCCTGAGGCAGACCTCTACCAAGGCCGTGCAGCATTTCTACAACATCAAACTA
GAAGGCAAAGTCCCAATGCACAAACTTTTTTTGGAAATGTTGGAGGCCAAGGTCTGA
Target 5 GenBank Gene ID Not Available
Target 5 GeneCard ID ESRRG Link Image
Target 5 GenAtlas ID ESRRG Link Image
Target 5 HGNC ID HGNC:3474 Link Image
Target 5 Chromosome Location Not Available
Target 5 Locus 1q41
Target 5 SNPs SNPJam Report Link Image
Target 5 Toxin References
  • S295 - Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y: Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. J Biochem. 2007 Oct;142(4):517-24. Epub 2007 Aug 30. [PubMed Link Image]
Target 5 General References 10072763; 10048485; 9676434; 10707956; 14702039; 17974005; 16710414; 15489334; 10428842

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.