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T3D0189 - Carbon monoxide

Record Information
Version 1.0
Creation Date 2009-03-06 18:58:15 UTC
Update Date 2013-04-25 08:33:12 UTC
Accession Number T3D0189
Identification
Common Name Carbon monoxide
Description Carbon monoxide is a colorless, odorless, tasteless, and highly toxic gas. It is produced from the partial oxidation of carbon-containing compounds in limited oxygen availability conditions. Carbon monoxide has significant fuel value. It is a major atmospheric pollutant in urban areas, chiefly from exhaust of internal combustion engines, but also from improper burning of various other fuels. (S311)
Compound Type
  • Organic Compound
  • Industrial By-product/Pollutant
Chemical Structure
Thumb
MOL SDF SMILES InChI
Synonyms
  1. Carbon oxide
  2. Carbon(II) oxide
  3. Carbone (oxyde de) [french]
  4. Carboneum oxygenisatum
  5. Carbonic oxide
  6. Carbonio
  7. Carbonio (ossido di) [italian]
  8. Flue gas
  9. Flue gasnide
  10. Kohlenmonoxid [german]
  11. Kohlenoxyd [german]
  12. Koolmonoxyde [dutch]
  13. Oxyde de carbone [french]
  14. Wegla tlenek [polish]
Chemical Formula CO
Average Molecular Weight 28.0101
Monoisotopic Molecular Weight 27.994914622
Chemical IUPAC Name
hydroxymethyl group
CAS Registry Number 630-08-0
SMILES
[C]#[O]
InChI Identifier
InChI=1S/CO/c1-2
InChI Key InChIKey=UGFAIRIUMAVXCW-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Organooxygen Compounds
Class Oxocarbons
Sub Class Not Available
Direct Parent Oxocarbons
Alternative Parents Not Available
Molecular Framework Aliphatic Acyclic Compounds
Substituents Not Available
External Descriptors
  • a small molecule(Cyc)
  • one-carbon compound(ChEBI)
  • carbon oxide(ChEBI)
DrugBank ID Not Available
PubChem Compound ID 281 Link_out
KEGG ID C00237 Link_out
UniProt ID Not Available
OMIM ID 141250 172460 259900 266500 Link_out
ChEBI ID 17245 Link_out
BioCyc ID CARBON-MONOXIDE Link_out
CTD ID D002248 Link_out
Stitch ID Carbon monoxide Link_out
PDB ID Not Available
ACToR ID 3844
Wikipedia Link http://en.wikipedia.org/wiki/Carbon monoxide Link_out
Physical Properties
Appearance Colorless gas.
Melting Point -56.5 C
Solubility Not Available
Predicted LogP Not Available
Toxicity Profile
Route of Exposure Inhalation (S311)
Mechanism of Action Carbon monoxide possesses a higher affinity than oxygen for hemoglobin, leading to the formation of carboxyhemoglobin, this provoking anoxemia. Carbon monoxide also binds to myoglobin, impairing its ability to utilize oxygen. It can also bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. Carbon monoxide also causes endothelial cell and platelet release of nitric oxide, and the formation of oxygen free radicals. This results in lipid peroxidation, leading to edema and necrosis within the brain. (S312)
Metabolism Not Available
Toxicity Values Not Available
Lethal Dose 5000 ppm over 5 minutes for an adult human. (R293)
Carcinogenicity (IARC Classification) Not Available
Uses/Sources Carbon monoxide is a major atmospheric pollutant in urban areas, chiefly from exhaust of internal combustion engines, but also from improper burning of various other fuels. (S311)
Minimum Risk Level Not Available
Health Effects Chronic exposure to low levels of carbon monoxide may cause persistent headaches, lightheadedness, depression, confusion, memory loss, and nausea and vomiting. (S312)
Symptoms Early symptoms of acute carbon monoxide poisoning are nonspecific and include headaches, nausea, and fatigue. Symptoms may progress to tachycardia and hypertension. The central nervous system is one of the organ systems most sensitive to poisoning and symptoms displayed include dizziness, ataxia, confusion, convulsions, unconsciousness, respiratory arrest, and even death. (S312)
Treatment Carbon monoxide poisoning is first treated by immediate removal from the source of exposure. High-flow or 100% oxygen should then be administered by a nonrebreather reservoir oxygen mask. Oxygen hastens the dissociation of carbon monoxide from hemoglobin, improving tissue oxygenation by reducing carbon monoxides biological half-life. Hyperbaric oxygen may also be used, as it increases carboxyhemoglobin dissociation to a greater extent than normal oxygen. (S312)
References
General References
  • S311 — Wikipedia. Carbon monoxide. Last Updated 29 June 2009. [Link]
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]
  • R293 — National Institute for Occupational Safety and Health (2002). RTECS: Registry of Toxic Effects of Chemical Substances.

Targets

1. Hemoglobin subunit alpha

Involved in oxygen transport from the lung to the various peripheral tissues.

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P69905 Link_out
Gene: HBA1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

2. Hemoglobin subunit beta

Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P68871 Link_out
Gene: HBB Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

3. Hemoglobin subunit delta

Involved in oxygen transport from the lung to the various peripheral tissues.

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P02042 Link_out
Gene: HBD Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

4. Hemoglobin subunit epsilon

The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P02100 Link_out
Gene: HBE1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

5. Hemoglobin subunit gamma-1

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P69891 Link_out
Gene: HBG1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

6. Hemoglobin subunit gamma-2

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P69892 Link_out
Gene: HBG2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

7. Hemoglobin subunit mu

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: Q6B0K9 Link_out
Gene: HBM Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

8. Hemoglobin subunit theta-1

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P09105 Link_out
Gene: HBQ1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

9. Hemoglobin subunit zeta

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac.

Carbon monoxide combines with hemoglobin to form carboxyhemoglobin (HbCO) in the blood. As carbon moxoxide has a higher affinity for hemoglobin than oxygen, this prevents the transport, delivery, and utilization of oxygen, causing anoxemia. (S312)
UniProt ID: P02008 Link_out
Gene: HBZ Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

10. Myoglobin

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Carbon monoxide binds to myoglobin, impairing its ability to utilize oxygen. (S312)
UniProt ID: P02144 Link_out
Gene: MB Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

11. Cytochrome c oxidase subunit 7A1, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P24310 Link_out
Gene: COX7A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

12. Cytochrome c oxidase subunit 7A2, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P14406 Link_out
Gene: COX7A2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

13. Cytochrome c oxidase subunit 1

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P00395 Link_out
Gene: MT-CO1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

14. Cytochrome c oxidase subunit 2

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P00403 Link_out
Gene: MT-CO2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

15. Cytochrome c oxidase subunit 3

Subunits I, II and III form the functional core of the enzyme complex.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P00414 Link_out
Gene: MT-CO3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

16. Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P13073 Link_out
Gene: COX4I1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

17. Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: Q96KJ9 Link_out
Gene: COX4I2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

18. Cytochrome c oxidase subunit 5A, mitochondrial

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P20674 Link_out
Gene: COX5A Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

19. Cytochrome c oxidase subunit 5B, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P10606 Link_out
Gene: COX5B Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

20. Cytochrome c oxidase subunit 6A1, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P12074 Link_out
Gene: COX6A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

21. Cytochrome c oxidase subunit 6A2, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: Q02221 Link_out
Gene: COX6A2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

22. Cytochrome c oxidase subunit 6B1

Connects the two COX monomers into the physiological dimeric form (By similarity).

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P14854 Link_out
Gene: COX6B1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

23. Cytochrome c oxidase subunit 6B2

Connects the two COX monomers into the physiological dimeric form (By similarity).

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: Q6YFQ2 Link_out
Gene: COX6B2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

24. Cytochrome c oxidase subunit 6C

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P09669 Link_out
Gene: COX6C Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

25. Putative cytochrome c oxidase subunit 7A3, mitochondrial

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: O60397 Link_out
Gene: COX7A2P2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

26. Cytochrome c oxidase subunit 7B, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P24311 Link_out
Gene: COX7B Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

27. Cytochrome c oxidase subunit 7B2, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: Q8TF08 Link_out
Gene: COX7B2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

28. Cytochrome c oxidase subunit 7C, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P15954 Link_out
Gene: COX7C Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

29. Cytochrome c oxidase subunit 8A, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: P10176 Link_out
Gene: COX8A Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]

30. Cytochrome c oxidase subunit 8C, mitochondrial

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Carbon monoxide can bind to cytochrome c oxidase, though with a lesser affinity than oxygen. This interferes with aerobic metabolism and efficient ATP synthesis. As a result, cells switch to anaerobic metabolism, causing anoxia, lactic acidosis, and eventual cell death. (S312)
UniProt ID: Q7Z4L0 Link_out
Gene: COX8C Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
References:
  • S312 — Wikipedia. Carbon monoxide poisoning. Last Updated 27 June 2009. [Link]