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Showing toxin card for Methylene chloride (T3D0080)

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Version 1.0
Creation Date 2009-03-06 18:58:02
Update Date 2010-03-18 21:52:20
Accession Number T3D0080
Name Methylene chloride
Compound Type
  • Organic Compound
  • Organochloride
  • Solvent
Description Methylene chloride is a manufactured chemical used as an industrial solvent and as a paint stripper. It may also be found in some aerosol and pesticide products and is used in the manufacture of photographic film. (R366)
Synonyms
  1. Aerothene
  2. Bichloride, methylene
  3. Chloride, methylene
  4. Chlorure de methylene (french)
  5. Dichloride, methylene
  6. Dichloromethane
  7. Distillex DS3
  8. Driverit
  9. Freon 30
  10. M-clean d
  11. Methane dichloride
  12. Methoklone
  13. Methylene bichloride
  14. Methylene dichloride
  15. Metylenu chlorek (polish)
  16. Narkotil
  17. Nevolin
  18. Salesthin
  19. Solaesthin
  20. Solmethine
Chemical IUPAC Name dichloromethane
Chemical Formula CH2Cl2
Chemical Structure Structure
CAS Registry Number 75-09-2
InChI Identifier InChI=1S/CH2Cl2/c2-1-3/h1H2
InChI Key InChIKey=YMWUJEATGCHHMB-UHFFFAOYSA-N
PubChem Compound ID 6344 Link Image
KEGG ID C02271 Link Image
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID 15767 Link Image
BioCyc ID CPD-4521 Link Image
SuperToxic ID Not Available
CTD ID D008752 Link Image
Stitch ID Methylene chloride Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID 885
Wikipedia Link http://en.wikipedia.org/wiki/Methylene chloride Link Image
Monoisotopic Mass 83.953355
MOL File Show
PDB File Show
SDF File Show
SMILES ClCCl
Appearance Colorless liquid.
Melting Point -95.1 °C
Solubility 13 mg/mL at 25 °C [HORVATH,AL (1982)]
Predicted LogP 1.2889
Route of Exposure Oral (R366) ; inhalation (R366) ; dermal (R366)
Mechanism of Action Methylene chloride targets the lungs, blood system, and nervous system. In the lungs its metabolites damage Clara cells. It is also metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). Methylene chloride is also believed to cause neurotoxicity by interfering with signal transmission in a manner similar to general anesthetics. Certain metabolites, such as formaldehyde, may result in carcinogenic effects by causing DNA single strand breaks, DNA-protein crosslinks, and other mutations. (R029, R366)
Metabolism Absorption mainly occurs via inhalation, but may also result from oral or dermal exposure. Methylene chloride is mainly distributed to the adipose tissue and liver. It may be metabolized by cytochrome P-450 2E1, which ultimately produces carbon monoxide and carbon dioxide via formyl chloride. Methylene chloride can also be metabolized by theta glutathione-S-transferase, which produces carbon dioxide via a postulated glutathione conjugate (S-chloromethyl glutathione) and formaldehyde. Both pathways produce toxic metabolites which are excreted mainly in expired air, but also in the urine. (R029, R366)
Toxicity Values LD50: 437 mg/kg (Intraperitoneal, Mouse) (R263) LD50: 6460 mg/kg (Subcutaneous, Mouse) (R263) LD50: 1600 mg/kg (Oral, Rat) (R353) LC50: 14 400 ppm over 7 hours (Inhalation, Mouse) (R263)
Lethal Dose 357 mg/kg (oral) or 50 000 ppm (inhalation) for an adult human. (R371)
Carcinogenicity (IARC Classification) 2B, possibly carcinogenic to humans. (R264)
Uses/Sources Methylene chloride is widely used as a solvent in industrial processes, paint stripper, and degreaser. It is also used in food preparation, aerosol propellants, pesticides, and the manufacture of photographic film. (R029, R366)
Minimum Risk Level Acute Inhalation: 0.6 ppm (R260) Intermediate Inhalation: 0.3 ppm (R260) Chronic Inhalation: 0.3 ppm (R260) Acute Oral: 0.2 mg/kg/day (R260) Chronic Oral: 0.06 mg/kg/day (R260)
Health Effects Exposure to methylene chloride may cause optic neuropathy and hepatitis. Very high concentrations can lead to unconciousness, coma, and death. It is metabolized to carbon monoxide, potentially leading to carbon monoxide poisoning. Methylene chloride also causes liver and kidney injury, and may be a carcinogen. (R029, R367)
Symptoms Breathing large amounts of methylene chloride causes dizziness, nausea, tingling or numbness of the finger and toes, loss of concentration, and reduced hand-eye coordination. Very high concentrations can lead to unconciousness, coma, and death. Skin contact with methylene chloride causes burning and redness of the skin. (R366, R367)
Treatment Treatment of methylene chloride exposure is mainly symptomatic. Ingested methylene chloride may be removed by emesis and/or gastric lavage, and activated charcoal. Hyperbaric oxygen may be used to treat the carbon monoxide poisoning that can result from inhalation of methylene chloride. (R368)
General References
  • R029 - Casarett LJ, Klaassen CD, and Watkins JB (2003). Casarett and Doull's essentials of toxicology. New York: McGraw-Hill/Medical Pub. Div.
  • R367 - Wikipedia. Dichloromethane. Last Updated 20 May 2009.
  • R353 - Verschueren K (1983). Handbook of Environmental Data of Organic Chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold Co.
  • R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R263 - Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
  • R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R368 - International Programme on Chemical Safety (IPCS) INCHEM (1997). Poison Information Monograph for Methylene Chloride.
  • R371 - Lewis RJ (2000). Sax's Dangerous Properties of Industrial Materials. 10th ed. New York, NY: Van Nostrand Reinhold Company.
Targets
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
  3. Hemoglobin subunit delta
  4. Hemoglobin subunit epsilon
  5. Hemoglobin subunit gamma-1
  6. Hemoglobin subunit gamma-2
  7. Hemoglobin subunit mu
  8. Hemoglobin subunit theta-1
  9. Hemoglobin subunit zeta
  10. Estrogen receptor
  11. Estrogen receptor beta
Target 1 [top]
Target 1 ID 4
Target 1 Name Hemoglobin subunit alpha
Target 1 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 1 Description Involved in oxygen transport from the lung to the various peripheral tissues
Target 1 Synonyms
  1. Hemoglobin alpha chain; Alpha-globin
Target 1 Gene Name HBA1
Target 1 Protein Sequence >Hemoglobin subunit alpha 
MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG
KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP
AVHASLDKFLASVSTVLTSKYR
Target 1 Number of Residues 142
Target 1 Molecular Weight 15257.4
Target 1 Theoretical pI 9.09
Target 1 GO Classification
Function
oxygen binding
binding
Process
gas transport
oxygen transport
physiological process
cellular physiological process
transport
Component
protein complex
hemoglobin complex
Target 1 General Function Involved in heme binding
Target 1 Pathways Not Available
Target 1 Reactions Not Available
Target 1 Signals
  • None
Target 1 Transmembrane Regions
  • None
Target 1 Essentiality Non Essential
Target 1 Domain Function PF00042:Globin
Target 1 GenBank ID Protein Not Available
Target 1 UniProtKB ID P69905 Link Image
Target 1 Cellular Location Not Available
Target 1 Gene Sequence >429 bp 
ATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGGCAAGGTTGGCGCG
CACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCCTGTCCTTCCCCACCACC
AAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTGCCCAGGTTAAGGGCCACGGC
AAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCGCACGTGGACGACATGCCCAACGCG
CTGTCCGCCCTGAGCGACCTGCACGCGCACAAGCTTCGGGTGGACCCGGTCAACTTCAAG
CTCCTAAGCCACTGCCTGCTGGTGACCCTGGCCGCCCACCTCCCCGCCGAGTTCACCCCT
GCGGTGCACGCCTCCCTGGACAAGTTCCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAA
TACCGTTAA
Target 1 GenBank Gene ID Not Available
Target 1 GeneCard ID HBA1 Link Image
Target 1 GenAtlas ID HBA1 Link Image
Target 1 HGNC ID HGNC:4823 Link Image
Target 1 Chromosome Location Chromosome:16
Target 1 Locus 16p13.3
Target 1 SNPs SNPJam Report Link Image
Target 1 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 1 General References 7448866; 6244294; 6452630; 6946451; 11410421; 11402454; 16728641
Target 2 [top]
Target 2 ID 3
Target 2 Name Hemoglobin subunit beta
Target 2 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 2 Description LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure
Target 2 Synonyms
  1. Hemoglobin beta chain; Beta-globin; LVV-hemorphin-7
Target 2 Gene Name HBB
Target 2 Protein Sequence >Hemoglobin subunit beta 
MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG
KEFTPPVQAAYQKVVAGVANALAHKYH
Target 2 Number of Residues 147
Target 2 Molecular Weight 15998.3
Target 2 Theoretical pI 7.32
Target 2 GO Classification
Function
oxygen binding
binding
tetrapyrrole binding
heme binding
Process
physiological process
cellular physiological process
transport
gas transport
oxygen transport
Component
protein complex
hemoglobin complex
Target 2 General Function Involved in heme binding
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Signals
  • None
Target 2 Transmembrane Regions
  • None
Target 2 Essentiality Non Essential
Target 2 Domain Function PF00042:Globin
Target 2 GenBank ID Protein Not Available
Target 2 UniProtKB ID P68871 Link Image
Target 2 Cellular Location Not Available
Target 2 Gene Sequence >444 bp 
ATGGTNCAYYTNACNCCNGTGGAGAAGTCYGCYGTNACNGCNCTNTGGGGYAAGGTNAAY
GTGGATGAAGYYGGYGGYGAGGCCCTGGGCAGNCTGCTNGTGGTCTACCCTTGGACCCAG
AGGTTCTTNGANTCNTTYGGGGATCTGNNNACNCCNGANGCAGTTATGGGCAACCCTAAG
GTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGAC
AACCTCAAGGGCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTNCAYGTGGAT
CCTGAGAACTTCAGGCTNCTNGGCAACGTGYTNGTCTGYGTGCTGGCCCATCACTTTGGC
AAAGAATTCACCCCACCAGTGCANGCNGCCTATCAGAAAGTGGTNGCTGGTGTNGCTAAT
GCCCTGGCCCACAAGTATCACTAA
Target 2 GenBank Gene ID Not Available
Target 2 GeneCard ID HBB Link Image
Target 2 GenAtlas ID HBB Link Image
Target 2 HGNC ID HGNC:4827 Link Image
Target 2 Chromosome Location Chromosome:11
Target 2 Locus 11p15.5
Target 2 SNPs SNPJam Report Link Image
Target 2 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 2 General References 1019344; 6254664; 16175509
Target 3 [top]
Target 3 ID 78
Target 3 Name Hemoglobin subunit delta
Target 3 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 3 Description Involved in oxygen transport from the lung to the various peripheral tissues
Target 3 Synonyms
  1. Hemoglobin delta chain; Delta-globin
Target 3 Gene Name HBD
Target 3 Protein Sequence >Hemoglobin subunit delta 
MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFG
KEFTPQMQAAYQKVVAGVANALAHKYH
Target 3 Number of Residues 147
Target 3 Molecular Weight 16055.4
Target 3 Theoretical pI 8.26
Target 3 GO Classification
Function
oxygen binding
binding
tetrapyrrole binding
heme binding
Process
physiological process
cellular physiological process
transport
gas transport
oxygen transport
Component
protein complex
hemoglobin complex
Target 3 General Function Involved in heme binding
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • None
Target 3 Essentiality Non Essential
Target 3 Domain Function PF00042:Globin
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB ID P02042 Link Image
Target 3 Cellular Location Not Available
Target 3 Gene Sequence >444 bp 
ATGGTGCATCTGACTCCTGAGGAGAAGACTGCTGTCAATGCCCTGTGGGGCAAAGTGAAC
GTGGATGCAGTTGGTGGTGAGGCCCTGGGCAGATTACTGGTGGTCTACCCTTGGACCCAG
AGGTTCTTTGAGTCCTTTGGGGATCTGTCCTCTCCTGATGCTGTTATGGGCAACCCTAAG
GTGAAGGCTCATGGCAAGAAGGTGCTAGGTGCCTTTAGTGATGGCCTGGCTCACCTGGAC
AACCTCAAGGGCACTTTTTCTCAGCTGAGTGAGCTGCACTGTGACAAGCTGCACGTGGAT
CCTGAGAACTTCAGGCTCTTGGGCAATGTGCTGGTGTGTGTGCTGGCCCGCAACTTTGGC
AAGGAATTCACCCCACAAATGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCTAAT
GCCCTGGCTCACAAGTACCATTGA
Target 3 GenBank Gene ID Not Available
Target 3 GeneCard ID HBD Link Image
Target 3 GenAtlas ID HBD Link Image
Target 3 HGNC ID HGNC:4829 Link Image
Target 3 Chromosome Location Chromosome:11
Target 3 Locus 11p15.5
Target 3 SNPs SNPJam Report Link Image
Target 3 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 3 General References 7438204; 16370491; 15489334; 680638; 18083107; 5956309; 5678016
Target 4 [top]
Target 4 ID 33
Target 4 Name Hemoglobin subunit epsilon
Target 4 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 4 Description The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin
Target 4 Synonyms
  1. Hemoglobin epsilon chain; Epsilon-globin
Target 4 Gene Name HBE1
Target 4 Protein Sequence >Hemoglobin subunit epsilon 
MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPK
VKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFG
KEFTPEVQAAWQKLVSAVAIALAHKYH
Target 4 Number of Residues 147
Target 4 Molecular Weight 16202.7
Target 4 Theoretical pI 9.10
Target 4 GO Classification
Function
oxygen binding
binding
tetrapyrrole binding
heme binding
Process
physiological process
cellular physiological process
transport
gas transport
oxygen transport
Component
protein complex
hemoglobin complex
Target 4 General Function Involved in heme binding
Target 4 Pathways Not Available
Target 4 Reactions Not Available
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Non Essential
Target 4 Domain Function PF00042:Globin
Target 4 GenBank ID Protein Not Available
Target 4 UniProtKB ID P02100 Link Image
Target 4 Cellular Location Not Available
Target 4 Gene Sequence >444 bp 
ATGGTGCATTTTACTGCTGAGGAGAAGGCTGCCGTCACTAGCCTGTGGAGCAAGATGAAT
GTGGAAGAGGCTGGAGGTGAAGCCTTGGGCAGACTCCTCGTTGTTTACCCCTGGACCCAG
AGATTTTTTGACAGCTTTGGAAACCTGTCGTCTCCCTCTGCCATCCTGGGCAACCCCAAG
GTCAAGGCCCATGGCAAGAAGGTGCTGACTTCCTTTGGAGATGCTATTAAAAACATGGAC
AACCTCAAGCCCGCCTTTGCTAAGCTGAGTGAGCTGCACTGTGACAAGCTGCATGTGGAT
CCTGAGAACTTCAAGCTCCTGGGTAACGTGATGGTGATTATTCTGGCTACTCACTTTGGC
AAGGAGTTCACCCCTGAAGTGCAGGCTGCCTGGCAGAAGCTGGTGTCTGCTGTCGCCATT
GCCCTGGCCCATAAGTACCACTGA
Target 4 GenBank Gene ID Not Available
Target 4 GeneCard ID HBE1 Link Image
Target 4 GenAtlas ID HBE1 Link Image
Target 4 HGNC ID HGNC:4830 Link Image
Target 4 Chromosome Location Chromosome:11
Target 4 Locus 11p15.5
Target 4 SNPs SNPJam Report Link Image
Target 4 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 4 General References 6254663; 15489334; 6172865; 18083107; 9665850
Target 5 [top]
Target 5 ID 38
Target 5 Name Hemoglobin subunit gamma-1
Target 5 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 5 Description Gamma chains make up the fetal hemoglobin F, in combination with alpha chains
Target 5 Synonyms
  1. Hemoglobin gamma-1 chain; Gamma-1-globin; Hemoglobin gamma-A chain; Hb F Agamma
Target 5 Gene Name HBG1
Target 5 Protein Sequence >Hemoglobin subunit gamma-1 
MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPK
VKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFG
KEFTPEVQASWQKMVTAVASALSSRYH
Target 5 Number of Residues 147
Target 5 Molecular Weight 16140.4
Target 5 Theoretical pI 7.23
Target 5 GO Classification
Function
oxygen binding
binding
tetrapyrrole binding
heme binding
Process
physiological process
cellular physiological process
transport
gas transport
oxygen transport
Component
protein complex
hemoglobin complex
Target 5 General Function Involved in heme binding
Target 5 Pathways Not Available
Target 5 Reactions Not Available
Target 5 Signals
  • None
Target 5 Transmembrane Regions
  • None
Target 5 Essentiality Non Essential
Target 5 Domain Function PF00042:Globin
Target 5 GenBank ID Protein Not Available
Target 5 UniProtKB ID P69891 Link Image
Target 5 Cellular Location Not Available
Target 5 Gene Sequence >444 bp 
ATGGGTCATTTCACAGAGGAGGACAAGGCTACTATCACAAGCCTGTGGGGCAAGGTGAAT
GTGGAAGATGCTGGAGGAGAAACCCTGGGAAGGCTCCTGGTTGTCTACCCATGGACCCAG
AGGTTCTTTGACAGCTTTGGCAACCTGTCCTCTGCCTCTGCCATCATGGGCAACCCCAAA
GTCAAGGCACATGGCAAGAAGGTGCTGACTTCCTTGGGAGATGCCACAAAGCACCTGGAT
GATCTCAAGGGCACCTTTGCCCAGCTGAGTGAACTGCACTGTGACAAGCTGCATGTGGAT
CCTGAGAACTTCAAGCTCCTGGGAAATGTGCTGGTGACCGTTTTGGCAATCCATTTCGGC
AAAGAATTCACCCCTGAGGTGCAGGCTTCCTGGCAGAAGATGGTGACTGCAGTGGCCAGT
GCCCTGTCCTCCAGATACCACTGA
Target 5 GenBank Gene ID Not Available
Target 5 GeneCard ID HBG1 Link Image
Target 5 GenAtlas ID HBG1 Link Image
Target 5 HGNC ID HGNC:4831 Link Image
Target 5 Chromosome Location Chromosome:11
Target 5 Locus 11p15.5
Target 5 SNPs SNPJam Report Link Image
Target 5 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 5 General References 7438203; 7332928; 15489334; 7690768; 11514664; 5554303; 2454900; 2417989
Target 6 [top]
Target 6 ID 99
Target 6 Name Hemoglobin subunit gamma-2
Target 6 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 6 Description Gamma chains make up the fetal hemoglobin F, in combination with alpha chains
Target 6 Synonyms
  1. Hemoglobin gamma-2 chain; Gamma-2-globin; Hemoglobin gamma-G chain; Hb F Ggamma
Target 6 Gene Name HBG2
Target 6 Protein Sequence >Hemoglobin subunit gamma-2 
MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPK
VKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFG
KEFTPEVQASWQKMVTGVASALSSRYH
Target 6 Number of Residues 147
Target 6 Molecular Weight 16126.3
Target 6 Theoretical pI 7.23
Target 6 GO Classification
Function
oxygen binding
binding
tetrapyrrole binding
heme binding
Process
physiological process
cellular physiological process
transport
gas transport
oxygen transport
Component
protein complex
hemoglobin complex
Target 6 General Function Involved in heme binding
Target 6 Pathways Not Available
Target 6 Reactions Not Available
Target 6 Signals
  • None
Target 6 Transmembrane Regions
  • None
Target 6 Essentiality Non Essential
Target 6 Domain Function PF00042:Globin
Target 6 GenBank ID Protein Not Available
Target 6 UniProtKB ID P69892 Link Image
Target 6 Cellular Location Not Available
Target 6 Gene Sequence >444 bp 
ATGGGTCATTTCACAGAGGAGGACAAGGCTACTATCACAAGCCTGTGGGGCAAGGTGAAT
GTGGAAGATGCTGGAGGAGAAACCCTGGGAAGGCTCCTGGTTGTCTACCCATGGACCCAG
AGGTTCTTTGACAGCTTTGGCAACCTGTCCTCTGCCTCTGCCATCATGGGCAACCCCAAA
GTCAAGGCACATGGCAAGAAGGTGCTGACTTCCTTGGGAGATGCCATAAAGCACCTGGAT
GATCTCAAGGGCACCTTTGCCCAGCTGAGTGAACTGCACTGTGACAAGCTGCATGTGGAT
CCTGAGAACTTCAAGCTCCTGGGAAATGTGCTGGTGACCGTTTTGGCAATCCATTTCGGC
AAAGAATTCACCCCTGAGGTGCAGGCTTCCTGGCAGAAGATGGTGACTGGAGTGGCCAGT
GCCCTGTCCTCCAGATACCACTGA
Target 6 GenBank Gene ID Not Available
Target 6 GeneCard ID HBG2 Link Image
Target 6 GenAtlas ID HBG2 Link Image
Target 6 HGNC ID HGNC:4832 Link Image
Target 6 Chromosome Location Chromosome:11
Target 6 Locus 11p15.5
Target 6 SNPs SNPJam Report Link Image
Target 6 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 6 General References 7438203; 7250702; 15489334; 14087393; 2581851; 18083107; 881729
Target 7 [top]
Target 7 ID 77
Target 7 Name Hemoglobin subunit mu
Target 7 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 7 Description Not Available
Target 7 Synonyms
  1. Hemoglobin mu chain; Mu-globin
Target 7 Gene Name HBM
Target 7 Protein Sequence >Hemoglobin subunit mu 
MLSAQERAQIAQVWDLIAGHEAQFGAELLLRLFTVYPSTKVYFPHLSACQDATQLLSHGQ
RMLAAVGAAVQHVDNLRAALSPLADLHALVLRVDPANFPLLIQCFHVVLASHLQDEFTVQ
MQAAWDKFLTGVAVVLTEKYR
Target 7 Number of Residues 141
Target 7 Molecular Weight 15618.0
Target 7 Theoretical pI 6.62
Target 7 GO Classification
Function
oxygen binding
binding
tetrapyrrole binding
heme binding
Process
physiological process
cellular physiological process
transport
gas transport
oxygen transport
Component
protein complex
hemoglobin complex
Target 7 General Function Involved in heme binding
Target 7 Pathways Not Available
Target 7 Reactions Not Available
Target 7 Signals
  • None
Target 7 Transmembrane Regions
  • None
Target 7 Essentiality Non Essential
Target 7 Domain Function PF00042:Globin
Target 7 GenBank ID Protein Not Available
Target 7 UniProtKB ID Q6B0K9 Link Image
Target 7 Cellular Location Not Available
Target 7 Gene Sequence >426 bp 
ATGCTCAGCGCCCAGGAGCGCGCCCAAATCGCGCAGGTCTGGGACCTGATTGCGGGCCAC
GAGGCGCAATTCGGGGCGGAGCTGCTGCTCAGGCTCTTCACGGTGTACCCCAGCACCAAG
GTCTACTTCCCGCACCTGAGCGCCTGCCAGGACGCGACGCAGCTGCTGAGCCACGGGCAG
CGCATGCTGGCGGCTGTGGGCGCGGCGGTGCAGCACGTGGACAACCTGCGCGCCGCGCTG
AGCCCGCTGGCGGACCTGCACGCGCTCGTGCTGCGCGTGGACCCAGCCAACTTTCCGCTG
CTAATCCAGTGTTTCCACGTCGTGCTGGCCTCCCACCTGCAGGACGAGTTCACCGTGCAA
ATGCAAGCGGCGTGGGACAAGTTCCTGACTGGTGTGGCCGTGGTGCTGACCGAAAAATAC
CGCTGA
Target 7 GenBank Gene ID Not Available
Target 7 GeneCard ID HBM Link Image
Target 7 GenAtlas ID HBM Link Image
Target 7 HGNC ID HGNC:4826 Link Image
Target 7 Chromosome Location Chromosome:16
Target 7 Locus 16p13.3
Target 7 SNPs SNPJam Report Link Image
Target 7 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 7 General References 15855277; 16728641; 15489334
Target 8 [top]
Target 8 ID 190
Target 8 Name Hemoglobin subunit theta-1
Target 8 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 8 Description Not Available
Target 8 Synonyms
  1. Hemoglobin theta-1 chain; Theta-1-globin
Target 8 Gene Name HBQ1
Target 8 Protein Sequence >Hemoglobin subunit theta-1 
MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYFSHLDLSPGSSQVRAHG
QKVADALSLAVERLDDLPHALSALSHLHACQLRVDPASFQLLGHCLLVTLARHYPGDFSP
ALQASLDKFLSHVISALVSEYR
Target 8 Number of Residues 142
Target 8 Molecular Weight 15507.6
Target 8 Theoretical pI 7.74
Target 8 GO Classification
Function
oxygen binding
binding
tetrapyrrole binding
heme binding
Process
physiological process
cellular physiological process
transport
gas transport
oxygen transport
Component
protein complex
hemoglobin complex
Target 8 General Function Involved in heme binding
Target 8 Pathways Not Available
Target 8 Reactions Not Available
Target 8 Signals
  • None
Target 8 Transmembrane Regions
  • None
Target 8 Essentiality Non Essential
Target 8 Domain Function PF00042:Globin
Target 8 GenBank ID Protein Not Available
Target 8 UniProtKB ID P09105 Link Image
Target 8 Cellular Location Not Available
Target 8 Gene Sequence >429 bp 
ATGGCGCTGTCCGCGGAGGACCGGGCGCTGGTGCGCGCCCTGTGGAAGAAGCTGGGCAGC
AACGTCGGCGTCTACACGACAGAGGCCCTGGAAAGGACCTTCCTGGCTTTCCCCGCCACG
AAGACCTACTTCTCCCACCTGGACCTGAGCCCCGGCTCCTCACAAGTCAGAGCCCACGGC
CAGAAGGTGGCGGACGCGCTGAGCCTCGCCGTGGAGCGCCTGGACGACCTACCCCACGCG
CTGTCCGCGCTGAGCCACCTGCACGCGTGCCAGCTGCGAGTGGACCCGGCCAGCTTCCAG
CTCCTGGGCCACTGCCTGCTGGTAACCCTCGCCCGGCACTACCCCGGAGACTTCAGCCCC
GCGCTGCAGGCGTCGCTGGACAAGTTCCTGAGCCACGTTATCTCGGCGCTGGTTTCCGAG
TACCGCTGA
Target 8 GenBank Gene ID Not Available
Target 8 GeneCard ID HBQ1 Link Image
Target 8 GenAtlas ID HBQ1 Link Image
Target 8 HGNC ID HGNC:4833 Link Image
Target 8 Chromosome Location Chromosome:16
Target 8 Locus 16p13.3
Target 8 SNPs SNPJam Report Link Image
Target 8 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 8 General References 3422341; 3408475; 16728641; 11157797; 15489334; 2569721
Target 9 [top]
Target 9 ID 167
Target 9 Name Hemoglobin subunit zeta
Target 9 Mechanism of Action Methylene chloride is metabolized into carbon monoxide, which binds to hemoglobin to produce dose-dependent increases in carboxyhemoglobin. This results in the reduced oxygen transport and neurological dysfunction characteristic of carboxyhemoglobinemia (carbon monoxide poisoning). (R366)
Target 9 Description The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac
Target 9 Synonyms
  1. Hemoglobin zeta chain; Zeta-globin; HBAZ
Target 9 Gene Name HBZ
Target 9 Protein Sequence >Hemoglobin subunit zeta 
MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHG
SKVVAAVGDAVKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTA
EAHAAWDKFLSVVSSVLTEKYR
Target 9 Number of Residues 142
Target 9 Molecular Weight 15636.8
Target 9 Theoretical pI 8.51
Target 9 GO Classification
Function
oxygen binding
binding
Process
gas transport
oxygen transport
physiological process
cellular physiological process
transport
Component
protein complex
hemoglobin complex
Target 9 General Function Involved in heme binding
Target 9 Pathways Not Available
Target 9 Reactions Not Available
Target 9 Signals
  • None
Target 9 Transmembrane Regions
  • None
Target 9 Essentiality Non Essential
Target 9 Domain Function PF00042:Globin
Target 9 GenBank ID Protein Not Available
Target 9 UniProtKB ID P02008 Link Image
Target 9 Cellular Location Not Available
Target 9 Gene Sequence >429 bp 
TGCAGCTGCCCACCCTGCCGCCATGTCTCTGACCAAGACTGAGAGGACCATCATTGTGTC
CATGTGGGCCAAGATCTCCACGCAGGCCGACACCATCGGCACCGAGACTCTGGAGAGGCT
CTTCCTCAGCCACCCGCAGACCAAGACCTACTTCCCGCACTTCGACCTGCACCCGGGGTC
CGCGCAGTTGCGCGCGCACGGCTCCAAGGTGGTGGCCGCCGTGGGCGACGCGGTGAAGAG
CATCGACGACATCGGCGGCGCCCTGTCCAAGCTGAGCGAGCTGCACGCCTACATCCTGCG
CGTGGACCCGGTCAACTTCAAGCTCCTGTCCCACTGCCTGCTGGTCACCCTGGCCGCGCG
CTTCCCCGCCGACTTCACGGCCGAGGCCCACGCCGCCTGGGACAAGTTCCTATCGGTCGT
ATCCTCTGT
Target 9 GenBank Gene ID Not Available
Target 9 GeneCard ID HBZ Link Image
Target 9 GenAtlas ID HBZ Link Image
Target 9 HGNC ID HGNC:4835 Link Image
Target 9 Chromosome Location Chromosome:16
Target 9 Locus 16p13.3
Target 9 SNPs SNPJam Report Link Image
Target 9 Toxin References
  • R366 - ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for methylene chloride. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 9 General References 6297773; 6963223; 9054936; 11157797; 15489334; 6179844; 6171809; 6172357
Target 10 [top]
Target 10 ID 5
Target 10 Name Estrogen receptor
Target 10 Mechanism of Action Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
Target 10 Description Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues
Target 10 Synonyms
  1. ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
Target 10 Gene Name ESR1
Target 10 Protein Sequence >Estrogen receptor 
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Target 10 Number of Residues 595
Target 10 Molecular Weight 66215.4
Target 10 Theoretical pI 8.14
Target 10 GO Classification
Function
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 10 General Function Involved in estrogen receptor activity
Target 10 Pathways Not Available
Target 10 Reactions Not Available
Target 10 Signals
  • None
Target 10 Transmembrane Regions
  • None
Target 10 Essentiality Non Essential
Target 10 Domain Function PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4
Target 10 GenBank ID Protein Not Available
Target 10 UniProtKB ID P03372 Link Image
Target 10 Cellular Location Nucleus
Target 10 Gene Sequence >63 bp 
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
Target 10 GenBank Gene ID Not Available
Target 10 GeneCard ID ESR1 Link Image
Target 10 GenAtlas ID ESR1 Link Image
Target 10 HGNC ID HGNC:3467 Link Image
Target 10 Chromosome Location Not Available
Target 10 Locus 6q25.1
Target 10 SNPs SNPJam Report Link Image
Target 10 Toxin References
  • S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
Target 10 General References 3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106
Target 11 [top]
Target 11 ID 208
Target 11 Name Estrogen receptor beta
Target 11 Mechanism of Action Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
Target 11 Description Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
Target 11 Synonyms
  1. ER-beta; Nuclear receptor subfamily 3 group A member 2
Target 11 Gene Name ESR2
Target 11 Protein Sequence >Estrogen receptor beta 
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Target 11 Number of Residues 530
Target 11 Molecular Weight 59215.8
Target 11 Theoretical pI 8.55
Target 11 GO Classification
Function
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 11 General Function Involved in estrogen receptor activity
Target 11 Pathways Not Available
Target 11 Reactions Not Available
Target 11 Signals
  • None
Target 11 Transmembrane Regions
  • None
Target 11 Essentiality Non Essential
Target 11 Domain Function PF00104:Hormone_recep PF00105:zf-C4
Target 11 GenBank ID Protein Not Available
Target 11 UniProtKB ID Q92731 Link Image
Target 11 Cellular Location Nucleus
Target 11 Gene Sequence >1593 bp 
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA
Target 11 GenBank Gene ID Not Available
Target 11 GeneCard ID ESR2 Link Image
Target 11 GenAtlas ID ESR2 Link Image
Target 11 HGNC ID HGNC:3468 Link Image
Target 11 Chromosome Location Chromosome:14
Target 11 Locus 14q23.2
Target 11 SNPs SNPJam Report Link Image
Target 11 Toxin References
  • S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
Target 11 General References 9473491; 9636657; 9685228; 9671811; 16938840; 15489334; 10964723; 8769313

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.