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Showing toxin card for 1,2-Dibromoethane (T3D0035)

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Version 1.0
Creation Date 2009-03-06 18:57:57
Update Date 2010-03-18 21:52:16
Accession Number T3D0035
Name 1,2-Dibromoethane
Compound Type
  • Gasoline Additive/Component
  • Organic Compound
  • Organochloride
  • Pesticide
Description 1,2-Dibromoethane is a mainly synthetic chemical that also occurs in small amounts naturally in the ocean. It was once widely used as an additive in leaded gasoline and a pesticide, however, today it's use is restricted to only certain pesticides and dye preparations. (R222)
Synonyms
  1. 1,2,Dibromoethane
  2. 1,2-Dibromo tetradeutero Ethane
  3. 1,2-Dibromaethan [German]
  4. 1,2-Dibromoetano [Italian]
  5. 1,2-Dibromoethane
  6. 1,2-Dibromoethane(Ethylene bromide)
  7. 1,2-Dibromomethane
  8. 1,2-Dibroomethaan [Dutch]
  9. 1,2-Ethylene dibromide
  10. 1,2-dibromoethane (EDB)
  11. Aadibroom
  12. Aethylenbromid [german]
  13. Alpha,beta-dibromoethane
  14. Alpha,omega-dibromoethane
  15. Ethylene Bromide
  16. Bromofume
  17. Bromuro di etile [italian]
  18. Celmide
  19. Ethylene Dibromide
  20. Dibromoet hane
  21. Dibromoethane
  22. 1,2-Dibromoethane
  23. Dibromoethylene
  24. Dibromure d'ethylene [french]
  25. Dibromure d'ethylene [iso-french]
  26. Dowfume
  27. Dwubromoetan [polish]
  28. Edabrom
  29. Ethylene bromide
  30. Ethylene dibromide
  31. Garden dowfume
  32. Glycol bromide
  33. Glycol dibromide
  34. Iscobrome d
  35. Kopfume
  36. Nefis
  37. Nephis
  38. SYM dibromoethane
  39. SYM-dibromoethane
  40. Sanhyuum
  41. Soilbrom
  42. Soilfume
  43. Unifume
Chemical IUPAC Name 1,2-dibromoethane
Chemical Formula C2H4Br2
Chemical Structure Structure
CAS Registry Number 106-93-4
InChI Identifier InChI=1S/C2H4Br2/c3-1-2-4/h1-2H2
InChI Key InChIKey=PAAZPARNPHGIKF-UHFFFAOYSA-N
PubChem Compound ID 7839 Link Image
KEGG ID C11088 Link Image
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID 28534 Link Image
BioCyc ID CPD-8985 Link Image
SuperToxic ID Not Available
CTD ID D015946 Link Image
Stitch ID 1,2-Dibromoethane Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID 418
Wikipedia Link Not Available
Monoisotopic Mass 185.867975
MOL File Show
PDB File Show
SDF File Show
SMILES BrCCBr
Appearance Colorless liquid.
Melting Point 9.9 °C
Solubility 3.91 mg/mL at 25 °C [HORVATH,AL et al. (1999)]
Predicted LogP 1.8715
Route of Exposure Oral (R222) ; inhalation (R222) ; dermal (R222)
Mechanism of Action The metabolite 2-bromoacetaldehyde produces liver damage by binding to cellular proteins. S-(2-bromoethyl)glutathione, another metabolite, exerts genotoxic and carcinogenic effects by binding to DNA. Antispermatogenic effects of 1,2-dibromoethanes metabolites may be caused by their covalent binding to thiol groups of nucleoproteins in nuclei of spermatozoa. Such adduct formation interferes with DNA, causing improper packing of the chromatin. (R222)
Metabolism 1,2-Dibromoethane is rapidly absorbed by ingestion, inhalation, and dermal routes, then distributed mainly to the kidneys, liver, and spleen. It can be metabolized by either the cytochrome P-450 system or the glutathione S-transferase system. Many of the metabolites are toxic, and include 2-bromoacetaldehyde and S-(2-bromoethyl)glutathione. These metabolites may be further broken down and excreted in the urine. (R222)
Toxicity Values LD50: 108 mg/kg (Oral, Rat) (R263) LD50: 300 mg/kg (Dermal, Rat) (R263) LD50: 220 mg/kg (Intraperitoneal, Mouse) (R263) LC50: 14 300 mg/m3 over 30 minutes (Inhalation, Rat) (R263)
Lethal Dose Not Available
Carcinogenicity (IARC Classification) 2A, probably carcinogenic to humans. (R264)
Uses/Sources 1,2-Dibromoethane was once widely used as an additive in leaded gasoline and a pesticide, however, today it's use is restricted to only certain pesticides (treatment of logs for termites and beetles, control of moths in beehives) and dye preparations. (R222)
Minimum Risk Level Not Available
Health Effects Long term exposure can result in liver, kidney, and reproductive system damage. 1,2-Dibromoethane is also known to have adverse effects on the brain. (R222)
Symptoms Redness and inflammation, including skin blisters and mouth and stomach ulcers, can occur if large amounts of 1,2-dibromoethane are swallowed. Breathing high levels may cause depression and collapse. (R222)
Treatment Not Available
General References
  • R263 - Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
  • R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • R222 - ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for 1,2-dibromoethane. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Targets
  1. Serum albumin
  2. DNA
  3. Estrogen receptor
  4. Estrogen receptor beta
Target 1 [top]
Target 1 ID 250
Target 1 Name Serum albumin
Target 1 Mechanism of Action 1,2-Dibromoethane binds to serum albumin. (R223)
Target 1 Description Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood
Target 1 Synonyms Not Available
Target 1 Gene Name ALB
Target 1 Protein Sequence >Serum albumin 
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
Target 1 Number of Residues 609
Target 1 Molecular Weight 69365.9
Target 1 Theoretical pI 6.21
Target 1 GO Classification
Function
transporter activity
carrier activity
Process
physiological process
cellular physiological process
transport
Component
extracellular region
extracellular space
Target 1 General Function Involved in antioxidant activity
Target 1 Pathways REACT_604-Hemostasis;
Target 1 Reactions Not Available
Target 1 Signals
  • 1-18
Target 1 Transmembrane Regions
  • None
Target 1 Essentiality Non Essential
Target 1 Domain Function PF00273:Serum_albumin
Target 1 GenBank ID Protein Not Available
Target 1 UniProtKB ID P02768 Link Image
Target 1 Cellular Location Secreted
Target 1 Gene Sequence >1830 bp 
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA
Target 1 GenBank Gene ID Not Available
Target 1 GeneCard ID ALB Link Image
Target 1 GenAtlas ID ALB Link Image
Target 1 HGNC ID HGNC:399 Link Image
Target 1 Chromosome Location Not Available
Target 1 Locus 4q11-q13
Target 1 SNPs SNPJam Report Link Image
Target 1 Toxin References
  • R223 - Kaphalia BS, Ansari GA: Covalent binding of ethylene dibromide and its metabolites to albumin. Toxicol Lett. 1992 Sep;62(2-3):221-30. [PubMed Link Image]
Target 1 General References 6171778; 6275391; 3009475; 11483580
Target 2 [top]
Target 2 ID 632
Target 2 Name DNA
Target 2 Mechanism of Action S-(2-bromoethyl)glutathione, a metabolite of 1,2-dibromoethane, exerts genotoxic and carcinogenic effects by binding to DNA. (R222)
Target 2 Description Not Available
Target 2 Synonyms Not Available
Target 2 Gene Name Not Available
Target 2 Protein Sequence Not Available
Target 2 Number of Residues Not Available
Target 2 Molecular Weight 0.0
Target 2 Theoretical pI Not Available
Target 2 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 2 General Function Not Available
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Signals Not Available
Target 2 Transmembrane Regions Not Available
Target 2 Essentiality Not Available
Target 2 Domain Function Not Available
Target 2 GenBank ID Protein Not Available
Target 2 UniProtKB ID DNA Link Image
Target 2 Cellular Location Not Available
Target 2 Gene Sequence Not Available
Target 2 GenBank Gene ID Not Available
Target 2 GeneCard ID Not Available
Target 2 GenAtlas ID Not Available
Target 2 HGNC ID Not Available
Target 2 Chromosome Location Not Available
Target 2 Locus Not Available
Target 2 SNPs Not Available
Target 2 Toxin References
  • R222 - ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for 1,2-dibromoethane. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 2 General References Not Available
Target 3 [top]
Target 3 ID 5
Target 3 Name Estrogen receptor
Target 3 Mechanism of Action Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
Target 3 Description Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues
Target 3 Synonyms
  1. ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
Target 3 Gene Name ESR1
Target 3 Protein Sequence >Estrogen receptor 
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Target 3 Number of Residues 595
Target 3 Molecular Weight 66215.4
Target 3 Theoretical pI 8.14
Target 3 GO Classification
Function
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 3 General Function Involved in estrogen receptor activity
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • None
Target 3 Essentiality Non Essential
Target 3 Domain Function PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB ID P03372 Link Image
Target 3 Cellular Location Nucleus
Target 3 Gene Sequence >63 bp 
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
Target 3 GenBank Gene ID Not Available
Target 3 GeneCard ID ESR1 Link Image
Target 3 GenAtlas ID ESR1 Link Image
Target 3 HGNC ID HGNC:3467 Link Image
Target 3 Chromosome Location Not Available
Target 3 Locus 6q25.1
Target 3 SNPs SNPJam Report Link Image
Target 3 Toxin References
  • S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
Target 3 General References 3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106
Target 4 [top]
Target 4 ID 208
Target 4 Name Estrogen receptor beta
Target 4 Mechanism of Action Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
Target 4 Description Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
Target 4 Synonyms
  1. ER-beta; Nuclear receptor subfamily 3 group A member 2
Target 4 Gene Name ESR2
Target 4 Protein Sequence >Estrogen receptor beta 
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Target 4 Number of Residues 530
Target 4 Molecular Weight 59215.8
Target 4 Theoretical pI 8.55
Target 4 GO Classification
Function
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 4 General Function Involved in estrogen receptor activity
Target 4 Pathways Not Available
Target 4 Reactions Not Available
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Non Essential
Target 4 Domain Function PF00104:Hormone_recep PF00105:zf-C4
Target 4 GenBank ID Protein Not Available
Target 4 UniProtKB ID Q92731 Link Image
Target 4 Cellular Location Nucleus
Target 4 Gene Sequence >1593 bp 
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA
Target 4 GenBank Gene ID Not Available
Target 4 GeneCard ID ESR2 Link Image
Target 4 GenAtlas ID ESR2 Link Image
Target 4 HGNC ID HGNC:3468 Link Image
Target 4 Chromosome Location Chromosome:14
Target 4 Locus 14q23.2
Target 4 SNPs SNPJam Report Link Image
Target 4 Toxin References
  • S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
Target 4 General References 9473491; 9636657; 9685228; 9671811; 16938840; 15489334; 10964723; 8769313

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