Potassium voltage-gated channel subfamily B member 2
| Name | Potassium voltage-gated channel subfamily B member 2 |
|---|---|
| Synonyms |
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| Gene Name | KCNB2 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0008573|Potassium voltage-gated channel subfamily B member 2 MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTR LGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFG QELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLW DLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVC IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKD SADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKL EMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKST SSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGP AARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFK ENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGP SKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSD GRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGD TGYCPTRETSM |
| Number of residues | 911 |
| Molecular Weight | 102561.99 |
| Theoretical pI | Not Available |
| GO Classification | Functions
Processes
Components
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| General Function | Protein heterodimerization activity |
| Specific Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. |
| Pfam Domain Function | |
| Transmembrane Regions | 191-212 233-254 266-284 297-317 333-354 396-424 |
| GenBank Protein ID | Not Available |
| UniProtKB ID | Q92953 |
| UniProtKB Entry Name | KCNB2_HUMAN |
| Cellular Location | Cell membrane |
| Gene sequence | >lcl|BSEQ0013282|Potassium voltage-gated channel subfamily B member 2 (KCNB2) ATGGCAGAAAAGGCTCCCCCGGGCTTAAACAGGAAGACTTCAAGGTCGACACTTTCCCTT CCTCCAGAGCCTGTGGACATTATCCGGAGCAAAACATGCTCCAGGAGAGTTAAGATCAAT GTGGGGGGCCTCAACCACGAAGTCCTGTGGAGAACGCTGGACAGGCTGCCCAGGACGCGC CTGGGGAAGCTTCGAGACTGCAACACACACGAGAGCCTCCTGGAAGTGTGCGACGACTAT AATCTGAACGAGAACGAGTATTTCTTTGATCGGCATCCAGGAGCCTTCACTTCCATTTTA AATTTCTACCGGACCGGGAAACTCCATATGATGGAAGAAATGTGTGCACTTTCGTTTGGC CAAGAACTTGATTACTGGGGGATTGATGAGATCTACTTGGAGTCCTGCTGCCAGGCCAGA TATCATCAAAAAAAAGAACAAATGAACGAAGAACTGAGGCGAGAGGCAGAGACTATGCGA GAGCGAGAAGGAGAAGAGTTTGATAATACCTGCTGCCCTGATAAAAGGAAGAAACTGTGG GACTTGCTGGAGAAACCTAACTCATCAGTGGCTGCAAAGATCCTGGCCATCGTGTCTATC CTGTTCATTGTGCTTTCCACCATTGCTTTGTCTCTCAATACGCTGCCGGAGCTGCAGGAA ACGGACGAATTTGGACAACTCAATGACAACCGCCAATTAGCACACGTGGAGGCTGTGTGT ATTGCATGGTTTACCATGGAGTACCTTTTGCGATTCTTATCCTCACCAAATAAATGGAAG TTCTTCAAAGGCCCACTGAATGTCATTGATTTGCTGGCCATCTTGCCGTACTATGTCACC ATTTTTCTGACGGAGTCCAACAAGAGCGTGCTGCAGTTCCAAAACGTGAGGCGCGTGGTC CAGATCTTCCGAATCATGCGCATCCTCAGGATCCTGAAACTCGCCAGGCATTCGACAGGC CTGCAGTCTCTGGGTTTCACCCTTAGGCGGAGTTACAATGAATTGGGCTTGTTGATATTG TTTCTGGCCATGGGGATAATGATATTTTCCAGCCTGGTATTTTTTGCTGAGAAGGATGAA GATGCTACCAAGTTCACCAGTATCCCTGCATCATTTTGGTGGGCCACCATCACCATGACC ACTGTTGGCTATGGTGACATTTACCCTAAAACATTACTAGGGAAAATTGTGGGAGGTCTG TGCTGTATTGCTGGGGTTCTGGTTATTGCCCTTCCTATCCCAATTATTGTGAACAATTTT TCTGAGTTTTACAAGGAGCAGAAACGCCAAGAGAAAGCAATTAAAAGGAGGGAGGCTCTT GAGCGGGCCAAAAGGAACGGAAGCATCGTTTCTATGAACTTAAAAGATGCCTTCGCTCGA AGTATGGAACTGATAGATGTGGCTGTTGAGAAGGCCGGAGAGTCCGCCAACACAAAGGAC TCCGCCGACGATAATCACCTGTCGCCAAGCCGGTGGAAGTGGGCCAGGAAGGCTCTGTCG GAAACAAGCTCCAACAAGTCTTTCGAGAATAAGTACCAGGAGGTTAGCCAAAAAGACTCC CACGAGCAGCTGAACAACACGTCTTCCTCCAGCCCACAGCATCTGAGTGCCCAGAAACTG GAGATGCTATACAATGAAATCACCAAGACACAGCCTCATTCTCACCCAAACCCAGACTGC CAAGAAAAGCCTGAGAGGCCATCTGCATATGAAGAAGAGATTGAAATGGAAGAAGTGGTG TGTCCACAGGAGCAGCTGGCCGTGGCACAGACCGAGGTCATTGTGGACATGAAGAGCACC TCCAGCATCGACAGCTTCACCAGCTGTGCCACCGACTTCACAGAGACAGAGAGATCGCCG CTGCCGCCGCCCTCCGCCTCTCACTTGCAGATGAAGTTCCCAACCGACCTCCCAGGGACA GAAGAGCACCAAAGAGCTAGGGGCCCCCCGTTTCTAACTCTATCCAGAGAGAAAGGACCT GCTGCCAGGGATGGCACGCTGGAGTATGCCCCAGTTGACATAACTGTGAACCTCGATGCC AGTGGCTCCCAGTGTGGGCTACATAGTCCTTTGCAGTCTGACAATGCCACCGACAGTCCT AAGAGCTCTCTAAAAGGCAGCAACCCACTAAAGTCCAGATCCCTCAAAGTGAACTTTAAG GAAAATAGAGGCAGTGCACCACAGACCCCGCCCAGCACAGCCAGGCCACTGCCAGTCACC ACAGCTGACTTTTCGCTCACTACCCCGCAGCACATCAGTACCATCCTCTTAGAAGAAACC CCCTCCCAGGGAGACAGACCCTTGCTGGGCACTGAGGTTTCAGCGCCTTGTCAGGGACCT TCCAAAGGGCTGTCCCCCAGGTTTCCCAAGCAGAAACTGTTCCCTTTCTCTTCAAGAGAG AGGAGGAGCTTCACTGAAATAGATACTGGTGACGACGAAGACTTCTTAGAGCTCCCAGGG GCAAGGGAGGAGAAGCAGGTGGACTCCAGCCCAAATTGCTTTGCAGATAAGCCTAGTGAT GGGAGAGACCCTTTAAGAGAAGAGGGCAGTGTGGGCTCTTCCTCCCCGCAGGACACAGGT CACAACTGTAGGCAAGACATTTACCATGCTGTGAGTGAAGTCAAAAAGGACAGTAGTCAA GAAGGGTGCAAGATGGAAAATCACTTGTTTGCCCCAGAAATTCATTCCAACCCAGGAGAC ACAGGTTATTGTCCCACACGTGAAACCAGCATGTGA |
| GenBank Gene ID | Not Available |
| GeneCard ID | Not Available |
| GenAtlas ID | Not Available |
| HGNC ID | HGNC:6232 |
| Chromosome Location | 8 |
| Locus | Not Available |
| References |
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