Neuropeptide Y receptor type 2

NameNeuropeptide Y receptor type 2
Synonyms
  • NPY-Y2 receptor
  • NPY2-R
  • Y2 receptor
Gene NameNPY2R
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019283|Neuropeptide Y receptor type 2
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV
Number of residues381
Molecular Weight42730.69
Theoretical pI7.26
GO Classification
Functions
  • neuropeptide Y receptor activity
  • calcium channel regulator activity
  • peptide YY receptor activity
  • receptor activity
Processes
  • behavioral fear response
  • synaptic transmission
  • negative regulation of cAMP biosynthetic process
  • feeding behavior
  • positive regulation of dopamine secretion
  • positive regulation of cytosolic calcium ion concentration
  • positive regulation of smooth muscle contraction
  • cell surface receptor signaling pathway
  • secretion
  • locomotory behavior
  • outflow tract morphogenesis
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • cardiac left ventricle morphogenesis
  • negative regulation of secretion
  • positive regulation of cell-substrate adhesion
  • negative regulation of feeding behavior
  • negative regulation of synaptic transmission, glutamatergic
  • negative regulation of excitatory postsynaptic potential
  • positive regulation of peptide secretion
  • negative regulation of neurological system process
  • regulation of sensory perception of pain
  • nitric oxide mediated signal transduction
  • positive regulation of circadian sleep/wake cycle, non-REM sleep
  • neuropeptide signaling pathway
Components
  • cytosol
  • integral component of plasma membrane
  • nonmotile primary cilium
  • plasma membrane
General FunctionReceptor activity
Specific FunctionReceptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Pfam Domain Function
Transmembrane Regions52-72 87-107 125-145 166-186 217-237 269-289 305-325
GenBank Protein IDNot Available
UniProtKB IDP49146
UniProtKB Entry NameNPY2R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019284|Neuropeptide Y receptor type 2 (NPY2R)
ATGGGTCCAATAGGTGCAGAGGCTGATGAGAACCAGACAGTGGAAGAAATGAAGGTGGAA
CAATACGGGCCACAAACAACTCCTAGAGGTGAACTGGTCCCTGACCCTGAGCCAGAGCTT
ATAGATAGTACCAAGCTGATTGAGGTACAAGTTGTTCTCATATTGGCCTACTGCTCCATC
ATCTTGCTTGGGGTAATTGGCAACTCCTTGGTGATCCATGTGGTGATCAAATTCAAGAGC
ATGCGCACAGTAACCAACTTTTTCATTGCCAATCTGGCTGTGGCAGATCTTTTGGTGAAC
ACTCTGTGTCTACCGTTCACTCTTACCTATACCTTAATGGGGGAGTGGAAAATGGGTCCT
GTCCTGTGCCACCTGGTGCCCTATGCCCAGGGCCTGGCAGTACAAGTATCCACAATCACC
TTGACAGTAATTGCCCTGGACCGGCACAGGTGCATCGTCTACCACCTAGAGAGCAAGATC
TCCAAGCGAATCAGCTTCCTGATTATTGGCTTGGCCTGGGGCATCAGTGCCCTGCTGGCA
AGTCCCCTGGCCATCTTCCGGGAGTATTCGCTGATTGAGATCATCCCGGACTTTGAGATT
GTGGCCTGTACTGAAAAGTGGCCTGGCGAGGAGAAGAGCATCTATGGCACTGTCTATAGT
CTTTCTTCCTTGTTGATCTTGTATGTTTTGCCTCTGGGCATTATATCATTTTCCTACACT
CGCATTTGGAGTAAATTGAAGAACCATGTCAGTCCTGGAGCTGCAAATGACCACTACCAT
CAGCGAAGGCAAAAAACCACCAAAATGCTGGTGTGTGTGGTGGTGGTGTTTGCGGTCAGC
TGGCTGCCTCTCCATGCCTTCCAGCTTGCCGTTGACATTGACAGCCAGGTCCTGGACCTG
AAGGAGTACAAACTCATCTTCACAGTGTTCCACATCATCGCCATGTGCTCCACTTTTGCC
AATCCCCTTCTCTATGGCTGGATGAACAGCAACTACAGAAAGGCTTTCCTCTCGGCCTTC
CGCTGTGAGCAGCGGTTGGATGCCATTCACTCTGAGGTGTCCGTGACATTCAAGGCTAAA
AAGAACCTGGAGGTCAGAAAGAACAGTGGCCCCAATGACTCTTTCACAGAGGCTACCAAT
GTCTAA
GenBank Gene IDU36269
GeneCard IDNot Available
GenAtlas IDNPY2R
HGNC IDHGNC:7957
Chromosome Location4
Locus4q31
References
  1. Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL: Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J Biol Chem. 1995 Nov 10;270(45):26758-61. 7592910
  2. Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA: Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol. 1996 Feb;49(2):224-8. 8632753
  3. Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R: Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J Biol Chem. 1995 Sep 29;270(39):22661-4. 7559383
  4. Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W: Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4661-5. 8643460
  5. Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF Jr, Yang-Feng TL, Thompson DA: Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. Genomics. 1996 Dec 15;38(3):392-8. 8975716
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