NamePOU domain, class 2, transcription factor 1
Synonyms
  • NF-A1
  • Oct-1
  • OCT1
  • Octamer-binding protein 1
  • Octamer-binding transcription factor 1
  • OTF-1
  • OTF1
Gene NamePOU2F1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009276|POU domain, class 2, transcription factor 1
MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS
LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ
LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ
QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQ
PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI
KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS
SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK
EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP
VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA
SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP
SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV
FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ
NSLFTVASASGAASTTTTASKAQ
Number of residues743
Molecular Weight76470.82
Theoretical pINot Available
GO Classification
Functions
  • chromatin binding
  • sequence-specific DNA binding
  • transcription factor activity, sequence-specific DNA binding
  • transcription regulatory region sequence-specific DNA binding
Processes
  • liver regeneration
  • transcription from RNA polymerase III promoter
  • gene expression
  • negative regulation of transcription, DNA-templated
Components
  • nucleus
  • endoplasmic reticulum
  • nucleoplasm
  • intracellular membrane-bounded organelle
General FunctionTranscription regulatory region sequence-specific dna binding
Specific FunctionTranscription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP14859
UniProtKB Entry NamePO2F1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021737|POU domain, class 2, transcription factor 1 (POU2F1)
ATGCTGGACTGCAGTGACTATGTTCTAGACTCAAGAATGAACAATCCGTCAGAAACCAGT
AAACCATCTATGGAGAGTGGAGATGGCAACACAGGCACACAAACCAATGGTCTGGACTTT
CAGAAGCAGCCTGTGCCTGTAGGAGGAGCAATCTCAACAGCCCAGGCGCAGGCTTTCCTT
GGACATCTCCATCAGGTCCAACTCGCTGGAACAAGTTTACAGGCTGCTGCTCAGTCTTTA
AATGTACAGTCTAAATCTAATGAAGAATCGGGGGATTCGCAGCAGCCAAGCCAGCCTTCC
CAGCAGCCTTCAGTGCAGGCAGCCATTCCCCAGACCCAGCTTATGCTAGCTGGAGGACAG
ATAACTGGGCTTACTTTGACGCCTGCCCAGCAACAGTTACTACTCCAGCAGGCACAGGCA
CAGGCACAGCTGCTGGCTGCTGCAGTGCAGCAGCACTCCGCCAGCCAGCAGCACAGTGCT
GCTGGAGCCACCATCTCCGCCTCTGCTGCCACGCCCATGACGCAGATCCCCCTGTCTCAG
CCCATACAGATCGCACAGGATCTTCAACAACTGCAACAGCTTCAACAGCAGAATCTCAAC
CTGCAACAGTTTGTGTTGGTGCATCCAACCACCAATTTGCAGCCAGCGCAGTTTATCATC
TCACAGACGCCCCAGGGCCAGCAGGGTCTCCTGCAAGCGCAAAATCTTCTAACGCAACTA
CCTCAGCAAAGCCAAGCCAACCTCCTACAGTCGCAGCCAAGCATCACCCTCACCTCCCAG
CCAGCAACCCCAACACGCACAATAGCAGCAACCCCAATTCAGACACTTCCACAGAGCCAG
TCAACACCAAAGCGAATTGATACTCCCAGCTTGGAGGAGCCCAGTGACCTTGAGGAGCTT
GAGCAGTTTGCCAAGACCTTCAAACAAAGACGAATCAAACTTGGATTCACTCAGGGTGAT
GTTGGGCTCGCTATGGGGAAACTATATGGAAATGACTTCAGCCAAACTACCATCTCTCGA
TTTGAAGCCTTGAACCTCAGCTTTAAGAACATGTGCAAGTTGAAGCCACTTTTAGAGAAG
TGGCTAAATGATGCAGAGAACCTCTCATCTGATTCGTCCCTCTCCAGCCCAAGTGCCCTG
AATTCTCCAGGAATTGAGGGCTTGAGCCGTAGGAGGAAGAAACGCACCAGCATAGAGACC
AACATCCGTGTGGCCTTAGAGAAGAGTTTCTTGGAGAATCAAAAGCCTACCTCGGAAGAG
ATCACTATGATTGCTGATCAGCTCAATATGGAAAAAGAGGTGATTCGTGTTTGGTTCTGT
AACCGCCGCCAGAAAGAAAAAAGAATCAACCCACCAAGCAGTGGTGGGACCAGCAGCTCA
CCTATTAAAGCAATTTTCCCCAGCCCAACTTCACTGGTGGCGACCACACCAAGCCTTGTG
ACTAGCAGTGCAGCAACTACCCTCACAGTCAGCCCTGTCCTCCCTCTGACCAGTGCTGCT
GTGACGAATCTTTCAGTTACAGGCACTTCAGACACCACCTCCAACAACACAGCAACCGTG
ATTTCCACAGCGCCTCCAGCTTCCTCAGCAGTCACGTCCCCCTCTCTGAGTCCCTCCCCT
TCTGCCTCAGCCTCCACCTCCGAGGCATCCAGTGCCAGTGAGACCAGCACAACACAGACC
ACCTCCACTCCTTTGTCCTCCCCTCTTGGGACCAGCCAGGTGATGGTGACAGCATCAGGT
TTGCAAACAGCAGCAGCTGCTGCCCTTCAAGGAGCTGCACAGTTGCCAGCAAATGCCAGT
CTTGCTGCCATGGCAGCTGCTGCAGGACTAAACCCAAGCCTGATGGCACCCTCACAGTTT
GCGGCTGGAGGTGCCTTACTCAGTCTGAATCCAGGGACCCTGAGCGGTGCTCTCAGCCCA
GCTCTAATGAGCAACAGTACACTGGCAACTATTCAAGCTCTTGCTTCTGGTGGCTCTCTT
CCAATAACATCACTTGATGCAACTGGGAACCTGGTATTTGCCAATGCGGGAGGAGCCCCC
AACATCGTGACTGCCCCTCTGTTCCTGAACCCTCAGAACCTCTCTCTGCTCACCAGCAAC
CCTGTTAGCTTGGTCTCTGCCGCCGCAGCATCTGCAGGGAACTCTGCACCTGTAGCCAGC
CTTCACGCCACCTCCACCTCTGCTGAGTCCATCCAGAACTCTCTCTTCACAGTGGCCTCT
GCCAGCGGGGCTGCGTCCACCACCACCACCGCCTCCAAGGCACAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9212
Chromosome Location1
LocusNot Available
References
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