5032 Cobalt-60 Cobalt-60, ⁶⁰Co, is a synthetic radioactive isotope of cobalt with a half-life of 5.2714 years. It is produced artificially by neutron activation of the isotope ⁵⁹Co. ⁶⁰Co decays by beta decay to the stable isotope nickel-60 (⁶⁰Ni). Cobalt is a metallic element with the atomic number 27. It is found naturally in rocks, soil, water, plants, and animals. In small amounts cobalt is an essential element for life, as it is part of vitamin B12. However, excess exposure is known to exhibit toxic effects. (L29, L30, L2088) 10198-40-0 61492 Co Gray-blue metal Inhalational (L29) ; oral (L29) ; dermal (L29); radiation (L29) Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. Radioactive cobalt damages DNA, RNA, and lipids through ionizing events. (L29) Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29) LD50: 503 mg/kg (Oral, Rat) (A195) LD50: 25 mg/kg (Intravenous, Rabbit) (T14) Internalized radionuclides that emit β particles are carcinogenic to humans (Group 1) (L2150). Cobalt-60 undergoes beta decay. Radioactive cobalt is used for commercial and medical purposes, such as for sterilizing medical equipment and consumer products, radiation therapy for treating cancer patients, manufacturing plastics, and irradiating food. (L29) Chronic Inhalation: 0.0001 mg/m3 (L134) Intermediate Oral: 0.01 mg/kg/day (L134) Acute Radiation: 4 mSv (L134) Chronic Radiation: 1 mSv/yr (L134) Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitus. Cobalt may also have mutagenic and carcinogenic effects. Exposure to cobalt radiation causes cell damage and can lead to severe burns and death at high doses. (L29, L30) Exposure to cobalt radiation may cause acute radiation syndrome, which is characterized by nausea, vomiting, diarrhea, bleeding, and possibly coma. (L29) Treatment of cobalt poisoning is symptomatic. (L29) 2014-10-10T20:38:48Z 2014-12-24T20:27:01Z http://en.wikipedia.org/wiki/Cobalt-60 true [60Co] Co InChI=1S/Co/i1+1 InChIKey=GUTLYIVDDKVIGB-OUBTZVSYSA-N 59.9338 59.933822196 Exogenous Solid