5029 Bromide ion In nature, bromine is most abundant as a bromide ion. Physiologically, it exists as an ion in the body. A bromide is a chemical compound containing a bromide ion or ligand. Bromide compounds, especially potassium bromide, were frequently used as sedatives in the 19th and early 20th century. Their use in over-the-counter sedatives and headache remedies (such as Bromo-Seltzer) in the United States extended to 1975, when bromides were withdrawn as ingredients, due to chronic toxicity. Bromide is present in typical seawater (35 PSU) with a concentration of around 65 mg/L, which is around 0.2% of all dissolved salts. Bromide is needed by eosinophils (white blood cells of the granulocyte class, specialized for dealing with multi-cellular parasites), which use it to generate antiparasitic brominating compounds such as hypobromite, by the action of eosinophil peroxidase, a haloperoxidase enzyme which is able to use chloride, but preferentially uses bromide when available. 24959-67-9 259 Br Clear liquid Depends on salt form Depends on salt form >100 mg/mL at 25°C Oral (L626) ; inhalation (L626) ; dermal (L626) The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543) Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626) LD50: 85.2 ppm (Intraperitoneal, Rat) (A542) LD50: 2600 mg/kg (Oral, Rat) (A542) LC50: 750 ppm over 9 minutes (Inhalation, Mouse) (A542) No indication of carcinogenicity (not listed by IARC). (L135) Bromide is present in typical seawater (35 PSU) with a concentration of around 65 mg/L, which is around 0.2% of all dissolved salts. Bromide ions can be found in almost all living organisms, though it is not essential for life. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627) The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. (L626, L627) In case of acute exposure, bromide salts should be washed with water from any areas of dermal or ocular contact. If inhaled, treatment is mainly symptomatic and may include maintaining an adequate airway, administering oxygen, antibronchospasm therapy, and/or antibiotics. (L626) 2014-10-02T22:31:28Z 2014-12-24T20:27:01Z http://en.wikipedia.org/wiki/Bromide C01324 15858 true [Br-] Br InChI=1S/BrH/h1H/p-1 InChIKey=CPELXLSAUQHCOX-UHFFFAOYSA-M 79.905 78.918886227 Exogenous Solid or Liquid HMDB02500 CHEMBL11685 254