4870 T3D4815 1,10-Phenanthroline Phenanthroline is a heterocyclic organic compound. 1,10-Phenanthroline is an inhibitor of metallopeptidases, especially carboxypeptidase A. Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic activity, leaving an inactive apoenzyme. 1,10-Phenanthroline targets mainly zinc metallopeptidases, with a much lower affinity for calcium metallopeptidases. 66-71-7 1318 C12H8N2 White powder. 117°C > 300°C 2690 mg/L (at 25°C) No indication of carcinogenicity to humans (not listed by IARC). 2014-09-11T05:17:48Z 2014-12-24T20:26:57Z C00604 476 DB02365 true C1=CC2=C(N=C1)C1=C(C=CC=N1)C=C2 C12H8N2 InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H InChIKey=DGEZNRSVGBDHLK-UHFFFAOYSA-N 180.2053 180.068748266 Exogenous Solid 1.78 1278 <p>Judith N. Burstyn, Omar Green, Bhavesh A. Gandhi, &#8220;<acronym title="2,9-DI-TERT-BUTYL-1,10-PHENANTHROLINE"><span class="caps">BIS</span></acronym><acronym title="I"><span class="caps">COPPER</span></acronym> <span class="caps">COMPLEXES</span>, <span class="caps">METHODS</span> OF <span class="caps">SYNTHESIS</span>, <span class="caps">AND</span> <span class="caps">USES</span> <span class="caps">THEROF</span>.&#8221; U.S. Patent US20080206890, issued August 28, 2008.</p>