4782 T3D4727 Streptokinase Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. 9002-01-1 50139.69499999991 Clear solution. >10 mg/mL Oral Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting cascade. Streptokinase forms a highly specific 1:1 enzymatic complex with plasminogen which converts inactive plasminogen molecules into active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins. This in turn leads to the degradation of blood clots. Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). For the treatment of acute evolving transmural myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis or emolism and occlusion of arteriovenous cannulae 2014-09-11T05:13:41Z 2014-12-24T20:26:56Z Streptokinase P00779 Streptokinase DB00086 1BML true Exogenous Liquid CHEMBL2108147 DB00086.png image/png 303177 2014-10-14T18:14:26Z BSEQ0008536 <p>Lawrence Isaac Galler, &#8220;Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy.&#8221; U.S. Patent US6087332, issued July, 1997.</p>