4751 T3D4696 Griseofulvin Griseofulvin is only found in individuals that have used or taken this drug. It is an antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis. 126-07-8 441140 C17H17ClO6 White powder. 220°C 8.64 mg/L (at 25°C) Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal. Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis. Primarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate. Half Life: 9-21 hours 2B, possibly carcinogenic to humans. (L135) Griseofulvin is used both in animals and in humans, to treat fungal infections of the skin (commonly known as ringworm) and nails. Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. Griseofulvin is reserved for cases with nail, hair or large body surface involvement. (Wikipedia) Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions 2014-09-11T02:05:24Z 2014-12-24T20:26:55Z http://en.wikipedia.org/wiki/Griseofulvin C06686 27779 DB00400 true [H][C@@]1(C)CC(=O)C=C(OC)[C@@]11OC2=C(C1=O)C(OC)=CC(OC)=C2Cl C17H17ClO6 InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1 InChIKey=DDUHZTYCFQRHIY-RBHXEPJQSA-N 352.766 352.071365983 Exogenous Solid 2.18 HMDB14544 CHEMBL562 389934 <p>Gary Liversidge, &#8220;Methods of making and using novel griseofulvin compositions.&#8221; U.S. Patent US20070098805, issued May 03, 2007.</p>