4617 Dexmethylphenidate Dexmethylphenidate is the dextrorotary form of methylphenidate. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD). 40431-64-9 4158 C14H19NO2 White powder. 11-52% Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Methylphenidate is a catecholamine reuptake inhibitor that indirectly increases catecholaminergic neurotransmission by inhibiting the dopamine transporter (DAT) and norepinephrine transporter (NET), which are responsible for clearing catecholamines from the synapse, particularly in the striatum and meso-limbic system. epatic, methylphenidate is metabolized primarily by de-esterification to ritalinic acid (&alpha;-phenyl-2-piperidine acetic acid, PPAA), which has little to no pharmacologic activity. Route of Elimination: Renal Half Life: 2-4 hours Oral, Mouse: LD₅₀=190mg/kg No indication of carcinogenicity to humans (not listed by IARC). Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment. Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. 2014-08-30T21:04:54Z 2014-12-24T20:26:52Z Dexmethylphenidate DB06701 true [H][C@@](C(=O)OC)(C1=CC=CC=C1)[C@@]1([H])CCCCN1 C14H19NO2 InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1 InChIKey=DUGOZIWVEXMGBE-CHWSQXEVSA-N 233.3062 233.141578857 Exogenous Solid <p>Arie Gutman, &#8220;Process for the preparation of dexmethylphenidate hydrochloride.&#8221; U.S. Patent US20040180928, issued September 16, 2004.</p>