4610 Guaifenesin An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem] 93-14-1 3516 C10H14O4 White powder. 78.5-79°C 215 °C at 1.90E+01 mm Hg highly water-soluble Rapidly absorbed from the GI tract Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing. Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite. Half Life: 1 hour Oral, Rat: LD₅₀ 1510 mg/kg No indication of carcinogenicity to humans (not listed by IARC). Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections. 2014-08-30T21:03:55Z 2014-12-24T20:26:52Z Guaifenesin DB00874 true COC1=CC=CC=C1OCC(O)CO C10H14O4 InChI=1/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3 InChIKey=HSRJKNPTNIJEKV-UHFFFAOYNA-N 198.2158 198.089208936 Exogenous Solid 1.39 CHEMBL980 3396 <p>Wilfred P. Shum, Harry Mazurek, Jian Chen, &#8220;Process for producing enantiomerically enriched guaifenesin.&#8221; U.S. Patent US5495052, issued August, 1949.</p>