4605 T3D4551 Doxylamine Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem] 469-21-6 3162 C17H22N2O < 25 °C 139 °C at 5.00E-01 mm Hg 1 g/ml (succinate salt) Readily absorbed via the gastrointestinal tract. Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1&nbsp;receptors. It also has substantial sedative and anticholinergic effects. Hepatic. Half Life: 10 hours No indication of carcinogenicity to humans (not listed by IARC). Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women. Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat. 2014-08-30T21:03:25Z 2014-12-24T20:26:52Z Doxylamine 51380 DB00366 true CN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1 C17H22N2O InChI=1/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3 InChIKey=HCFDWZZGGLSKEP-UHFFFAOYNA-N 270.3694 270.173213336 Exogenous Liquid 2.5 CHEMBL1004 3050