4554 Diuron Diuron, also known as DCMU (3-(3,4-dichlorophenyl)-1,1-dimethylurea), is an herbicide in the urea chemical family that inhibits photosynthesis. It was introduced by Bayer in 1954 under the trade name of Diuron. DCMU is a very specific and sensitive inhibitor of photosynthesis, the process by which plants use light, water, and carbon di-oxide from the atmosphere to form plant sugars and cellulose. Diuron blocks electron transport at a critical point in this process. It blocks the plastoquinone binding site of photosystem II, disallowing the electron flow from where it is generated, in photosystem II, to plastoquinone. This interrupts the photosynthetic electron transport chain in photosynthesis and thus reduces the ability of the plant to turn light energy into chemical energy (ATP and reductant potential). 330-54-1 3120 C9H10Cl2N2O White powder. Diuron has been reported to bind to androgen receptors. This suggests that diuron may block the receptors and result in the toxicity on the reproductive system. Not listed by IARC. This is a man-made compound that is used as a pesticide. Diuron has reproductive, teratogenic effects and organ toxicity to mammals. Diuron induces urinary bladder cancer, mammary gland carcinoma and hepatocellular adenomas in mice, kidney toumors and testicular interstitial cell adenomas in rats. High level diuron exposure can cause central nervous system depression. Chronic exposure can affect bone marrow, spleen in rats. Anemia, increase mortality, growth retardation are also seen. 2014-08-29T06:51:42Z 2014-12-24T20:26:51Z C18428 CHEBI:116509 true CN(C)C(O)=NC1=CC(Cl)=C(Cl)C=C1 C9H10Cl2N2O InChI=1S/C9H10Cl2N2O/c1-13(2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14) InChIKey=XMTQQYYKAHVGBJ-UHFFFAOYSA-N 233.095 232.017018366 Exogenous Solid CHEMBL278489 3008