3965 Propiconazole Propiconazole is a triazole fungicide, also known as a DMI, or demethylation inhibiting fungicide due to its binding with and inhibiting the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. Without this demethylation step, the ergosterols are not incorporated into the growing fungal cell membranes, and cellular growth is stopped. Propiconazole is used agriculturally on turfgrasses grown for seed and aesthetic or athletic value, mushrooms, corn, wild rice, peanuts, almonds, sorghum, oats, pecans, apricots, peaches, nectarines, plums and prunes. It is also used in combination with permethrin in formulations of wood preserver. Propiconazole is a mixture of four stereoisomers and was first developed in 1979 by Janssen Pharmaceutica. 60207-90-1 43234 C15H17Cl2N3O2 White powder. Propiconazole can decrease cholesterol levels that may cause polyploidy and disruption of mitotic cell cycling. It down-regulates the PTEN pathway and up-regulates the WNT-beta-catenin signaling pathway, that would stimulate cell proliferation and may lead to the tumorigenic outcome. (A15329) Not listed by IARC. This is a man-made compound that is used as a pesticide. Propiconazole can cause corneal opacity that is reversible with 72 hours. In animal chronic toxicity tests, the benign and malignant liver tumors were found in rats and mice. Propiconazole is categorized as a possible human carcinogen. Propiconazole is also a developmental toxin that caused skeletal deformations in newborn pups. 2013-04-25T07:56:54Z 2014-12-24T20:26:34Z C11121 8489 true CCCC1COC(CN2C=NC=N2)(O1)C1=CC=C(Cl)C=C1Cl C15H17Cl2N3O2 InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3 InChIKey=STJLVHWMYQXCPB-UHFFFAOYSA-N 342.22 341.069782217 Exogenous Solid CHEMBL560579 39402