3679 Diazolidinyl urea Diazolidinyl urea is an antimicrobial preservative that acts as a formaldehyde releaser. It is used in many cosmetics, skin care products, shampoos and conditioners, as well as a wide range of products including bubble baths, baby wipes and household detergents. Diazolidinyl urea is found in the commercially available preservative Germaben. Diazolidinyl urea may cause contact dermatitis. Its toxicity is also due to it's ability to release formaldehyde, which is believed to be carcinogenic. (L1895) 78491-02-8 62277 C8H14N4O7 White powder. 1000 mg/mL at 25°C Oral (L962) ; inhalation (L962) ; dermal (L962) Diazolidinyl urea is a formaldehyde releaser. It is likely that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, allowing the unmetabolized intact molecule to exert its effects. Formaldehyde is known to form cross links between protein and DNA and undergo metabolic incorporation into macromolecules (DNA, RNA, and proteins). (L962, L1895) Formaldehyde may be absorbed following inhalation, oral, or dermal exposure. It is an essential metabolic intermediate in all cells and is produced during the normal metabolism of serine, glycine, methionine, and choline and also by the demethylation of N-, S-, and O-methyl compounds. Exogenous formaldehyde is metabolized to formate by the enzyme formaldehyde dehydrogenase at the initial site of contact. After oxidation of formaldehyde to formate, the carbon atom is further oxidized to carbon dioxide or incorporated into purines, thymidine, and amino acids via tetrahydrofolatedependent one-carbon biosynthetic pathways. Formaldehyde is not stored in the body and is excreted in the urine (primarily as formic acid), incorporated into other cellular molecules, or exhaled as carbon dioxide. (L962) 1, carcinogenic to humans (for formaldehyde). (L135) Diazolidinyl urea is an antimicrobial preservative used in many cosmetics, skin care products, shampoos and conditioners, as well as a wide range of products including bubble baths, baby wipes and household detergents. Diazolidinyl urea is found in the commercially available preservative Germaben. (L1895) Diazolidinyl urea releases formaldehyde, a known human carcinogen. (L962, L1895) Some people have a contact allergy to diazolidinyl urea, causing dermatitis. (L1895) 2009-11-23T23:08:08Z 2014-12-24T20:26:14Z http://en.wikipedia.org/wiki/Diazolidinyl_urea true Alcohol dehydrogenase class-3 (P11766) (L962) OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O C8H14N4O7 InChI=1S/C8H14N4O7/c13-1-9-7(18)10(2-14)5-6(17)12(4-16)8(19)11(5)3-15/h5,13-16H,1-4H2,(H,9,18) InChIKey=SOROIESOUPGGFO-UHFFFAOYSA-N 278.2194 278.086248822 Exogenous Solid 56078