3574 Salvinorin A Salvinorin A is the main active psychotropic molecule in Salvia divinorum, a Mexican plant which has a long history of use as an entheogen by indigenous Mazatec shamans. Salvinorin A is a hallucinogenic compound with dissociative effects (L1181). 83729-01-5 128563 C23H28O8 432.178420 Colorless crystals from methanol (A646). 238-244°C Ingestion (L1817) ; dermal (L1817) Salvinorin A, the active component of the hallucinogenic sage Salvia divinorum, is an apparently selective and highly potent kappa-opioid receptor (KOR) agonist. Salvinorin A is unique among ligands for peptidergic G protein-coupled receptors in being nonnitrogenous and lipid-like in character (A647). Salvinorin A’s chemical structure suggests that it may be a substrate of CYP450 (oxidative metabolism), UGT (hydrolysis) or carboxylesterases (ChEs) (hydrolysis). In addition, as observed for CYP1A1, CPY2C18 and CYP2E1, Salvinorin A metabolism via UGTB27 appears to be saturable at higher concentrations. No indication of carcinogenicity (not listed by IARC). (L135) Traditional medicine used by the Mazatec people of Oaxaca, Mexico (A646). Psychedelic-like changes in visual perception, mood, and body sensations (A645). Hallucinations or delusional episodes that mimic psychosis. ; emotional swings; feelings of detachment; and importantly, a highly modified perception of external reality and the self, which leads to a decreased ability to interact with one's surroundings (A645). Treatment for salvinorin A overdose would be similar to the treatments for hallucinogen intoxication. (A648) 2009-07-30T17:59:08Z 2014-12-24T20:26:07Z Cytochrome P450 1A1 (CYP1A1) (P04798) (A332) Cytochrome P450 2C18 (CYP2C18) (P33260) (A332) Cytochrome P450 2E1 (CYP2E1) (P05181) (A332) http://en.wikipedia.org/wiki/Salvinorin Salvinorin A true Cytochrome P450 1A1 (P04798) Cytochrome P450 2C18 (P33260) Cytochrome P450 2E1 (P05181) (A332) COC(=O)C1CC(OC(C)=O)C(=O)C2C1(C)CCC1C(=O)OC(CC21C)C1=COC=C1 C23H28O8 InChI=1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3 InChIKey=OBSYBRPAKCASQB-UHFFFAOYSA-N 432.4636 432.178417872 Exogenous Solid