3568 Pentamidine Pentamidine is only found in individuals that have used or taken this drug. It is an antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. [PubChem] The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins. 100-33-4 4735 C19H24N4O2 340.189930 White powder. 186.0°C (decomposes) Complete Absorbed poorly through the gastrointestinal tract and is usually administered parenterally. The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins. Hepatic. Half Life: 9.1-13.2 hours No indication of carcinogenicity to humans (not listed by IARC). For the treatment of pneumonia due to <i>Pneumocystis carinii</i>. Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea. 2009-07-30T17:59:04Z 2014-12-24T20:26:07Z Pentamidine C07420 45081 Pentamidine DB00738 PNT true NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1 C19H24N4O2 InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23) InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N 340.4195 340.189926032 Exogenous Solid 4 HMDB14876 CHEMBL55 4573