3001 T3D2959 Phytonadione Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation. 84-80-0 5284607 C31H46O2 450.349780 -20°C 142.5°C at 1.00E-03 mm Hg Insoluble in water Subcutaneous, Intramuscular, Intravenous injection. Oral phylloquinone is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phylloquinone is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues. Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phylloquinone results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria. Route of Elimination: Almost no free unmetabolized vitamin K appears in bile or urine. LD50: 41.5 mL/kg at 0.2% (Intravenous, Mouse) (A308) LD50: 52 mL/kg at 1% (Intravenous, Mouse) (A308) 3, not classifiable as to its carcinogenicity to humans. (L135) For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia. 2009-07-21T20:28:11Z 2014-12-24T20:25:54Z Phytonadione C02059 118650 122700 176860 176880 176930 188055 215100 227600 277450 306900 607473 18067 3-HYDROXY-2-METHYL-3-PHYTYL-23-DIHYDRONA Phytonadione DB01022 PQN true [H]\C(CC1=C(C)C(=O)C2=CC=CC=C2C1=O)=C(\C)CCC[C@]([H])(C)CCC[C@]([H])(C)CCCC(C)C C31H46O2 InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1 InChIKey=MBWXNTAXLNYFJB-NKFFZRIASA-N 450.6957 450.349780716 Exogenous Liquid 9.3 HMDB15157 CHEMBL1550 4447652 <p>Manfred Dorner, &#8220;Method of making vitamin K1.&#8221; U.S. Patent US5744624, issued June, 1964.</p>