3000 Bethanechol Bethanechol is a synthetic ester structurally and pharmacologically related to acetylcholine. A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. [PubChem] 674-38-4 2370 C7H17N2O2 White powder. about 220°C 10 mg/mL (chloride salt) Oral Bethanechol directly stimulates cholinergic receptors in the parasympathetic nervous system while stimulating the ganglia to a lesser extent. Its effects are predominantly muscarinic, inducing little effect on nicotinic receptors and negligible effects on the cardiovascular system. No indication of carcinogenicity to humans (not listed by IARC). For the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Atropine Sulfate is a specific antidote. The recommended dose for adults is 0.6 mg. Repeat doses can be given every two hours, according to clinical response. The recommended dosage in infants and children up to 12 years of age is 0.01 mg/kg (to a maximum single dose of 0.4 mg) repeated every two hours as needed until the desired effect is obtained or adverse effects of atropine preclude further usage. Subcutaneous injection of atropine is preferred except in emergencies when the intravenous route may be employed. (L1712) 2009-07-21T20:28:10Z 2014-12-24T20:25:54Z Bethanechol C06850 3084 Bethanechol DB01019 true CC(C[N+](C)(C)C)OC(O)=N C7H17N2O2 InChI=1/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1 InChIKey=NZUPCNDJBJXXRF-UHFFFAOYNA-O 161.2215 161.128454218 Exogenous Solid HMDB15154 CHEMBL1482 2280 <p>Major, R.T. and Bonnett, H.T.; U.S. Patent 2,322,375: June 22,1943; assigned to Merck &amp;<br /> Co., Inc.</p>