2892 Pentazocine Pentazocine is only found in individuals that have used or taken this drug. It is the first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)The preponderance of evidence suggests that pentazocine antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. 359-83-1 441278 C19H27NO 285.209260 White powder. 146.3°C 1.22e-01 g/L Intravenous, Oral. Well absorbed from the gastro-intestinal tract. The preponderance of evidence suggests that pentazocine antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Hepatic Half Life: 2 to 3 hours No indication of carcinogenicity to humans (not listed by IARC). Used to treat mild to moderately severe pain. [Wikipedia] Medical problems can include congested lungs, liver disease, tetanus, cardiovascular effects, infection of the heart valves, skin abscesses, anemia and pneumonia. Death can occur from overdose. hallucinations and other psychotomimetic effects; cardiovascular effects Adequate measures to maintain ventilation and general circulatory support should be employed. Assisted or controlled ventilation, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated. Consideration should be given to gastric lavage and gastric aspiration. For respiratory depression due to overdosage or unusual sensitivity to pentazocine, parenteral naloxone is a specific and effective antagonist. Initial doses of 0.4 to 2.0 mg of naloxone are recommended, repeated at 2-3 minute intervals, if needed, up to a total of 10 mg. Anti 2009-07-21T20:27:20Z 2014-12-24T20:25:52Z Pentazocine C07421 116117 Pentazocine DB00652 true [H][C@]12CC3=C(C=C(O)C=C3)[C@](C)(CCN1CC=C(C)C)[C@@]2([H])C C19H27NO InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m0/s1 InChIKey=VOKSWYLNZZRQPF-GDIGMMSISA-N 285.4238 285.209264491 Exogenous Solid 4.64 HMDB14790 CHEMBL560 390041