2688 Stonustoxin Stonustoxin is a peptide toxin found in the venom of the Estuarine stonefish (Synanceia horrida). They are the most venomous known fish in the world. (L1118, T170) 79523.6399999999 Clear solution. >10 mg/mL Injection (sting/bite) (L1815) Stonustoxin induces hemolytic activities due to its ability to form pores in the cell membrane. It is also myotoxic and interferes irreversibly with neuromuscular function. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Stonustoxin is a peptide toxin found in the venom of the Estuarine stonefish (Synanceia horrida). (L1118, T170) Stonefish venom is hemolytic, neurotoxic, and cardiotoxin, and can be fatal if untreated. Surviving victims often suffer localized nerve damage occasionally leading to atrophy of adjoining muscle tissues.(L1118) Stonefish venom causes severe pain with possible shock, paralysis, and tissue death. (L1118) Treatment of stonefish venom immersion of the affected limb in hot water to denature the protein. Local anaesthetic may be administered for pain relief. There is also an available antivenom. (L1118) 2009-07-06T21:35:53Z 2014-12-24T20:25:48Z Q98989 Stonustoxin true Exogenous Liquid BSEQ0008511