2681 Pseudechetoxin Pseudechetoxin is a peptide toxin produced by the King brown snake (Pseudechis australis). It blocks olfactory and retinal cyclic nucleotide-gated ion channel currents. (T170) 26474.44499999998 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Pseudechetoxin blocks olfactory and retinal cyclic nucleotide-gated (CNG) ion channel currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 1.94 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 0.3 mg/kg (Intravenous, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Pseudechetoxin is a peptide toxin produced by the King brown snake (Pseudechis australis). (T170) Pseudechetoxin is a neurotoxinn and affects sensory transduction in the visual and olfactory systems. (T170) Bites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (T156) An antivenom exists for brown snake venom. (L1044) 2009-07-06T21:35:46Z 2014-12-24T20:25:48Z Q8AVA4 2DDA true Exogenous Liquid 2dda_bio_r_500.jpg image/jpeg 38917 2014-10-14T18:13:56Z BSEQ0008507