2679 Notexin Notexin is a peptide toxin produced by the Common tiger snake (Notechis scutatus scutatus). It is myotoxic and inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. (T170) 37233-96-4 13593.310000000007 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Notexin is myotoxic and inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.214 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 0.04 mg/kg (Intravenous, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Notexin is a peptide toxin produced by the Common tiger snake (Notechis scutatus scutatus). (T170) Notexin is myotoxic. (T170) Bites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (T156) An antivenom exists for tiger snake venom. (L1044) 2009-07-06T21:35:45Z 2014-12-24T20:25:47Z P00608 1AE7 true Exogenous Liquid 4e4c_bio_r_500.jpg image/jpeg 41431 2014-10-14T18:13:54Z BSEQ0008505