<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">2678</id>
  <title>T3D2637</title>
  <common-name>Nigroxin</common-name>
  <description>Nigroxin is a peptide toxin produced by the Central American coral snake (Micrurus nigrocinctus). It is myotoxic. (T170)</description>
  <cas>9001-84-7</cas>
  <pubchem-id></pubchem-id>
  <chemical-formula nil="true"/>
  <weight>13341.125000000007</weight>
  <appearance>Clear solution.</appearance>
  <melting-point></melting-point>
  <boiling-point></boiling-point>
  <density nil="true"/>
  <solubility>&gt;10 mg/mL</solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure>Injection (sting/bite) (L1814)</route-of-exposure>
  <target nil="true"/>
  <mechanism-of-toxicity>Nigroxin is myotoxic. (T170)</mechanism-of-toxicity>
  <metabolism>Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.</metabolism>
  <toxicity>LD50: 0.394 mg/kg (Intravenous, Mouse) (L1830)
LD50: 0.701 mg/kg (Intraperitoneal, Mouse) (L1830)</toxicity>
  <lethaldose></lethaldose>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>Nigroxin is a peptide toxin produced by the Central American coral snake (Micrurus nigrocinctus). (T170)</use-source>
  <min-risk-level></min-risk-level>
  <health-effects>Nigroxin is myotoxic. (T170)</health-effects>
  <symptoms>Bites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (T156)</symptoms>
  <treatment>An antivenom exists for coral snake venom. (L1044)</treatment>
  <created-at type="dateTime">2009-07-06T21:35:45Z</created-at>
  <updated-at type="dateTime">2014-12-24T20:25:47Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia></wikipedia>
  <uniprot-id>P81166</uniprot-id>
  <kegg-compound-id></kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id></chebi-id>
  <biocyc-id></biocyc-id>
  <ctd-id></ctd-id>
  <stitch-id></stitch-id>
  <drugbank-id></drugbank-id>
  <pdb-id></pdb-id>
  <actor-id></actor-id>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles nil="true"/>
  <moldb-formula nil="true"/>
  <moldb-inchi nil="true"/>
  <moldb-inchikey nil="true"/>
  <moldb-average-mass type="decimal" nil="true"/>
  <moldb-mono-mass type="decimal" nil="true"/>
  <origin>Exogenous</origin>
  <state>Liquid</state>
  <logp></logp>
  <hmdb-id></hmdb-id>
  <chembl-id></chembl-id>
  <chemspider-id></chemspider-id>
  <structure-image-file-name>Nigroxin.jpg</structure-image-file-name>
  <structure-image-content-type>image/jpeg</structure-image-content-type>
  <structure-image-file-size type="integer">36660</structure-image-file-size>
  <structure-image-updated-at type="dateTime">2014-10-14T18:13:53Z</structure-image-updated-at>
  <biodb-id>BSEQ0008504</biodb-id>
  <synthesis-reference></synthesis-reference>
  <structure-image-caption nil="true"/>
</compound>
