2676 Erabutoxin Erabutoxin is a peptide toxin produced by the Broad-banded blue sea snake (Laticauda semifasciata). It binds to muscular and neuronal nicotinic acetylcholine receptors (nAChRs), produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. (T170) 59536-69-5 9136.509999999995 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Erabutoxin binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. This produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.273 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 0.34 mg/kg (Intravenous, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Erabutoxin is a peptide toxin produced by the Broad-banded blue sea snake (Laticauda semifasciata). (T170) Erabutoxin is neurotoxic and causes peripheral paralysis. (T170) Erabutoxin causes peripheral paralysis. (T170) An antivenom exists for Broad-banded blue sea snake venom. (L1044) 2009-07-06T21:35:44Z 2014-12-24T20:25:47Z P60775 1QKD true Exogenous Liquid 1nxb_bio_r_500.jpg image/jpeg 27375 2014-10-14T18:13:52Z BSEQ0008502