2674 Acanthophin Acanthophin is a peptide toxin produced by the Common death adder (Acanthophis antarcticus). It binds to certain nicotinic acetylcholine receptors. (T170) 126601-49-8 8386.794999999998 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Acanthophin produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. It does this by binding to certain muscular and neuronal nicotinic acetylcholine receptors. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.5 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 0.25 mg/kg (Intravenous, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Acanthophin is a peptide toxin produced by the Common death adder (Acanthophis antarcticus). (T170) Acanthophis venom is neurotoxic. (L1088) Acanthophis bites cause paralysis that can lead to death from a complete respiratory shutdown. (T170, L1088) Acanthophis bites can be treated with death adder antivenom or using anticholinesterases, which break the synaptic blockade by making acetylcholine more available to the parasympathetic nervous system, thus mitigating the effects of the venom. (L1088) 2009-07-06T21:35:41Z 2014-12-24T20:25:47Z P34073 true Exogenous Liquid BSEQ0008501