2671 Sphingomyelinase D (Loxosceles intermedia) Sphingomyelinase D is a dermonecrotic agent produces by the Recluse spiders (genus Loxosceles). It is highly necrotic and causes significant tissue damage. (L1030) 9031-54-3 34158.12499999994 Clear solution. >10 mg/mL Injection (sting/bite) (L1812) Sphingomyelinase D catalyzes the hydrolysis of sphingomyelin, inducing complement-dependent haemolysis, dermonecrosis, blood vessel permeability and platelet aggregation. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Sphingomyelinase D is a dermonecrotic agent produces by the Recluse spiders (genus Loxosceles). (L1030) Sphingomyelinase D can produce symptoms ranging from minor localized effects to severe dermonecrotic lesions, up to and including severe systemic reactions including renal failure, and in some cases, death. Even in the absence of systemic effects, serious bites may form a necrotising ulcer that destroys soft tissue and may take months and very rarely years to heal, leaving deep scars. (L1030) Sphingomyelinase D is highly necrotic and causes significant tissue damage. Symptoms include nausea, vomiting, fever, rashes, and muscle and joint pain. Rarely more severe symptoms occur including haemolysis, thrombocytopenia, and disseminated intravascular coagulation. This condition is termed loxoscelism. (L1030) Several antivenoms exists for Loxosceles stings. (L1044) 2009-07-06T21:35:33Z 2014-12-24T20:25:47Z P0CE80 Sphingomyelinase D true Exogenous Liquid 3rlg_bio_r_500.jpg image/jpeg 59655 2014-10-14T18:13:50Z BSEQ0009833