2669 kappa-Atracotoxin (Hadronyche versuta) Atracotoxins are a peptide toxins produced by funnel web spiders (family Hexathelidae). kappa-Atracotoxins inhibit insect voltage-gated potassium channels. (T170, L1812) 3685.155000000001 Clear solution. >10 mg/mL Injection (sting/bite) (L1812) kappa-Atracotoxins inhibit insect voltage-gated potassium channels. (T170, L1812) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Atracotoxins are a peptide toxins produced by funnel web spiders (family Hexathelidae). (L1812) Death from funnel web spider bites can result from progressive hypotension or possibly raised intracranial pressure resulting from cerebral oedema. (L1036) The bites of funnel-web spiders may cause tingling around the mouth and tongue, facial muscle twitching, nausea, vomiting, profuse sweating, salivation, and shortness of breath. Patients may also rapidly develop agitation, confusion and coma associated with hypertension, metabolic acidosis, dilation of the pupils, generalised muscle twitching and pulmonary oedema. (L1036) First aid for funnel-web bites consists of applying a pressure immobilization bandage to slow venom movement. Further supportive care may be necessary, but the mainstay of treatment is antivenom. (L1036) 2009-07-06T21:35:30Z 2014-12-24T20:25:47Z P82227 kappa-Atracotoxin true Exogenous Liquid 1dl0_asym_r_500.jpg image/jpeg 33729 2014-10-14T18:13:49Z BSEQ0008498