2668 mu-Agatoxin Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders, in particular the North American funnel-web spider (Agelenopsis aperta), after which agatoxins are named. mu-Agatoxins are C-terminally amidated peptides that consist of 35-37 amino acids and are constrained by four intramolecular disulfide bonds. They modify presynaptic voltage-activated sodium channels in the neuromuscular joints of insects. (L1024) 120500-28-9 4272.715 Clear solution. >10 mg/mL Injection (sting/bite) (L1812) mu-Agatoxins modify presynaptic voltage-activated sodium channels in the neuromuscular joints of insects. Modifying sodium channels leads to an increased sensitivity of these channels, resulting in increased frequency of spontaneous excitatory postsynaptic currents, neurotransmitter release, and repetitive action potentials of motor neurons. (L1024) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders, in particular the North American funnel-web spider (Agelenopsis aperta). (L1024) mu-Agatoxin causes a slow long-lasting paralysis. Death can result from progressive hypotension or possibly raised intracranial pressure resulting from cerebral oedema. (L1036, L1024) The bites of funnel-web spiders may cause tingling around the mouth and tongue, facial muscle twitching, nausea, vomiting, profuse sweating, salivation, and shortness of breath. Patients may also rapidly develop agitation, confusion and coma associated with hypertension, metabolic acidosis, dilation of the pupils, generalised muscle twitching and pulmonary oedema. (L1036) First aid for funnel-web bites consists of applying a pressure immobilization bandage to slow venom movement. Further supportive care may be necessary, but the mainstay of treatment is antivenom. (L1036) 2009-07-06T21:35:29Z 2014-12-24T20:25:47Z P11057 Agatoxin 1EIT true Exogenous Liquid 1eit_asym_r_500.jpg image/jpeg 27056 2014-10-14T18:13:48Z BSEQ0008497