2667 alpha-Agatoxin Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders, in particular the North American funnel-web spider (Agelenopsis aperta), after which agatoxins are named. alpha-Agatoxins are composed of polyamines which are attached to an aromatic moiety. They block the glutamate-activated receptor channels in the neuronal postsynaptic terminals of insects and mammals. (L1024) 128549-96-2 131007 C26H47N7O2 489.379120 White powder. Injection (sting/bite) (L1812) alpha-Agatoxins block the glutamate-activated receptor channels in the neuronal postsynaptic terminals of insects and mammals, preventing excitory junction potential from developing. (L1024) No indication of carcinogenicity to humans (not listed by IARC). Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders, in particular the North American funnel-web spider (Agelenopsis aperta). (L1024) alpha-Agatoxin causes a rapid reversible paralysis. Death can result from progressive hypotension or possibly raised intracranial pressure resulting from cerebral oedema. (L1024, L1036) The bites of funnel-web spiders may cause tingling around the mouth and tongue, facial muscle twitching, nausea, vomiting, profuse sweating, salivation, and shortness of breath. Patients may also rapidly develop agitation, confusion and coma associated with hypertension, metabolic acidosis, dilation of the pupils, generalised muscle twitching and pulmonary oedema. (L1036) First aid for funnel-web bites consists of applying a pressure immobilization bandage to slow venom movement. Further supportive care may be necessary, but the mainstay of treatment is antivenom. (L1036) 2009-07-06T21:35:29Z 2014-12-24T20:25:47Z alpha-Agatoxin true NCCCNCCCCNCCCNCCCN(O)CCCNC(=O)CC1=CNC2=CC=CC=C12 C26H47N7O2 InChI=1S/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34) InChIKey=LIURIBSBVUMOJS-UHFFFAOYSA-N 489.6971 489.379123783 Exogenous Solid 115840