2666 Lopap Lopap is a toxin produced by the caterpillars of the Lonomia moths (especially the species Lonomia obliqua). It is an anticoagulant and is being researched for pharmaceutical purposes. (L1020) 22432.279999999973 Clear solution. >10 mg/mL Dermal (L1020) Lopap activates thrombin by cleavage of prothrombin, causing thrombus formation, fibrinogen depletion, uncoagulable blood, decreased platelet count, inhibition of collagen-induced platelet aggregation, leukocyte infiltration in lungs, congestion and haemorrhage in renal glomeruli and necrosis in renal distal tubules. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Lopap is a toxin produced by the caterpillars of the Lonomia moths (especially the species Lonomia obliqua). It is an anticoagulant and is being researched for pharmaceutical purposes. (L1020) Contact with Lonomia venom can cause massive internal haemorrhaging, kidney failure, and destruction of blood cells (haemolysis). This resulting medical syndrome is sometimes called Lonomiasis. (L1020) Contact with Lonomia venom can cause massive internal haemorrhaging, kidney failure, and destruction of blood cells (haemolysis). This resulting medical syndrome is sometimes called Lonomiasis. (L1020) An antivenom exists for Lonomia poisoning. (L1044) 2009-07-06T21:35:28Z 2014-12-24T20:25:47Z Q5ECE3 true Exogenous Liquid BSEQ0008496