2665 Melittin (Apis mellifera) Melittin is the main component of bee venom. It is a powerful stimulator of phospholipase A2 and also exhibits potent anti-microbial activity. (L1014) 20449-79-0 16129627 7584.7750000000015 Clear solution. >10 mg/mL Injection (sting/bite) (L1811) Melittin has strong haemolytic activity. It integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. Melittin inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase, and increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. (A608) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 6.00 mg/kg (Intravenous, Mouse) (A686) No indication of carcinogenicity to humans (not listed by IARC). Melittin is the main component of bee venom. (L1014) Melittin poisoning may cause development of optic neuritis and atrophy. Serious cases may lead to atrial fibrillation, cerebral infarction, acute myocardial infarction, Fisher's syndrome, Guillain-Barre syndrome, claw hand caused by Ulnar nerve entrapment, and haemorrhaging in the lungs. (L1012) Melittin poisoning is characterized by burning or stinging pain, swelling, and redness at the site of the bee sting, and may be followed by swelling of the tongue and throat, difficulty breathing, and shock. (L1012) 2009-07-06T21:35:27Z 2014-12-24T20:25:47Z P01501 C11198 25520 Melittin 1BH1 true Exogenous Liquid 17286438 2mlt_bio_r_500.jpg image/jpeg 31684 2014-10-14T18:13:46Z BSEQ0008495