2655 Leukocidin F Leukocidin F is a cytotoxin produced by Staphylococcus aureus. The presence of leukocidins is associated with increased virulence of certain strains (isolates) of Staphylococcus aureus. (L1779) 147096-70-6 36566.729999999996 Clear solution. >10 mg/mL Ingestion (L1816) ; inhalation (L1816) ; dermal (L1816) Leukocidin S and leukocidin F act together as subunits, assembling in the membrane of host defense cells, particularly white blood cells, monocytes and macrophages. The subunits fit together and form a ring with a central pore through which cell contents leak and which acts as a superantigen. (L1779) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Leukocidin F is a cytotoxin produced by Staphylococcus aureus. (L1779) Leukocidin F is a cytotoxin produced by Staphylococcus aureus. The presence of leukocidins is associated with increased virulence of certain strains (isolates) of Staphylococcus aureus, and it is the cause of necrotic lesions involving the skin or mucosa, including necrotic hemorrhagic pneumonia. (L1779) Staphylococcus aureus is the most common cause of staph infections. It can also cause a range of illnesses from minor skin infections, such as pimples, impetigo, boils, cellulitis folliculitis, carbuncles, scalded skin syndrome, and abscesses, to life-threatening diseases such as pneumonia, meningitis, osteomyelitis, endocarditis, Toxic shock syndrome (TSS), and septicemia. (L1734, L1773) The treatment of choice for S. aureus infection is penicillin, but in most countries, penicillin-resistance is extremely common and first-line therapy is most commonly a penicillinase-resistant penicillin (for example, oxacillin or flucloxacillin). Combination therapy with gentamicin may be used to treat serious infections like endocarditis, but its use is controversial because of the high risk of damage to the kidneys. The duration of treatment depends on the site of infection and on severity. (L1773) 2009-07-06T18:11:33Z 2014-12-24T20:25:46Z P31715 Leukocidin F true Exogenous Liquid 2lkf_bio_r_500.jpg image/jpeg 41188 2014-10-14T18:13:41Z BSEQ0008490