2651 Alpha-hemolysin Alpha-hemolysin is the major cytotoxic agent released by bacterium Staphylococcus aureus. (L1734) 94716-94-6 35904.06999999995 Clear solution. >10 mg/mL Ingestion (L1816) ; inhalation (L1816) ; dermal (L1816) Alpha-hemolysin consists mainly of beta-sheets forms heptameric units on the cellular membrane, producing a complete beta-barrel pore. This pore allows the exchange of monovalent ions, resulting in DNA fragmentation and eventually apoptosis. (L1734) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 40-60 ng/kg (Intravenous, Mouse) (A2855) No indication of carcinogenicity to humans (not listed by IARC). Alpha-hemolysin is the major cytotoxic agent released by bacterium Staphylococcus aureus. (L1734) Alpha-toxin is a potent cytotoxin produced by Staphylococcus aureus. Staphylococcus aureus is the most common cause of staph infections. It can also cause a range of illnesses from minor skin infections, such as pimples, impetigo, boils, cellulitis folliculitis, carbuncles, scalded skin syndrome, and abscesses, to life-threatening diseases such as pneumonia, meningitis, osteomyelitis, endocarditis, Toxic shock syndrome (TSS), and septicemia. (L1734, L1773) Staphylococcus aureus is the most common cause of staph infections. It can also cause a range of illnesses from minor skin infections, such as pimples, impetigo, boils, cellulitis folliculitis, carbuncles, scalded skin syndrome, and abscesses, to life-threatening diseases such as pneumonia, meningitis, osteomyelitis, endocarditis, Toxic shock syndrome (TSS), and septicemia. (L1734, L1773) The treatment of choice for S. aureus infection is penicillin, but in most countries, penicillin-resistance is extremely common and first-line therapy is most commonly a penicillinase-resistant penicillin (for example, oxacillin or flucloxacillin). Combination therapy with gentamicin may be used to treat serious infections like endocarditis, but its use is controversial because of the high risk of damage to the kidneys. The duration of treatment depends on the site of infection and on severity. (L1773) 2009-07-06T18:11:31Z 2014-12-24T20:25:46Z P09616 Alpha-hemolysin 3M2L true Exogenous Liquid 3m2l_bio_r_500.jpg image/jpeg 87925 2014-10-14T18:13:38Z BSEQ0008487