2648 Exotoxin A (Pseudomonas aeruginosa) Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. (L1784) 69283.3449999998 Clear solution. >10 mg/mL Ingestion (L1816) ; inhalation (L1816) ; dermal (L1816) Pseudomonas exotoxin has exactly the same mechanism of action as the diphtheria toxin; it causes the ADP ribosylation of eucaryotic elongation factor 2 resulting in inhibition of protein synthesis in the affected cell. Although it is partially-identical to diphtheria toxin, it is antigenically-distinct. It utilizes a different receptor on host cells than diphtheria toxin, but otherwise it enters cells in the same manner and has the exact enzymatic mechanism. (L1785) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 3 ug/mg (Intravenous, Mouse) (A2855) No indication of carcinogenicity to humans (not listed by IARC). Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. (L1784) Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Pseudomonas aeruginosa can infect damaged tissues or people with reduced immunity. If such colonisations occur in critical body organs such as the lungs, the urinary tract, and kidneys, the results can be fatal. (L1784) Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Pseudomonas aeruginosa can infect damaged tissues or people with reduced immunity. The symptoms of such infections are generalised inflammation and sepsis. (L1784) 2009-07-06T18:11:30Z 2014-12-24T20:25:46Z http://en.wikipedia.org/wiki/Pseudomonas_exotoxin P11439 Pseudomonas exotoxin 1AER true Exogenous Liquid 1aer_bio_r_500.jpg image/jpeg 58663 2014-10-14T18:13:37Z BSEQ0003703