2647 Dermonecrotic toxin (Pasteurella multocida) Pasteurella multocida toxin (PMT) is the major pathogenic deteriment of Pasteurella multocida. Pasteurella multocida can cause a zoonotic infection in humans, which typically is a result of bites or scratches from domestic pets. (L1742) 146382.00000000044 Clear solution. >10 mg/mL Ingestion (L1816) ; inhalation (L1816) ; dermal (L1816) Stimulation of several signalling pathways is induced by PMT. Most remarkable is a potent mitogenic effect. Phospholipase C-beta and the small GTPase Rho are activated due to stimulation of heterotrimeric G proteins of the Galpha(q), Galpha(i), and Galpha(12/13) families. (A2701) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Pasteurella multocida toxin (PMT) is the major pathogenic deteriment of Pasteurella multocida. (L1742) Pasteurella multocida toxin (PMT) is the major pathogenic deteriment of Pasteurella multocida. Pasteurella multocida can cause a zoonotic infection in humans, which typically is a result of bites or scratches from domestic pets. This causes an inflammatory reaction at the infection site (generally a diffuse localized cellulitis). It can also infect other locales, such as the respiratory tract. In more serious cases, a bacteremia can result, causing an osteomyelitis or endocarditis. The bacteria may also cross the blood-brain barrier and cause a meningitis. (L1742) Pasteurella multocida can cause a zoonotic infection in humans, which causes an inflammatory reaction at the infection site (generally a diffuse localized cellulitis). It can also infect other locales, such as the respiratory tract. In more serious cases, a bacteremia can result, causing an osteomyelitis or endocarditis. The bacteria may also cross the blood-brain barrier and cause a meningitis. (L1742) This bacterium can be effectively treated with beta-lactam antibiotics, which inhibit cell wall synthesis. It can also be treated with fluoroquinolones or tetracyclines; fluoroquinolones inhibit bacterial DNA synthesis and tetracyclines interfere with protein synthesis by binding to the bacterial 30S ribosomal subunit. Because P. multocida is most often acquired as a result of a bite (notably dog), infections are frequently polymicrobial and involve anaerobic bacteria. As a result, amoxicillin-clavulanate (a beta-lactamase inhibitor/penicillin combination) is seen as the treatment of choice. (L1742) 2009-07-06T18:11:29Z 2014-12-24T20:25:46Z P17452 Dermonecrotic toxin 2EBF true Exogenous Liquid 2ebf_bio_r_500.jpg image/jpeg 64812 2014-10-14T18:13:36Z BSEQ0008485