2641 Heat-labile enterotoxin (Escherichia coli) Heat-labile enterotoxin is a type of labile toxin found in Escherichia coli. This toxin is responsible for many cases of a mild type of food poisoning. (L1736) 35330.13999999994 Clear solution. >10 mg/mL Ingestion (L1816) ; inhalation (L1816) ; dermal (L1816) Through ADP-ribosylation of a G-protein, heat-labile enterotoxin stimulates adenylate cyclase leading to increased cAMP in epithelial cells. Elevated cAMP levels stimulate secretion of Chlorine ions and water from the enterocyte into the gut lumen, thus causing watery diarrhea. (L1736, A2696) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 250 ug/kg (Intravenous, Mouse) (A2855) No indication of carcinogenicity to humans (not listed by IARC). Heat-labile enterotoxin is a type of labile toxin found in Escherichia coli. (L1736) Heat-labile enterotoxin is responsible for many cases of a mild type of food poisoning. However, certain virulent strains of E. coli can cause gastroenteritis, urinary tract infections, and neonatal meningitis. In rarer cases, virulent strains are also responsible for hemolytic-uremic syndrome (HUS), peritonitis, mastitis, septicemia and Gram-negative pneumonia. (L1736) The major symptom of heat-labile enterotoxin food poisoning is diarrhea. (L1737) Antibiotics which may be used to treat E. coli infection include amoxicillin as well as other semi-synthetic penicillins, many cephalosporins, carbapenems, aztreonam, trimethoprim-sulfamethoxazole, ciprofloxacin, nitrofurantoin and the aminoglycosides. (L1737) 2009-07-06T18:11:26Z 2014-12-24T20:25:45Z P01558 Heat-labile enterotoxin 2QUO true Exogenous Liquid 1htl_bio_r_500.jpg image/jpeg 52287 2014-10-14T18:13:32Z BSEQ0008482