2631 Calitoxin Calitoxin is a peptide neurotoxin produced by the Sea anemone (Calliactis parasitica). It acts on the voltage-gated sodium channels of nerve cells. (L1117) 118354-83-9 8727.96 Clear solution. >10 mg/mL Injection (sting/bite) (L1815) Calitoxin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of mammalian cardiac muscle contraction. It also increased neurotransmitter release, causing repetitive firing of the axons. (L1117, T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Calitoxin is a peptide neurotoxin produced by the Sea anemone (Calliactis parasitica). (L1117) Calitoxin is neurotoxic and cardiotoxic. (L1117, T170) Sea anemone neurotoxin causes paralysis of its prey. (L1820) 2009-07-05T17:25:25Z 2014-12-24T20:25:44Z P14531 Calitoxin true Exogenous Liquid BSEQ0008475