2621 Mastoparan (Vespa tropica) Mastoparan is a peptide toxin produced from the venom of the hornet (Vespa analis). (T170) 72093-21-1 1625.0550000000003 Clear solution. >10 mg/mL Injection (sting/bite) (L1811) Mastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the release serotonin and catecholamines occurs, respectively. Mastoporan activity in the anterior pituitary gland leads to prolactin release. It is believed to stimate the release of these substance by mimicking receptors and activating G proteins. (L1719, A2695) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Mastoparan is a peptide toxin produced from the venom of the hornet (Vespa analis). (T170) Mastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the release serotonin and catecholamines occurs, respectively. Mastoporan activity in the anterior pituitary gland leads to prolactin release. (L1719) Hornet stings are painful and may cause allergic reactions in some individuals. (L1821) 2009-07-05T17:25:09Z 2014-12-24T20:25:43Z P0C1Q6 Mastoparan true Exogenous Liquid 1d7n_asym_r_500.jpg image/jpeg 22055 2014-10-14T18:13:20Z BSEQ0008469