2592 Saxitoxin Saxitoxin is a paralytic poison from Alaska butter clams (<i>Saxidomus giganteus</i>), toxic mussels (<i>Mytilus californianus</i>), the plankton <i>Gonyaulax cantenella</i> and <i>Protogonyaulax tamarensis</i>. Ingestion of saxitoxin (usually through shellfish contaminated by toxic algal blooms) is responsible for the human illness known as paralytic shellfish poisoning. Saxitoxin (STX) is a neurotoxin naturally produced by certain species of marine dinoflagellates (<i>Alexandrium sp.</i>, <i>Gymnodinium sp.</i>, <i>Pyrodinium sp.</i>) and cyanobacteria (<i>Anabaena sp.</i>, some <i>Aphanizomenon</i> species, <i>Cylindrospermopsis sp.</i>, <i>Lyngbya sp.</i>, <i>Planktothrix sp.</i>). (Wikipedia) Saxitoxin has been shown to exhibit emetic function (A7817). 35523-89-8 37165 C10H17N7O4 299.134200 White powder. Injection (sting/bite) (L1815) Saxitoxin blocks voltage-gated sodium channels of nerve cells. (L1115) No indication of carcinogenicity to humans (not listed by IARC). Saxitoxin is naturally produced by certain species of marine dinoflagellates (genus Alexandrium, Gymnodinium, Pyrodinium) and cyanobacteria (genus Anabaena, Aphanizomenon, Cylindrospermopsis, Lyngbya, Planktothrix). It is found in puffer fish and shellfish and is responsible for the human illness known as paralytic shellfish poisoning (PSP). (L1115) Saxitoxin is a neurotoxin. It causes a syndrome known as paralytic shellfish poisoning, which produces paralysis and may be fatal due to respiratory failure in extreme cases. (L1115) Ingestion of shellfish containing saxitoxin causes a syndrome known as paralytic shellfish poisoning. Symptoms include nausea, vomiting, diarrhoea, abdominal pain, and tingling or burning lips, gums, tongue, face, neck, arms, legs, and toes. Shortness of breath, dry mouth, a choking feeling, confused or slurred speech, and lack of coordination are also possible. (L1115, L1116) 2009-07-03T22:19:21Z 2014-12-24T20:25:41Z http://en.wikipedia.org/wiki/Saxitoxin C13757 610951 D012530 Saxitoxin true OC(=N)OCC1NC(=N)N2CCC(O)(O)C22NC(=N)NC12 C10H17N7O4 InChI=1/C10H17N7O4/c11-6-15-5-4(3-21-8(13)18)14-7(12)17-2-1-9(19,20)10(5,17)16-6/h4-5,19-20H,1-3H2,(H2,12,14)(H2,13,18)(H3,11,15,16) InChIKey=RPQXVSUAYFXFJA-UHFFFAOYNA-N 299.2865 299.134202067 Exogenous Solid HMDB29368 34106