2588 Taicatoxin Taicatoxin is a peptide toxin produced by the Australian taipan (Oxyuranus scutellatus scutellatus). It acts on the voltage-dependent L-type calcium channels from the heart, and on the small conductance calcium-activated potassium channels in the brain. (L1105) 112154-17-3 9711.255 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Taicatoxin blocks the voltage-dependent L-type calcium channels from the heart and on the small conductance calcium-activated potassium channels in the brain. (L1105) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.106 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 0.013 mg/kg (Intravenous, Mouse) (L1830) Ld50: 0.009 mg/kg (Intraperitoneal, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Taicatoxin is a peptide toxin produced by the Australian taipan (Oxyuranus scutellatus scutellatus). (L1105) Taicatoxin blocks the calcium currents in heart cells and may evoke severe arrhythmias. (L1105) Bites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (T156) An antivenom exists for taipan venom. (L1044) 2009-07-03T22:19:20Z 2014-12-24T20:25:41Z http://en.wikipedia.org/wiki/Taicatoxin Q7LZE4 true Exogenous Liquid BSEQ0008466